MicroRNA-21 dysregulates the expression of MEF2C in neurons in monkey and human SIV/HIV neurological disease

Cell Death and Disease

Volumn 1, Issue 9, 2010, Pages

  Yelamanchili, S V ^a   Datta Chaudhuri, A ^a   Chen, L N ^a   Xiong, H ^a   Fox, H S ^a  

^a NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Dementia; HIV; MEF2C; Monkey; Neurodegeneration; NMDA; SIV

Indexed keywords

MICRORNA 142; MICRORNA 193; MICRORNA 21; MYOCYTE ENHANCER FACTOR 2C; RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; MESSENGER RNA; MICRORNA; MIRN21 MICRORNA, HUMAN; MYOCYTE SPECIFIC ENHANCER BINDING FACTOR 2; MYOCYTE-SPECIFIC ENHANCER-BINDING FACTOR 2; MYOGENIC FACTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; BRAIN TISSUE; CAUDATE NUCLEUS; CELL STRAIN HEK293; CONTROLLED STUDY; DOWN REGULATION; ENCEPHALITIS; HAPLORHINI; HIPPOCAMPUS; HIV ASSOCIATED DEMENTIA; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROVIRUS INFECTION; SIMIAN IMMUNODEFICIENCY VIRUS ENCEPHALITIS; UPREGULATION; ANIMAL; DEGENERATIVE DISEASE; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; NERVE CELL; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS; SIMIAN IMMUNODEFICIENCY VIRUS;

ANIMALS; DOWN-REGULATION; HAPLORHINI; HIV INFECTIONS; HUMANS; MICRORNAS; MYOGENIC REGULATORY FACTORS; NEURODEGENERATIVE DISEASES; NEURONS; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME;

EID: 79958278799     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2010.56     Document Type: Article

References (40)

1. Makeyev EV, Maniatis T. Multilevel regulation of gene expression by microRNAs. Science 2008; 319: 1789-1790. (Pubitemid 351451555)
2. Hebert SS, De Strooper B. Alterations of the microRNA network cause neurodegenerative disease. Trends Neurosci 2009; 32: 199-206.
3. Yelamanchili SV, Fox HS. Defining larger roles for 'tiny' RNA molecules: role of miRNAs in neurodegeneration research. J Neuroimmune Pharmacol 2010; 5: 63-69.
4. Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M et al. Updated research nosology for HIV-associated neurocognitive disorders. Neurology 2007; 69: 1789-1799. (Pubitemid 350059308)
5. Kaul M, Garden GA, Lipton SA. Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 2001; 410: 988-994. (Pubitemid 32335850)
6. Kraft-Terry SD, Buch SJ, Fox HS, Gendelman HE. A coat of many colors: neuroimmune crosstalk in human immunodeficiency virus infection. Neuron 2009; 64: 133-145.
7. Roberts ES, Zandonatti MA, Watry DD, Madden LJ, Henriksen SJ, Taffe MA et al. Induction of pathogenic sets of genes in macrophages and neurons in neuroAIDS. Am J Pathol 2003; 162: 2041-2057. (Pubitemid 36613060)
8. Masliah E, Roberts ES, Langford D, Everall I, Crews L, Adame A et al. Patterns of gene dysregulation in the frontal cortex of patients with HIV encephalitis. J Neuroimmunol 2004; 157: 163-175. (Pubitemid 39576651)
9. Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 1994; 330: 613-622.
10. Xia Z, Dudek H, Miranti CK, Greenberg ME. Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism. J Neurosci 1996; 16: 5425-5436. (Pubitemid 26277871)
11. Zhang SJ, Steijaert MN, Lau D, Schutz G, Delucinge-Vivier C, Descombes P et al. Decoding NMDA receptor signaling: identification of genomic programs specifying neuronal survival and death. Neuron 2007; 53: 549-562. (Pubitemid 46216756)
12. Krichevsky AM, Gabriely G. miR-21: a small multi-faceted RNA. J Cell Mol Med 2009; 13: 39-53.
13. Li H, Radford JC, Ragusa MJ, Shea KL, McKercher SR, Zaremba JD et al. Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proc Natl Acad Sci USA 2008; 105: 9397-9402.
14. Li Z, McKercher SR, Cui J, Nie Z, Soussou W, Roberts AJ et al. Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells. J Neurosci 2008; 28: 6557-6568.
15. Tang X, Wang X, Gong X, Tong M, Park D, Xia Z et al. Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2. J Neurosci 2005; 25: 4823-4834. (Pubitemid 40664130)
16. Barbosa AC, Kim MS, Ertunc M, Adachi M, Nelson ED, McAnally J et al. MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc Natl Acad Sci USA 2008; 105: 9391-9396.
17. Leifer D, Golden J, Kowall NW. Myocyte-specific enhancer binding factor 2C expression in human brain development. Neuroscience 1994; 63: 1067-1079. (Pubitemid 24366156)
18. Lyons GE, Micales BK, Schwarz J, Martin JF, Olson EN. Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation. J Neurosci 1995; 15: 5727-5738.
19. Selcuklu SD, Donoghue MT, Spillane C. miR-21 as a key regulator of oncogenic processes. Biochem Soc Trans 2009; 37: 918-925.
20. Lipton SA, Sucher NJ, Kaiser PK, Dreyer EB. Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity. Neuron 1991; 7: 111-118.
21. Nath A, Psooy K, Martin C, Knudsen B, Magnuson DS, Haughey N et al. Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic. J Virol 1996; 70: 1475-1480. (Pubitemid 26062905)
22. Giulian D, Yu J, Li X, Tom D, Li J, Wendt E et al. Study of receptor-mediated neurotoxins released by HIV-1-infected mononuclear phagocytes found in human brain. J Neurosci 1996; 16: 3139-3153. (Pubitemid 26142350)
23. O'Donnell LA, Agrawal A, Jordan-Sciutto KL, Dichter MA, Lynch DR, Kolson DL. Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes. J Neurosci 2006; 26: 981-990.
24. Le Meur N, Holder-Espinasse M, Jaillard S, Goldenberg A, Joriot S, Amati-Bonneau P et al. MEF2C haploinsufficiency caused by either microdeletion of the 5q14.3 region or mutation is responsible for severe mental retardation with stereotypic movements, epilepsy and/or cerebral malformations. J Med Genet 2010; 47: 22-29.
25. Yu SP, Yeh CH, Sensi SL, Gwag BJ, Canzoniero LM, Farhangrazi ZS et al. Mediation of neuronal apoptosis by enhancement of outward potassium current. Science 1997; 278: 114-117. (Pubitemid 27446288)
26. Giese KP, Peters M, Vernon J. Modulation of excitability as a learning and memory mechanism: a molecular genetic perspective. Physiol Behav 2001; 73: 803-810. (Pubitemid 32885568)
27. Giese KP, Storm JF, Reuter D, Fedorov NB, Shao LR, Leicher T et al. Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning. Learn Mem 1998; 5: 257-273. (Pubitemid 29115258)
28. Flavell SW, Kim TK, Gray JM, Harmin DA, Hemberg M, Hong EJ et al. Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection. Neuron 2008; 60: 1022-1038.
29. Tatro ET, Scott ER, Nguyen TB, Salaria S, Banerjee S, Moore DJ et al. Evidence for Alteration of Gene Regulatory Networks through MicroRNAs of the HIV-infected brain: novel analysis of retrospective cases. PLoS ONE 2010; 5: e10337.
30. Eletto D, Russo G, Passiatore G, Del Valle L, Giordano A, Khalili K et al. Inhibition of SNAP25 expression by HIV-1 Tat involves the activity of mir-128a. J Cell Physiol 2008; 216: 764-770.
31. Eugenin EA, King JE, Hazleton JE, Major EO, Bennett MV, Zukin RS et al. Differences in NMDA Receptor Expression During Human Development Determine the Response of Neurons to HIV-Tat-mediated Neurotoxicity. Neurotox Res, e-pub ahead of print 22 January 2010, PMID: 20094923.
32. Noorbakhsh F, Ramachandran R, Barsby N, Ellestad KK, LeBlanc A, Dickie P et al. MicroRNA profiling reveals new aspects of HIV neurodegeneration: caspase-6 regulates astrocyte survival. FASEB J 2010; 24: 1799-1812.
33. Luers AJ, Loudig OD, Berman JW. MicroRNAs are expressed and processed by human primary macrophages. Cell Immunol 2010; 263: 1-8.
34. Witwer KW, Sisk JM, Gama L, Clements JE. MicroRNA regulation of IFN-beta protein expression: rapid and sensitive modulation of the innate immune response. J Immunol 2010; 184: 2369-2376.
35. Martin B, Ji S, Maudsley S, Mattson MP. 'Control' laboratory rodents are metabolically morbid: why it matters. Proc Natl Acad Sci USA 2010; 107: 6127-6133.
36. Burdo TH, Marcondes MC, Lanigan CM, Penedo MC, Fox HS. Susceptibility of Chinese rhesus monkeys to SIV infection. AIDS (London, England) 2005; 19: 1704-1706. (Pubitemid 41502689)
37. Huitron-Resendiz S, Marcondes MC, Flynn CT, Lanigan CM, Fox HS. Effects of simian immunodeficiency virus on the circadian rhythms of body temperature and gross locomotor activity. Proc Natl Acad Sci USA 2007; 104: 15138-15143. (Pubitemid 47619606)
38. Woods SP, Rippeth JD, Frol AB, Levy JK, Ryan E, Soukup VM et al. Interrater reliability of clinical ratings and neurocognitive diagnoses in HIV. J Clin Exp Neuropsychol 2004; 26: 759-778. (Pubitemid 39362659)
39. Nuovo G. In situ detection of precursor and mature microRNAs in paraffin embedded, formalin fixed tissues and cell preparations. Methods 2008; 44: 39-46. (Pubitemid 350297988)
40. Sodickson DL, Bean BP. GABAB receptor-activated inwardly rectifying potassium current in dissociated hippocampal CA3 neurons. J Neurosci 1996; 16: 6374-6385. (Pubitemid 26337361)