Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain

Nature Cell Biology

Volumn 6, Issue 7, 2004, Pages 634-641

  Flick, Karin ^a   Ouni, Ikram ^a   Wohlschlegel, James A ^b   Capati, Chrissy ^a   McDonald, W Hayes ^b,c   Yates III, John R ^b   Kaiser, Peter ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c OAK RIDGE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CELL CYCLE PROTEIN; LYSINE; PROTEASOME; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MET4; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STRUCTURE; PROTEIN TARGETING; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UBIQUITINATION; YEAST CELL;

BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CATALYTIC DOMAIN; CYSTEINE ENDOPEPTIDASES; DNA-BINDING PROTEINS; LYSINE; MACROMOLECULAR SUBSTANCES; MULTIENZYME COMPLEXES; PEPTIDE HYDROLASES; POLYMERS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATORS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASE COMPLEXES;

SACCHAROMYCETALES;

EID: 3242696232     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1143     Document Type: Article

References (32)

1. Hochstrasser, M. Ubiquitin-dependent protein degradation. Annu. Rev. Genet. 30, 405-439 (1996).
2. Hershko, A. & Ciechanover, A. The ubiquitin system. Annu. Rev. Biochem. 67, 425-479 (1998).
3. Schnell, J. D. & Hicke, L. Non-traditional functions of ubiquitin and ubiquitin-binding proteins. J. Biol. Chem. 278, 35857-35860 (2003).
4. Thrower, J. S., Hoffman, L., Rechsteiner, M. & Pickart, C. M. Recognition of the polyubiquitin proteolytic signal. EMBO J. 19, 94-102 (2000).
5. Spence, J. et al. Cell cycle-regulated modification ofthe ribosome by a variant multi-ubiquitin chain. Cell 102, 67-76 (2000).
6. Spence, J., Sadis, S., Haas, A. L. & Finley, D. A Ubiquitin Mutant with Specific Defects in DNA repair and Multiubiquitination. Mol. Cell. Biol. 15, 1265-1273 (1995).
7. Hofmann, R. M. & Pickart, C. M. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell 96, 645-653 (1999).
8. Hoege, C., Pfander, B., Moldovan, G. L., Pyrowolakis, G. & Jentsch, S. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 419, 135-141 (2002).
9. Wang, C. et at. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346-351 (2001).
10. Hicke, L. Protein regulation by monoubiquitin. Nature Rev. Mol. Cell Biol. 2, 195-201 (2001).
11. Kaiser, P., Flick, K., Wittenberg, C. & Reed, S. I. Regulation of transcription by ubiquitination without proteolysis: Cdc34/SCF(Met30)-mediated inactivation of the transcription factor Met4. Cell 102, 303-314 (2000).
12. Kuras, L. et al. Dual regulation of the met4 transcription factor by ubiquitin-dependent degradation and inhibition of promoter recruitment. Mol. Cell 10, 69-80 (2002).
13. Thomas, D., Jacquemin, I. & Surdin-Kerjan, Y. MET4, a leucine zipper protein, and centromere-binding factor 1 are both required for transcriptional activation of sulfur metabolism in Saccharomyces cerevisiae. Mol. Cell. Biol. 12, 1719-1727 (1992).
14. Thomas, D. & Surdin-Kerjan, Y. Metabolism of sulfur amino acids in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 61, 503-532 (1997).
15. Patton, E. E. et al. SCF(Met30)-mediated control of the transcriptional activator Met4 is required for the G(1)-S transition. EMBO J. 19, 1613-1624 (2000).
16. MacCoss, M. J. et al. Shotgun identification of protein modifications from protein complexes and lens tissue. Proc. Natl Acad. Sci. USA 99, 7900-7905 (2002).
17. Rouillon, A., Barbey, R., Patton, E. E., Tyers, M. & Thomas, D. Feedback-regulated degradation of the transcriptional activator Met4 is triggered by the SCF(Met30)complex. EMBO J. 19, 282-294 (2000).
18. Skowyra, D., Craig, K. L., Tyers, M., Elledge, S. J. & Harper, J. W. F-Box Proteins are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex. Cell 91, 209-219 (1997).
19. Grr1 and Rbx1. Science 284, 662-665 (1999).
20. Kornitzer, D., Raboy, B., Kulka, R. G. & Fink, G. R. Regulated degradation of the transcription factor Gcn4. EMBO J. 13, 6021-6030 (1994).
21. Nakamura, S., Roth, J. A. & Mukhopadhyay, T. Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination. Mol. Cell. Biol. 20, 9391-9398 (2000).
22. Petroski, M. D. & Deshaies, R. J. Context of multiubiquitin chain attachment influences the rate of Sic1 degradation. Mol. Cell 11, 1435-1444 (2003).
23. Deffenbaugh, A. E. et al. Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1. Cell 114, 611-622 (2003).
24. Lee, C., Schwartz, M. P., Prakash, S., Iwakura, M. & Matouschek, A. ATP-dependent proteases degrade their substrates by processively unraveling them from the degradation signal. Mol. Cell 7, 627-637 (2001).
25. Verma, R. & Deshaies, R. J. A proteasome howdunit: the case of the missing signal. Cell 101, 341-344 (2000).
26. Elsasser, S. et al. Proteasome subunit Rpn1 binds ubiquitin-like protein domains. Nature Cell Biol. 4, 725-730 (2002).
27. Muratani, M. & Tansey, W. P. How the ubiquitin-proteasome system controls transcription. Nature Rev. Mol. Cell Biol. 4, 192-201 (2003).
28. Reed, S. I., Hadwiger, J. A. & Lorincz, A. T. Protein kinase activity associated with the product of the yeast cell division cycle gene CDC28. Proc. Natl Acad. Sci. USA 82, 4055-4059 (1985).
29. Guthrie, C. & Fink, G. R. Guide to Yeast Genetics and Molecular Biology (Academic Press, San Diego, 1991).
30. Cherest, H. & Surdin-Kerjan, Y. Genetic analysis of a new mutation conferring cysteine auxotrophy in Saccharomyces cerevisiae: updating of the sulfur metabolism pathway. Genetics 130, 51-58 (1992).
31. Peng, J. et al. A proteomics approach to understanding protein ubiquitination. Nature Biotechnol. 21, 921-926 (2003).
32. Gatlin, C. L., Kleemann, G. R., Hays, L. G., Link, A. J. & Yates, J. R., 3rd. Protein identification at the low femtomole level from silver-stained gels using a new fritless electrospray interface for liquid chromatography-microspray and nanospray mass spectrometry. Anal. Biochem. 263, 93-101 (1998).