Esculetin reverses histone H2A/H2B ubiquitination, H3 dimethylation, acetylation and phosphorylation in preventing type 2 diabetic cardiomyopathy

Journal of Functional Foods

Volumn 17, Issue , 2015, Pages 127-136

  Kadakol, Almesh ^a   Malek, Vajir ^a   Goru, Santosh Kumar ^a   Pandey, Anuradha ^a   Gaikwad, Anil Bhanudas ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Diabetic cardiomyopathy; Epigenetics; Esculetin; Histone H3 and H2 modifications

Indexed keywords

RATTUS;

EID: 84938864455     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2015.05.017     Document Type: Article

References (36)

1. Asrih M., Steffens S. Emerging role of epigenetics and miRNA in diabetic cardiomyopathy. Cardiovascular Pathology 2013, 22(2):117-125.
2. Awad S., Kunhi M., Little G.H., Bai Y., An W., Bers D., Kedes L., Poizat C. Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy. Nucleic Acids Research 2013, 41:7656-7672.
3. Backs J., Olson E.N. Control of cardiac growth by histone acetylation/deacetylation. Circulation Research 2006, 98(1):15-24.
4. Cooper M.E., El-Osta A. Epigenetics mechanisms and implications for diabetic complications. Circulation Research 2010, 107(12):1403-1413.
5. Ernst J., Kheradpour P., Mikkelsen T.S., Shoresh N., Ward L.D., Epstein C.B., Zhang X., Wang L., Issner R., Coyne M. Mapping and analysis of chromatin state dynamics in nine human cell types. Nature 2011, 473(7345):43-49.
6. Gaikwad A., Gupta J., Tikoo K. Epigenetic changes and alteration of Fbn1 and Col3A1 gene expression under hyperglycaemic and hyperinsulinaemic conditions. The Biochemical Journal 2010, 432:333-341.
7. Gaikwad A., Sayyed S.G., Lichtnekert J., Tikoo K., Anders H.-J. Renal failure increases cardiac histone h3 acetylation, dimethylation, and phosphorylation and the induction of cardiomyopathy-related genes in type 2 diabetes. American Journal of Pathology 2010, 176(3):1079-1083.
8. Gao C., Chen G., Liu L., Li X., He J., Jiang L., Zhu J., Xu Y. Impact of high glucose and proteasome inhibitor MG132 on histone H2A and H2B ubiquitination in rat glomerular mesangial cells. Journal of Diabetes Research 2013, 2013:1-10.
9. Hayden M.R., Sowers K.M., Pulakat L., Joginpally T., Krueger B., Whaley-Connell A., Sowers J.R. Possible mechanisms of local tissue renin-angiotensin system activation in the cardiorenal metabolic syndrome and type 2 diabetes mellitus. Cardiorenal Medicine 2011, 1(3):193-210.
10. Kadakol A., Malek V., Goru S.K., Pandey A., Bagal S., Gaikwad A.B. Esculetin attenuates alterations in ang II and Acetylcholine mediated vascular reactivity associated with hyperinsulinemia and hyperglycemia. Biochemical and Biophysical Research Communications 2015, 461(2):342-347.
11. Karpe P.A., Tikoo K. Heat shock prevents insulin resistance-induced vascular complications by augmenting angiotensin-(1-7) signaling. Diabetes 2014, 63(3):1124-1139.
12. Keating S., El Osta A. Epigenetic changes in diabetes. Clinical Genetics 2013, 84(1):1-10.
13. Kim Y., Lee J. Esculetin, a coumarin derivative, suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes. Journal of Functional Foods 2015, 12:509-515.
14. Kouzarides T. Chromatin modifications and their function. Cell 2007, 128(4):693-705.
15. Lee S.-Y., Lim T.-G., Chen H., Jung S.K., Lee H.-J., Lee M.-H., Kim D.J., Shin A., Lee K.W., Bode A.M. Esculetin suppresses proliferation of human colon cancer cells by directly targeting β-catenin. Cancer Prevention Research 2013, 6(12):1356-1364.
16. Mahmoud S.A., Poizat C. Epigenetics and chromatin remodeling in adult cardiomyopathy. The Journal of Pathology 2013, 231(2):147-157.
17. Morrish N., Wang S.-L., Stevens L., Fuller J., Keen H. Mortality and causes of death in the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia 2001, 44(2):S14-S21.
18. Okabe J., Orlowski C., Balcerczyk A., Tikellis C., Thomas M.C., Cooper M.E., El-Osta A. Distinguishing hyperglycemic changes by Set7 in vascular endothelial cells. Circulation Research 2012, 110(8):1067-1076.
19. Paneni F., Volpe M., Lüscher T.F., Cosentino F. SIRT1, p66Shc, and Set7/9 in vascular hyperglycemic memory bringing all the strands together. Diabetes 2013, 62(6):1800-1807.
20. Papait R., Cattaneo P., Kunderfranco P., Greco C., Carullo P., Guffanti A., Viganò V., Stirparo G.G., Latronico M.V., Hasenfuss G. Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy. Proceedings of the National Academy of Sciences of the United States of America 2013, 110(50):20164-20169.
21. Prabakaran D., Ashokkumar N. Antihyperglycemic effect of esculetin modulated carbohydrate metabolic enzymes activities in streptozotocin induced diabetic rats. Journal of Functional Foods 2012, 4(4):776-783.
22. Prabakaran D., Ashokkumar N. Protective effect of esculetin on hyperglycemia-mediated oxidative damage in the hepatic and renal tissues of experimental diabetic rats. Biochimie 2013, 95(2):366-373.
23. Reddy M.A., Natarajan R. Epigenetic mechanisms in diabetic vascular complications. Cardiovascular Research 2011, 90:421-429.
24. Reddy M.A., Sumanth P., Lanting L., Yuan H., Wang M., Mar D., Alpers C.E., Bomsztyk K., Natarajan R. Losartan reverses permissive epigenetic changes in renal glomeruli of diabetic db/db mice. Kidney International 2013, 85(2):362-373.
25. Reddy M.A., Villeneuve L.M., Wang M., Lanting L., Natarajan R. Role of the lysine-specific demethylase 1 in the proinflammatory phenotype of vascular smooth muscle cells of diabetic mice. Circulation Research 2008, 103(6):615-623.
26. Santos R.A., Ferreira A.J., Verano-Braga T., Bader M. Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: New players of the renin-angiotensin system. The Journal of Endocrinology 2013, 216(2):R1-R17.
27. Shahbazian M.D., Zhang K., Grunstein M. Histone H2B ubiquitylation controls processive methylation but not monomethylation by Dot1 and Set1. Molecular Cell 2005, 19(2):271-277.
28. Sim M.O., Lee H.I., Ham J.R., Seo K.I., Lee M.K. Long-term supplementation of esculetin ameliorates hepatosteatosis and insulin resistance partly by activating AdipoR2-AMPK pathway in diet-induced obese mice. Journal of Functional Foods 2015, 15:160-171.
29. Sun G., Reddy M.A., Yuan H., Lanting L., Kato M., Natarajan R. Epigenetic histone methylation modulates fibrotic gene expression. Journal of the American Society of Nephrology 2010, 21:2069-2080.
30. Surse V.M., Gupta J., Tikoo K. Esculetin induced changes in Mmp13 and Bmp6 gene expression and histone H3 modifications attenuate development of glomerulosclerosis in diabetic rats. Journal of Molecular Endocrinology 2011, 46(3):245-254.
31. Tikoo K., Patel G., Kumar S., Karpe P.A., Sanghavi M., Malek V., Srinivasan K. Tissue specific up regulation of ACE2 in rabbit model of atherosclerosis by atorvastatin: Role of epigenetic histone modifications. Biochemical Pharmacology 2015, 93:343-351.
32. Tomohiro N., Yasuko K., Sei-Itsu M. Inhibitory effect of esculetin on 5-lipoxygenase and leukotriene biosynthesis. Biochimica Et Biophysica Acta (bba) - Lipids And Lipid Metabolism 1983, 753(1):130-132.
33. Vlaming H., Welsem T., Graaf E.L., Ontoso D., Altelaar A., San-Segundo P.A., Heck A.J., Leeuwen F. Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo. EMBO Reports 2014, 15(10):1077-1084.
34. Wang Y., Wang Y., Luo M., Wu H., Kong L., Xin Y., Cui W., Zhao Y., Wang J., Liang G. Novel curcumin analog C66 prevents diabetic nephropathy via JNK pathway with the involvement of p300/CBP-mediated histone acetylation. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2015, 1852:34-46.
35. Yuan H., Reddy M.A., Sun G., Lanting L., Wang M., Kato M., Natarajan R. Involvement of p300/CBP and epigenetic histone acetylation in TGF-β1-mediated gene transcription in mesangial cells. American Journal Of Physiology-renal Physiology 2013, 304(5):F601-F613.
36. Yun E.-S., Park S.-S., Shin H.-C., Choi Y.H., Kim W.-J., Moon S.-K. p38 MAPK activation is required for esculetin-induced inhibition of vascular smooth muscle cells proliferation. Toxicology in Vitro: An International Journal Published in Association With BIBRA 2011, 25(7):1335-1342.