The Interplay of Disulfide Bonds, α-Helicity, and Hydrophobic Interactions Leads to Ultrahigh Proteolytic Stability of Peptides

Biomacromolecules

Volumn 16, Issue 8, 2015, Pages 2347-2355

  Chen, Yaqi ^a   Yang, Chaoqiong ^a   Li, Tao ^a   Zhang, Miao ^a   Liu, Yang ^a   Gauthier, Marc A ^b   Zhao, Yibing ^a   Wu, Chuanliu ^a  

^a XIAMEN UNIVERSITY   (China)

^b INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COVALENT BONDS; HYDROPHOBICITY; IONS; PROTEINS; STABILITY; SULFUR COMPOUNDS;

HELICAL CONFORMATION; HYDROPHOBIC INTERACTIONS; NATURALLY OCCURRING; NON-COVALENT INTERACTION; PEPTIDE THERAPEUTICS; PROTEOLYTIC RESISTANCE; PROTEOLYTIC STABILITY; THERAPEUTIC PEPTIDES;

PEPTIDES;

ACID PROTEINASE; CHYMOTRYPSIN; CYSTEINE; DIMER; DISULFIDE; HOMODIMER; MONOMER; PEPTIDE; PEPTIDE FRAGMENT; PHENYLALANINE; PROTEIN MDM2; PROTEIN MDMX; PROTEIN P53; RIBONUCLEASE A; TRYPSIN; TRYPTOPHAN; TYROSINE; PANCREATIC RIBONUCLEASE; PROTEIN;

AMINO ACID SEQUENCE; AQUEOUS SOLUTION; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DIMERIZATION; DISULFIDE BOND; FLUORESCENCE POLARIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; QUANTITATIVE ANALYSIS; ANTAGONISTS AND INHIBITORS; CHEMICAL PHENOMENA; CHEMISTRY;

AMINO ACID SEQUENCE; CIRCULAR DICHROISM; DIMERIZATION; DISULFIDES; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; PROTEINS; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-MDM2; RIBONUCLEASE, PANCREATIC;

EID: 84938921989     PISSN: 15257797     EISSN: 15264602     Source Type: Journal    
DOI: 10.1021/acs.biomac.5b00567     Document Type: Article

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