MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer

Journal of Translational Medicine

Volumn 13, Issue 1, 2015, Pages

  Zheng, Lin ^a   Zhang, Yuqin ^b   Liu, Yan ^a   Zhou, Min ^a   Lu, Yanxia ^a   Yuan, Li ^a   Zhang, Chao ^a,c   Hong, Min ^a   Wang, Shuang ^a   Li, Xuenong ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF JINAN UNIVERSITY   (China)

^c SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

Colorectal cancer; MiR 106b; p21; PTEN; Radioresistance; Stemness

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CD133 ANTIGEN; HISTONE H2AX; LUCIFERASE; MICRORNA; MICRORNA 106B; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P21; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; CYCLIN DEPENDENT KINASE INHIBITOR 1A; MIRN106 MICRORNA, HUMAN;

ALGORITHM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL LINE; CD133 GENE; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; ENZYME ASSAY; GENE; GENE OVEREXPRESSION; GENETIC STABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PREDICTION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RADIATION DOSE; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; SOX2 GENE; SW480 CELL LINE; SW620 CELL LINE; TUMOR GROWTH; TUMOR XENOGRAFT; UPREGULATION; ANIMAL; CANCER STEM CELL; COLORECTAL TUMOR; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; NUDE MOUSE; PATHOLOGY; RADIATION RESPONSE; RADIATION TOLERANCE; TUMOR CELL LINE;

ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HUMANS; MICE, NUDE; MICRORNAS; MOLECULAR SEQUENCE DATA; NEOPLASTIC STEM CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RADIATION TOLERANCE; RADIATION, IONIZING; SIGNAL TRANSDUCTION;

EID: 84938692632     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-015-0592-z     Document Type: Article

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