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Volumn 21, Issue 4, 2015, Pages 299-306

Orchestrating the Tumor Microenvironment to Improve Survival for Patients with Pancreatic Cancer

Author keywords

Extracellular matrix; metastasis; pancreatic cancer; tumor microenvironment

Indexed keywords

COLLAGEN; GEMCITABINE; HYALURONIC ACID; OSTEONECTIN; PACLITAXEL; STRUCTURAL PROTEIN; TRANSFORMING GROWTH FACTOR BETA; 130-NM ALBUMIN-BOUND PACLITAXEL; ALBUMINOID; ANTINEOPLASTIC AGENT; DEOXYCYTIDINE; HYALURONOGLUCOSAMINIDASE; MACROGOL DERIVATIVE; SPARC PROTEIN, HUMAN;

EID: 84938566955     PISSN: 15289117     EISSN: 1540336X     Source Type: Journal    
DOI: 10.1097/PPO.0000000000000140     Document Type: Review
Times cited : (76)

References (103)
  • 3
    • 84902147062 scopus 로고    scopus 로고
    • Projecting cancer incidence and deaths to 2030: The unexpected burden of thyroid, liver, and pancreas cancers in the United States
    • Rahib L, Smith BD, Aizenberg R, et al. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 2014;74:2913-2921.
    • (2014) Cancer Res. , vol.74 , pp. 2913-2921
    • Rahib, L.1    Smith, B.D.2    Aizenberg, R.3
  • 4
    • 84878396462 scopus 로고    scopus 로고
    • Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
    • Commisso C, Davidson SM, Soydaner-Azeloglu RG, et al. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature. 2013;497:633-637.
    • (2013) Nature , vol.497 , pp. 633-637
    • Commisso, C.1    Davidson, S.M.2    Soydaner-Azeloglu, R.G.3
  • 5
    • 84878464291 scopus 로고    scopus 로고
    • Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
    • Kamphorst JJ, Cross JR, Fan J, et al. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci U S A. 2013;110:8882-8887.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 8882-8887
    • Kamphorst, J.J.1    Cross, J.R.2    Fan, J.3
  • 6
    • 33847052127 scopus 로고    scopus 로고
    • Identification of pancreatic cancer stem cells
    • Li C, Heidt DG, Dalerba P, et al. Identification of pancreatic cancer stem cells. Cancer Res. 2007;67:1030-1037.
    • (2007) Cancer Res. , vol.67 , pp. 1030-1037
    • Li, C.1    Heidt, D.G.2    Dalerba, P.3
  • 7
    • 84886741654 scopus 로고    scopus 로고
    • Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
    • Von Hoff DD, Ervin T, Arena FP, et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. 2013;369: 1691-1703.
    • (2013) N Engl J Med. , vol.369 , pp. 1691-1703
    • Von Hoff, D.D.1    Ervin, T.2    Arena, F.P.3
  • 8
    • 34248141223 scopus 로고    scopus 로고
    • Tumor-stroma interactions in pancreatic ductal adenocarcinoma
    • Mahadevan D, Von Hoff DD. Tumor-stroma interactions in pancreatic ductal adenocarcinoma. Mol Cancer Ther. 2007;6:1186-1197.
    • (2007) Mol Cancer Ther. , vol.6 , pp. 1186-1197
    • Mahadevan, D.1    Von Hoff, D.D.2
  • 10
    • 0034193258 scopus 로고    scopus 로고
    • Role of extracellular matrix assembly in interstitial transport in solid tumors
    • Netti PA, Berk DA, SwartzMA, et al. Role of extracellular matrix assembly in interstitial transport in solid tumors. Cancer Res. 2000;60:2497-2503.
    • (2000) Cancer Res. , vol.60 , pp. 2497-2503
    • Netti, P.A.1    Berk, D.A.2    Swartz, M.A.3
  • 11
    • 58149102321 scopus 로고    scopus 로고
    • Molecular basis of metastasis
    • Chiang AC, Massague J. Molecular basis of metastasis. N Engl J Med. 2008;359:2814-2823.
    • (2008) N Engl J Med. , vol.359 , pp. 2814-2823
    • Chiang, A.C.1    Massague, J.2
  • 12
    • 0018833498 scopus 로고
    • An investigation of the cause of death fromcancer
    • Houten L, Reilley AA. An investigation of the cause of death fromcancer. J Surg Oncol. 1980;13:111-116.
    • (1980) J Surg Oncol. , vol.13 , pp. 111-116
    • Houten, L.1    Reilley, A.A.2
  • 13
    • 84876993950 scopus 로고    scopus 로고
    • Normalizing tumor microenvironment to treat cancer: Bench to bedside to biomarkers
    • Jain RK. Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. J Clin Oncol. 2013;31:2205-2218.
    • (2013) J Clin Oncol. , vol.31 , pp. 2205-2218
    • Jain, R.K.1
  • 14
    • 84880658054 scopus 로고    scopus 로고
    • CTGF antagonism with mAb FG-3019 enhances chemotherapy responsewithout increasing drug delivery in murine ductal pancreas cancer
    • Neesse A, Frese KK, Bapiro TE, et al. CTGF antagonism with mAb FG-3019 enhances chemotherapy responsewithout increasing drug delivery in murine ductal pancreas cancer. Proc Natl Acad Sci U S A. 2013; 110:12325-12330.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 12325-12330
    • Neesse, A.1    Frese, K.K.2    Bapiro, T.E.3
  • 15
    • 84858602107 scopus 로고    scopus 로고
    • Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
    • Provenzano PP, Cuevas C, Chang AE, et al. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell. 2012;21:418-429.
    • (2012) Cancer Cell , vol.21 , pp. 418-429
    • Provenzano, P.P.1    Cuevas, C.2    Chang, A.E.3
  • 16
    • 83355169753 scopus 로고    scopus 로고
    • Gemcitabine plus nabpaclitaxel is an active regimen in patients with advanced pancreatic cancer: A phase I/II trial
    • Von Hoff DD, Ramanathan RK, Borad MJ, et al. Gemcitabine plus nabpaclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J Clin Oncol. 2011;29:4548-4554.
    • (2011) J Clin Oncol. , vol.29 , pp. 4548-4554
    • Von Hoff, D.D.1    Ramanathan, R.K.2    Borad, M.J.3
  • 17
    • 84938648673 scopus 로고    scopus 로고
    • Desmoplasia in primary tumors and metastatic lesions of pancreatic cancer
    • Whatcott CJ, Diep CH, Jiang P, et al. Desmoplasia in primary tumors and metastatic lesions of pancreatic cancer. Clin Cancer Res. 2015.
    • (2015) Clin Cancer Res
    • Whatcott, C.J.1    Diep, C.H.2    Jiang, P.3
  • 18
    • 0345251977 scopus 로고    scopus 로고
    • Myofibroblasts are responsible for collagen synthesis in the stroma of human hepatocellular carcinoma: An in vivo and in vitro study
    • Faouzi S, Le BailB,Neaud V, et al.Myofibroblasts are responsible for collagen synthesis in the stroma of human hepatocellular carcinoma: an in vivo and in vitro study. J Hepatol. 1999;30:275-284.
    • (1999) J Hepatol. , vol.30 , pp. 275-284
    • Faouzi, S.1    Le Bail, B.2    Neaud, V.3
  • 19
    • 0036186862 scopus 로고    scopus 로고
    • Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas
    • Yen TW, Aardal NP, BronnerMP, et al.Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas. Surgery. 2002;131:129-134.
    • (2002) Surgery , vol.131 , pp. 129-134
    • Yen, T.W.1    Aardal, N.P.2    Bronner, M.P.3
  • 20
    • 84866557942 scopus 로고    scopus 로고
    • Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors
    • Stylianopoulos T, Martin JD, Chauhan VP, et al. Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Proc Natl Acad Sci U S A. 2012;109:15101-15108.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 15101-15108
    • Stylianopoulos, T.1    Martin, J.D.2    Chauhan, V.P.3
  • 21
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive KP, Jacobetz MA, Davidson CJ, et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science. 2009;324:1457-1461.
    • (2009) Science , vol.324 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3
  • 22
    • 78650739435 scopus 로고    scopus 로고
    • Malignant cells facilitate lung metastasis by bringing their own soil
    • Duda DG, Duyverman AM, Kohno M, et al. Malignant cells facilitate lung metastasis by bringing their own soil. Proc Natl Acad Sci U S A. 2010;107:21677-21682.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 21677-21682
    • Duda, D.G.1    Duyverman, A.M.2    Kohno, M.3
  • 23
    • 0026674857 scopus 로고
    • Hyaluronan (hyaluronic acid) and hyaluronectin in the extracellular matrix of human breast carcinomas: Comparison between invasive and non-invasive areas
    • Bertrand P, Girard N, Delpech B, et al. Hyaluronan (hyaluronic acid) and hyaluronectin in the extracellular matrix of human breast carcinomas: comparison between invasive and non-invasive areas. Int J Cancer. 1992;52:1-6.
    • (1992) Int J Cancer , vol.52 , pp. 1-6
    • Bertrand, P.1    Girard, N.2    Delpech, B.3
  • 24
    • 0033970911 scopus 로고    scopus 로고
    • High levels of stromal hyaluronan predict poor disease outcome in epithelial ovarian cancer
    • Anttila MA, Tammi RH, Tammi MI, et al. High levels of stromal hyaluronan predict poor disease outcome in epithelial ovarian cancer. Cancer Res. 2000;60:150-155.
    • (2000) Cancer Res. , vol.60 , pp. 150-155
    • Anttila, M.A.1    Tammi, R.H.2    Tammi, M.I.3
  • 25
    • 0033889231 scopus 로고    scopus 로고
    • Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival
    • Auvinen P, Tammi R, Parkkinen J, et al. Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival. Am J Pathol. 2000;156:529-536.
    • (2000) Am J Pathol. , vol.156 , pp. 529-536
    • Auvinen, P.1    Tammi, R.2    Parkkinen, J.3
  • 26
    • 0033052479 scopus 로고    scopus 로고
    • Hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate
    • Setala LP, TammiMI, Tammi RH, et al. Hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate. Br J Cancer. 1999;79:1133-1138.
    • (1999) Br J Cancer , vol.79 , pp. 1133-1138
    • Setala, L.P.1    Tammi, M.I.2    Tammi, R.H.3
  • 27
    • 0034684279 scopus 로고    scopus 로고
    • Pancreatic carcinoma is characterized by elevated content of hyaluronan and chondroitin sulfate with altered disaccharide composition
    • Theocharis AD, Tsara ME, Papageorgacopoulou N, et al. Pancreatic carcinoma is characterized by elevated content of hyaluronan and chondroitin sulfate with altered disaccharide composition. Biochim Biophys Acta. 2000;1502:201-206.
    • (2000) Biochim Biophys Acta , vol.1502 , pp. 201-206
    • Theocharis, A.D.1    Tsara, M.E.2    Papageorgacopoulou, N.3
  • 28
    • 72049120401 scopus 로고    scopus 로고
    • Dermal hyaluronan is rapidly reduced by topical treatment with glucocorticoids
    • Gebhardt C, Averbeck M, Diedenhofen N, et al. Dermal hyaluronan is rapidly reduced by topical treatment with glucocorticoids. J Invest Dermatol. 2010;130:141-149.
    • (2010) J Invest Dermatol. , vol.130 , pp. 141-149
    • Gebhardt, C.1    Averbeck, M.2    Diedenhofen, N.3
  • 29
    • 18144391946 scopus 로고    scopus 로고
    • A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells
    • Yoshihara S, Kon A, Kudo D, et al. A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells. FEBS Lett. 2005;579:2722-2726.
    • (2005) FEBS Lett. , vol.579 , pp. 2722-2726
    • Yoshihara, S.1    Kon, A.2    Kudo, D.3
  • 30
    • 84926646329 scopus 로고    scopus 로고
    • 4-Methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer
    • Nagy N, Kuipers HF, Frymoyer AR, et al. 4-Methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer. Front Immunol. 2015;6:123.
    • (2015) Front Immunol. , vol.6 , pp. 123
    • Nagy, N.1    Kuipers, H.F.2    Frymoyer, A.R.3
  • 31
    • 84937138227 scopus 로고    scopus 로고
    • Dietary supplement 4-methylumbelliferone: An effective chemopreventive and therapeutic agent for prostate cancer
    • Yates TJ, Lopez LE, Lokeshwar SD, et al. Dietary supplement 4-methylumbelliferone: an effective chemopreventive and therapeutic agent for prostate cancer. J Natl Cancer Inst. 2015;107.
    • (2015) J Natl Cancer Inst. , vol.107
    • Yates, T.J.1    Lopez, L.E.2    Lokeshwar, S.D.3
  • 32
    • 0028167173 scopus 로고
    • Effects of hyaluronidase on doxorubicin penetration into squamous carcinoma multicellular tumor spheroids and its cell lethality
    • Kohno N, Ohnuma T, Truog P. Effects of hyaluronidase on doxorubicin penetration into squamous carcinoma multicellular tumor spheroids and its cell lethality. J Cancer Res Clin Oncol. 1994;120:293-297.
    • (1994) J Cancer Res Clin Oncol , vol.120 , pp. 293-297
    • Kohno, N.1    Ohnuma, T.2    Truog, P.3
  • 33
    • 0026715206 scopus 로고
    • Hyaluronidase enhances the activity of adriamycin in breast cancer models in vitro and in vivo
    • Beckenlehner K, Bannke S, Spruss T, et al. Hyaluronidase enhances the activity of adriamycin in breast cancer models in vitro and in vivo. J Cancer Res Clin Oncol. 1992;118:591-596.
    • (1992) J Cancer Res Clin Oncol. , vol.118 , pp. 591-596
    • Beckenlehner, K.1    Bannke, S.2    Spruss, T.3
  • 34
    • 0029918307 scopus 로고    scopus 로고
    • Hyaluronidase pretreatment produces selective melphalan enrichment in malignant melanoma implanted in nude mice
    • Muckenschnabel I, Bernhardt G, Spruss T, et al. Hyaluronidase pretreatment produces selective melphalan enrichment in malignant melanoma implanted in nude mice. Cancer Chemother Pharmacol. 1996; 38:88-94.
    • (1996) Cancer Chemother Pharmacol. , vol.38 , pp. 88-94
    • Muckenschnabel, I.1    Bernhardt, G.2    Spruss, T.3
  • 35
    • 0031671794 scopus 로고    scopus 로고
    • The impact of extracellular matrix on chemoresistance of solid tumors-experimental and clinical results of hyaluronidase as additive to cytostatic chemotherapy
    • Baumgartner G. The impact of extracellular matrix on chemoresistance of solid tumors-experimental and clinical results of hyaluronidase as additive to cytostatic chemotherapy. Cancer Lett. 1998;131:1-2.
    • (1998) Cancer Lett. , vol.131 , pp. 1-2
    • Baumgartner, G.1
  • 36
    • 0031048011 scopus 로고    scopus 로고
    • Hyaluronidase enhances the therapeutic effect of vinblastine in intralesional treatment of kaposi's sarcoma,military medical consortium for the advancement of retroviral research (mmcarr)
    • Smith KJ, Skelton HG, Turiansky G, et al. Hyaluronidase enhances the therapeutic effect of vinblastine in intralesional treatment of Kaposi's sarcoma. Military Medical Consortium for the Advancement of Retroviral Research (MMCARR). J Am Acad Dermatol. 1997;36:239-242.
    • (1997) J Am Acad Dermatol. , vol.36 , pp. 239-242
    • Smith, K.J.1    Skelton, H.G.2    Turiansky, G.3
  • 37
    • 0032508591 scopus 로고    scopus 로고
    • Hyaluronidase additional to standard chemotherapy improves outcome for children with malignant brain tumors
    • Pillwein K, Fuiko R, Slavc I, et al. Hyaluronidase additional to standard chemotherapy improves outcome for children with malignant brain tumors. Cancer Lett. 1998;131:101-108.
    • (1998) Cancer Lett. , vol.131 , pp. 101-108
    • Pillwein, K.1    Fuiko, R.2    Slavc, I.3
  • 38
    • 0024512041 scopus 로고
    • Metaphylactic effect of mitomycin C with and without hyaluronidase after transurethral resection of bladder cancer: Randomized trial
    • Maier U, Baumgartner G. Metaphylactic effect of mitomycin C with and without hyaluronidase after transurethral resection of bladder cancer: randomized trial. J Urol. 1989;141:529-530.
    • (1989) J Urol. , vol.141 , pp. 529-530
    • Maier, U.1    Baumgartner, G.2
  • 39
    • 35348831347 scopus 로고    scopus 로고
    • Assessment and implication of the allergic sensitivity to a single dose of recombinant human hyaluronidase injection: A double-blind, placebo-controlled clinical trial
    • Yocum RC, Kennard D, Heiner LS. Assessment and implication of the allergic sensitivity to a single dose of recombinant human hyaluronidase injection: a double-blind, placebo-controlled clinical trial. J Infus Nurs. 2007;30:293-299.
    • (2007) J Infus Nurs. , vol.30 , pp. 293-299
    • Yocum, R.C.1    Kennard, D.2    Heiner, L.S.3
  • 40
    • 84938648674 scopus 로고    scopus 로고
    • Targeting hyaluronan (HA) in tumor stroma: Translational evaluation of pegylated hyaluronidase (PEGPH20, P) in animal models and patients (PTS) with advanced solid tumors
    • Hollywood, Florida; abstract 114
    • Shepard HM, Frost GI, Rybak ME, et al. Targeting hyaluronan (HA) in tumor stroma: translational evaluation of pegylated hyaluronidase (PEGPH20, P) in animal models and patients (PTS) with advanced solid tumors. Presented at the 2010 ASCO-NCI-EORTC Annual Meeting on Molecular Markers in Cancer October 18-20, 2010; Hollywood, Florida; abstract 114.
    • (2010) Presented at the 2010 ASCO-NCI-EORTC Annual Meeting on Molecular Markers in Cancer October 18-20
    • Shepard, H.M.1    Frost, G.I.2    Rybak, M.E.3
  • 41
    • 84938562889 scopus 로고    scopus 로고
    • High response rate and PFS with PEGPH20 added to nab-paclitaxel/gemcitabine in stage IV previously untreated pancreatic cancer patients with high-HA tumors,interim results of a randomized phase II study
    • (suppl):Abstr 4006
    • Hingorani SR, Harris WP, Hendifar AE, et al. High response rate and PFS with PEGPH20 added to nab-paclitaxel/gemcitabine in stage IV previously untreated pancreatic cancer patients with high-HA tumors: interim results of a randomized phase II study. J Clin Oncol. 2015;33 (suppl):Abstr 4006.
    • (2015) J Clin Oncol , vol.33
    • Hingorani, S.R.1    Harris, W.P.2    Hendifar, A.E.3
  • 42
    • 84904244854 scopus 로고    scopus 로고
    • Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure
    • Chauhan VP, Boucher Y, Ferrone CR, et al. Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Cancer Cell. 2014;26:14-15.
    • (2014) Cancer Cell , vol.26 , pp. 14-15
    • Chauhan, V.P.1    Boucher, Y.2    Ferrone, C.R.3
  • 43
    • 84904269126 scopus 로고    scopus 로고
    • Interstitial pressure and vascular collapse in pancreas cancer-fluids and solids, measurement and meaning
    • Response to Chauhan et al
    • DelGiorno KE, CarlsonMA, Osgood R, et al. Response to Chauhan et al.: interstitial pressure and vascular collapse in pancreas cancer-fluids and solids, measurement and meaning. Cancer Cell. 2014;26:16-17.
    • (2014) Cancer Cell , vol.26 , pp. 16-17
    • DelGiorno, K.E.1    Carlson, M.A.2    Osgood, R.3
  • 44
    • 84872611820 scopus 로고    scopus 로고
    • Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer
    • Provenzano PP, Hingorani SR. Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer. Br J Cancer. 2013;108:1-8.
    • (2013) Br J Cancer , vol.108 , pp. 1-8
    • Provenzano, P.P.1    Hingorani, S.R.2
  • 45
    • 79551509386 scopus 로고    scopus 로고
    • Three-dimensional collagen i promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2
    • Dangi-Garimella S, Krantz SB, BarronMR, et al. Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2. Cancer Res. 2011;71:1019-1028.
    • (2011) Cancer Res. , vol.71 , pp. 1019-1028
    • Dangi-Garimella, S.1    Krantz, S.B.2    Barron, M.R.3
  • 46
    • 79952594233 scopus 로고    scopus 로고
    • Losartan inhibits collagen i synthesis and improves the distribution and efficacy of nanotherapeutics in tumors
    • Diop-Frimpong B, Chauhan VP, Krane S, et al. Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors. Proc Natl Acad Sci U S A. 2011;108:2909-2914.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 2909-2914
    • Diop-Frimpong, B.1    Chauhan, V.P.2    Krane, S.3
  • 47
    • 79953230450 scopus 로고    scopus 로고
    • Pancreatic cancer cells respond to type i collagen by inducing snail expression to promote membrane type 1 matrix metalloproteinase-dependent collagen invasion
    • Shields MA, Dangi-Garimella S, Krantz SB, et al. Pancreatic cancer cells respond to type I collagen by inducing snail expression to promote membrane type 1 matrix metalloproteinase-dependent collagen invasion. J Biol Chem. 2011;286:10495-10504.
    • (2011) J Biol Chem. , vol.286 , pp. 10495-10504
    • Shields, M.A.1    Dangi-Garimella, S.2    Krantz, S.B.3
  • 48
    • 33846263431 scopus 로고    scopus 로고
    • Collagen i promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression
    • Shintani Y, Hollingsworth MA, Wheelock MJ, et al. Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression. Cancer Res. 2006; 66:11745-11753.
    • (2006) Cancer Res. , vol.66 , pp. 11745-11753
    • Shintani, Y.1    Hollingsworth, M.A.2    Wheelock, M.J.3
  • 49
    • 0038578294 scopus 로고    scopus 로고
    • Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation
    • Brown E, McKee T, diTomaso E, et al. Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation. Nat Med. 2003;9:796-800.
    • (2003) Nat Med. , vol.9 , pp. 796-800
    • Brown, E.1    McKee, T.2    Ditomaso, E.3
  • 50
    • 0346157370 scopus 로고    scopus 로고
    • Tumor-stroma interaction of human pancreatic cancer: Acquired resistance to anticancer drugs and proliferation regulation is dependent on extracellular matrix proteins
    • MiyamotoH,Murakami T, TsuchidaK, et al. Tumor-stroma interaction of human pancreatic cancer: acquired resistance to anticancer drugs and proliferation regulation is dependent on extracellular matrix proteins. Pancreas. 2004;28:38-44.
    • (2004) Pancreas , vol.28 , pp. 38-44
    • Miyamoto, H.1    Murakami, T.2    Tsuchida, K.3
  • 52
    • 84938648676 scopus 로고    scopus 로고
    • The extracellular matrix regulates pancreatic cancer stem cell function via focal adhesion kinase signaling
    • abstract A70
    • Rasheed ZA, Jung C, Huang A, et al. The extracellular matrix regulates pancreatic cancer stem cell function via focal adhesion kinase signaling. Presented at the AACR Pancreatic Cancer Special Conference; 2012; abstract A70.
    • (2012) Presented at the AACR Pancreatic Cancer Special Conference
    • Rasheed, Z.A.1    Jung, C.2    Huang, A.3
  • 53
    • 84938648677 scopus 로고    scopus 로고
    • The exploration of novel strategy for treatment of pancreatic ductal adenocarcinoma targeting tumormicroenvironment
    • abstract A85
    • TadaM, Omata M, Moses HL, et al. The exploration of novel strategy for treatment of pancreatic ductal adenocarcinoma targeting tumormicroenvironment. Presented at the AACR Pancreatic Cancer Special Conference; 2012; abstract A85.
    • (2012) Presented at the AACR Pancreatic Cancer Special Conference
    • Tada, M.1    Omata, M.2    Moses, H.L.3
  • 54
    • 38049156416 scopus 로고    scopus 로고
    • Enhanced macromolecule diffusion deep in tumors after enzymatic digestion of extracellular matrix collagen and its associated proteoglycan decorin
    • Magzoub M, Jin S, Verkman AS. Enhanced macromolecule diffusion deep in tumors after enzymatic digestion of extracellular matrix collagen and its associated proteoglycan decorin. FASEB J. 2008;22:276-284.
    • (2008) FASEB J , vol.22 , pp. 276-284
    • Magzoub, M.1    Jin, S.2    Verkman, A.S.3
  • 55
    • 37349018272 scopus 로고    scopus 로고
    • The integrin-extracellular matrix axis in pancreatic cancer
    • Grzesiak JJ, Ho JC, Moossa AR, et al. The integrin-extracellular matrix axis in pancreatic cancer. Pancreas. 2007;35:293-301.
    • (2007) Pancreas , vol.35 , pp. 293-301
    • Grzesiak, J.J.1    Ho, J.C.2    Moossa, A.R.3
  • 56
    • 5044238876 scopus 로고    scopus 로고
    • Integrin signalling during tumour progression
    • Guo W, Giancotti FG. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol. 2004;5:816-826.
    • (2004) Nat Rev Mol Cell Biol. , vol.5 , pp. 816-826
    • Guo, W.1    Giancotti, F.G.2
  • 57
    • 0034776908 scopus 로고    scopus 로고
    • Immunohistochemical expression of extracellular matrix proteins and adhesion molecules in pancreatic carcinoma
    • Linder S, Castanos-Velez E, von Rosen A, et al. Immunohistochemical expression of extracellular matrix proteins and adhesion molecules in pancreatic carcinoma. Hepatogastroenterology. 2001;48:1321-1327.
    • (2001) Hepatogastroenterology , vol.48 , pp. 1321-1327
    • Linder, S.1    Castanos-Velez, E.2    Von Rosen, A.3
  • 58
    • 52149094275 scopus 로고    scopus 로고
    • The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma
    • Erkan M, Michalski CW, Rieder S, et al. The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma. Clin Gastroenterol Hepatol. 2008;6:1155-1161.
    • (2008) Clin Gastroenterol Hepatol. , vol.6 , pp. 1155-1161
    • Erkan, M.1    Michalski, C.W.2    Rieder, S.3
  • 59
    • 84929672151 scopus 로고    scopus 로고
    • Imaging the interaction of pancreatic cancer and stellate cells in the tumor microenvironment during metastasis
    • Suetsugu A, Snyder CS, Moriwaki H, et al. Imaging the interaction of pancreatic cancer and stellate cells in the tumor microenvironment during metastasis. Anticancer Res. 2015;35:2545-2551.
    • (2015) Anticancer Res. , vol.35 , pp. 2545-2551
    • Suetsugu, A.1    Snyder, C.S.2    Moriwaki, H.3
  • 60
    • 84884498449 scopus 로고    scopus 로고
    • Snail cooperates with KrasG12D to promote pancreatic fibrosis
    • Shields MA, Ebine K, Sahai V, et al. Snail cooperates with KrasG12D to promote pancreatic fibrosis. Mol Cancer Res. 2013;11:1078-1087.
    • (2013) Mol Cancer Res. , vol.11 , pp. 1078-1087
    • Shields, M.A.1    Ebine, K.2    Sahai, V.3
  • 61
    • 33745515023 scopus 로고    scopus 로고
    • Tumour microenvironment: Tgfbeta: the molecular jekyll and hyde of cancer
    • Bierie B,Moses HL. Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer. 2006;6:506-520.
    • (2006) Nat Rev Cancer , vol.6 , pp. 506-520
    • Bierie, B.1    Moses, H.L.2
  • 62
    • 0036467496 scopus 로고    scopus 로고
    • TGF-beta signaling: Positive and negative effects on tumorigenesis
    • Wakefield LM, Roberts AB. TGF-beta signaling: positive and negative effects on tumorigenesis. Curr Opin Genet Dev. 2002;12:22-29.
    • (2002) Curr Opin Genet Dev. , vol.12 , pp. 22-29
    • Wakefield, L.M.1    Roberts, A.B.2
  • 64
    • 0030593038 scopus 로고    scopus 로고
    • DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
    • Hahn SA, Schutte M, Hoque AT, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science. 1996;271:350-353.
    • (1996) Science , vol.271 , pp. 350-353
    • Hahn, S.A.1    Schutte, M.2    Hoque, A.T.3
  • 65
    • 68049115773 scopus 로고    scopus 로고
    • SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer
    • Blackford A, Serrano OK, Wolfgang CL, et al. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res. 2009;15:4674-4679.
    • (2009) Clin Cancer Res. , vol.15 , pp. 4674-4679
    • Blackford, A.1    Serrano, O.K.2    Wolfgang, C.L.3
  • 66
    • 62249176551 scopus 로고    scopus 로고
    • DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
    • Iacobuzio-Donahue CA, Fu B, Yachida S, et al. DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol. 2009;27:1806-1813.
    • (2009) J Clin Oncol. , vol.27 , pp. 1806-1813
    • Iacobuzio-Donahue, C.A.1    Fu, B.2    Yachida, S.3
  • 67
    • 0035185853 scopus 로고    scopus 로고
    • Transforming growth factorbeta1 mediates epithelial to mesenchymal transdifferentiation through a RHOA-dependent mechanism
    • Bhowmick NA, Ghiassi M, Bakin A, et al. Transforming growth factorbeta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism.Mol Biol Cell. 2001;12:27-36.
    • (2001) Mol Biol Cell , vol.12 , pp. 27-36
    • Bhowmick, N.A.1    Ghiassi, M.2    Bakin, A.3
  • 68
    • 0026612306 scopus 로고
    • Activation of p21ras by transforming growth factor beta in epithelial cells
    • Mulder KM, Morris SL. Activation of p21ras by transforming growth factor beta in epithelial cells. J Biol Chem. 1992;267:5029-5031.
    • (1992) J Biol Chem. , vol.267 , pp. 5029-5031
    • Mulder, K.M.1    Morris, S.L.2
  • 69
    • 0029551805 scopus 로고
    • Identification of a member of theMAPKKK family as a potential mediator of TGF-beta signal transduction
    • Yamaguchi K, Shirakabe K, Shibuya H, et al. Identification of a member of theMAPKKK family as a potential mediator of TGF-beta signal transduction. Science. 1995;270:2008-2011.
    • (1995) Science , vol.270 , pp. 2008-2011
    • Yamaguchi, K.1    Shirakabe, K.2    Shibuya, H.3
  • 70
    • 15444372825 scopus 로고    scopus 로고
    • Type i transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase
    • Yi JY, Shin I, Arteaga CL. Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase. J Biol Chem. 2005; 280:10870-10876.
    • (2005) J Biol Chem. , vol.280 , pp. 10870-10876
    • Yi, J.Y.1    Shin, I.2    Arteaga, C.L.3
  • 71
    • 10844224603 scopus 로고    scopus 로고
    • Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors
    • Muraoka-Cook RS, Kurokawa H, Koh Y, et al. Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors. Cancer Res. 2004;64:9002-9011.
    • (2004) Cancer Res. , vol.64 , pp. 9002-9011
    • Muraoka-Cook, R.S.1    Kurokawa, H.2    Koh, Y.3
  • 72
    • 0036086409 scopus 로고    scopus 로고
    • Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases
    • Muraoka RS, Dumont N, Ritter CA, et al. Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest. 2002;109:1551-1559.
    • (2002) J Clin Invest. , vol.109 , pp. 1551-1559
    • Muraoka, R.S.1    Dumont, N.2    Ritter, C.A.3
  • 73
    • 0036087521 scopus 로고    scopus 로고
    • Lifetime exposure to a soluble TGF-beta antagonist protects mice againstmetastasiswithout adverse side effects
    • Yang YA, Dukhanina O, Tang B, et al. Lifetime exposure to a soluble TGF-beta antagonist protects mice againstmetastasiswithout adverse side effects. J Clin Invest. 2002;109:1607-1615.
    • (2002) J Clin Invest , vol.109 , pp. 1607-1615
    • Yang, Y.A.1    Dukhanina, O.2    Tang, B.3
  • 74
    • 66149156949 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor beta signaling by halofuginone as a modality for pancreas fibrosis prevention
    • Zion O, Genin O, Kawada N, et al. Inhibition of transforming growth factor beta signaling by halofuginone as a modality for pancreas fibrosis prevention. Pancreas. 2009;38:427-435.
    • (2009) Pancreas , vol.38 , pp. 427-435
    • Zion, O.1    Genin, O.2    Kawada, N.3
  • 75
    • 73649096622 scopus 로고    scopus 로고
    • Tgfbr1 haploinsufficiency inhibits the development of murine mutant Kras-induced pancreatic precancer
    • Adrian K, Strouch MJ, Zeng Q, et al. Tgfbr1 haploinsufficiency inhibits the development of murine mutant Kras-induced pancreatic precancer. Cancer Res. 2009;69:9169-9174.
    • (2009) Cancer Res. , vol.69 , pp. 9169-9174
    • Adrian, K.1    Strouch, M.J.2    Zeng, Q.3
  • 76
    • 59449092007 scopus 로고    scopus 로고
    • Delta-crystallin enhancer binding factor 1 controls the epithelial to mesenchymal transition phenotype and resistance to the epidermal growth factor receptor inhibitor erlotinib in human head and neck squamous cell carcinoma lines
    • Haddad Y, Choi W, McConkey DJ. Delta-crystallin enhancer binding factor 1 controls the epithelial to mesenchymal transition phenotype and resistance to the epidermal growth factor receptor inhibitor erlotinib in human head and neck squamous cell carcinoma lines. Clin Cancer Res. 2009;15:532-542.
    • (2009) Clin Cancer Res. , vol.15 , pp. 532-542
    • Haddad, Y.1    Choi, W.2    McConkey, D.J.3
  • 77
    • 0038324071 scopus 로고    scopus 로고
    • Opposing functions of ZEB proteins in the regulation of the TGFBETA/BMP signaling pathway
    • Postigo AA. Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway. EMBO J. 2003;22:2443-2452.
    • (2003) EMBO J , vol.22 , pp. 2443-2452
    • Postigo, A.A.1
  • 78
    • 37549037486 scopus 로고    scopus 로고
    • PAM4-reactive MUC1 is a biomarker for early pancreatic adenocarcinoma
    • Gold DV, Karanjawala Z, Modrak DE, et al. PAM4-reactive MUC1 is a biomarker for early pancreatic adenocarcinoma. Clin Cancer Res. 2007; 13:7380-7387.
    • (2007) Clin Cancer Res. , vol.13 , pp. 7380-7387
    • Gold, D.V.1    Karanjawala, Z.2    Modrak, D.E.3
  • 79
    • 33644815924 scopus 로고    scopus 로고
    • NEWMUC1 serum immunoassay differentiates pancreatic cancer from pancreatitis
    • Gold DV, Modrak DE, Ying Z, et al. NewMUC1 serum immunoassay differentiates pancreatic cancer from pancreatitis. J Clin Oncol. 2006;24:252-258.
    • (2006) J Clin Oncol. , vol.24 , pp. 252-258
    • Gold, D.V.1    Modrak, D.E.2    Ying, Z.3
  • 80
    • 84868191187 scopus 로고    scopus 로고
    • Fractionated radioimmunotherapy with (90) Y-clivatuzumab tetraxetan and low-dose gemcitabine is active in advanced pancreatic cancer: A phase 1 trial
    • Ocean AJ, Pennington KL, Guarino MJ, et al. Fractionated radioimmunotherapy with (90) Y-clivatuzumab tetraxetan and low-dose gemcitabine is active in advanced pancreatic cancer: a phase 1 trial. Cancer. 2012;118:5497-5506.
    • (2012) Cancer , vol.118 , pp. 5497-5506
    • Ocean, A.J.1    Pennington, K.L.2    Guarino, M.J.3
  • 81
    • 32944482677 scopus 로고    scopus 로고
    • Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oilbased paclitaxel in women with breast cancer
    • Gradishar WJ, Tjulandin S, Davidson N, et al. Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oilbased paclitaxel in women with breast cancer. J Clin Oncol. 2005;23: 7794-7803.
    • (2005) J Clin Oncol. , vol.23 , pp. 7794-7803
    • Gradishar, W.J.1    Tjulandin, S.2    Davidson, N.3
  • 82
    • 77953150067 scopus 로고    scopus 로고
    • A dose finding study of weekly and every-3-week nab-paclitaxel followed by carboplatin as first-line therapy in patients with advanced non-small cell lung cancer
    • Socinski MA, Manikhas GM, Stroyakovsky DL, et al. A dose finding study of weekly and every-3-week nab-paclitaxel followed by carboplatin as first-line therapy in patients with advanced non-small cell lung cancer. J Thorac Oncol. 2010;5:852-861.
    • (2010) J Thorac Oncol. , vol.5 , pp. 852-861
    • Socinski, M.A.1    Manikhas, G.M.2    Stroyakovsky, D.L.3
  • 83
    • 83355163765 scopus 로고    scopus 로고
    • SPARC microenvironment signature (SMS) analysis of a phase II trial of neoadjuvant gemcitabine (G), epirubicin (E), and nab-paclitaxel (nab-P) in locally advanced breast cancer (LABC)
    • 2010; (suppl; abstr 10574) 28, 15s (suppl; abstr 10574)
    • Yardley DA, Daniel BR, Inhorn RC, et al. SPARC microenvironment signature (SMS) analysis of a phase II trial of neoadjuvant gemcitabine (G), epirubicin (E), and nab-paclitaxel (nab-P) in locally advanced breast cancer (LABC). J Clin Oncol. 2010;28:15s, 2010; (suppl; abstr 10574) 28, 15s (suppl; abstr 10574).
    • (2010) J Clin Oncol. , vol.28 , pp. 15s
    • Yardley, D.A.1    Daniel, B.R.2    Inhorn, R.C.3
  • 84
    • 22744442244 scopus 로고    scopus 로고
    • Osteonectin influences growth and invasion of pancreatic cancer cells
    • Guweidhi A, Kleeff J, Adwan H, et al. Osteonectin influences growth and invasion of pancreatic cancer cells. Ann Surg. 2005;242:224-234.
    • (2005) Ann Surg. , vol.242 , pp. 224-234
    • Guweidhi, A.1    Kleeff, J.2    Adwan, H.3
  • 85
    • 33846916208 scopus 로고    scopus 로고
    • Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma
    • Infante JR, Matsubayashi H, Sato N, et al. Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma. J Clin Oncol. 2007;25:319-325.
    • (2007) J Clin Oncol. , vol.25 , pp. 319-325
    • Infante, J.R.1    Matsubayashi, H.2    Sato, N.3
  • 86
    • 14844282766 scopus 로고    scopus 로고
    • Increased levels of SPARC (osteonectin) in human breast cancer tissues and its association with clinical outcomes
    • Watkins G, Douglas-Jones A, Bryce R, et al. Increased levels of SPARC (osteonectin) in human breast cancer tissues and its association with clinical outcomes. Prostaglandins Leukot Essent Fatty Acids. 2005;72:267-272.
    • (2005) Prostaglandins Leukot Essent Fatty Acids , vol.72 , pp. 267-272
    • Watkins, G.1    Douglas-Jones, A.2    Bryce, R.3
  • 87
    • 0141482120 scopus 로고    scopus 로고
    • Enhanced expression of SPARC/osteonectin in the tumor-associated stroma of non-small cell lung cancer is correlated with markers of hypoxia/acidity and with poor prognosis of patients
    • Koukourakis MI,GiatromanolakiA, Brekken RA, et al. Enhanced expression of SPARC/osteonectin in the tumor-associated stroma of non-small cell lung cancer is correlated with markers of hypoxia/acidity and with poor prognosis of patients. Cancer Res. 2003;63:5376-5380.
    • (2003) Cancer Res. , vol.63 , pp. 5376-5380
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Brekken, R.A.3
  • 88
    • 0032982090 scopus 로고    scopus 로고
    • Osteonectin expression correlates with clinical outcome in thin cutaneous malignant melanomas
    • Massi D, Franchi A, Borgognoni L, et al. Osteonectin expression correlates with clinical outcome in thin cutaneous malignant melanomas. Hum Pathol. 1999;30:339-344.
    • (1999) Hum Pathol. , vol.30 , pp. 339-344
    • Massi, D.1    Franchi, A.2    Borgognoni, L.3
  • 89
    • 84918524596 scopus 로고    scopus 로고
    • Updated survival from a randomized phase III trial (MPACT) of nab-paclitaxel plus gemcitabine versus gemcitabine alone for patients (pts) with metastatic adenocarcinoma of the pancreas
    • (suppl 3; abstr 178) 32, abstr 178
    • Goldstein D, Maraghi RHE, Hammel P, et al. Updated survival from a randomized phase III trial (MPACT) of nab-paclitaxel plus gemcitabine versus gemcitabine alone for patients (pts) with metastatic adenocarcinoma of the pancreas. J Clin Oncol. 2014;32:2014; (suppl 3; abstr 178) 32, abstr 178.
    • (2014) J Clin Oncol. , vol.32 , pp. 2014
    • Goldstein, D.1    Maraghi, R.H.E.2    Hammel, P.3
  • 90
    • 84928389785 scopus 로고    scopus 로고
    • SPARC analysis in the phase IIIMPACT trial of nab-paclitaxel (nab-p) plus gemcitabine (gem) vs gemalone for patients with metastatic pancreatic cancer
    • Hidalgo M, Plaza C, Illei P, et al. SPARC analysis in the phase IIIMPACT trial of nab-paclitaxel (nab-p) plus gemcitabine (gem) vs gemalone for patients with metastatic pancreatic cancer. Ann Oncol. 2014;25(suppl-2): ii105-ii117.
    • (2014) Ann Oncol. , vol.25 , pp. ii105-ii117
    • Hidalgo, M.1    Plaza, C.2    Illei, P.3
  • 91
    • 84883143193 scopus 로고    scopus 로고
    • Stromal disrupting effects of nab-paclitaxel in pancreatic cancer
    • Alvarez R, Musteanu M, Garcia-Garcia E, et al. Stromal disrupting effects of nab-paclitaxel in pancreatic cancer. Br J Cancer. 2013;109:926-933.
    • (2013) Br J Cancer , vol.109 , pp. 926-933
    • Alvarez, R.1    Musteanu, M.2    Garcia-Garcia, E.3
  • 92
    • 84902469661 scopus 로고    scopus 로고
    • Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
    • Ozdemir BC, Pentcheva-Hoang T, Carstens JL, et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell. 2014;25:719-734.
    • (2014) Cancer Cell , vol.25 , pp. 719-734
    • Ozdemir, B.C.1    Pentcheva-Hoang, T.2    Carstens, J.L.3
  • 93
    • 84902435628 scopus 로고    scopus 로고
    • Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
    • Rhim AD, Oberstein PE, Thomas DH, et al. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell. 2014;25:735-747.
    • (2014) Cancer Cell , vol.25 , pp. 735-747
    • Rhim, A.D.1    Oberstein, P.E.2    Thomas, D.H.3
  • 94
    • 84907485104 scopus 로고    scopus 로고
    • Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy
    • ShermanMH, Yu RT, Engle DD, et al. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell. 2014;159:80-93.
    • (2014) Cell , vol.159 , pp. 80-93
    • Sherman, M.H.1    Yu, R.T.2    Engle, D.D.3
  • 95
    • 84894098516 scopus 로고    scopus 로고
    • Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity
    • Stromnes IM, Brockenbrough JS, Izeradjene K, et al. Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity. Gut. 2014;63:1769-1781.
    • (2014) Gut , vol.63 , pp. 1769-1781
    • Stromnes, I.M.1    Brockenbrough, J.S.2    Izeradjene, K.3
  • 97
    • 84892942381 scopus 로고    scopus 로고
    • New and emerging HDAC inhibitors for cancer treatment
    • West AC, Johnstone RW. New and emerging HDAC inhibitors for cancer treatment. J Clin Invest. 2014;124:30-39.
    • (2014) J Clin Invest , vol.124 , pp. 30-39
    • West, A.C.1    Johnstone, R.W.2
  • 98
    • 84895785410 scopus 로고    scopus 로고
    • Analysis of the tumor-initiating and metastatic capacity of PDX1-positive cells from the adult pancreas
    • Ischenko I, Petrenko O, HaymanMJ. Analysis of the tumor-initiating and metastatic capacity of PDX1-positive cells from the adult pancreas. Proc Natl Acad Sci U S A. 2014;111:3466-3471.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 3466-3471
    • Ischenko, I.1    Petrenko, O.2    Hayman, M.J.3
  • 99
    • 84904201075 scopus 로고    scopus 로고
    • BET bromodomain inhibitors block growth of pancreatic cancer cells in three-dimensional collagen
    • Sahai V, Kumar K, Knab LM, et al. BET bromodomain inhibitors block growth of pancreatic cancer cells in three-dimensional collagen. Mol Cancer Ther. 2014;13:1907-1917.
    • (2014) Mol Cancer Ther. , vol.13 , pp. 1907-1917
    • Sahai, V.1    Kumar, K.2    Knab, L.M.3
  • 100
    • 84867793735 scopus 로고    scopus 로고
    • A preclinical evaluation ofminnelide as a therapeutic agent against pancreatic cancer
    • Chugh R, Sangwan V, Patil SP, et al. A preclinical evaluation ofminnelide as a therapeutic agent against pancreatic cancer. Sci Transl Med. 2012; 4:156ra139.
    • (2012) Sci Transl Med. , vol.4 , pp. 156-139
    • Chugh, R.1    Sangwan, V.2    Patil, S.P.3
  • 101
    • 84938648678 scopus 로고    scopus 로고
    • Phase i dose escalation and pharmokinetic study of 14-O-phosphonooxymethyltriptolide
    • Philadelphia, PA abstract CT207
    • Greeno E, Borazanci E, Gockerman J, et al. Phase I dose escalation and pharmokinetic study of 14-O-phosphonooxymethyltriptolide. Presented at the AACR 2015 Annual Meeting; Philadelphia, PA; 2015; abstract CT207.
    • (2015) AACR 2015 Annual Meeting
    • Greeno, E.1    Borazanci, E.2    Gockerman, J.3
  • 102
    • 84903188335 scopus 로고    scopus 로고
    • Inactivation of PI(3)Kp110delta breaks regulatory T-cell-mediated immune tolerance to cancer
    • Ali K, Soond DR, Pineiro R, et al. Inactivation of PI(3)Kp110delta breaks regulatory T-cell-mediated immune tolerance to cancer. Nature. 2014; 510:407-411.
    • (2014) Nature , vol.510 , pp. 407-411
    • Ali, K.1    Soond, D.R.2    Pineiro, R.3
  • 103
    • 84865080615 scopus 로고    scopus 로고
    • The pancreas cancer microenvironment
    • Feig C, Gopinathan A, Neesse A, et al. The pancreas cancer microenvironment. Clin Cancer Res. 2012;18:4266-4276.
    • (2012) Clin Cancer Res. , vol.18 , pp. 4266-4276
    • Feig, C.1    Gopinathan, A.2    Neesse, A.3


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