Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA

PLoS Genetics

Volumn 11, Issue 7, 2015, Pages

  Gemble, Simon ^a,b   Ahuja, Akshay ^c   Buhagiar Labarchède, Géraldine ^a,b   Onclercq Delic, Rosine ^a,b   Dairou, Julien ^d   Biard, Denis S F ^e   Lambert, Sarah ^a,b   Lopes, Massimo ^c   Amor Guéret, Mounira ^a,b  

^a INSTITUT CURIE   (France)

^b CNRS UMR3348   (France)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYTIDINE DEAMINASE; DEOXYCYTIDINE TRIPHOSPHATE; DEOXYRIBONUCLEOTIDE; DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PYRIMIDINE; BLOOM SYNDROME HELICASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PARP1 PROTEIN, HUMAN; PYRIMIDINE DERIVATIVE; RECQ HELICASE;

ANAPHASE; ARTICLE; BLOOM SYNDROME; CELL CYCLE S PHASE; CELL LEVEL; CENTROMERE; CHROMOSOME SEGREGATION; CONTROLLED STUDY; DNA REPLICATION; ELECTRON MICROSCOPY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INHIBITION; ULTRAFINE ANAPHASE BRIDGE; BIOSYNTHESIS; CELL LINE; CHROMOSOME FRAGILE SITE; DEFICIENCY; GENETICS; GENOMIC INSTABILITY; HUMAN; METABOLISM; MITOSIS; PATHOLOGY; SISTER CHROMATID EXCHANGE;

BLOOM SYNDROME; CELL LINE; CENTROMERE; CHROMOSOME FRAGILE SITES; CHROMOSOME SEGREGATION; CYTIDINE DEAMINASE; DNA REPLICATION; GENOMIC INSTABILITY; HUMANS; MITOSIS; POLY (ADP-RIBOSE) POLYMERASE-1; POLY(ADP-RIBOSE) POLYMERASES; PYRIMIDINES; RECQ HELICASES; SISTER CHROMATID EXCHANGE;

EID: 84938776344     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005384     Document Type: Article

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