Metabolomics analysis reveals that AICAR affects glycerolipid, ceramide and nucleotide synthesis pathways in INS-1 cells

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Elazzouny, Mahmoud A ^a,b   Evans, Charles R ^b   Burant, Charles F ^b   Kennedy, Robert T ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACYL COENZYME A; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CARBON 13; CERAMIDE; DIACYLGLYCEROL; FARNESYL DIPHOSPHATE; GLUCOSE; GLYCEROLIPID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; AICA RIBONUCLEOTIDE; ANTIDIABETIC AGENT; CARBON; INSULIN; ISOPRENOID PHOSPHATE; MALONYL COENZYME A; RIBONUCLEOTIDE; SESQUITERPENE;

ARTICLE; CELL PROTECTION; CELL STIMULATION; CELL SURVIVAL; DRUG EFFECT; ENZYME ACTIVATION; GLUCOSE TRANSPORT; INS 1 CELL LINE; INSULIN RELEASE; ISOTOPE LABELING; LIPOGENESIS; LIPOTOXICITY; METABOLITE; METABOLOMICS; NUCLEOTIDE METABOLISM; PANCREAS ISLET BETA CELL; PURINE METABOLISM; PYRIMIDINE METABOLISM; ANALOGS AND DERIVATIVES; ANIMAL; CELL LINE; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; RAT; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

ACYL COENZYME A; AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CARBON ISOTOPES; CELL LINE; CERAMIDES; DIGLYCERIDES; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GLUCOSE; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; MALONYL COENZYME A; METABOLIC NETWORKS AND PATHWAYS; METABOLOMICS; POLYISOPRENYL PHOSPHATES; RATS; RIBONUCLEOTIDES; SESQUITERPENES; SIGNAL TRANSDUCTION;

EID: 84939126896     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0129029     Document Type: Article

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