Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template

Genes and Development

Volumn 27, Issue 23, 2013, Pages 2537-2542

  Neelsen, Kai J ^a,c   Zanini, Isabella M Y ^a,d   Mijic, Sofija ^a   Herrador, Raquel ^a   Zellweger, Ralph ^a   Chaudhuri, Arnab Ray ^a,e   Creavin, Kevin D ^b   Julian Blow, J ^b   Lopes, Massimo ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c University of Copenhagen   (Denmark)

^d ETH ZURICH   (Switzerland)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

DNA replication; Genome integrity; Origin licensing; Rereplication; Tumorigenesis

Indexed keywords

DNA FRAGMENT; EARLY MITOTIC INHIBITOR 1; GEMININ; PROTEIN; REPLICATION LICENSING FACTOR CDT1; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ARTICLE; CHROMATIN; CHROMOSOME BREAKAGE; CONTROLLED STUDY; DNA CONTENT; DNA DAMAGE; DNA DAMAGE CHECKPOINT; DNA REPLICATION ORIGIN; DNA STRAND BREAKAGE; DNA SYNTHESIS; DNA TEMPLATE; GENE ACTIVATION; GENE CONTROL; GENOTOXICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEPLETION;

DNA REPLICATION; GENOME INTEGRITY; ORIGIN LICENSING; REREPLICATION; TUMORIGENESIS;

CELL CYCLE PROTEINS; CELL LINE; CHROMOSOME BREAKAGE; DNA; DNA REPLICATION; F-BOX PROTEINS; HUMANS; REPLICATION ORIGIN; RNA, SMALL INTERFERING; TEMPLATES, GENETIC;

EID: 84888788310     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.226373.113     Document Type: Article

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