Lung surfactant microbubbles increase lipophilic drug payload for ultrasound-targeted delivery

Theranostics

Volumn 3, Issue 6, 2013, Pages 409-419

  Sirsi, Shashank R ^a   Fung, Chinpong ^b   Garg, Sumit ^a   Tianning, Mary Y ^b   Mountford, Paul A ^a   Borden, Mark A ^a  

^a UCB 450   (United States)

^b Columbia University ^*  (United States)

Author keywords

Acoustic radiation force; Contrast agent; Echogenicity; SP B and SP C.; Survanta

Indexed keywords

DRUG; LIPID; LUNG SURFACTANT EXTRACT; SURFACTANT PROTEIN B; SURFACTANT PROTEIN C;

ANALYTICAL PARAMETERS; ARTICLE; CHEMICAL COMPOSITION; CHEMICAL PARAMETERS; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG PAYLOAD; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; LIPID ANALYSIS; LIPID FOLDING; LIPID MONOLAYER; LIPID RETENTION; LIPID STORAGE; LIPOPHILICITY; MICROBUBBLE; RADIATION; SOUND INTENSITY;

ACOUSTIC RADIATION FORCE; CONTRAST AGENT; ECHOGENICITY; SP-B AND SP-C.; SURVANTA®;

CHEMISTRY, PHARMACEUTICAL; CONTRAST MEDIA; LIPIDS; MICROBUBBLES; PULMONARY SURFACTANTS; ULTRASONICS;

EID: 84883196945     PISSN: None     EISSN: 18387640     Source Type: Journal    
DOI: 10.7150/thno.5616     Document Type: Article

References (57)

1. Wei K. Future applications of contrast ultrasound. J Cardiovasc Ultrasound. 2010; 19: 107-14.
2. Suzuki R, Oda Y, Utoguchi N, Maruyama K. Progress in the development of ultrasound-mediated gene delivery systems utilizing nano- and microbubbles. J Control Release. 2010; 149: 36-41.
3. Geis NA, Katus HA, Bekeredjian R. Microbubbles as a vehicle for gene and drug delivery: current clinical implications and future perspectives. Curr Pharm Des. 2012; 18: 2166-83.
4. Ferrara K, Pollard R, Borden M. Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery. Annu Rev Biomed Eng. 2007; 9: 415-47.
5. Sheffield P, Trehan A, Boyd B, Wong OL. Microbubbles as ultrasound contrast agents and in targeted drug delivery. Crit Rev Biomed Eng. 2008; 36: 225-55.
6. Sirsi S, Borden M. Microbubble Compositions, Properties and Biomedical Applications. Bubble Sci Eng Technol. 2009; 1: 3-17.
7. Schmitz G. Ultrasonic imaging of molecular targets. Basic Res Cardiol. 2008; 103: 174-81.
8. Lindner JR. Molecular imaging with contrast ultrasound and targeted microbubbles. J Nucl Cardiol. 2004; 11: 215-21.
9. Stride E. Physical principles of microbubbles for ultrasound imaging and therapy. Cerebrovasc Dis. 2009; 27 Suppl 2: 1-13.
10. Stride EP, Coussios CC. Cavitation and contrast: the use of bubbles in ultrasound imaging and therapy. Proc Inst Mech Eng H. 2010; 224: 171-91.
11. Azmin M, Harfield C, Ahmad Z, Edirisinghe M, Stride E. How do microbubbles and ultrasound interact? Basic physical, dynamic and engineering principles. Curr Pharm Des. 2012; 18: 2118-34.
12. Qin S, Caskey CF, Ferrara KW. Ultrasound contrast microbubbles in imaging and therapy: physical principles and engineering. Phys Med Biol. 2009; 54: R27-57.
13. Dayton PA, Morgan KE, Klibanov ALS, Brandenburger G, Nightingale KR, Ferrara KW. A preliminary evaluation of the effects of primary and secondary radiation forces on acoustic contrast agents. IEEE Trans Ultrason Ferroelectr Freq Control. 1997; 44: 1264-77.
14. Dayton P, Klibanov A, Brandenburger G, Ferrara K. Acoustic radiation force in vivo: a mechanism to assist targeting of microbubbles. Ultrasound Med Biol. 1999; 25: 1195-201.
15. Dayton PA, Allen JS, Ferrara KW. The magnitude of radiation force on ultrasound contrast agents. J Acoust Soc Am. 2002; 112: 2183-92.
16. Zhao S, Borden M, Bloch SH, Kruse D, Ferrara KW, Dayton PA. Radiation- force assisted targeting facilitates ultrasonic molecular imaging. Mol Imaging. 2004; 3: 135-48.
17. Gessner RC, Streeter JE, Kothadia R, Feingold S, Dayton PA. An in vivo validation of the application of acoustic radiation force to enhance the diagnostic utility of molecular imaging using 3-D ultrasound. Ultrasound Med Biol. 2012; 38: 651-60.
18. Thomas DH, Butler M, Anderson T, Emmer M, Vos H, Borden M, et al. The "quasi-stable" lipid shelled microbubble in response to consecutive ultrasound pulses. Appl Phys Lett. 2012; 101.
19. Stieger SM, Caskey CF, Adamson RH, Qin SP, Curry FRE, Wisner ER, et al. Enhancement of vascular permeability with low-frequency contrast- enhanced ultrasound in the chorioallantoic membrane model. Radiology. 2007; 243: 112-21.
20. Bekeredjian R, Chen S, Grayburn PA, Shohet RV. Augmentation of cardiac protein delivery using ultrasound targeted microbubble destruction. Ultrasound Med Biol. 2005; 31: 687-91.
21. Frenkel PA, Chen S, Thai T, Shohet RV, Grayburn PA. DNA-loaded albumin microbubbles enhance ultrasound-mediated transfection in vitro. Ultrasound Med Biol. 2002; 28: 817-22.
22. Lentacker I, Geers B, Demeester J, De Smedt SC, Sanders NN. Design and evaluation of doxorubicin-containing microbubbles for ultrasound- triggered doxorubicin delivery: cytotoxicity and mechanisms involved. Mol Ther. 2010; 18: 101-8.
23. Lentacker I, De Smedt SC, Sanders NN. Drug loaded microbubble design for ultrasound triggered delivery. Soft Matter. 2009; 5: 2161-70.
24. Panje CM, Wang DS, Pysz MA, Paulmurugan R, Ren Y, Tranquart F, et al. Ultrasound-mediated gene delivery with cationic versus neutral microbubbles: effect of DNA and microbubble dose on in vivo transfection efficiency. Theranostics. 2012; 2: 1078-91.
25. Sirsi S, Borden M. Advances in Ultrasound Mediated Gene Therapy Using Microbubble Contrast Agents. Theranostics. 2012; 2(12): 1208-1222.
26. Borden MA, Caskey CF, Little E, Gillies RJ, Ferrara KW. DNA and polylysine adsorption and multilayer construction onto cationic lipid- coated microbubbles. Langmuir. 2007; 23: 9401-8.
27. Lentacker I, De Geest BG, Vandenbroucke RE, Peeters L, Demeester J, De Smedt SC, et al. Ultrasound-responsive polymer-coated microbubbles that bind and protect DNA. Langmuir. 2006; 22: 7273-8.
28. Hernot S, Klibanov AL. Microbubbles in ultrasound-triggered drug and gene delivery. Adv Drug Deliv Rev. 2008; 60: 1153-66.
29. Eisenbrey JR, Huang P, Hsu J, Wheatley MA. Ultrasound triggered cell death in vitro with doxorubicin loaded poly lactic-acid contrast agents. Ultrasonics. 2009; 49: 628-33.
30. Eisenbrey JR, Burstein OM, Kambhampati R, Forsberg F, Liu JB, Wheatley MA. Development and optimization of a doxorubicin loaded poly(lactic acid) contrast agent for ultrasound directed drug delivery. J Control Release. 2010; 143: 38-44.
31. Cochran MC, Eisenbrey J, Ouma RO, Soulen M, Wheatley MA. Doxorubicin and paclitaxel loaded microbubbles for ultrasound triggered drug delivery. Int J Pharm. 2011; 414: 161-70.
32. Bloch SH, Wan M, Dayton PA, Ferrara KW. Optical observation of lipidand polymer-shelled ultrasound microbubble contrast agents. Appl Phys Lett. 2004; 84: 631-3.
33. Zhang S, Zong Y, Wan M, Yu X, Fu Q, Ding T, et al. Compare ultrasound- mediated heating and cavitation between flowing polymer- and lipid-shelled microbubbles during focused ultrasound exposures. J Acoust Soc Am. 2012; 131: 4845-55.
34. Perez-Gil J. Structure of pulmonary surfactant membranes and films: the role of proteins and lipid-protein interactions. Biochim Biophys Acta. 2008; 1778: 1676-95.
35. Perez-Gil J. Lipid-protein interactions of hydrophobic proteins SP-B and SP-C in lung surfactant assembly and dynamics. Pediatr Pathol Mol Med. 2001; 20: 445-69.
36. Lee KY. Collapse mechanisms of Langmuir monolayers. Annu Rev Phys Chem. 2008; 59: 771-91.
37. Discher BM, Schief WR, Vogel V, Hall SB. Phase separation in monolayers of pulmonary surfactant phospholipids at the air-water interface: Composition and structure. Biophys J. 1999; 77: 2051-61.
38. Gomez-Gil L, Schurch D, Goormaghtigh E, Perez-Gil J. Pulmonary surfactant protein SP-C counteracts the deleterious effects of cholesterol on the activity of surfactant films under physiologically relevant compression- expansion dynamics. Biophys J. 2009; 97: 2736-45.
39. Sirsi S, Pae C, Oh DKT, Blomback H, Koubaa A, Papahadjopoulos-Sternberg B, et al. Lung surfactant microbubbles. Soft Matter. 2009; 5: 4835-42.
40. Stenger PC, Isbell SG, St Hillaire D, Zasadzinski JA. Rediscovering the Schulze-Hardy Rule in Competitive Adsorption to an Air-Water Interface. Langmuir. 2009; 25: 10045-50.
41. Bernhard W, Mottaghian J, Gebert A, Rau GA, von der Hardt H, Poets CF. Commercial versus native surfactants -Surface activity, molecular components, and the effect of calcium. American Journal of Respiratory and Critical Care Medicine. 2000; 162: 1524-33.
42. Blanco O, Perez-Gil J. Biochemical and pharmacological differences between preparations of exogenous natural surfactant used to treat Respiratory Distress Syndrome: Role of the different components in an efficient pulmonary surfactant. European Journal of Pharmacology. 2007; 568: 1-15.
43. Braun A, Stenger PC, Warriner HE, Zasadzinski JA, Lu KW, Taeusch HW. A freeze-fracture transmission electron microscopy and small angle X-ray diffraction study of the effects of albumin, serum, and polymers on clinical lung surfactant microstructure. Biophys J. 2007; 93: 123-39.
44. Walther FJ, Waring AJ, Sherman MA, Zasadzinski JA, Gordon LM. Hydrophobic surfactant proteins and their analogues. Neonatology. 2007; 91: 303-10.
45. Unger EC, McCreery DC, Yellowhair D, Barrett T. Apparatus and method of making gas-filled vesicles of optimal size. In: Office USP, editor. USA; 1997.
46. Feshitan JA, Chen CC, Kwan JJ, Borden MA. Microbubble size isolation by differential centrifugation. J Colloid Interface Sci. 2009; 329: 316-24.
47. Chen CC, Borden MA. Ligand conjugation to bimodal poly(ethylene glycol) brush layers on microbubbles. Langmuir. 2010; 26: 13183-94.
48. Chen PS, Toribara TV, Warner H. Microdetermination of Phosphorus. Anal Chem. 1956; 28: 1756-8.
49. Rychak JJ, Lindner JR, Ley K, Klibanov AL. Deformable gas-filled microbubbles targeted to P-selectin. J Control Release. 2006; 114: 288-99.
50. Kwan JJ, Borden MA. Microbubble dissolution in a multigas environment. Langmuir. 2010; 26: 6542-8.
51. Lum AF, Borden MA, Dayton PA, Kruse DE, Simon SI, Ferrara KW. Ultrasound radiation force enables targeted deposition of model drug carriers loaded on microbubbles. J Control Release. 2006; 111: 128-34.
52. Borden MA, Martinez GV, Ricker J, Tsvetkova N, Longo M, Gillies RJ, et al. Lateral phase separation in lipid-coated microbubbles. Langmuir. 2006; 22: 4291-7.
53. Kwan JJ, Borden MA. Lipid monolayer collapse and microbubble stability. Adv Colloid Interface Sci. 2012; 183-184: 82-99.
54. Kwan JJ, Borden MA. Lipid monolayer dilatational mechanics during microbubble gas exchange. Soft Matter. 2012; 8: 4756-66.
55. Borden MA, Kruse DE, Caskey CF, Zhao S, Dayton PA, Ferrara KW. Influence of lipid shell physicochemical properties on ultrasound-induced microbubble destruction. IEEE Trans Ultrason Ferroelectr Freq Control. 2005; 52: 1992-2002.
56. Ding J, Takamoto DY, von Nahmen A, Lipp MM, Lee KY, Waring AJ, et al. Effects of lung surfactant proteins, SP-B and SP-C, and palmitic acid on monolayer stability. Biophys J. 2001; 80: 2262-72.
57. Holten-Andersen N, Michael Henderson J, Walther FJ, Waring AJ, Ruchala P, Notter RH, et al. KL(4) peptide induces reversible collapse structures on multiple length scales in model lung surfactant. Biophys J. 2011; 101: 2957-65.