Novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, MHY-449, induces apoptosis and cell cycle arrest in HCT116 human colon cancer cells

International Journal of Oncology

Volumn 41, Issue 6, 2012, Pages 2057-2064

  Hwang, Hye Jung ^a   Kang, Yong Jung ^a   Hossain, Mohammad Akbar ^a   Kim, Dong Hwan ^a   Jang, Jung Yoon ^a   Lee, Sun Hwa ^a   Yoon, Jeong Hyun ^a   Moon, Hyung Ryong ^a   Kim, Hyung Sik ^a   Chung, Hae Young ^a   Kim, Nam Deuk ^a  

^a Pusan National University   (South Korea)

Author keywords

Apoptosis; Cell cycle regulation; Colon cancer cells; Cytotoxic activity; Dihydrobenzofuro 4,5 b 1,8 naphthyridin 6 one derivatives

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN DEPENDENT KINASE 1; MHY 449; MHY 450; NAPHTHYRIDINE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P27; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL CYCLE PROGRESSION; CELL STRAIN HCT116; CELL VIABILITY; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; ENZYME ACTIVATION; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BENZOFURANS; CASPASES; CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELL SURVIVAL; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HCT116 CELLS; HUMANS; NAPHTHYRIDINES; SIGNAL TRANSDUCTION;

EID: 84869787238     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1659     Document Type: Article

References (34)

1. Cooper K, Squires H, Carrol C, Papaioannou D, Booth A, Logan RF, Maguire C, Hind D and Tappenden P: Chemoprevention of colorectal cancer: systematic review and economic evaluation. Health Technol Assess 14: 1-206, 2010.
2. Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin 60: 277-300, 2010.
3. National Cancer Information Center: Cancer incidence. Goyang. http://www.cancer.go.kr/ncic/cics. Accessed Dec 29, 2011.
4. Kelly C and Cassidy J: Chemotherapy in metastatic colorectal cancer. Surg Oncol 16: 65-70, 2007. (Pubitemid 46880340)
5. Yang SY, Sales KM, Fuller BF, Seifalian AM and Winslet MC: Apoptosis and colorectal cancer: implications for therapy. Trends Mol Med 15: 225-233, 2009.
6. Peter ME: The flip side of FLIP. Biochem J 382: E1-E3, 2004.
7. Ashkenazi A: Targeting the extrinsic apoptosis pathway in cancer. Cytokine Growth Factor Rev 19: 325-331, 2008.
8. Inada H, Izawa I, Nishizawa M, Fujita E, Kiyono T, Takahashi T, Momoi T and Inagaki I: Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD. J Cell Biol 155: 415-426, 2001.
9. Cory S and Adams JM: The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2: 647-656, 2002. (Pubitemid 37328916)
10. Kuwana T, Mackey MR, Perkins G, Ellisman MH, Latterich M, Schneiter R, Green DR and Newmeyer DD: Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 111: 331-342, 2002. (Pubitemid 35341388)
11. Oliver L and Vallette FM: The role of caspases in cell death and differentiation. Drug Resist Updat 8: 163-170, 2005. (Pubitemid 41267066)
12. Iannolo G, Conticello C, Memeo L and De Maria R: Apoptosis in normal and cancer stem cells. Crit Rev Oncol Hematol 66: 42-51, 2008. (Pubitemid 351330196)
13. Kupchan SM, Streelman DR and Sneden AT: Psorospermin, a new antileukemic xanthone from Psorospermum febrifugum. J Nat Prod 43: 296-301, 1980. (Pubitemid 10020148)
14. Cassady JM, Baird WM and Chang CJ: Natural products as a source of potential cancer chemotherapeutic and chemopreventive agents. J Nat Prod 53: 23-41, 1990. (Pubitemid 20152034)
15. Dorr RT, Liddil JD, Von Hoff DD, Soble M and Osborne CK: Antitumor activity and murine pharmacokinetics of parenteral acronycine. Cancer Res 49: 340-344, 1989. (Pubitemid 19049524)
16. Kang JA, Yang Z, Lee JY, De U, Kim TH, Park JY, Lee HJ, Park YJ, Chu P, Kim KS, Jeong LS and Moon HR. Design, synthesis and anticancer activity of novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivatives. Bioorg Med Chem Lett 21: 5730-5734, 2011.
17. Harris MH and Thompson CB: The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability. Cell Death Differ 7: 1182-1191, 2000. (Pubitemid 32042225)
18. Call JA, Eckhardt SG and Camidge DR: Targeted manipulation of apoptosis in cancer treatment. Lancet Oncol 9: 1002-1011, 2008.
19. Lorenzo HK and Susin SA: Therapeutic potential of AIF-mediated caspase-independent programmed cell death. Drug Resist Updat 10: 235-255, 2007.
20. Antonsson B and Martinou JC: The Bcl-2 protein family. Exp Cell Res 256: 50-57, 2000. (Pubitemid 30211166)
21. Guo B, Godzik A and Reed JC: Bcl-G, a novel pro-apoptotic member of the Bcl-2 family. J Biol Chem 276: 2780-2785, 2001.
22. Molinari M: Cell cycle checkpoints and their inactivation in human cancer. Cell Prolif 33: 261-274, 2000.
23. Sherr CJ: Cancer cell cycles. Science 274: 1672-1677, 1996.
24. Murray AW: Recycling the cell cycle: cyclins revisited. Cell 116: 221-234, 2004.
25. Sancar A, Lindsey-Boltz LA, Unsal-Kaçmaz K and Linn S: Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 73: 39-85, 2004. (Pubitemid 39050363)
26. Taylor WR and Stark GR: Regulation of the G2/M transition by p53. Oncogene 20: 1803-1815, 2001. (Pubitemid 32458690)
27. Le Gac G, Estève PO, Ferec C and Pradhan S: DNA damage-induced down-regulation of human Cdc25C and Cdc2 is mediated by cooperation between p53 and maintenance DNA (cytosine-5) methyltransferase 1. J Biol Chem 281: 24161-24170, 2006. (Pubitemid 44274190)
28. Malumbres M and Barbacid M: Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 9: 153-166, 2009.
29. Baus F, Gire V, Fisher D, Piette J and Dulić V: Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts. EMBO J 22: 3992-4002, 2003. (Pubitemid 36975725)
30. Hsu YL, Kuo PL, Lin LT and Lin CC: Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells. J Pharmacol Exp Ther 313: 333-344, 2005.
31. Niculescu AB III, Chen X, Smeets M, Hengst L, Prives C and Reed SI: Effects of p21(Cip/Waf1) at both the G1/S and the G2/M cell cycle transition: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol 18: 629-643, 1998. (Pubitemid 28021073)
32. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW and Vogelstein B: WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825, 1993. (Pubitemid 23346378)
33. Gartel AL and Tyner AL: Transcriptional regulation of the p21(WAF1/CIP1) gene. Exp Cell Res 246: 280-289, 1999.
34. Lee J and Kim SS: The function of p27 KIP1 during tumor development. Exp Mol Med 41: 765-771, 2009.