Tissue specific up regulation of ACE2 in rabbit model of atherosclerosis by atorvastatin: Role of epigenetic histone modifications

Biochemical Pharmacology

Volumn 93, Issue 3, 2015, Pages 343-351

  Tikoo, Kulbhushan ^a   Patel, Gaurang ^a   Kumar, Sandeep ^a   Karpe, Pinakin Arun ^a   Sanghavi, Maitri ^a   Malek, Vajir ^a   Srinivasan, K ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

ACE2; Atherosclerosis; Histone H3 acetylation

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN II; ATORVASTATIN; HISTONE H3; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; TRIACYLGLYCEROL; DIPEPTIDYL CARBOXYPEPTIDASE; HEPTANOIC ACID DERIVATIVE; HISTONE; PYRROLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL REACTIVITY; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEART; HISTONE ACETYLATION; HISTONE MODIFICATION; HISTONE PHOSPHORYLATION; KIDNEY; MALE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RABBIT MODEL; REAL TIME POLYMERASE CHAIN REACTION; THORACIC AORTA; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; WESTERN BLOTTING; ANIMAL; ATHEROSCLEROSIS; BIOSYNTHESIS; DISEASE MODEL; DRUG EFFECTS; GENETIC EPIGENESIS; GENETICS; METABOLISM; PHYSIOLOGY; RABBIT; TISSUE DISTRIBUTION;

ANIMALS; ATHEROSCLEROSIS; DISEASE MODELS, ANIMAL; EPIGENESIS, GENETIC; HEPTANOIC ACIDS; HISTONES; MALE; PEPTIDYL-DIPEPTIDASE A; PYRROLES; RABBITS; TISSUE DISTRIBUTION; UP-REGULATION;

EID: 84921872869     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.11.013     Document Type: Article

References (35)

1. Zhang C, Zhao YX, Zhang YH, Zhu L, Deng BP, Zhou ZL, et al. Angiotensin-converting enzyme 2 attenuates atherosclerotic lesions by targeting vascular cells. Proc Natl Acad Sci USA 2010;107:15886-91.
2. Doran DE, Weiss D, Zhang Y, Griendling KK, Taylor WR. Differential effects of AT1-receptor and Calcium channel blockade on atherosclerosis, inflammatory gene expression, and production of reactive oxygen species. Atherosclerosis 2007;195:39-47.
3. Lu H, Rateri DL, Feldman DL, Charnigo Jr RJ, Fukamizu A, Ishida J, et al. Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice. J Clin Investig 2008;118:984-93.
4. Santos RAS, Ferreira AJ, Simaes e Silva AC. Recent advances in the angiotensin converting enzyme 2- angiotensin-(1-7) Mas axis. Exp Physiol 2008;93:519-27.
5. Sluimer JC, Gasc JM, Hamming I, van Goor H, Michaud A, van den Akker LH, et al. Angiotensin converting enzyme 2 (ACE2) expression and activity in human carotid atherosclerotic lesions. J Pathol 2008;215:273-9.
6. Zulli A, Burrell LM, Widdop RE, Black MJ, Buxton BF, Hare DL. Immunolocalization of ACE2 and AT2 receptors in rabbit atherosclerotic plaques. J Histochem Cytochem 2006;54:147-50.
7. Dong B, Zhang C, Feng JB, Zhao YX, Li SY, Yang YP, et al. Overexpression of ACE2 enhances plaque stability in a rabbit model of atherosclerosis. Arterioscler Thromb Vasc Biol 2008;28:1270-6.
8. Lovren F, Pan Y, Quan A, Teoh H, Wang G, Shukla PC, et al. Angiotensin converting enzyme-2 (ACE2) confers endothelial protection and attenuates atherosclerosis, 295. 2008;p. H1377-84.
9. Thomas MC, Pickering RJ, Tsorotes D, Koitka A, Sheehy K, Bernardi S, et al. Genetic ACE2 deficiency accentuates vascular inflammation and atherosclerosis in the ApoE knockout mouse. Circ Res 2010;107:888-97.
10. Koka V, Huang XR, Chung ACK, Wang W, Truong LD, Lan HY. Angiotensin II upregulates angiotensin I-converting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway. Am J Pathol 2008;172:1174-83.
11. Zhang R, Wu Y, Zhao M, Liu C, Zhou L, Shen S, et al. Role of HIF-1alpha in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2009;297:L631-40.
12. Karpe PA, Tikoo K. Heat shock prevents insulin resistance induced vascular complications by augmenting angiotensin-(1-7) signalling. Diabetes 2014;63:1124-39.
13. Epelman S, Shrestha K, Troughton RW, Francis GS, Sen S, Klein AL, et al. Soluble angiotensin-converting enzyme 2 in human heart failure: relation with myocardial function and clinical outcomes. J Card Fail 2009;15:565-71.
14. Bogdarina I, Welham S, King PJ, Burns SP, Clark AJL. Epigenetic modification of the renin-angiotensin system in the fetal programming of hypertension. Circ Res 2007;100:520-6.
15. Lee H-A, Cho H-M, Lee D-Y, Kim K-C, Han HS, Kim IK. Tissue-specific upregulation of angiotensin-converting enzyme 1 in spontaneously hypertensive rats through histone code modifications. Hypertension 2012;59:621-6.
16. Karpe PA, Gupta J, Marthong RF, Ramarao P, Tikoo K. Insulin resistance induces a segmental difference in thoracic and abdominal aorta: differential expression of AT1 and AT2 receptors. J Hypertens 2012;30:132-46.
17. Gallagher PE, Ferrario CM, Tallant EA. Regulation of ACE2 in cardiac myocytes and fibroblasts. Am J Physiol Heart Circ Physiol 2008;295:H2373-79.
18. Suski M, Gabska A, Olszanecki R, Stachowicz A, Uracz D, Madej J, et al. Influence of atorvastatin on angiotensin I metabolism in resting and TNF-alpha-activated rat vascular smooth muscle cells. J Renin Angiotensin Aldosterone Syst 2013. http://dx.doi.org/10.1177/1470320313475907. Epub ahead of print.
19. Aguilar C, Ventura F, Rodriguez-Delfn L. Atorvastatin induced increase in homologous angiotensin 1 converting enzyme (ACE2) mRNA is associated to decreased fibrosis and decreased left ventricular hypertrophy in a rat model of diabetic cardiomyopathy. Rev Peru Med Exp Salud Publica 2011;28:264-72.
20. Qin XT, Jia CW, Pan M, Shen AG, Jing HM. Effect of atorvastatin on ACE2 expression in pressure overload induced cardiac hypertrophy in rats. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2008;33:438-42.
21. Daugherty A, Manning MW, Cassis LA. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E -/- deficient mice. J Clin Investig 2000;105:1605-12.
22. Keidar S, Heinrich R, Kaplan M, Hayek T, Aviram M. Angiotensin II administration to atherosclerotic mice increases macrophage uptake of oxidized ldl a possible role for interleukin-6. Arterioscler Thromb Vasc Biol 2001;21:1464-9.
23. Cassis LA, Rateri DL, Lu H, Daugherty A. Bone marrow transplantation reveals that recipient AT1a receptors are required to initiate Angiotensin II- induced atherosclerosis and aneurysms. Arterioscler Thromb Vasc Biol 2007;27:380-6.
24. Kunieda T, Minamino T, Nishi J-i, Tateno K, Oyama T, Katsuno T, et al. Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation 2006;114:953-60.
25. Frantz EDC, Crespo-Mascarenhas C, Barreto-Vianna ARC, Aguila MB, Mandarim-de-Lacerda CA. Renin-angiotensin system blockers protect pancreatic islets against diet-induced obesity and insulin resistance in mice. PloS One 2013;8:e67192.
26. Jia HP, Look DC, Tan P, Shi L, Hickey M, Gakhar L, et al. Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia. Am J Physiol Lung Cell Mol Physiol 2009;297:L84-96.
27. Pons D, de Vries FR, van den Elsen PJ, Heijmans BT, Quax PHA, Jukema JW. Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease. Eur Heart J 2009;30:266-77.
28. Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G, Turner AJ. A human homolog of angiotensin-converting enzyme cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem 2000;275:33238-43.
29. Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res 2000;87:e1-9.
30. Danilczyk U, Penninger JM. Angiotensin-converting enzyme II in the heart and the kidney. Circ Res 2006;98:463-71.
31. Chappell MC. Emerging evidence for a functional angiotensin-converting enzyme 2-angiotensin-(1-7)-mas receptor axis more than regulation of blood pressure. Hypertension 2007;50:596-9.
32. Diez-Freire C, Vazquez J, de Adjounian MaFC, Ferrari MFR, Yuan L, Silver X, et al. ACE2 gene transfer attenuates hypertension-linked pathophysiological changes in the SHR. Physiol Genom 2006;27:12-9.
33. Oudit GY, Kassiri Z, Patel MP, Chappell M, Butany J, Backx PH, et al. Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. Cardiovasc Res 2007;75:29-39.
34. Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, et al. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature 2002;417:822-8.
35. Tikellis C, Johnston CI, Forbes JM, Burns WC, Burrell LM, Risvanis J, et al. Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy. Hypertension 2003;41:392-7.