Metabolomics identifies pyrimidine starvation as the mechanism of 5-aminoimidazole-4-carboxamide-1-β-riboside-induced apoptosis in multiple myeloma cells

Molecular Cancer Therapeutics

Volumn 12, Issue 7, 2013, Pages 1310-1321

  Bardeleben, Carolyne ^a   Sharma, Sanjai ^a   Reeve, Joseph R ^c   Bassilian, Sara ^c   Frost, Patrick ^a   Hoang, Bao ^a   Shi, Yijiang ^a   Lichtenstein, Alan ^a,b  

^a Greater Los Angeles VA Healthcare Center   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINOIMIDAZOLE 4 CARBOXAMIDE 1 BETA RIBOSIDE; 5 PHOSPHORIBOSYL ALPHA PYROPHOSPHATE; ANTINEOPLASTIC AGENT; DNA; OROTIC ACID; PYRIMIDINE; PYROPHOSPHORIC ACID DERIVATIVE; RIBOSE; SYNTHETASE; UNCLASSIFIED DRUG; URIDINE MONOPHOSPHATE SYNTHETASE; URIDINE PHOSPHATE;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; DRUG MECHANISM; HUMAN; HUMAN CELL; IN VITRO STUDY; METABOLOMICS; MULTIPLE MYELOMA; PRIORITY JOURNAL;

EID: 84880069843     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-12-1042     Document Type: Article

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