Mitochondria apoptosis pathway synergistically activated by hierarchical targeted nanoparticles co-delivering siRNA and lonidamine

Biomaterials

Volumn 61, Issue , 2015, Pages 178-189

  Zhang, Bing Feng ^a,b   Xing, Lei ^a   Cui, Peng Fei ^a   Wang, Feng Zhen ^a   Xie, Rong Lin ^a   Zhang, Jia Liang ^a   Zhang, Mei ^a   He, Yu Jing ^a   Lyu, Jin Yuan ^a   Qiao, Jian Bin ^a   Chen, Bao An ^c   Jiang, Hu Lin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b YICHUN UNIVERSITY   (China)

^c AFFILIATED ZHONGDA HOSPITAL OF SOUTHEAST UNIVERSITY   (China)

Author keywords

Co delivery; Hierarchical targeting; Lonidamine; Mitochondria apoptosis pathway; Multifunctional nanoparticle; SiRNA

Indexed keywords

CARBOXYLIC ACIDS; CELL DEATH; CHEMOTHERAPY; CONTROLLED DRUG DELIVERY; DISEASES; MITOCHONDRIA; NANOPARTICLES; ONCOLOGY; POLYETHYLENES; PROTEINS; TUMORS;

APOPTOSIS PATHWAYS; CO DELIVERIES; HIERARCHICAL TARGETING; LONIDAMINE; MULTI-FUNCTIONAL NANOPARTICLES; SIRNA;

TARGETED DRUG DELIVERY;

CASPASE 3; CASPASE 9; CHITOSAN; CYTOCHROME C; FOLIC ACID; LONIDAMINE; MACROGOL; NANOPARTICLE; POLYACRYLIC ACID; POLYETHYLENEIMINE; PROTEIN BAX; PROTEIN BCL 2; SMALL INTERFERING RNA; TRIPHENYLPHOSPHINE; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; INDAZOLE DERIVATIVE; MITOCHONDRIAL PROTEIN; NANOCAPSULE;

APOPTOSIS; ARTICLE; BIOCOMPATIBILITY; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DOWN REGULATION; DRUG STABILITY; ENDOCYTOSIS; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE SILENCING; HELA CELL LINE; IN VITRO STUDY; LYMPHATIC DRAINAGE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; SURFACE CHARGE; TRANSMISSION ELECTRON MICROSCOPY; TUMOR MICROENVIRONMENT; ULTRAVIOLET SPECTROPHOTOMETRY; WESTERN BLOTTING; ZETA POTENTIAL; CHEMISTRY; DIFFUSION; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; ULTRASTRUCTURE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; DIFFUSION; HELA CELLS; HUMANS; INDAZOLES; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NANOCAPSULES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 84939186307     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.05.027     Document Type: Article

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