Apoptosis inducing, conformationally constrained, dimeric peptide analogs of KLA with submicromolar cell penetrating abilities

Biomacromolecules

Volumn 15, Issue 10, 2014, Pages 3746-3752

  Hyun, Soonsil ^a   Lee, Seonju ^a   Kim, Seoyeon ^a   Jang, Sangmok ^a   Yu, Jaehoon ^a   Lee, Yan ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CELL MEMBRANES; COVALENT BONDS; DIMERS; MITOCHONDRIA;

CASPASE ACTIVATION; CELL-PENETRATING PEPTIDE; EUKARYOTIC CELLS; INTERMOLECULAR DISULFIDE BOND; MICROMOLAR CONCENTRATION; MITOCHONDRIAL MEMBRANES; REDUCTIVE CLEAVAGE; SUBMICROMOLAR CONCENTRATIONS;

PEPTIDES;

CASPASE 3; CELL PENETRATING PEPTIDE; CYSTEINE; CYTOCHROME C; DIMER; DIMER B; KLA PEPTIDE DERIVATIVE; MONOMER; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG; KLA PEPTIDE; PEPTIDE;

APOPTOSIS; ARTICLE; BLOOD LEVEL; CELL ACTIVITY; CELL FUNCTION; CELL MEMBRANE DEPOLARIZATION; CELL TRANSPORT; CONCENTRATION PROCESS; DIMERIZATION; DISULFIDE BOND; ENZYME ACTIVATION; EUKARYOTIC CELL; FEMALE; FLUORESCENCE ANALYSIS; HELA CELL LINE; HUMAN; HUMAN TISSUE; HYDROPHOBICITY; INTERNALIZATION; LD 50; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; PEPTIDE SYNTHESIS; CONFORMATION; METABOLISM; MITOCHONDRION; PHYSIOLOGY; TUMOR CELL LINE;

APOPTOSIS; CELL LINE, TUMOR; CELL-PENETRATING PEPTIDES; DIMERIZATION; HELA CELLS; HUMANS; MITOCHONDRIA; MOLECULAR CONFORMATION; PEPTIDES;

EID: 84907990376     PISSN: 15257797     EISSN: 15264602     Source Type: Journal    
DOI: 10.1021/bm501026e     Document Type: Article

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