Small-angle neutron scattering study of a monoclonal antibody using free-energy constraints

Journal of Physical Chemistry B

Volumn 117, Issue 45, 2013, Pages 14029-14038

  Clark, Nicholas J ^a   Zhang, Hailiang ^b   Krueger, Susan ^a   Lee, Hyo Jin ^c   Ketchem, Randal R ^d   Kerwin, Bruce ^c   Kanapuram, Sekhar R ^c   Treuheit, Michael J ^d   McAuley, Arnold ^c   Curtis, Joseph E ^a  

^a NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c AMGEN INC   (United States)

^d AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FREE-ENERGY CALCULATIONS; INTERCHAIN DISULFIDE BONDS; INTRAMOLECULAR INTERACTIONS; MOLECULAR DYNAMICS SIMULATIONS; MONOCLONAL ANTIBODIES (MABS); SMALL-ANGLE NEUTRON SCATTERING; STRUCTURAL CONFIGURATIONS; STRUCTURAL FLEXIBILITIES;

COVALENT BONDS; FREE ENERGY; MOLECULAR DYNAMICS; MONOCLONAL ANTIBODIES; MONTE CARLO METHODS;

NEUTRON SCATTERING;

IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; STREPTAVIDIN;

ARTICLE; CHEMISTRY; HUMAN; IMMUNOLOGY; METABOLISM; MOLECULAR DYNAMICS; MONTE CARLO METHOD; NEUTRON DIFFRACTION; SMALL ANGLE SCATTERING; THERMODYNAMICS;

ANTIBODIES, MONOCLONAL; HUMANS; IMMUNOGLOBULIN G; MOLECULAR DYNAMICS SIMULATION; MONTE CARLO METHOD; NEUTRON DIFFRACTION; SCATTERING, SMALL ANGLE; STREPTAVIDIN; THERMODYNAMICS;

EID: 84887975602     PISSN: 15206106     EISSN: 15205207     Source Type: Journal    
DOI: 10.1021/jp408710r     Document Type: Article

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