p21 functions in a post-mitotic block checkpoint in the apoptotic response to vinblastine

Biochemical and Biophysical Research Communications

Volumn 380, Issue 2, 2009, Pages 211-217

  Bene, Anca ^a   Chambers, Timothy C ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Apoptosis; Caspase 3; Microtubule inhibitor; p21Cip1 WAF1; Vinblastine

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; PROTEIN P21; VINBLASTINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL FATE; CELL LINE; CELL PROTECTION; CELL STRAIN HCT116; CELL STRAIN KB 3; DOWN REGULATION; DRUG RESPONSE; FEMALE; HUMAN; HUMAN CELL; MITOSIS; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN FUNCTION; WILD TYPE;

EID: 85042590739     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.01.032     Document Type: Article

References (18)

1. Xiong Y., Hannon G.J., Zhang H., Casso D., Kobasashi R., and Beach D. P21 is a universal inhibitor of cyclin kinases. Nature 366 (1993) 701-704
2. Gartel A.L., and Tyner A. The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol. Cancer Ther. 1 (2002) 639-649
3. Liu S., Bishop R., and Liu M. Differential effects of cell cycle regulatory protein p21 (WAF1/Cip1) on apoptosis and sensitivity to cancer chemotherapy. Drug Resist. Update 4 (2003) 183-195
4. (CIP1WAF1) in apoptosis. Leukemia Res. 29 (2005) 1237-1238
5. Berry A., Goodwin M., Moran C.L., and Chambers T.C. AP-1 activation and altered AP-1 composition in association with increased phosphorylation and expression of specific Jun and Fos family proteins induced by vinblastine in KB-3 cells. Biochem. Pharmacol. 62 (2001) 581-591
6. Brantley-Finley C., Lyle C.S., Du L., Goodwin M., Hall T., Szwedo D., Kaushal G.P., and Chambers T.C. The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin and etoposide. Biochem. Pharmacol. 66 (2003) 459-469
7. 1Co-first authors.
8. 2-terminal protein kinase/AP-1 pathway is required for efficient apoptosis induced by vinblastine. Cancer Res. 61 (2001) 4450-4458
9. Niculescu A.B., Chen X., Smeets M., Hengst L., Prives C., and Reed S.I. Effects of p21 (Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol. Cell. Biol. 18 (1998) 629-643
10. Dyson N., Howley P.M., Münger K., and Harlow E. The human papilloma virus-16 E7 oncoprotein is able to bind to retinoblastoma gene product. Science 243 (1989) 934-937
11. Scheffner M., Huibregtse J.M., Vierstra R.D., and Howley P.M. The HPV-16 E6 and E6AP function as an ubiquitin protein ligase in the ubiquitination of p53. Cell 75 (1993) 495-505
12. Kondo S., Barna B.P., Kondo Y., Tanaka Y., Casey G., Liu J., Morimura T., Kaakaji R., Peterson J.W., Werbel B., and Barnett G.H. WAF1/CIP1 increases the susceptibility of p53 non-functional malignant glioma cells to cisplatin-induced apoptosis. Oncogene 13 (1999) 1279-1285
13. Lincet H., Poulain L., Remy J.S., Deslandes E., Duigou F., Gauduchon P., and Staedel C. The p21(cip1/waf1) cyclin-dependent kinase inhibitor enhances the cytotoxic effect of cisplatin in human ovarian carcinoma cells. Cancer Lett. 161 (2000) 17-26
14. Wang Y., Blandino G., and Givol D. Induced p21 waf expression in H1299 cell line promotes cell senescence and protects against cytotoxic effect of radiation and doxorubicin. Oncogene 18 (1999) 2643-2649
15. Han Z., Wei W., Dunaway S., Darnowski J.W., Calabresi P., Sedivy J., Hendrickson E.A., Balan K.V., Pantazis P., and Wyche J.H. Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin. J. Biol. Chem. 277 (2002) 17154-17160
16. Li W., Fan J., Banerjee D., and Bertino J.R. Overexpression of p21(waf1) decreases G2-M arrest and apoptosis induced by paclitaxel in human sarcoma cells lacking both p53 and functional Rb protein. Mol. Pharmacol. 55 (1999) 1088-1093
17. Stewart Z.A., Mays D., and Pietenpol J.A. Defective G1-S cell cycle checkpoint function sensitizes cells to microtubule inhibitor-induced apoptosis. Cancer Res. 59 (1999) 3831-3837
18. Lanni J.S., and Jacks T. Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol. Cell. Biol. 18 (1998) 1055-1064