Molecular network of neuronal autophagy in the pathophysiology and treatment of depression

Neuroscience Bulletin

Volumn 31, Issue 4, 2015, Pages 427-434

  Jia, Jack ^a,b   Le, Weidong ^c  

^a Temple University   (United States)

^b New Jersey State Library   (United States)

^c First Affil Hosp Dalian Med U   (China)

Author keywords

antidepressant; autophagy; major depressive disorder; mTOR

Indexed keywords

ANTIDEPRESSANT AGENT; BECLIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PARKIN; PROTEIN AGGREGATE; PROTEIN KINASE B; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ANTIDEPRESSANT ACTIVITY; AUTOPHAGOSOME; AUTOPHAGY; CELL COMMUNICATION; CELL FUNCTION; CELL SURVIVAL; CELLULAR DISTRIBUTION; HUMAN; MAJOR DEPRESSION; MITOPHAGY; NERVE CELL DIFFERENTIATION; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NEURONAL AUTOPHAGY; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION; SURVIVAL RATE; SYNAPTOGENESIS; UPREGULATION; ANIMAL; BRAIN; DEGENERATIVE DISEASE; DEPRESSIVE DISORDER, MAJOR; DRUG EFFECTS; METABOLISM; NERVE CELL; PHYSIOLOGY;

ANIMALS; ANTIDEPRESSIVE AGENTS; AUTOPHAGY; BRAIN; DEPRESSIVE DISORDER, MAJOR; HUMANS; NEURODEGENERATIVE DISEASES; NEURONS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84938848059     PISSN: 16737067     EISSN: 19958218     Source Type: Journal    
DOI: 10.1007/s12264-015-1548-2     Document Type: Review

References (77)

1. Eshel N, Roiser JP. Reward and punishment processing in depression. Biol Psychiatry 2010, 68: 118–124.
2. Ito M. Long-term depression. Annu Rev Neurosci 1989, 12: 85–102.
3. Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE. Prevalence, severity, and comorbidity of 12-month DSMIV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005, 62: 617–627.
4. Wang PS, Simon G, Kessler RC. The economic burden of depression and the cost-effectiveness of treatment. Int J Methods Psychiatr Res 2003, 12: 22–33.
5. Nierenberg AA, Ostacher MJ, Huffman JC, Ametrano RM, Fava M, Perlis RH. A brief review of antidepressant effi cacy, effectiveness, indications, and usage for major depressive disorder. J Occup Environ Med 2008, 50: 428–436.
6. Schmidt HD, Shelton RC, Duman RS. Functional biomarkers of depression: diagnosis, treatment, and pathophysiology. Neuropsychopharmacology 2011, 36: 2375–2394.
7. Meyer JH, Ginovart N, Boovariwala A, Sagrati S, Hussey D, Garcia A, et al. Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression. Arch Gen Psychiatry 2006, 63: 1209–1216.
8. Villanueva R. Neurobiology of major depressive disorder. Neural Plast 2013, 2013: 873278.
9. Hasler G. Pathophysiology of depression: do we have any solid evidence. World Psychiatry 2010, 9: 155–161.
10. Kuhn M, Höger N, Feige B, Blechert J, Normann C, Nissen C. Fear Extinction as a model for synaptic plasticity in major depressive disorder. PLoS ONE 2014, 9: e115280.
11. Wainwright SR, Galea LA. The neural plasticity theory of depression: assessing the roles of adult neurogenesis and PSA-NCAM within the hippocampus. Neural Plast 2013, 2013: 805497.
12. Shelton RC, Claiborne J, Sidoryk-Wegrzynowicz M, Reddy R, Aschner M, Lewis DA, et al. Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression. Mol Psychiatry 2011, 16: 751–762.
13. Miguel-Hidalgo JJ, Whittom A, Villarreal A, Soni M, Meshram A, Pickett JC, et al. Apoptosis-related proteins and proliferation markers in the orbitofrontal cortex in major depressive disorder. J Affect Disord 2014, 158: 62–70.
14. Nikoletopoulou V, Papandreou ME, Tavernarakis N. Autophagy in the physiology and pathology of the central nervous system. Cell Death Differ 2015, 22: 398–407.
15. Takacs-Vellai K, Bayci A, Vellai T. Autophagy in neuronal cell loss: a road to death. Bioessays 2006, 28: 1126–1131.
16. Nixon RA, Yang DS. Autophagy and neuronal cell death in neurological disorders. Cold Spring Harb Perspect Biol 2012, 4.
17. Gassen NC, Hartmann J, Schmidt MV, Rein T. FKBP5/ FKBP51 enhances autophagy to synergize with antidepressant action. Autophagy 2015, 11: 578–580.
18. Shehata M, Matsumura H, Okubo-Suzuki R, Ohkawa N, Inokuchi K. Neuronal stimulation induces autophagy in hippocampal neurons that is involved in AMPA receptor degradation after chemical long-term depression. J Neurosci 2012, 32: 10413–10422.
19. Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki- Migishima R, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006, 441: 885–889.
20. Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006, 441: 880–884.
21. Jeong JK, Moon MH, Lee YJ, Seol JW, Park SY. Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity. Neurobiol Aging 2013, 34: 146–156.
22. Shen W, Ganetzky B. Autophagy promotes synapse development in Drosophila. J Cell Biol 2009, 187: 71–79.
23. Bateup HS, Takasaki KT, Saulnier JL, Denefrio CL, Sabatini BL. Loss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function. J Neurosci 2011, 31: 8862–8869.
24. Damme M, Suntio T, Saftig P, Eskelinen EL. Autophagy in neuronal cells: general principles and physiological and pathological functions. Acta Neuropathol 2015, 129: 337–362.
25. Lee KM, Hwang SK, Lee JA. Neuronal autophagy and neurodevelopmental disorders. Exp Neurobiol 2013, 22: 133–142.
26. Liu S, Sarkar C, Dinizo M, Faden AI, Koh EY, Lipinski MM, et al. Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death. Cell Death Dis 2015, 6: e1582.
27. Zare-Shahabadi A, Masliah E, Johnson GV, Rezaei N. Autophagy in Alzheimer's disease. Rev Neurosci 2015.
28. Nixon RA, Wegiel J, Kumar A, Yu WH, Peterhoff C, Cataldo A, et al. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J Neuropathol Exp Neurol 2005, 64: 113–122.
29. Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, et al. Macroautophagy—a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol 2005, 171: 87–98.
30. Giordano S, Darley-Usmar V, Zhang J. Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease. Redox Biol 2014, 2: 82-90.
31. Xilouri M, Vogiatzi T, Vekrellis K, Park D, Stefanis L. Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy. PLoS One 2009, 4: e5515.
32. Chen L, Xie Z, Turkson S, Zhuang X. A53T human alphasynuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration. J Neurosci 2015, 35: 890–905.
33. Deng HX, Chen W, Hong ST, Boycott KM, Gorrie GH, Siddique N, et al. Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset alS and ALS/dementia. Nature 2011, 477: 211–215.
34. Fecto F, Siddique T. UBQLN2/P62 cellular recycling pathways in amyotrophic lateral sclerosis and frontotemporal dementia. Muscle Nerve 2012, 45: 157–162.
35. Fecto F, Yan J, Vemula SP, Liu E, Yang Y, Chen W, et al. SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis. Arch Neurol 2011, 68: 1440–1446.
36. Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007, 282: 24131–24145.
37. Rothenberg C, Srinivasan D, Mah L, Kaushik S, Peterhoff CM, Ugolino J, et al. Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. Hum Mol Genet 2010, 19: 3219–3232.
38. Giorgi FS, Biagioni F, Lenzi P, Frati A, Fornai F. The role of autophagy in epileptogenesis and in epilepsy-induced neuronal alterations. J Neural Transm 2014.
39. In S, Hong CW, Choi B, Jang BG, Kim MJ. Inhibition of mitochondrial clearance and Cu/Zn-SOD activity enhance 6-hydroxydopamine-induced neuronal apoptosis. Mol Neurobiol 2015.
40. Son JH, Shim JH, Kim KH, Ha JY, Han JY. Neuronal autophagy and neurodegenerative diseases. Exp Mol Med 2012, 44: 89–98.
41. Ren J, Taegtmeyer H. Too much or not enough of a good thing - The Janus faces of autophagy in cardiac fuel and protein homeostasis. J Mol Cell Cardiol 2015, 84: 223–226.
42. Abelaira HM, Reus GZ, Neotti MV, Quevedo J. The role of mTOR in depression and antidepressant responses. Life Sci 2014, 101: 10–14.
43. Polajnar M, Zerovnik E. Impaired autophagy: a link between neurodegenerative and neuropsychiatric diseases. J Cell Mol Med 2014, 18: 1705–1711.
44. Zeng M, Zhou JN. Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells. Cell Signal 2008, 20: 659–665.
45. Pattingre S, Espert L, Biard-Piechaczyk M, Codogno P. Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie 2008, 90: 313–323.
46. Decuypere JP, Bultynck G, Parys JB. A dual role for Ca(2+) in autophagy regulation. Cell Calcium 2011, 50: 242–250.
47. Jernigan CS, Goswami DB, Austin MC, Iyo AH, Chandran A, Stockmeier CA, et al. The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2011, 35: 1774–1779.
48. Machado-Vieira R, Zanetti MV, Teixeira AL, Uno M, Valiengo LL, Soeiro-de- Souza MG, et al. Decreased AKT1/mTOR pathway mRNA expression in short-term bipolar disorder. Eur Neuropsychopharmacol 2015, 25: 468–473.
49. Thomas GM, Huganir RL. MAPK cascade signalling and synaptic plasticity. Nat Rev Neurosci 2004, 5: 173–183.
50. Hoeffer CA, Klann E. mTOR Signaling: At the Crossroads of Plasticity, Memory, and Disease. Trends Neurosci 2010, 33: 67.
51. Hands SL, Proud CG, Wyttenbach A. mTOR's role in ageing: protein synthesis or autophagy? Aging (Albany NY) 2009, 1: 586–597.
52. Wong YC, Holzbaur EL. Autophagosome dynamics in neurodegeneration at a glance. J Cell Sci 2015, 128: 1259–1267.
53. Tramutola A, Triplett JC, DiDomenico F, Niedowicz DM, Murphy MP, Coccia R, et al. Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD. J Neurochem 2015, 133: 739–749.
54. Numakawa T, Richards M, Nakajima S, Adachi N, Furuta M, Odaka H, et al. The role of brain-derived neurotrophic factor in comorbid depression: possible linkage with steroid hormones, cytokines, and nutrition. Frontiers in psychiatry 2014, 5: 136.
55. Smith E, Prieto G, Tong L, Sears-Kraxberger I, Rice J, Steward O, et al. Rapamycin and interleukin-1ß impair brainderived neurotrophic factor-dependent neuron survival by modulating autophagy. J Biol Chem 2014, 289: 20615–20629.
56. Chen A, Xiong L, Tong Y, Mao M. Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the PI3K/Akt/mTOR pathway. Mol Med Rep 2013, 8: 1011–1016.
57. Cummings JA, Mulkey RM, Nicoll RA, Malenka RC. Ca2+ signaling requirements for long-term depression in the hippocampus. Neuron 1996, 16: 825–833.
58. Rikiishi H. Novel insights into the interplay between apoptosis and autophagy. Int J Cell Biol 2012, 2012: 317645.
59. Marino G, Niso-Santano M, Baehrecke EH, Kroemer G. Selfconsumption: the interplay of autophagy and apoptosis. Nat Rev Mol Cell Biol 2014, 15: 81–94.
60. Shelton RC, Claiborne J, Sidoryk-Wegrzynowicz M, Reddy R, Aschner M, Lewis DA, et al. Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression. Mol Psychiatry 2011, 16: 751–762.
61. Ma J, Hou LN, Rong ZX, Liang P, Fang C, Li HF, et al. Antidepressant desipramine leads to C6 glioma cell autophagy: implication for the adjuvant therapy of cancer. Anticancer Agents Med Chem 2013, 13: 254–260.
62. Zschocke J, Rein T. Antidepressants encounter autophagy in neural cells. Autophagy 2011, 7: 1247–1248.
63. Cleary C, Linde JA, Hiscock KM, Hadas I, Belmaker RH, Agam G, et al. Antidepressive-like effects of rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders. Brain Res Bull 2008, 76: 469–473.
64. Gassen NC, Hartmann J, Zschocke J, Stepan J, Hafner K, Zellner A, et al. Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans. PLoS Med 2014, 11: e1001755.
65. Zschocke J, Zimmermann N, Berning B, Ganal V, Holsboer F, Rein T. Antidepressant drugs diversely affect autophagy pathways in astrocytes and neurons[mdash]dissociation from cholesterol homeostasis. Neuropsychopharmacology 2011, 36: 1754–1768.
66. Kara NZ, Toker L, Agam G, Anderson GW, Belmaker RH, Einat H. Trehalose induced antidepressant-like effects and autophagy enhancement in mice. Psychopharmacology (Berl) 2013, 229: 367–375.
67. Heiseke A, Aguib Y, Riemer C, Baier M, Schätzl H. Lithium induces clearance of protease resistant prion protein in prioninfected cells by induction of autophagy. J Neurochem 2009, 109: 25–34.
68. Jeon SH, Kim SH, Kim Y, Kim YS, Lim Y, Lee YH, et al. The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun 2011, 413: 311–317.
69. Cloonan SM, Williams DC. The antidepressants maprotiline and fl uoxetine induce Type II autophagic cell death in drugresistant Burkitt's lymphoma. Int J Cancer 2011, 128: 1712–1723.
70. Kitagishi Y, Kobayashi M, Kikuta K, Matsuda S. Roles of PI3K/AKT/GSK3/mTOR pathway in cell signaling of mental illnesses. Depress Res Treat 2012, 2012: 752563.
71. Park SW, Lee JG, Seo MK, Lee CH, Cho HY, Lee BJ, et al. Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons. Int J Neuropsychopharmacol 2014, 17: 1831–1846.
72. Warren BL, Iniguez SD, Alcantara LF, Wright KN, Parise EM, Weakley SK, et al. Juvenile administration of concomitant methylphenidate and fluoxetine alters behavioral reactivity to reward- and mood-related stimuli and disrupts ventral tegmental area gene expression in adulthood. J Neurosci 2011, 31: 10347–10358.
73. Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M, et al. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science 2010, 329: 959–964.
74. Duman RS, Li N. A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists. Philos Trans R Soc Lond B Biol Sci 2012, 367: 2475–2484.
75. Takebayashi M, Kagaya A, Inagaki M, Kozuru T, Jitsuiki H, Kurata K, et al. Effects of antidepressants on gammaaminobutyric acid- and N-methyl-D-aspartate-induced intracellular Ca(2+) concentration increases in primary cultured rat cortical neurons. Neuropsychobiology 2000, 42: 120–126.
76. Hsu SS, Chen WC, Lo YK, Cheng JS, Yeh JH, Cheng HH, et al. Effect of the antidepressant maprotiline on Ca2+ movement and proliferation in human prostate cancer cells. Clin Exp Pharmacol Physiol 2004, 31: 444–449.
77. Nalepa I, Kowalska M, Kreiner G, Vetulani J. Does Ca2+ channel blockade modulate the antidepressant-induced changes in mechanisms of adrenergic transduction? J Neural Transm 1997, 104: 535–547.