Erratum: MiR-21 in extracellular vesicles leads to neurotoxicity via TLR7 signaling in SIV neurological disease (PLoS Pathog (2015) 11:7 (e1005032) DOI: 10.1371/journal.ppat.1005032);MiR-21 in Extracellular Vesicles Leads to Neurotoxicity via TLR7 Signaling in SIV Neurological Disease

PLoS Pathogens

Volumn 11, Issue 7, 2015, Pages

  Yelamanchili, Sowmya V ^a   Lamberty, Benjamin G ^a   Rennard, Deborah A ^a   Morsey, Brenda M ^a   Hochfelder, Colleen G ^a   Meays, Brittney M ^a   Levy, Efrat ^b,c   Fox, Howard S ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^c NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 21; NEURON SPECIFIC NUCLEAR PROTEIN; TOLL LIKE RECEPTOR 7;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; EXOSOME; FLUORESCENCE IN SITU HYBRIDIZATION; GENE SEQUENCE; HIPPOCAMPUS; HUMAN; HUMAN CELL; MOUSE; NEUROTOXICITY; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; RHESUS MONKEY; RNA SEQUENCE; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ANIMAL; BRAIN; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; SIMIAN IMMUNODEFICIENCY VIRUS; VIROLOGY;

ANIMALIA; MACACA MULATTA; MUS; SIMIAN IMMUNODEFICIENCY VIRUS;

ANIMALS; BLOTTING, WESTERN; BRAIN; EXTRACELLULAR VESICLES; FLUORESCENT ANTIBODY TECHNIQUE; IN SITU HYBRIDIZATION, FLUORESCENCE; MACACA MULATTA; MACROPHAGES; MICE; MICE, KNOCKOUT; MICRORNAS; MICROSCOPY, ELECTRON, TRANSMISSION; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; TOLL-LIKE RECEPTOR 7;

EID: 84938810279     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/JOURNAL.PPAT.1007068     Document Type: Erratum

References (70)

1. Wiley CA, Achim C, (1994) Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome. Ann Neurol 36: 673–676. 7944304
2. Budka H, (1991) Neuropathology of human immunodeficiency virus infection. Brain Pathol 1: 163–175. 1669705
3. Everall IP, Luthert PJ, Lantos PL, (1991) Neuronal loss in the frontal cortex in HIV infection. Lancet 337: 1119–1121. 1674013
4. Crews L, Lentz MR, Gonzalez RG, Fox HS, Masliah E, (2008) Neuronal injury in simian immunodeficiency virus and other animal models of neuroAIDS. J Neurovirol 14: 327–339. doi: 10.1080/13550280802132840 18780234
5. Kraft-Terry SD, Buch SJ, Fox HS, Gendelman HE, (2009) A coat of many colors: neuroimmune crosstalk in human immunodeficiency virus infection. Neuron 64: 133–145. doi: 10.1016/j.neuron.2009.09.042 19840555
6. del Palacio M, Alvarez S, Munoz-Fernandez MA, (2012) HIV-1 infection and neurocognitive impairment in the current era. Rev Med Virol 22: 33–45. doi: 10.1002/rmv.711 21990255
7. Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, et al. (2007) Updated research nosology for HIV-associated neurocognitive disorders. Neurology 69: 1789–1799. 17914061
8. Yelamanchili SV, Fox HS, (2010) Defining larger roles for "tiny" RNA molecules: role of miRNAs in neurodegeneration research. J Neuroimmune Pharmacol 5: 63–69. doi: 10.1007/s11481-009-9172-4 19757077
9. Noorbakhsh F, Ramachandran R, Barsby N, Ellestad KK, LeBlanc A, et al. (2010) MicroRNA profiling reveals new aspects of HIV neurodegeneration: caspase-6 regulates astrocyte survival. FASEB J 24: 1799–1812. doi: 10.1096/fj.09-147819 20097875
10. Chaudhuri AD, Yelamanchili SV, Marcondes MC, Fox HS, (2013) Up-regulation of microRNA-142 in simian immunodeficiency virus encephalitis leads to repression of sirtuin1. FASEB J 27: 3720–3729. doi: 10.1096/fj.13-232678 23752207
11. Yelamanchili SV, Chaudhuri AD, Chen LN, Xiong H, Fox HS, (2010) MicroRNA-21 dysregulates the expression of MEF2C in neurons in monkey and human SIV/HIV neurological disease. Cell Death Dis 1: e77. doi: 10.1038/cddis.2010.56 21170291
12. Hu G, Yao H, Chaudhuri AD, Duan M, Yelamanchili SV, et al. (2012) Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated neuronal dysfunction. Cell Death Dis 3: e381. doi: 10.1038/cddis.2012.114 22932723
13. Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, et al. (2007) Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9: 654–659. 17486113
14. Thery C, Exosomes: secreted vesicles and intercellular communications. F1000 Biol Rep 3: 15. doi: 10.3410/B3-15 21876726
15. Lopez-Verrilli MA, Court FA, (2012) Transfer of vesicles from schwann cells to axons: a novel mechanism of communication in the peripheral nervous system. Front Physiol 3: 205. doi: 10.3389/fphys.2012.00205 22707941
16. Fruhbeis C, Frohlich D, Kuo WP, Kramer-Albers EM, (2013) Extracellular vesicles as mediators of neuron-glia communication. Front Cell Neurosci 7: 182. doi: 10.3389/fncel.2013.00182 24194697
17. Valenti R, Huber V, Iero M, Filipazzi P, Parmiani G, et al. (2007) Tumor-released microvesicles as vehicles of immunosuppression. Cancer Res 67: 2912–2915. 17409393
18. Nour AM, Modis Y (2014) Endosomal vesicles as vehicles for viral genomes. Trends Cell Biol.
19. Sampey GC, Meyering SS, Asad Zadeh M, Saifuddin M, Hakami RM, et al. (2014) Exosomes and their role in CNS viral infections. J Neurovirol.
20. Pegtel DM, Cosmopoulos K, Thorley-Lawson DA, van Eijndhoven MA, Hopmans ES, et al. (2010) Functional delivery of viral miRNAs via exosomes. Proc Natl Acad Sci U S A 107: 6328–6333. doi: 10.1073/pnas.0914843107 20304794
21. Taylor AR, Robinson MB, Gifondorwa DJ, Tytell M, Milligan CE, (2007) Regulation of heat shock protein 70 release in astrocytes: role of signaling kinases. Dev Neurobiol 67: 1815–1829. 17701989
22. Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, et al. (2005) Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism. J Immunol 175: 2237–2243. 16081791
23. Faure J, Lachenal G, Court M, Hirrlinger J, Chatellard-Causse C, et al. (2006) Exosomes are released by cultured cortical neurones. Mol Cell Neurosci 31: 642–648. 16446100
24. Gupta A, Pulliam L, (2014) Exosomes as mediators of neuroinflammation. J Neuroinflammation 11: 68. doi: 10.1186/1742-2094-11-68 24694258
25. Lehmann SM, Kruger C, Park B, Derkow K, Rosenberger K, et al. (2012) An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci 15: 827–835. doi: 10.1038/nn.3113 22610069
26. Fabbri M, Paone A, Calore F, Galli R, Gaudio E, et al. (2012) MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci U S A 109: E2110–2116. doi: 10.1073/pnas.1209414109 22753494
27. Park CK, Xu ZZ, Berta T, Han Q, Chen G, et al. (2014) Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1. Neuron 82: 47–54. doi: 10.1016/j.neuron.2014.02.011 24698267
28. Perez-Gonzalez R, Gauthier SA, Kumar A, Levy E, (2012) The exosome secretory pathway transports amyloid precursor protein carboxyl-terminal fragments from the cell into the brain extracellular space. J Biol Chem 287: 43108–43115. doi: 10.1074/jbc.M112.404467 23129776
29. Diebold SS, Massacrier C, Akira S, Paturel C, Morel Y, et al. (2006) Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides. Eur J Immunol 36: 3256–3267. 17111347
30. Linkermann A, Green DR, (2014) Necroptosis. N Engl J Med 370: 455–465. doi: 10.1056/NEJMra1310050 24476434
31. Peferoen L, Kipp M, van der Valk P, van Noort JM, Amor S, (2014) Oligodendrocyte-microglia cross-talk in the central nervous system. Immunology 141: 302–313. doi: 10.1111/imm.12163 23981039
32. Kalani A, Tyagi A, Tyagi N, (2014) Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics. Mol Neurobiol 49: 590–600. doi: 10.1007/s12035-013-8544-1 23999871
33. Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, et al. (2004) Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303: 1526–1529. 14976262
34. Lund JM, Alexopoulou L, Sato A, Karow M, Adams NC, et al. (2004) Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A 101: 5598–5603. 15034168
35. Buscaglia LE, Li Y, (2011) Apoptosis and the target genes of microRNA-21. Chin J Cancer 30: 371–380. 21627859
36. Roy S, Sen CK, (2012) miRNA in wound inflammation and angiogenesis. Microcirculation 19: 224–232. doi: 10.1111/j.1549-8719.2011.00156.x 22211762
37. Jaworski E, Narayanan A, Van Duyne R, Shabbeer-Meyering S, Iordanskiy S, et al. (2014) Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain Tax protein. J Biol Chem 289: 22284–22305. doi: 10.1074/jbc.M114.549659 24939845
38. Bobrie A, Colombo M, Raposo G, Thery C, (2011) Exosome secretion: molecular mechanisms and roles in immune responses. Traffic 12: 1659–1668. doi: 10.1111/j.1600-0854.2011.01225.x 21645191
39. Thery C, Ostrowski M, Segura E, (2009) Membrane vesicles as conveyors of immune responses. Nat Rev Immunol 9: 581–593. doi: 10.1038/nri2567 19498381
40. Schneider A, Simons M, (2013) Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders. Cell Tissue Res 352: 33–47. doi: 10.1007/s00441-012-1428-2 22610588
41. Ziu M, Fletcher L, Rana S, Jimenez DF, Digicaylioglu M, (2011) Temporal differences in microRNA expression patterns in astrocytes and neurons after ischemic injury. PLoS One 6: e14724. doi: 10.1371/journal.pone.0014724 21373187
42. Wada T, Penninger JM, (2004) Mitogen-activated protein kinases in apoptosis regulation. Oncogene 23: 2838–2849. 15077147
43. Cho YS, Challa S, Moquin D, Genga R, Ray TD, et al. (2009) Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 137: 1112–1123. doi: 10.1016/j.cell.2009.05.037 19524513
44. He S, Wang L, Miao L, Wang T, Du F, et al. (2009) Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 137: 1100–1111. doi: 10.1016/j.cell.2009.05.021 19524512
45. Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G, (2010) Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol 11: 700–714. doi: 10.1038/nrm2970 20823910
46. Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, et al. (2009) RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 325: 332–336. doi: 10.1126/science.1172308 19498109
47. Holler N, Zaru R, Micheau O, Thome M, Attinger A, et al. (2000) Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol 1: 489–495. 11101870
48. Kim SO, Ono K, Han J, (2001) Apoptosis by pan-caspase inhibitors in lipopolysaccharide-activated macrophages. Am J Physiol Lung Cell Mol Physiol 281: L1095–1105. 11597900
49. Upton JW, Kaiser WJ, Mocarski ES, (2012) DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA. Cell Host Microbe 11: 290–297. doi: 10.1016/j.chom.2012.01.016 22423968
50. Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, et al. (2005) Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 1: 112–119. 16408008
51. Tan IL, McArthur JC, (2011) HIV-associated central nervous system diseases in the era of combination antiretroviral therapy. Eur J Neurol 18: 371–372. doi: 10.1111/j.1468-1331.2010.03287.x 21159069
52. Cheng Y, Zhu P, Yang J, Liu X, Dong S, et al. (2010) Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4. Cardiovasc Res 87: 431–439. doi: 10.1093/cvr/cvq082 20219857
53. Bhalala OG, Pan L, Sahni V, McGuire TL, Gruner K, et al. (2012) microRNA-21 regulates astrocytic response following spinal cord injury. J Neurosci 32: 17935–17947. doi: 10.1523/JNEUROSCI.3860-12.2012 23238710
54. Lei P, Li Y, Chen X, Yang S, Zhang J, (2009) Microarray based analysis of microRNA expression in rat cerebral cortex after traumatic brain injury. Brain Res 1284: 191–201. doi: 10.1016/j.brainres.2009.05.074 19501075
55. Redell JB, Zhao J, Dash PK, (2011) Altered expression of miRNA-21 and its targets in the hippocampus after traumatic brain injury. J Neurosci Res 89: 212–221. doi: 10.1002/jnr.22539 21162128
56. Han Z, Chen F, Ge X, Tan J, Lei P, et al. (2014) miR-21 alleviated apoptosis of cortical neurons through promoting PTEN-Akt signaling pathway in vitro after experimental traumatic brain injury. Brain Res 1582: 12–20. doi: 10.1016/j.brainres.2014.07.045 25108037
57. Sandhir R, Gregory E, Berman NE (2014) Differential response of miRNA-21 and its targets after traumatic brain injury in aging mice. Neurochem Int.
58. Ge XT, Lei P, Wang HC, Zhang AL, Han ZL, et al. (2014) miR-21 improves the neurological outcome after traumatic brain injury in rats. Sci Rep 4: 6718. doi: 10.1038/srep06718 25342226
59. Iliopoulos D, Jaeger SA, Hirsch HA, Bulyk ML, Struhl K, (2010) STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol Cell 39: 493–506. doi: 10.1016/j.molcel.2010.07.023 20797623
60. Chaudhuri AD, Yelamanchili SV, Fox HS, (2013) Combined fluorescent in situ hybridization for detection of microRNAs and immunofluorescent labeling for cell-type markers. Front Cell Neurosci 7: 160. doi: 10.3389/fncel.2013.00160 24065888
61. Li M, Xia Y, Gu Y, Zhang K, Lang Q, et al. (2010) MicroRNAome of porcine pre- and postnatal development. PLoS One 5: e11541. doi: 10.1371/journal.pone.0011541 20634961
62. Wei Z, Liu X, Feng T, Chang Y, (2011) Novel and conserved micrornas in Dalian purple urchin (Strongylocentrotus nudus) identified by next generation sequencing. Int J Biol Sci 7: 180–192. 21383954
63. Meyer C, Grey F, Kreklywich CN, Andoh TF, Tirabassi RS, et al. (2011) Cytomegalovirus microRNA expression is tissue specific and is associated with persistence. J Virol 85: 378–389. doi: 10.1128/JVI.01900-10 20980502
64. Kozomara A, Griffiths-Jones S, (2014) miRBase: annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res 42: D68–73. doi: 10.1093/nar/gkt1181 24275495
65. Baldi P, Long AD, (2001) A Bayesian framework for the analysis of microarray expression data: regularized t-test and statistical inferences of gene changes. Bioinformatics 17: 509–519. 11395427
66. Kayala MA, Baldi P, (2012) Cyber-T web server: differential analysis of high-throughput data. Nucleic Acids Res 40: W553–559. doi: 10.1093/nar/gks420 22600740
67. Caby MP, Lankar D, Vincendeau-Scherrer C, Raposo G, Bonnerot C, (2005) Exosomal-like vesicles are present in human blood plasma. Int Immunol 17: 879–887. 15908444
68. Zeringer E, Li M, Barta T, Schageman J, Pedersen KW, et al. (2013) Methods for the extraction and RNA profiling of exosomes. World J Methodol 3: 11–18. doi: 10.5662/wjm.v3.i1.11 25237619
69. Bobrie A, Colombo M, Krumeich S, Raposo G, Thery C, (2012) Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation. J Extracell Vesicles 1.
70. Beaudoin GM, 3rdLee SH, Singh D, Yuan Y, Ng YG, et al. (2012) Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex. Nat Protoc 7: 1741–1754. doi: 10.1038/nprot.2012.099 22936216