메뉴 건너뛰기




Volumn 2, Issue 1, 2014, Pages

Conjugates of small molecule drugs with antibodies and other proteins

Author keywords

ADC; Antibody drug conjugates; Biologics; Biotherapeutics; Drugs

Indexed keywords


EID: 84938751906     PISSN: None     EISSN: 22279059     Source Type: Journal    
DOI: 10.3390/biomedicines2010001     Document Type: Review
Times cited : (24)

References (67)
  • 1
    • 84873053339 scopus 로고    scopus 로고
    • Antibody-drug conjugates in cancer therapy
    • Sievers, E.L.; Senter, P.D. Antibody-drug conjugates in cancer therapy. Annu. Rev. Med. 2013, 64, 15-29
    • (2013) Annu. Rev. Med , vol.64 , pp. 15-29
    • Sievers, E.L.1    Senter, P.D.2
  • 2
    • 84874343465 scopus 로고    scopus 로고
    • Drug-conjugated antibodies for the treatment of cancer
    • Lambert, J.M. Drug-conjugated antibodies for the treatment of cancer. Br. J. Clin. Pharmacol. 2013, 76, 248-262
    • (2013) Br. J. Clin. Pharmacol , vol.76 , pp. 248-262
    • Lambert, J.M.1
  • 5
    • 84877310777 scopus 로고    scopus 로고
    • Maturing antibody-drug conjugate pipeline hits 30
    • Mullard, A. Maturing antibody-drug conjugate pipeline hits 30. Nat. Rev. Drug Discov. 2013, 12, 329-332
    • (2013) Nat. Rev. Drug Discov , vol.12 , pp. 329-332
    • Mullard, A.1
  • 6
    • 84869164607 scopus 로고    scopus 로고
    • Risks and untoward toxicities of antibody-based immunoconjugates
    • Litvak-Greenfeld, D.; Benhar, I. Risks and untoward toxicities of antibody-based immunoconjugates. Adv. Drug Deliv. Rev. 2012, 64, 1782-1799
    • (2012) Adv. Drug Deliv. Rev , vol.64 , pp. 1782-1799
    • Litvak-Greenfeld, D.1    Benhar, I.2
  • 7
    • 84901857665 scopus 로고    scopus 로고
    • Management of relapsed or refractory hodgkin lymphoma with second-generation antibody-drug conjugates: Focus on brentuximab vedotin
    • Mei, M.; Thomas, S.; Chen, R. Management of relapsed or refractory hodgkin lymphoma with second-generation antibody-drug conjugates: Focus on brentuximab vedotin. BioDrugs 2013, doi:10.1007/s40259-013-0077-7
    • (2013) BioDrugs
    • Mei, M.1    Thomas, S.2    Chen, R.3
  • 9
    • 84899498662 scopus 로고    scopus 로고
    • Trends in cancer-targeted antibody-drug conjugates
    • Bidard, F.C.; Tredan, O. Trends in cancer-targeted antibody-drug conjugates. Target Oncol. 2013, doi:10.1007/s11523-013-0302-9
    • (2013) Target Oncol
    • Bidard, F.C.1    Tredan, O.2
  • 10
    • 84890560162 scopus 로고    scopus 로고
    • Trends in translational medicine and drug targeting and delivery: New insights on an old concept-targeted drug delivery with antibody-drug conjugates for cancers
    • Ho, R.J.; Chien, J. Trends in translational medicine and drug targeting and delivery: New insights on an old concept-targeted drug delivery with antibody-drug conjugates for cancers. J. Pharm. Sci. 2013, 103, 71-77
    • (2013) J. Pharm. Sci , vol.103 , pp. 71-77
    • Ho, R.J.1    Chien, J.2
  • 11
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • Presta, L.G.; Chen, H.; O'Connor, S.J.; Chisholm, V.; Meng, Y.G.; Krummen, L.; Winkler, M.; Ferrara, N. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res. 1997, 57, 4593-4599
    • (1997) Cancer Res , vol.57 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O'Connor, S.J.3    Chisholm, V.4    Meng, Y.G.5    Krummen, L.6    Winkler, M.7    Ferrara, N.8
  • 13
    • 0023765625 scopus 로고
    • Human monoclonal IgG isotypes differ in complement activating function at the level of C4 as well as C1q
    • Bindon, C.I.; Hale, G.; Bruggemann, M.; Waldmann, H. Human monoclonal IgG isotypes differ in complement activating function at the level of C4 as well as C1q. J. Exp. Med. 1988, 168, 127-142
    • (1988) J. Exp. Med , vol.168 , pp. 127-142
    • Bindon, C.I.1    Hale, G.2    Bruggemann, M.3    Waldmann, H.4
  • 14
    • 1242271202 scopus 로고    scopus 로고
    • Herceptin-geldanamycin immunoconjugates: Pharmacokinetics, biodistribution, and enhanced antitumor activity
    • Mandler, R.; Kobayashi, H.; Hinson, E.R.; Brechbiel, M.W.; Waldmann, T.A. Herceptin-geldanamycin immunoconjugates: Pharmacokinetics, biodistribution, and enhanced antitumor activity. Cancer Res. 2004, 64, 1460-1467
    • (2004) Cancer Res , vol.64 , pp. 1460-1467
    • Mandler, R.1    Kobayashi, H.2    Hinson, E.R.3    Brechbiel, M.W.4    Waldmann, T.A.5
  • 15
    • 0023465512 scopus 로고
    • Stage-and tissue-specific expression of the neu oncogene in rat development
    • Kokai, Y.; Cohen, J.A.; Drebin, J.A.; Greene, M.I. Stage-and tissue-specific expression of the neu oncogene in rat development. Proc. Natl. Acad. Sci. USA 1987, 84, 8498-8501
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 8498-8501
    • Kokai, Y.1    Cohen, J.A.2    Drebin, J.A.3    Greene, M.I.4
  • 16
    • 84872846418 scopus 로고    scopus 로고
    • Implications of receptor-mediated endocytosis and intracellular trafficking dynamics in the development of antibody drug conjugates
    • Ritchie, M.; Tchistiakova, L.; Scott, N. Implications of receptor-mediated endocytosis and intracellular trafficking dynamics in the development of antibody drug conjugates. mAbs 2013, 5, 13-21
    • (2013) MAbs , vol.5 , pp. 13-21
    • Ritchie, M.1    Tchistiakova, L.2    Scott, N.3
  • 17
    • 80054113954 scopus 로고    scopus 로고
    • Antibody-drug conjugates of calicheamicin derivative: Gemtuzumab ozogamicin and inotuzumab ozogamicin
    • Ricart, A.D. Antibody-drug conjugates of calicheamicin derivative: Gemtuzumab ozogamicin and inotuzumab ozogamicin. Clin. Cancer Res. 2011, 17, 6417-6427
    • (2011) Clin. Cancer Res , vol.17 , pp. 6417-6427
    • Ricart, A.D.1
  • 19
    • 77955312203 scopus 로고    scopus 로고
    • Antibody-drug conjugates: Targeted drug delivery for cancer
    • Alley, S.C.; Okeley, N.M.; Senter, P.D. Antibody-drug conjugates: Targeted drug delivery for cancer. Curr. Opin. Chem. Biol. 2010, 14, 529-537
    • (2010) Curr. Opin. Chem. Biol , vol.14 , pp. 529-537
    • Alley, S.C.1    Okeley, N.M.2    Senter, P.D.3
  • 20
    • 0030756892 scopus 로고    scopus 로고
    • Endocytosis and recycling of G protein-coupled receptors
    • Koenig, J.A.; Edwardson, J.M. Endocytosis and recycling of G protein-coupled receptors. Trends Pharmacol. Sci. 1997, 18, 276-287
    • (1997) Trends Pharmacol. Sci , vol.18 , pp. 276-287
    • Koenig, J.A.1    Edwardson, J.M.2
  • 21
    • 84934444640 scopus 로고    scopus 로고
    • Antibody-drug conjugate (ADC) clinical pipeline: A review
    • Sassoon, I.; Blanc, V. Antibody-drug conjugate (ADC) clinical pipeline: A review. Methods Mol. Biol. 2013, 1045, 1-27
    • (2013) Methods Mol. Biol , vol.1045 , pp. 1-27
    • Sassoon, I.1    Blanc, V.2
  • 23
    • 84876059306 scopus 로고    scopus 로고
    • Antibody-based candidate therapeutics against HIV-1: Implications for virus eradication and vaccine design
    • Chen, W.; Ying, T.; Dimitrov, D.S. Antibody-based candidate therapeutics against HIV-1: Implications for virus eradication and vaccine design. Expert Opin. Biol. Ther. 2013, 13, 657-671
    • (2013) Expert Opin. Biol. Ther , vol.13 , pp. 657-671
    • Chen, W.1    Ying, T.2    Dimitrov, D.S.3
  • 24
    • 80052499557 scopus 로고    scopus 로고
    • Engineered single human CD4 domains as potent HIV-1 inhibitors and components of vaccine immunogens
    • Chen, W.; Feng, Y.; Gong, R.; Zhu, Z.; Wang, Y.; Zhao, Q.; Dimitrov, D.S. Engineered single human CD4 domains as potent HIV-1 inhibitors and components of vaccine immunogens. J. Virol. 2011, 85, 9395-9405
    • (2011) J. Virol , vol.85 , pp. 9395-9405
    • Chen, W.1    Feng, Y.2    Gong, R.3    Zhu, Z.4    Wang, Y.5    Zhao, Q.6    Dimitrov, D.S.7
  • 26
    • 55949131238 scopus 로고    scopus 로고
    • Human domain antibodies to conserved sterically restricted regions on gp120 as exceptionally potent cross-reactive HIV-1 neutralizers
    • Chen, W.; Zhu, Z.; Feng, Y.; Dimitrov, D.S. Human domain antibodies to conserved sterically restricted regions on gp120 as exceptionally potent cross-reactive HIV-1 neutralizers. Proc. Natl. Acad. Sci. USA 2008, 105, 17121-17126
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 17121-17126
    • Chen, W.1    Zhu, Z.2    Feng, Y.3    Dimitrov, D.S.4
  • 27
    • 77956913427 scopus 로고    scopus 로고
    • Bifunctional fusion proteins of the human engineered antibody domain m36 with human soluble CD4 are potent inhibitors of diverse HIV-1 isolates
    • Chen, W.; Xiao, X.; Wang, Y.; Zhu, Z.; Dimitrov, D.S. Bifunctional fusion proteins of the human engineered antibody domain m36 with human soluble CD4 are potent inhibitors of diverse HIV-1 isolates. Antivir. Res. 2010, 88, 107-115
    • (2010) Antivir. Res , vol.88 , pp. 107-115
    • Chen, W.1    Xiao, X.2    Wang, Y.3    Zhu, Z.4    Dimitrov, D.S.5
  • 28
    • 0037372301 scopus 로고    scopus 로고
    • Neutralization of human immunodeficiency virus type 1 by sCD4-17b, a single-chain chimeric protein, based on sequential interaction of gp120 with CD4 and coreceptor
    • Dey, B.; Del Castillo, C.S.; Berger, E.A. Neutralization of human immunodeficiency virus type 1 by sCD4-17b, a single-chain chimeric protein, based on sequential interaction of gp120 with CD4 and coreceptor. J. Virol. 2003, 77, 2859-2865
    • (2003) J. Virol , vol.77 , pp. 2859-2865
    • Dey, B.1    Del Castillo, C.S.2    Berger, E.A.3
  • 29
    • 38949184547 scopus 로고    scopus 로고
    • Selection of reaction additives used in the preparation of monomeric antibody-calicheamicin conjugates
    • Hollander, I.; Kunz, A.; Hamann, P.R. Selection of reaction additives used in the preparation of monomeric antibody-calicheamicin conjugates. Bioconjug. Chem. 2008, 19, 358-361
    • (2008) Bioconjug. Chem , vol.19 , pp. 358-361
    • Hollander, I.1    Kunz, A.2    Hamann, P.R.3
  • 31
    • 0025923704 scopus 로고
    • Anti-MY9-blocked-ricin: An immunotoxin for selective targeting of acute myeloid leukemia cells
    • Roy, D.C.; Griffin, J.D.; Belvin, M.; Blattler, W.A.; Lambert, J.M.; Ritz, J. Anti-MY9-blocked-ricin: An immunotoxin for selective targeting of acute myeloid leukemia cells. Blood 1991, 77, 2404-2412
    • (1991) Blood , vol.77 , pp. 2404-2412
    • Roy, D.C.1    Griffin, J.D.2    Belvin, M.3    Blattler, W.A.4    Lambert, J.M.5    Ritz, J.6
  • 32
    • 0024323595 scopus 로고
    • Inhibition of human tumor growth in nude mice by a conjugate of doxorubicin with monoclonal antibodies to epidermal growth factor receptor
    • Aboud-Pirak, E.; Hurwitz, E.; Bellot, F.; Schlessinger, J.; Sela, M. Inhibition of human tumor growth in nude mice by a conjugate of doxorubicin with monoclonal antibodies to epidermal growth factor receptor. Proc. Natl. Acad. Sci. USA 1989, 86, 3778-3781
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 3778-3781
    • Aboud-Pirak, E.1    Hurwitz, E.2    Bellot, F.3    Schlessinger, J.4    Sela, M.5
  • 34
    • 0021803197 scopus 로고
    • Conjugation of methotrexate to IgG antibodies and their F(ab)2 fragments and the effect of conjugated methotrexate on tumor growth in vivo
    • Kulkarni, P.N.; Blair, A.H.; Ghose, T.; Mammen, M. Conjugation of methotrexate to IgG antibodies and their F(ab)2 fragments and the effect of conjugated methotrexate on tumor growth in vivo. Cancer Immunol. Immunother. 1985, 19, 211-214
    • (1985) Cancer Immunol. Immunother , vol.19 , pp. 211-214
    • Kulkarni, P.N.1    Blair, A.H.2    Ghose, T.3    Mammen, M.4
  • 36
    • 77957374075 scopus 로고    scopus 로고
    • Microtubule-binding agents: A dynamic field of cancer therapeutics
    • Dumontet, C.; Jordan, M.A. Microtubule-binding agents: A dynamic field of cancer therapeutics. Nat. Rev. Drug Discov. 2010, 9, 790-803
    • (2010) Nat. Rev. Drug Discov , vol.9 , pp. 790-803
    • Dumontet, C.1    Jordan, M.A.2
  • 37
    • 84858248304 scopus 로고    scopus 로고
    • Duocarmycin analogues target aldehyde dehydrogenase 1 in lung cancer cells
    • Wirth, T.; Schmuck, K.; Tietze, L.F.; Sieber, S.A. Duocarmycin analogues target aldehyde dehydrogenase 1 in lung cancer cells. Angew. Chem. Int. Ed. Engl. 2012, 51, 2874-2877
    • (2012) Angew. Chem. Int. Ed. Engl , vol.51 , pp. 2874-2877
    • Wirth, T.1    Schmuck, K.2    Tietze, L.F.3    Sieber, S.A.4
  • 38
    • 84877256505 scopus 로고    scopus 로고
    • Novel detection of DNA-alkylated adducts of antibody-drug conjugates with potentially unique preclinical and biomarker applications
    • Thevanayagam, L.; Bell, A.; Chakraborty, I.; Sufi, B.; Gangwar, S.; Zang, A.; Rangan, V.; Rao, C.; Wang, Z.; Pan, C.; et al. Novel detection of DNA-alkylated adducts of antibody-drug conjugates with potentially unique preclinical and biomarker applications. Bioanalysis 2013, 5, 1073-1081
    • (2013) Bioanalysis , vol.5 , pp. 1073-1081
    • Thevanayagam, L.1    Bell, A.2    Chakraborty, I.3    Sufi, B.4    Gangwar, S.5    Zang, A.6    Rangan, V.7    Rao, C.8    Wang, Z.9    Pan, C.10
  • 39
    • 0023820894 scopus 로고
    • Calicheamicin gamma 1I: An antitumor antibiotic that cleaves double-stranded DNA site specifically
    • Zein, N.; Sinha, A.M.; McGahren, W.J.; Ellestad, G.A. Calicheamicin gamma 1I: An antitumor antibiotic that cleaves double-stranded DNA site specifically. Science 1988, 240, 1198-1201
    • (1988) Science , vol.240 , pp. 1198-1201
    • Zein, N.1    Sinha, A.M.2    McGahren, W.J.3    Ellestad, G.A.4
  • 40
    • 84881278016 scopus 로고    scopus 로고
    • Why is it so difficult to use gemtuzumab ozogamicin?
    • Castaigne, S. Why is it so difficult to use gemtuzumab ozogamicin? Blood 2013, 121, 4813-4814
    • (2013) Blood , vol.121 , pp. 4813-4814
    • Castaigne, S.1
  • 41
    • 0002747476 scopus 로고    scopus 로고
    • The Dolastatins
    • Herz, W., Kirby, G.W., Moore, R.E., Steglich, W., Tamm, Ch., Eds.; Fortschritte der Chemie Organischer Naturstoffe/Progress in the Chemistry of Organic Natural Products; Springer Vienna: Vienna, Austria
    • Pettit, G.R. The Dolastatins; Herz, W., Kirby, G.W., Moore, R.E., Steglich, W., Tamm, Ch., Eds.; Fortschritte der Chemie Organischer Naturstoffe/Progress in the Chemistry of Organic Natural Products; Springer Vienna: Vienna, Austria, 1997; Volume 70
    • (1997) , vol.70
    • Pettit, G.R.1
  • 42
    • 0034005620 scopus 로고    scopus 로고
    • Novel marine-derived anticancer agents: A phase I clinical, pharmacological, and pharmacodynamic study of dolastatin 10 (NSC 376128) in patients with advanced solid tumors
    • Madden, T.; Tran, H.T.; Beck, D.; Huie, R.; Newman, R.A.; Pusztai, L.; Wright, J.J.; Abbruzzese, J.L. Novel marine-derived anticancer agents: A phase I clinical, pharmacological, and pharmacodynamic study of dolastatin 10 (NSC 376128) in patients with advanced solid tumors. Clin. Cancer Res. 2000, 6, 1293-1301
    • (2000) Clin. Cancer Res , vol.6 , pp. 1293-1301
    • Madden, T.1    Tran, H.T.2    Beck, D.3    Huie, R.4    Newman, R.A.5    Pusztai, L.6    Wright, J.J.7    Abbruzzese, J.L.8
  • 45
    • 77950835018 scopus 로고    scopus 로고
    • Glembatumumab vedotin, a conjugate of an anti-glycoprotein non-metastatic melanoma protein B mAb and monomethyl auristatin E for the treatment of melanoma and breast cancer
    • Naumovski, L.; Junutula, J.R. Glembatumumab vedotin, a conjugate of an anti-glycoprotein non-metastatic melanoma protein B mAb and monomethyl auristatin E for the treatment of melanoma and breast cancer. Curr. Opin. Mol. Ther. 2010, 12, 248-257
    • (2010) Curr. Opin. Mol. Ther , vol.12 , pp. 248-257
    • Naumovski, L.1    Junutula, J.R.2
  • 46
    • 84880072016 scopus 로고    scopus 로고
    • DCDT2980S, an anti-CD22-monomethyl auristatin E antibody-drug conjugate, is a potential treatment for non-Hodgkin lymphoma
    • Li, D.; Poon, K.A.; Yu, S.F.; Dere, R.; Go, M.; Lau, J.; Zheng, B.; Elkins, K.; Danilenko, D.; Kozak, K.R.; et al. DCDT2980S, an anti-CD22-monomethyl auristatin E antibody-drug conjugate, is a potential treatment for non-Hodgkin lymphoma. Mol. Cancer Ther. 2013, 12, 1255-1265
    • (2013) Mol. Cancer Ther , vol.12 , pp. 1255-1265
    • Li, D.1    Poon, K.A.2    Yu, S.F.3    Dere, R.4    Go, M.5    Lau, J.6    Zheng, B.7    Elkins, K.8    Danilenko, D.9    Kozak, K.R.10
  • 47
    • 33646385331 scopus 로고    scopus 로고
    • Potent antitumor activity of an auristatin-conjugated, fully human monoclonal antibody to prostate-specific membrane antigen
    • Ma, D.; Hopf, C.E.; Malewicz, A.D.; Donovan, G.P.; Senter, P.D.; Goeckeler, W.F.; Maddon, P.J.; Olson, W.C. Potent antitumor activity of an auristatin-conjugated, fully human monoclonal antibody to prostate-specific membrane antigen. Clin. Cancer Res. 2006, 12, 2591-2596
    • (2006) Clin. Cancer Res , vol.12 , pp. 2591-2596
    • Ma, D.1    Hopf, C.E.2    Malewicz, A.D.3    Donovan, G.P.4    Senter, P.D.5    Goeckeler, W.F.6    Maddon, P.J.7    Olson, W.C.8
  • 50
    • 36849018078 scopus 로고    scopus 로고
    • Novel method for in vitro O-glycosylation of proteins: Application for bioconjugation
    • Ramakrishnan, B.; Boeggeman, E.; Qasba, P.K. Novel method for in vitro O-glycosylation of proteins: Application for bioconjugation. Bioconjug. Chem. 2007, 18, 1912-1918
    • (2007) Bioconjug. Chem , vol.18 , pp. 1912-1918
    • Ramakrishnan, B.1    Boeggeman, E.2    Qasba, P.K.3
  • 52
    • 72449121780 scopus 로고    scopus 로고
    • Molecularly defined antibody conjugation through a selenocysteine interface
    • Hofer, T.; Skeffington, L.R.; Chapman, C.M.; Rader, C. Molecularly defined antibody conjugation through a selenocysteine interface. Biochemistry 2009, 48, 12047-12057
    • (2009) Biochemistry , vol.48 , pp. 12047-12057
    • Hofer, T.1    Skeffington, L.R.2    Chapman, C.M.3    Rader, C.4
  • 53
    • 84855379223 scopus 로고    scopus 로고
    • Conjugation of anticancer drugs through endogenous monoclonal antibody cysteine residues
    • Lyon, R.P.; Meyer, D.L.; Setter, J.R.; Senter, P.D. Conjugation of anticancer drugs through endogenous monoclonal antibody cysteine residues. Methods Enzymol. 2012, 502, 123-138
    • (2012) Methods Enzymol , vol.502 , pp. 123-138
    • Lyon, R.P.1    Meyer, D.L.2    Setter, J.R.3    Senter, P.D.4
  • 55
    • 84858727362 scopus 로고    scopus 로고
    • Native intact mass determination of antibodies conjugated with monomethyl Auristatin E and F at interchain cysteine residues
    • Valliere-Douglass, J.F.; McFee, W.A.; Salas-Solano, O. Native intact mass determination of antibodies conjugated with monomethyl Auristatin E and F at interchain cysteine residues. Anal. Chem. 2012, 84, 2843-2849
    • (2012) Anal. Chem , vol.84 , pp. 2843-2849
    • Valliere-Douglass, J.F.1    McFee, W.A.2    Salas-Solano, O.3
  • 58
    • 24344456964 scopus 로고    scopus 로고
    • Structural characterization of the maytansinoid-monoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry
    • Wang, L.; Amphlett, G.; Blattler, W.A.; Lambert, J.M.; Zhang, W. Structural characterization of the maytansinoid-monoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry. Protein Sci. 2005, 14, 2436-2446
    • (2005) Protein Sci , vol.14 , pp. 2436-2446
    • Wang, L.1    Amphlett, G.2    Blattler, W.A.3    Lambert, J.M.4    Zhang, W.5
  • 59
    • 84871362496 scopus 로고    scopus 로고
    • Antibody-drug conjugates for the treatment of cancer
    • Flygare, J.A.; Pillow, T.H.; Aristoff, P. Antibody-drug conjugates for the treatment of cancer. Chem. Biol. Drug Des. 2013, 81, 113-121
    • (2013) Chem. Biol. Drug Des , vol.81 , pp. 113-121
    • Flygare, J.A.1    Pillow, T.H.2    Aristoff, P.3
  • 60
    • 0016724870 scopus 로고
    • Antimitotic activity of the potent tumor inhibitor maytansine
    • Remillard, S.; Rebhun, L.I.; Howie, G.A.; Kupchan, S.M. Antimitotic activity of the potent tumor inhibitor maytansine. Science 1975, 189, 1002-1005
    • (1975) Science , vol.189 , pp. 1002-1005
    • Remillard, S.1    Rebhun, L.I.2    Howie, G.A.3    Kupchan, S.M.4
  • 61
    • 33645500289 scopus 로고    scopus 로고
    • Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing
    • Erickson, H.K.; Park, P.U.; Widdison, W.C.; Kovtun, Y.V.; Garrett, L.M.; Hoffman, K.; Lutz, R.J.; Goldmacher, V.S.; Blattler, W.A. Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing. Cancer Res. 2006, 66, 4426-4433
    • (2006) Cancer Res , vol.66 , pp. 4426-4433
    • Erickson, H.K.1    Park, P.U.2    Widdison, W.C.3    Kovtun, Y.V.4    Garrett, L.M.5    Hoffman, K.6    Lutz, R.J.7    Goldmacher, V.S.8    Blattler, W.A.9
  • 62
    • 84875434050 scopus 로고    scopus 로고
    • Safety and clinical activity of a combination therapy comprising two antibody-based targeting agents for the treatment of non-Hodgkin lymphoma: Results of a phase I/II study evaluating the immunoconjugate inotuzumab ozogamicin with rituximab
    • Fayad, L.; Offner, F.; Smith, M.R.; Verhoef, G.; Johnson, P.; Kaufman, J.L.; Rohatiner, A.; Advani, A.; Foran, J.; Hess, G.; et al. Safety and clinical activity of a combination therapy comprising two antibody-based targeting agents for the treatment of non-Hodgkin lymphoma: Results of a phase I/II study evaluating the immunoconjugate inotuzumab ozogamicin with rituximab. J. Clin. Oncol. 2013, 31, 573-583
    • (2013) J. Clin. Oncol , vol.31 , pp. 573-583
    • Fayad, L.1    Offner, F.2    Smith, M.R.3    Verhoef, G.4    Johnson, P.5    Kaufman, J.L.6    Rohatiner, A.7    Advani, A.8    Foran, J.9    Hess, G.10
  • 63
    • 0042303836 scopus 로고    scopus 로고
    • Antibody-targeted chemotherapy with immunoconjugates of calicheamicin
    • Damle, N.K.; Frost, P. Antibody-targeted chemotherapy with immunoconjugates of calicheamicin. Curr. Opin. Pharmacol. 2003, 3, 386-390
    • (2003) Curr. Opin. Pharmacol , vol.3 , pp. 386-390
    • Damle, N.K.1    Frost, P.2
  • 64
    • 84934441628 scopus 로고    scopus 로고
    • Protocols for lysine conjugation
    • Brun, M.P.; Gauzy-Lazo, L. Protocols for lysine conjugation. Methods Mol. Biol. 2013, 1045, 173-187
    • (2013) Methods Mol. Biol , vol.1045 , pp. 173-187
    • Brun, M.P.1    Gauzy-Lazo, L.2
  • 65
    • 74949107560 scopus 로고    scopus 로고
    • Antibody-drug conjugates: Linking cytotoxic payloads to monoclonal antibodies
    • Ducry, L.; Stump, B. Antibody-drug conjugates: Linking cytotoxic payloads to monoclonal antibodies. Bioconjug. Chem. 2010, 21, 5-13
    • (2010) Bioconjug. Chem , vol.21 , pp. 5-13
    • Ducry, L.1    Stump, B.2
  • 66
    • 74949139946 scopus 로고    scopus 로고
    • Tumor delivery and in vivo processing of disulfide-linked and thioether-linked antibody-maytansinoid conjugates
    • Erickson, H.K.; Widdison, W.C.; Mayo, M.F.; Whiteman, K.; Audette, C.; Wilhelm, S.D.; Singh, R. Tumor delivery and in vivo processing of disulfide-linked and thioether-linked antibody-maytansinoid conjugates. Bioconjug. Chem. 2010, 21, 84-92
    • (2010) Bioconjug. Chem , vol.21 , pp. 84-92
    • Erickson, H.K.1    Widdison, W.C.2    Mayo, M.F.3    Whiteman, K.4    Audette, C.5    Wilhelm, S.D.6    Singh, R.7
  • 67
    • 84860893742 scopus 로고    scopus 로고
    • Impact of linker and conjugation chemistry on antigen binding, Fc receptor binding and thermal stability of model antibody-drug conjugates
    • Acchione, M.; Kwon, H.; Jochheim, C.M.; Atkins, W.M. Impact of linker and conjugation chemistry on antigen binding, Fc receptor binding and thermal stability of model antibody-drug conjugates. mAbs 2012, 4, 362-372
    • (2012) MAbs , vol.4 , pp. 362-372
    • Acchione, M.1    Kwon, H.2    Jochheim, C.M.3    Atkins, W.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.