TGFβ-activated kinase 1 (TAK1) inhibition by 5Z-7-oxozeaenol attenuates early brain injury after experimental subarachnoid hemorrhage

Journal of Biological Chemistry

Volumn 290, Issue 32, 2015, Pages 19900-19909

  Zhang, Dingding ^a   Yan, Huiying ^a   Li, Hua ^a   Hao, Shuangying ^b   Zhuang, Zong ^a   Liu, Ming ^c   Sun, Qing ^a   Yang, Yiqing ^a   Zhou, Mengliang ^a   Li, Kuanyu ^b   Hang, Chunhua ^a,c  

^a NANJING UNIVERSITY   (China)

^b MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; ENZYMES; PHOSPHORYLATION;

CELLULAR SIGNALING; EXPRESSION LEVELS; MITOGEN ACTIVATED PROTEIN KINASE; MOLECULAR TARGETS; NEUROLOGICAL DEFICIT; NUCLEAR TRANSLOCATIONS; SIGNALING PATHWAYS; SUBARACHNOID HEMORRHAGES;

ENZYME ACTIVITY;

7 OXOZEAENOL; ENZYME INHIBITOR; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; SYNAPTOTAGMIN I; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; UNCLASSIFIED DRUG; 5-7-OXO-ZEAENOL; MAP KINASE KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUROPROTECTIVE AGENT; NF-KAPPAB INHIBITOR ALPHA; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN KINASE INHIBITOR; RELA PROTEIN, RAT; TRANSCRIPTION FACTOR RELA; ZEARALENONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN INJURY; BRAIN LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SUBARACHNOID HEMORRHAGE; TEMPORAL LOBE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CEREBROVASCULAR TRAUMA; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; METABOLISM; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; SPRAGUE DAWLEY RAT; STEREOTACTIC PROCEDURE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; CEREBROVASCULAR TRAUMA; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; I-KAPPA B PROTEINS; INJECTIONS, INTRAVENTRICULAR; MALE; MAP KINASE KINASE 4; MAP KINASE KINASE KINASES; NEURONS; NEUROPROTECTIVE AGENTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STEREOTAXIC TECHNIQUES; SUBARACHNOID HEMORRHAGE; TRANSCRIPTION FACTOR RELA; ZEARALENONE;

EID: 84939130289     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.636795     Document Type: Article

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