P38 MAPK activation is required for esculetin-induced inhibition of vascular smooth muscle cells proliferation

Toxicology in Vitro

Volumn 25, Issue 7, 2011, Pages 1335-1342

  Yun, Eun Sun ^b,e   Park, Sung Suk ^a,d   Shin, Ho Chul ^b   Choi, Yung Hyun ^c   Kim, Wun Jae ^d   Moon, Sung Kwon ^a,d  

^a Chungju National University   (South Korea)

^b Konkuk University   (South Korea)

^c Dong Eui University   (South Korea)

^d Chungbuk National University College of Medicine   (South Korea)

^e Seoul National University Boramae Hospital   (South Korea)

Author keywords

Esculetin; G1 cell cycle arrest; P21WAF1; P38 MAPK; Vascular smooth muscle cells

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN E; CYCLINE; ESCULETIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P27; PROTEIN P53;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; ENZYME ACTIVATION; GROWTH INHIBITION; IC 50; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR SMOOTH MUSCLE CELL;

ANIMALS; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINTS; IMIDAZOLES; MAP KINASE SIGNALING SYSTEM; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; UMBELLIFERONES; UP-REGULATION;

EID: 84860398973     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.05.001     Document Type: Article

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