Inhibition of Rho kinase by hydroxyfasudil attenuates brain edema after subarachnoid hemorrhage in rats

Neurochemistry International

Volumn 60, Issue 3, 2012, Pages 327-333

  Fujii, Mutsumi ^a   Duris, Kamil ^a   Altay, Orhan ^a   Soejima, Yoshiteru ^a   Sherchan, Prativa ^a   Zhang, John H ^a,b  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOMA LINDA UNIVERSITY   (United States)

Author keywords

Brain edema; Early brain injury; Hydroxyfasudil; Rho kinase inhibitor; Subarachnoid hemorrhage; Tight junction

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; BRAIN PROTEIN; EVANS BLUE; HYDROXYFASUDIL; OCCLUDIN; PROTEIN ZO1; RHO KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN INJURY; BRAIN WATER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; HEMISPHERE; MALE; NEUROLOGIC EXAMINATION; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; SUBARACHNOID HEMORRHAGE; WESTERN BLOTTING;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; AMIDES; ANIMALS; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; BODY WATER; BRAIN CHEMISTRY; BRAIN EDEMA; ENZYME INHIBITORS; FUNCTIONAL LATERALITY; MALE; MEMBRANE PROTEINS; NEUROSURGICAL PROCEDURES; OCCLUDIN; PHOSPHOPROTEINS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES; SUBARACHNOID HEMORRHAGE; TIGHT JUNCTIONS; TREATMENT OUTCOME; ZONULA OCCLUDENS-1 PROTEIN;

RATTUS;

EID: 84862820421     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2011.12.014     Document Type: Article

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