Lymphatic imaging: Focus on imaging probes

Theranostics

Volumn 5, Issue 7, 2015, Pages 686-697

  Niu, Gang ^a   Chen, Xiaoyuan ^a  

^a NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

Author keywords

Contrast agent; Fluorescence; Imaging; MRI; PET; Sentinel lymph node

Indexed keywords

ALBUMIN TC 99M; CHOLINE C 11; CONTRAST MEDIUM; EPITHELIAL CELL ADHESION MOLECULE; FLUORINE 1,4,7 TRIAZACYCLONONANE N,N',N'' TRIACETIC ACID EVANS BLUE CONJUGATE F 18; FLUORINE GALACTO ARGINYLGLYCYLASPARTIC ACID F 18; FLUORODEOXYGLUCOSE F 18; INTEGRIN; LYMPHATIC MAPPING AGENT; LYMPHATIC TARGETING AGENT; PROSTATE SPECIFIC MEMBRANE ANTIGEN; RADIOPHARMACEUTICAL AGENT; TILMANOCEPT TC 99M; TUMOR TARGETING AGENT; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE; UNCLASSIFIED DRUG; FLUORESCENT DYE;

DIAGNOSTIC IMAGING; ECHOGRAPHY; FLUORESCENCE IMAGING; HUMAN; IMAGE DISPLAY; INTERMETHOD COMPARISON; ISOTOPE LABELING; LYMPH NODE METASTASIS; LYMPH VESSEL; LYMPHANGIOGENESIS; LYMPHANGIOGRAPHY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; REVIEW; SENTINEL LYMPH NODE; ANIMAL; COMPUTER ASSISTED TOMOGRAPHY; NEAR INFRARED SPECTROSCOPY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY;

ANIMALS; CONTRAST MEDIA; FLUORESCENT DYES; HUMANS; LYMPHATIC METASTASIS; MAGNETIC RESONANCE IMAGING; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; SPECTROSCOPY, NEAR-INFRARED; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84938677058     PISSN: None     EISSN: 18387640     Source Type: Journal    
DOI: 10.7150/thno.11862     Document Type: Review

References (141)

1. Swartz MA. The physiology of the lymphatic system. Adv Drug Deliv Rev. 2001; 50: 3-20.
2. Wong SY, Hynes RO. Lymphatic or hematogenous dissemination: How does a metastatic tumor cell decide? Cell Cycle. 2006; 5: 812-7.
3. Picker LJ, Butcher EC. Physiological and molecular mechanisms of lymphocyte homing. Annu Rev Immunol. 1992; 10: 561-91.
4. Karaman S, Detmar M. Mechanisms of lymphatic metastasis. J Clin Invest. 2014; 124: 922-8.
5. Tammela T, Alitalo K. Lymphangiogenesis: Molecular mechanisms and future promise. Cell. 2010; 140: 460-76.
6. Veronesi U, Paganelli G, Galimberti V, Viale G, Zurrida S, Bedoni M, et al. Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes. Lancet. 1997; 349: 1864-7.
7. Davis GL. Sensitivity of frozen section examination of pelvic lymph nodes for metastatic prostate carcinoma. Cancer. 1995; 76: 661-8.
8. Torabi M, Aquino SL, Harisinghani MG. Current concepts in lymph node imaging. J Nucl Med. 2004; 45: 1509-18.
9. Qian CN, Berghuis B, Tsarfaty G, Bruch M, Kort EJ, Ditlev J, et al. Preparing the "soil": the primary tumor induces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cells. Cancer Res. 2006; 66: 10365-76.
10. Eiber M, Beer AJ, Holzapfel K, Tauber R, Ganter C, Weirich G, et al. Preliminary results for characterization of pelvic lymph nodes in patients with prostate cancer by diffusion-weighted MR-imaging. Invest Radiol. 2010; 45: 15-23.
11. Tiguert R, Gheiler EL, Tefilli MV, Oskanian P, Banerjee M, Grignon DJ, et al. Lymph node size does not correlate with the presence of prostate cancer metastasis. Urology. 1999; 53: 367-71.
12. Zhang F, Niu G, Lu G, Chen X. Preclinical lymphatic imaging. Mol Imaging Biol. 2011; 13: 599-612.
13. Ma W, Jia J, Wang S, Bai W, Yi J, Bai M, et al. The prognostic value of 18F-FDG PET/CT for hepatocellular carcinoma treated with transarterial chemoembolization (TACE). Theranostics. 2014; 4: 736-44.
14. Sorensen J. How does the patient benefit from clinical PET? Theranostics. 2012; 2: 427-36.
15. Delpassand ES, Samarghandi A, Mourtada JS, Zamanian S, Espenan GD, Sharif R, et al. Long-term survival, toxicity profile, and role of F-18 FDG PET/CT scan in patients with progressive neuroendocrine tumors following peptide receptor radionuclide therapy with high activity In-111 Pentetreotide. Theranostics. 2012; 2: 472-80.
16. Gambhir SS, Czernin J, Schwimmer J, Silverman DH, Coleman RE, Phelps ME. A tabulated summary of the FDG PET literature. J Nucl Med. 2001; 42: 1S-93S.
17. Thorek DL, Riedl CC, Grimm J. Clinical Cerenkov luminescence imaging of 18F-FDG. J Nucl Med. 2014; 55: 95-8.
18. Conti PS, Lilien DL, Hawley K, Keppler J, Grafton ST, Bading JR. PET and [18F]-FDG in oncology: a clinical update. Nucl Med Biol. 1996; 23: 717-35.
19. Hara T, Kosaka N, Kishi H. PET imaging of prostate cancer using carbon-11-choline. J Nucl Med. 1998; 39: 990-5.
20. Jadvar H. Can choline PET tackle the challenge of imaging prostate cancer? Theranostics. 2012; 2: 331-2.
21. Schwarzenbock S, Souvatzoglou M, Krause BJ. Choline PET and PET/CT in primary diagnosis and staging of prostate cancer. Theranostics. 2012; 2: 318-30.
22. Picchio M, Castellucci P. Clinical indications of 11C-choline PET/CT in prostate cancer patients with biochemical relapse. Theranostics. 2012; 2: 313-7.
23. de Jong IJ, Pruim J, Elsinga PH, Vaalburg W, Mensink HJ. Preoperative staging of pelvic lymph nodes in prostate cancer by 11C-choline PET. J Nucl Med. 2003; 44: 331-5.
24. Kitajima K, Murphy RC, Nathan MA, Froemming AT, Hagen CE, Takahashi N, et al. Detection of recurrent prostate cancer after radical prostatectomy: comparison of 11C-choline PET/CT with pelvic multiparametric MR imaging with endorectal coil. J Nucl Med. 2014; 55: 223-32.
25. Fricke E, Machtens S, Hofmann M, van den Hoff J, Bergh S, Brunkhorst T, et al. Positron emission tomography with 11C-acetate and 18F-FDG in prostate cancer patients. Eur J Nucl Med Mol Imaging. 2003; 30: 607-11.
26. Mannweiler S, Amersdorfer P, Trajanoski S, Terrett JA, King D, Mehes G. Heterogeneity of prostate-specific membrane antigen (PSMA) expression in prostate carcinoma with distant metastasis. Pathol Oncol Res. 2009; 15: 167-72.
27. Afshar-Oromieh A, Zechmann CM, Malcher A, Eder M, Eisenhut M, Linhart HG, et al. Comparison of PET imaging with a 68Ga-labelled PSMA ligand and 18F-choline-based PET/CT for the diagnosis of recurrent prostate cancer. Eur J Nucl Med Mol Imaging. 2014; 41: 11-20.
28. Baeuerle PA, Gires O. EpCAM (CD326) finding its role in cancer. Br J Cancer. 2007; 96: 417-23.
29. Jeon S, Hong W, Lee ES, Cho Y. High-purity isolation and recovery of circulating tumor cells using conducting polymer-deposited microfluidic device. Theranostics. 2014; 4: 1123-32.
30. Benko G, Spajic B, Kruslin B, Tomas D. Impact of the EpCAM expression on biochemical recurrence-free survival in clinically localized prostate cancer. Urol Oncol. 2013; 31: 468-74.
31. Hall MA, Pinkston KL, Wilganowski N, Robinson H, Ghosh P, Azhdarinia A, et al. Comparison of mAbs targeting epithelial cell adhesion molecule for the detection of prostate cancer lymph node metastases with multimodal contrast agents: quantitative small-animal PET/CT and NIRF. J Nucl Med. 2012; 53: 1427-37.
32. Yang M, Gao H, Yan Y, Sun X, Chen K, Quan Q, et al. PET imaging of early response to the tyrosine kinase inhibitor ZD4190. European journal of nuclear medicine and molecular imaging. 2011; 38: 1237-47.
33. Brooks PC, Montgomery AM, Rosenfeld M, Reisfeld RA, Hu T, Klier G, et al. Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell. 1994; 79: 1157-64.
34. Cai W, Chen X. Multimodality molecular imaging of tumor angiogenesis. J Nucl Med. 2008; 49 Suppl 2: 113S-28S.
35. Backer MV, Backer JM. Imaging key biomarkers of tumor angiogenesis. Theranostics. 2012; 2: 502-15.
36. Niu G, Chen X. Why integrin as a primary target for imaging and therapy. Theranostics. 2011; 1: 30-47.
37. Noiri E, Goligorsky MS, Wang GJ, Wang J, Cabahug CJ, Sharma S, et al. Biodistribution and clearance of 99mTc-labeled Arg-Gly-Asp (RGD) peptide in rats with ischemic acute renal failure. J Am Soc Nephrol. 1996; 7: 2682-8.
38. Ahmadi M, Sancey L, Briat A, Riou L, Boturyn D, Dumy P, et al. Chemical and biological evaluations of an 111In-labeled RGD-peptide targeting integrin αvβ3 in a preclinical tumor model. Cancer Biother Radiopharm. 2008; 23: 691-700.
39. Shi J, Fan D, Dong C, Liu H, Jia B, Zhao H, et al. Anti-tumor effect of integrin targeted 177Lu-3PRGD2 and combined therapy with Endostar. Theranostics. 2014; 4: 256-66. doi:10.7150/thno.7781.
40. Ji S, Zheng Y, Shao G, Zhou Y, Liu S. Integrin αvβ3-targeted radiotracer 99mTc-3P-RGD2 useful for noninvasive monitoring of breast tumor response to antiangiogenic linifanib therapy but not anti-integrin αvβ3 RGD2 therapy. Theranostics. 2013; 3: 816-30.
41. Haubner R, Maschauer S, Prante O. PET radiopharmaceuticals for imaging integrin expression: Tracers in clinical studies and recent developments. Biomed Res Int. 2014; 2014: 871609.
42. Beer AJ, Niemeyer M, Carlsen J, Sarbia M, Nahrig J, Watzlowik P, et al. Patterns of αvβ3 expression in primary and metastatic human breast cancer as shown by 18F-Galacto-RGD PET. J Nucl Med. 2008; 49: 255-9.
43. Zhu Z, Miao W, Li Q, Dai H, Ma Q, Wang F, et al. 99mTc-3PRGD2 for integrin receptor imaging of lung cancer: A multicenter study. J Nucl Med. 2012; 53: 716-22.
44. Willmann JK, van Bruggen N, Dinkelborg LM, Gambhir SS. Molecular imaging in drug development. Nat Rev Drug Discov. 2008; 7: 591-607.
45. Veit P, Ruehm S, Kuehl H, Stergar H, Mueller S, Bockisch A, et al. Lymph node staging with dual-modality PET/CT: enhancing the diagnostic accuracy in oncology. Eur J Radiol. 2006; 58: 383-9.
46. Antoch G, Stattaus J, Nemat AT, Marnitz S, Beyer T, Kuehl H, et al. Non-small cell lung cancer: dual-modality PET/CT in preoperative staging. Radiology. 2003; 229: 526-33.
47. Lardinois D, Weder W, Hany TF, Kamel EM, Korom S, Seifert B, et al. Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomography. N Engl J Med. 2003; 348: 2500-7.
48. Platzek I, Beuthien-Baumann B, Ordemann R, Maus J, Schramm G, Kitzler HH, et al. FDG PET/MR for the assessment of lymph node involvement in lymphoma: initial results and role of diffusion-weighted MR. Acad Radiol. 2014; 21: 1314-9.
49. Platzek I, Beuthien-Baumann B, Schneider M, Gudziol V, Kitzler HH, Maus J, et al. FDG PET/MR for lymph node staging in head and neck cancer. Eur J Radiol. 2014; 83: 1163-8.
50. Harrell MI, Iritani BM, Ruddell A. Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis. Am J Pathol. 2007; 170: 774-86.
51. Ji RC. Lymph node lymphangiogenesis: a new concept for modulating tumor metastasis and inflammatory process. Histol Histopathol. 2009; 24: 377-84.
52. Banerji S, Ni J, Wang SX, Clasper S, Su J, Tammi R, et al. LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J Cell Biol. 1999; 144: 789-801.
53. Breiteneder-Geleff S, Soleiman A, Horvat R, Amann G, Kowalski H, Kerjaschki D. [Podoplanin--a specific marker for lymphatic endothelium expressed in angiosarcoma]. Verh Dtsch Ges Pathol. 1999; 83: 270-5.
54. Laakkonen P, Porkka K, Hoffman JA, Ruoslahti E. A tumor-homing peptide with a targeting specificity related to lymphatic vessels. Nat Med. 2002; 8: 751-5.
55. Kishimoto TK, Jutila MA, Butcher EC. Identification of a human peripheral lymph node homing receptor: a rapidly down-regulated adhesion molecule. Proc Natl Acad Sci U S A. 1990; 87: 2244-8.
56. Licha K, Debus N, Emig-Vollmer S, Hofmann B, Hasbach M, Stibenz D, et al. Optical molecular imaging of lymph nodes using a targeted vascular contrast agent. J Biomed Opt. 2005; 10: 41205.
57. Hauff P, Reinhardt M, Briel A, Debus N, Schirner M. Molecular targeting of lymph nodes with L-selectin ligand-specific US contrast agent: A feasibility study in mice and dogs. Radiology. 2004; 231: 667-73.
58. Jackson DG, Prevo R, Clasper S, Banerji S. LYVE-1, the lymphatic system and tumor lymphangiogenesis. Trends Immunol. 2001; 22: 317-21.
59. Mumprecht V, Honer M, Vigl B, Proulx ST, Trachsel E, Kaspar M, et al. In vivo imaging of inflammation- and tumor-induced lymph node lymphangiogenesis by immuno-positron emission tomography. Cancer Res. 2010; 70: 8842-51.
60. Laakkonen P, Zhang L, Ruoslahti E. Peptide targeting of tumor lymph vessels. Ann N Y Acad Sci. 2008; 1131: 37-43.
61. Laakkonen P, Akerman ME, Biliran H, Yang M, Ferrer F, Karpanen T, et al. Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells. Proc Natl Acad Sci U S A. 2004; 101: 9381-6.
62. Zhang F, Niu G, Lin X, Jacobson O, Ma Y, Eden HS, et al. Imaging tumor-induced sentinel lymph node lymphangiogenesis with LyP-1 peptide. Amino Acids. 2012; 42: 2343-51.
63. Jaffer FA, Weissleder R. Molecular imaging in the clinical arena. JAMA. 2005; 293: 855-62.
64. Sharma R, Wendt JA, Rasmussen JC, Adams KE, Marshall MV, Sevick-Muraca EM. New horizons for imaging lymphatic function. Ann N Y Acad Sci. 2008; 1131: 13-36.
65. Winnard PT, Jr., Pathak AP, Dhara S, Cho SY, Raman V, Pomper MG. Molecular imaging of metastatic potential. J Nucl Med. 2008; 49 Suppl 2: 96S-112S.
66. Baluk P, Tammela T, Ator E, Lyubynska N, Achen MG, Hicklin DJ, et al. Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. J Clin Invest. 2005; 115: 247-57.
67. Newman EA, Newman LA. Lymphatic mapping techniques and sentinel lymph node biopsy in breast cancer. Surg Clin North Am. 2007; 87: 353-64, viii.
68. Tausch C, Baege A, Rageth C. Mapping lymph nodes in cancer management - role of 99mTc-tilmanocept injection. Onco Targets Ther. 2014; 7: 1151-8.
69. Mariani G, Moresco L, Viale G, Villa G, Bagnasco M, Canavese G, et al. Radioguided sentinel lymph node biopsy in breast cancer surgery. J Nucl Med. 2001; 42: 1198-215.
70. Mariani G, Gipponi M, Moresco L, Villa G, Bartolomei M, Mazzarol G, et al. Radioguided sentinel lymph node biopsy in malignant cutaneous melanoma. J Nucl Med. 2002; 43: 811-27.
71. Tsopelas C, Sutton R. Why certain dyes are useful for localizing the sentinel lymph node. J Nucl Med. 2002; 43: 1377-82.
72. Brouwer OR, van den Berg NS, Matheron HM, van der Poel HG, van Rhijn BW, Bex A, et al. A hybrid radioactive and fluorescent tracer for sentinel node biopsy in penile carcinoma as a potential replacement for blue dye. Eur Urol. 2014; 65: 600-9.
73. Ballou B, Ernst LA, Andreko S, Harper T, Fitzpatrick JA, Waggoner AS, et al. Sentinel lymph node imaging using quantum dots in mouse tumor models. Bioconjug Chem. 2007; 18: 389-96.
74. Kosaka N, Ogawa M, Sato N, Choyke PL, Kobayashi H. In vivo real-time, multicolor, quantum dot lymphatic imaging. J Invest Dermatol. 2009; 129: 2818-22.
75. Tsopelas C, Bevington E, Kollias J, Shibli S, Farshid G, Coventry B, et al. 99mTc-Evans blue dye for mapping contiguous lymph node sequences anddiscriminating the sentinel lymph node in an ovine model. Annals of surgical oncology. 2006; 13: 692-700.
76. Wallace AM, Hoh CK, Vera DR, Darrah DD, Schulteis G. Lymphoseek: a molecular radiopharmaceutical for sentinel node detection. Annals of surgical oncology. 2003; 10: 531-8.
77. Leong SP, Kim J, Ross M, Faries M, Scoggins CR, Metz WL, et al. A phase 2 study of 99mTc-tilmanocept in the detection of sentinel lymph nodes in melanoma and breast cancer. Annals of surgical oncology. 2011; 18: 961-9.
78. Brouwer OR, Buckle T, Vermeeren L, Klop WM, Balm AJ, van der Poel HG, et al. Comparing the hybrid fluorescent-radioactive tracer indocyanine green-99mTc-nanocolloid with 99mTc-nanocolloid for sentinel node identification: a validation study using lymphoscintigraphy and SPECT/CT. J Nucl Med. 2012; 53: 1034-40.
79. Thorek DL, Abou DS, Beattie BJ, Bartlett RM, Huang R, Zanzonico PB, et al. Positron lymphography: multimodal, high-resolution, dynamic mapping and resection of lymph nodes after intradermal injection of 18F-FDG. J Nucl Med. 2012; 53: 1438-45.
80. Niu G, Lang L, Kiesewetter DO, Ma Y, Sun Z, Guo N, et al. In Vivo Labeling of Serum Albumin for PET. J Nucl Med. 2014; 55: 1150-6.
81. Zhen Z, Tang W, Chuang YJ, Todd T, Zhang W, Lin X, et al. Tumor vasculature targeted photodynamic therapy for enhanced delivery of nanoparticles. ACS Nano. 2014; 8: 6004-13.
82. Feldman AS, McDougal WS, Harisinghani MG. The potential of nanoparticle-enhanced imaging. Urol Oncol. 2008; 26: 65-73.
83. Saokar A, Braschi M, Harisinghani MG. Lymphotrophic nanoparticle enhanced MR imaging (LNMRI) for lymph node imaging. Abdom Imaging. 2006; 31: 660-7.
84. Zhang F, Huang X, Qian C, Zhu L, Hida N, Niu G, et al. Synergistic enhancement of iron oxide nanoparticle and gadolinium for dual-contrast MRI. Biochem Biophys Res Commun. 2012; 425: 886-91.
85. Zhang F, Zhu L, Huang X, Niu G, Chen X. Differentiation of reactive and tumor metastatic lymph nodes with diffusion-weighted and SPIO-enhanced MRI. Mol Imaging Biol. 2013; 15: 40-7.
86. Weissleder R, Elizondo G, Wittenberg J, Lee AS, Josephson L, Brady TJ. Ultrasmall superparamagnetic iron oxide: an intravenous contrast agent for assessing lymph nodes with MR imaging. Radiology. 1990; 175: 494-8.
87. Bellin MF, Beigelman C, Precetti-Morel S. Iron oxide-enhanced MR lymphography: initial experience. Eur J Radiol. 2000; 34: 257-64.
88. Harisinghani MG, Barentsz J, Hahn PF, Deserno WM, Tabatabaei S, van de Kaa CH, et al. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med. 2003; 348: 2491-9.
89. Harisinghani MG, Dixon WT, Saksena MA, Brachtel E, Blezek DJ, Dhawale PJ, et al. MR lymphangiography: imaging strategies to optimize the imaging of lymph nodes with ferumoxtran-10. Radiographics. 2004; 24: 867-78.
90. Weissleder R, Stark DD, Engelstad BL, Bacon BR, Compton CC, White DL, et al. Superparamagnetic iron oxide: pharmacokinetics and toxicity. AJR Am J Roentgenol. 1989; 152: 167-73.
91. Taupitz M, Wagner S, Hamm B, Binder A, Pfefferer D. Interstitial MR lymphography with iron oxide particles: results in tumor-free and VX2 tumor-bearing rabbits. AJR Am J Roentgenol. 1993; 161: 193-200.
92. Herborn CU, Lauenstein TC, Vogt FM, Lauffer RB, Debatin JF, Ruehm SG. Interstitial MR lymphography with MS-325: characterization of normal and tumor-invaded lymph nodes in a rabbit model. AJR Am J Roentgenol. 2002; 179: 1567-72.
93. Nakajima T, Turkbey B, Sano K, Sato K, Bernardo M, Hoyt RF, et al. MR lymphangiography with intradermal gadofosveset and human serum albumin in mice and primates. J Magn Reson Imaging. 2014; 40: 691-7.
94. Kobayashi H, Kawamoto S, Choyke PL, Sato N, Knopp MV, Star RA, et al. Comparison of dendrimer-based macromolecular contrast agents for dynamic micro-magnetic resonance lymphangiography. Magn Reson Med. 2003; 50: 758-66.
95. Kobayashi H, Kawamoto S, Star RA, Waldmann TA, Tagaya Y, Brechbiel MW. Micro-magnetic resonance lymphangiography in mice using a novel dendrimer-based magnetic resonance imaging contrast agent. Cancer Res. 2003; 63: 271-6.
96. Kobayashi H, Kawamoto S, Sakai Y, Choyke PL, Star RA, Brechbiel MW, et al. Lymphatic drainage imaging of breast cancer in mice by micro-magnetic resonance lymphangiography using a nano-size paramagnetic contrast agent. J Natl Cancer Inst. 2004; 96: 703-8.
97. Nguyen QT, Tsien RY. Fluorescence-guided surgery with live molecular navigation--a new cutting edge. Nat Rev Cancer. 2013; 13: 653-62.
98. Chi C, Du Y, Ye J, Kou D, Qiu J, Wang J, et al. Intraoperative imaging-guided cancer surgery: from current fluorescence molecular imaging methods to future multi-modality imaging technology. Theranostics. 2014; 4: 1072-84.
99. Ashitate Y, Hyun H, Kim SH, Lee JH, Henary M, Frangioni JV, et al. Simultaneous mapping of pan and sentinel lymph nodes for real-time image-guided surgery. Theranostics. 2014; 4: 693-700.
100. Park MH, Hyun H, Ashitate Y, Wada H, Park G, Lee JH, et al. Prototype nerve-specific near-infrared fluorophores. Theranostics. 2014; 4: 823-33.
101. Wada H, Hyun H, Vargas C, Gravier J, Park G, Gioux S, et al. Pancreas-targeted NIR fluorophores for dual-channel image-guided abdominal surgery. Theranostics. 2015; 5: 1-11.
102. Hirano A, Kamimura M, Ogura K, Kim N, Hattori A, Setoguchi Y, et al. A comparison of indocyanine green fluorescence imaging plus blue dye and blue dye alone for sentinel node navigation surgery in breast cancer patients. Ann Surg Oncol. 2012; 19: 4112-6.
103. Koo J, Jeon M, Oh Y, Kang HW, Kim J, Kim C, et al. In vivo non-ionizing photoacoustic mapping of sentinel lymph nodes and bladders with ICG-enhanced carbon nanotubes. Phys Med Biol. 2012; 57: 7853-62.
104. Troyan SL, Kianzad V, Gibbs-Strauss SL, Gioux S, Matsui A, Oketokoun R, et al. The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in breast cancer sentinel lymph node mapping. Ann Surg Oncol. 2009; 16: 2943-52.
105. Huang X, Zhang F, Lee S, Swierczewska M, Kiesewetter DO, Lang L, et al. Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes. Biomaterials. 2012; 33: 4370-8.
106. Kim S, Lim YT, Soltesz EG, De Grand AM, Lee J, Nakayama A, et al. Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat Biotechnol. 2004; 22: 93-7.
107. Verbeek FP, Troyan SL, Mieog JS, Liefers GJ, Moffitt LA, Rosenberg M, et al. Near-infrared fluorescence sentinel lymph node mapping in breast cancer: a multicenter experience. Breast cancer research and treatment. 2014; 143: 333-42.
108. Dewitte H, Vanderperren K, Haers H, Stock E, Duchateau L, Hesta M, et al. Theranostic mRNA-loaded Microbubbles in the Lymphatics of Dogs: Implications for Drug Delivery. Theranostics. 2015; 5: 97-109.
109. Wu L, Luderer M, Yang X, Swain C, Zhang H, Nelson K, et al. Surface passivation of carbon nanoparticles with branched macromolecules influences near infrared bioimaging. Theranostics. 2013; 3: 677-86.
110. Proulx ST, Luciani P, Christiansen A, Karaman S, Blum KS, Rinderknecht M, et al. Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of tumor lymphatic drainage after sentinel lymph node metastasis. Biomaterials. 2013; 34: 5128-37.
111. Sirsi SR, Borden MA. Advances in ultrasound mediated gene therapy using microbubble contrast agents. Theranostics. 2012; 2: 1208-22.
112. Yoon YI, Kwon YS, Cho HS, Heo SH, Park KS, Park SG, et al. Ultrasound-mediated gene and drug delivery using a microbubble-liposome particle system. Theranostics. 2014; 4: 1133-44.
113. Jian J, Liu C, Gong Y, Su L, Zhang B, Wang Z, et al. India ink incorporated multifunctional phase-transition nanodroplets for photoacoustic/ultrasound dual-modality imaging and photoacoustic effect based tumor therapy. Theranostics. 2014; 4: 1026-38.
114. Fan CH, Lin WH, Ting CY, Chai WY, Yen TC, Liu HL, et al. Contrast-enhanced ultrasound imaging for the detection of focused ultrasound-induced blood-brain barrier opening. Theranostics. 2014; 4: 1014-25.
115. Liu HL, Fan CH, Ting CY, Yeh CK. Combining microbubbles and ultrasound for drug delivery to brain tumors: current progress and overview. Theranostics. 2014; 4: 432-44.
116. Vlaisavljevich E, Durmaz YY, Maxwell A, Elsayed M, Xu Z. Nanodroplet-mediated histotripsy for image-guided targeted ultrasound cell ablation. Theranostics. 2013; 3: 851-64.
117. Sirsi SR, Fung C, Garg S, Tianning MY, Mountford PA, Borden MA. Lung surfactant microbubbles increase lipophilic drug payload for ultrasound-targeted delivery. Theranostics. 2013; 3: 409-19.
118. Streeter JE, Dayton PA. An in vivo evaluation of the effect of repeated administration and clearance of targeted contrast agents on molecular imaging signal enhancement. Theranostics. 2013; 3: 93-8.
119. Lindner JR, Coggins MP, Kaul S, Klibanov AL, Brandenburger GH, Ley K. Microbubble persistence in the microcirculation during ischemia/reperfusion and inflammation is caused by integrin- and complement-mediated adherence to activated leukocytes. Circulation. 2000; 101: 668-75.
120. Lurie DM, Seguin B, Schneider PD, Verstraete FJ, Wisner ER. Contrast-assisted ultrasound for sentinel lymph node detection in spontaneously arising canine head and neck tumors. Invest Radiol. 2006; 41: 415-21.
121. Sever A, Jones S, Cox K, Weeks J, Mills P, Jones P. Preoperative localization of sentinel lymph nodes using intradermal microbubbles and contrast-enhanced ultrasonography in patients with breast cancer. Br J Surg. 2009; 96: 1295-9.
122. Goldberg BB, Merton DA, Liu JB, Thakur M, Murphy GF, Needleman L, et al. Sentinel lymph nodes in a swine model with melanoma: contrast-enhanced lymphatic US. Radiology. 2004; 230: 727-34.
123. Ravizzini G, Turkbey B, Barrett T, Kobayashi H, Choyke PL. Nanoparticles in sentinel lymph node mapping. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2009; 1: 610-23.
124. Wang LV, Hu S. Photoacoustic tomography: in vivo imaging from organelles to organs. Science. 2012; 335: 1458-62.
125. Mallidi S, Watanabe K, Timerman D, Schoenfeld D, Hasan T. Prediction of tumor recurrence and therapy monitoring using ultrasound-guided photoacoustic imaging. Theranostics. 2015; 5: 289-301.
126. Zhang R, Pan D, Cai X, Yang X, Senpan A, Allen JS, et al. alphanubeta3-targeted Copper Nanoparticles Incorporating an Sn 2 Lipase-Labile Fumagillin Prodrug for Photoacoustic Neovascular Imaging and Treatment. Theranostics. 2015; 5: 124-33.
127. Wilson KE, Bachawal SV, Tian L, Willmann JK. Multiparametric spectroscopic photoacoustic imaging of breast cancer development in a transgenic mouse model. Theranostics. 2014; 4: 1062-71.
128. Song KH, Stein EW, Margenthaler JA, Wang LV. Noninvasive photoacoustic identification of sentinel lymph nodes containing methylene blue in vivo in a rat model. J Biomed Opt. 2008; 13: 054033.
129. Dela Zerda A, Zavaleta C, Keren S, Vaithilingam S, Bodapati S, Liu Z, et al. Carbon nanotubes as photoacoustic molecular imaging agents in living mice. Nat Nanotechnol. 2008; 3: 557-62.
130. Kim JW, Galanzha EI, Shashkov EV, Moon HM, Zharov VP. Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents. Nat Nanotechnol. 2009; 4: 688-94.
131. Pan D, Pramanik M, Senpan A, Ghosh S, Wickline SA, Wang LV, et al. Near infrared photoacoustic detection of sentinel lymph nodes with gold nanobeacons. Biomaterials. 2010; 31: 4088-93.
132. Kobayashi H, Koyama Y, Barrett T, Hama Y, Regino CA, Shin IS, et al. Multimodal nanoprobes for radionuclide and five-color near-infrared optical lymphatic imaging. ACS Nano. 2007; 1: 258-64.
133. Boss A, Bisdas S, Kolb A, Hofmann M, Ernemann U, Claussen CD, et al. Hybrid PET/MRI of intracranial masses: initial experiences and comparison to PET/CT. J Nucl Med. 2010; 51: 1198-205.
134. Lutje S, Rijpkema M, Helfrich W, Oyen WJ, Boerman OC. Targeted radionuclide and fluorescence dual-modality imaging of cancer: preclinical advances and clinical translation. Mol Imaging Biol. 2014; 16: 747-55.
135. Ting R, Aguilera TA, Crisp JL, Hall DJ, Eckelman WC, Vera DR, et al. Fast 18F labeling of a near-infrared fluorophore enables positron emission tomography and optical imaging of sentinel lymph nodes. Bioconjug Chem. 2010; 21: 1811-9.
136. Wang Y, Lang L, Huang P, Wang Z, Jacobson O, Kiesewetter DO, et al. In vivo albumin labeling and lymphatic imaging. Proc Natl Acad Sci U S A. 2015; 112: 208-13.
137. Catana C, Procissi D, Wu Y, Judenhofer MS, Qi J, Pichler BJ, et al. Simultaneous in vivo positron emission tomography and magnetic resonance imaging. Proc Natl Acad Sci U S A. 2008; 105: 3705-10.
138. Judenhofer MS, Wehrl HF, Newport DF, Catana C, Siegel SB, Becker M, et al. Simultaneous PET-MRI: A new approach for functional and morphological imaging. Nat Med. 2008; 14: 459-65.
139. Partovi S, Kohan A, Rubbert C, Vercher-Conejero JL, Gaeta C, Yuh R, et al. Clinical oncologic applications of PET/MRI: a new horizon. Am J Nucl Med Mol Imaging. 2014; 4: 202-12.
140. Thorek DL, Ulmert D, Diop NF, Lupu ME, Doran MG, Huang R, et al. Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle. Nat Commun. 2014; 5: 3097.
141. Sengupta J, Ghosh S, Datta P, Gomes A. Physiologically important metal nanoparticles and their toxicity. J Nanosci Nanotechnol. 2014; 14: 990-1006.