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Volumn 88, Issue 2, 2015, Pages 321-331

Alternatively spliced isoforms of WT1 control podocyte-specific gene expression

Author keywords

glomerular disease; kidney development; nephrin; podocyte differentiation; slit diaphragm; WT1

Indexed keywords

MEMBRANE ASSOCIATED GUANYLATE KINASE 2; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; WT1 PROTEIN; ACVRINP1 PROTEIN, MOUSE; FORKHEAD TRANSCRIPTION FACTOR; FOXC1 PROTEIN, MOUSE; GUANYLATE KINASE; ISOPROTEIN; LIPOPOLYSACCHARIDE; NEPHRIN; REPRESSOR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; WT1 PROTEIN, MOUSE;

EID: 84938550657     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2015.140     Document Type: Article
Times cited : (38)

References (57)
  • 1
    • 75749101016 scopus 로고    scopus 로고
    • Nephrin-signature molecule of the glomerular podocyte?
    • Welsh GI, Saleem MA. Nephrin-signature molecule of the glomerular podocyte?. J Pathol 2010; 220: 328-337
    • (2010) J Pathol , vol.220 , pp. 328-337
    • Welsh, G.I.1    Saleem, M.A.2
  • 2
    • 22244466451 scopus 로고    scopus 로고
    • Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex
    • Lehtonen S, Ryan JJ, Kudlicka K et al. Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex. Proc Natl Acad Sci USA 2005; 102: 9814-9819
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 9814-9819
    • Lehtonen, S.1    Ryan, J.J.2    Kudlicka, K.3
  • 3
    • 84861469119 scopus 로고    scopus 로고
    • IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro
    • Rigothier C, Auguste P, Welsh GI et al. IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro. PLoS One 2012; 7: e37695
    • (2012) PLoS One , vol.7 , pp. e37695
    • Rigothier, C.1    Auguste, P.2    Welsh, G.I.3
  • 4
    • 33749031535 scopus 로고    scopus 로고
    • The many facets of the Wilms' tumour gene
    • Spec No 2 R196-R201
    • Hohenstein P, Hastie ND. The many facets of the Wilms' tumour gene, WT1. Hum Mol Genet 2006; 15(Spec No 2): R196-R201
    • (2006) WT1. Hum Mol Genet , vol.15
    • Hohenstein, P.1    Hastie, N.D.2
  • 5
    • 0032532734 scopus 로고    scopus 로고
    • WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes
    • Davies RC, Calvio C, Bratt E et al. WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes. Genes Dev 1998; 12: 3217-3225
    • (1998) Genes Dev , vol.12 , pp. 3217-3225
    • Davies, R.C.1    Calvio, C.2    Bratt, E.3
  • 6
    • 0029071508 scopus 로고
    • Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing
    • Larsson SH, Charlieu JP, Miyagawa K et al. Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing. Cell 1995; 81: 391-401
    • (1995) Cell , vol.81 , pp. 391-401
    • Larsson, S.H.1    Charlieu, J.P.2    Miyagawa, K.3
  • 7
    • 0026094584 scopus 로고
    • Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome
    • Pelletier J, Bruening W, Kashtan CE et al. Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome. Cell 1991; 67: 437-447
    • (1991) Cell , vol.67 , pp. 437-447
    • Pelletier, J.1    Bruening, W.2    Kashtan, C.E.3
  • 8
    • 16944365351 scopus 로고    scopus 로고
    • Donor splice-site mutations in WT1 are responsible for Frasier syndrome
    • Barbaux S, Niaudet P, Gubler MC et al. Donor splice-site mutations in WT1 are responsible for Frasier syndrome. Nat Genet 1997; 17: 467-470
    • (1997) Nat Genet , vol.17 , pp. 467-470
    • Barbaux, S.1    Niaudet, P.2    Gubler, M.C.3
  • 9
    • 0031922880 scopus 로고    scopus 로고
    • Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/-KTS splice isoforms
    • Klamt B, Koziell A, Poulat F et al. Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/-KTS splice isoforms. Hum Mol Genet 1998; 7: 709-714
    • (1998) Hum Mol Genet , vol.7 , pp. 709-714
    • Klamt, B.1    Koziell, A.2    Poulat, F.3
  • 10
    • 0026864939 scopus 로고
    • Germline intronic and exonic mutations in the Wilms' tumour gene (WT1) affecting urogenital development
    • Bruening W, Bardeesy N, Silverman BL et al. Germline intronic and exonic mutations in the Wilms' tumour gene (WT1) affecting urogenital development. Nat Genet 1992; 1: 144-148
    • (1992) Nat Genet , vol.1 , pp. 144-148
    • Bruening, W.1    Bardeesy, N.2    Silverman, B.L.3
  • 11
    • 0035839099 scopus 로고    scopus 로고
    • Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation
    • Hammes A, Guo JK, Lutsch G et al. Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation. Cell 2001; 106: 319-329
    • (2001) Cell , vol.106 , pp. 319-329
    • Hammes, A.1    Guo, J.K.2    Lutsch, G.3
  • 12
    • 9644281578 scopus 로고    scopus 로고
    • The major podocyte protein nephrin is transcriptionally activated by the Wilms' tumor suppressor WT1
    • Wagner N, Wagner KD, Xing Y et al. The major podocyte protein nephrin is transcriptionally activated by the Wilms' tumor suppressor WT1. J Am Soc Nephrol 2004; 15: 3044-3051
    • (2004) J Am Soc Nephrol , vol.15 , pp. 3044-3051
    • Wagner, N.1    Wagner, K.D.2    Xing, Y.3
  • 13
    • 84904706173 scopus 로고    scopus 로고
    • WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors
    • Motamedi FJ, Badro DA, Clarkson M et al. WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors. Nat Commun 2014; 5: 4444
    • (2014) Nat Commun , vol.5 , pp. 4444
    • Motamedi, F.J.1    Badro, D.A.2    Clarkson, M.3
  • 14
    • 80052527646 scopus 로고    scopus 로고
    • Defining the molecular character of the developing and adult kidney podocyte
    • Brunskill EW, Georgas K, Rumballe B et al. Defining the molecular character of the developing and adult kidney podocyte. PLoS One 2011; 6: e24640
    • (2011) PLoS One , vol.6 , pp. e24640
    • Brunskill, E.W.1    Georgas, K.2    Rumballe, B.3
  • 15
    • 33746493955 scopus 로고    scopus 로고
    • MafB is essential for renal development and F4/80 expression in macrophages
    • Moriguchi T, Hamada M, Morito N et al. MafB is essential for renal development and F4/80 expression in macrophages. Mol Cell Biol 2006; 26: 5715-5727
    • (2006) Mol Cell Biol , vol.26 , pp. 5715-5727
    • Moriguchi, T.1    Hamada, M.2    Morito, N.3
  • 16
    • 0032015551 scopus 로고    scopus 로고
    • Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome
    • Kestila M, Lenkkeri U, Mannikko M et al. Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome. Mol Cell 1998; 1: 575-582
    • (1998) Mol Cell , vol.1 , pp. 575-582
    • Kestila, M.1    Lenkkeri, U.2    Mannikko, M.3
  • 17
    • 0034034757 scopus 로고    scopus 로고
    • NPHS2 encoding the glomerular protein podocin is mutated in autosomal recessive steroid-resistant nephrotic syndrome [published erratum appears
    • Nat Genet 2000 25 1 125
    • Boute N, Gribouval O, Roselli S et al. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome [published erratum appears in Nat Genet 2000; 25 (1): 125]. Nat Genet 2000; 24: 349-354
    • Nat Genet , vol.2000 , Issue.24 , pp. 349-354
    • Boute, N.1    Gribouval, O.2    Roselli, S.3
  • 18
    • 77950529946 scopus 로고    scopus 로고
    • Motif Enrichment Analysis a unified framework and an evaluation on ChIP data
    • McLeay RC, Bailey TL. Motif Enrichment Analysis: a unified framework and an evaluation on ChIP data. BMC Bioinformatics 2010; 11: 165
    • (2010) BMC Bioinformatics , vol.11 , pp. 165
    • McLeay, R.C.1    Bailey, T.L.2
  • 19
    • 60849139395 scopus 로고    scopus 로고
    • GOrilla: A tool for discovery and visualization of enriched GO terms in ranked gene lists
    • Eden E, Navon R, Steinfeld I et al. GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists. BMC Bioinformatics 2009; 10: 48
    • (2009) BMC Bioinformatics , vol.10 , pp. 48
    • Eden, E.1    Navon, R.2    Steinfeld, I.3
  • 20
    • 0032516885 scopus 로고    scopus 로고
    • A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins
    • Hirao K, Hata Y, Ide N et al. A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins. J Biol Chem 1998; 273: 21105-21110
    • (1998) J Biol Chem , vol.273 , pp. 21105-21110
    • Hirao, K.1    Hata, Y.2    Ide, N.3
  • 21
    • 84857682609 scopus 로고    scopus 로고
    • Generation of Venus reporter knockin mice revealed MAGI-2 expression patterns in adult mice
    • Ihara KI, Nishimura T, Fukuda T et al. Generation of Venus reporter knockin mice revealed MAGI-2 expression patterns in adult mice. Gene Expr Patterns 2012; 12: 95-101
    • (2012) Gene Expr Patterns , vol.12 , pp. 95-101
    • Ihara, K.I.1    Nishimura, T.2    Fukuda, T.3
  • 22
    • 34250189863 scopus 로고    scopus 로고
    • Synaptic scaffolding molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA activation in dendrites
    • Iida J, Ishizaki H, Okamoto-Tanaka M et al. Synaptic scaffolding molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA activation in dendrites. Mol Cell Biol 2007; 27: 4388-4405
    • (2007) Mol Cell Biol , vol.27 , pp. 4388-4405
    • Iida, J.1    Ishizaki, H.2    Okamoto-Tanaka, M.3
  • 23
    • 0034723359 scopus 로고    scopus 로고
    • Three isoforms of synaptic scaffolding molecule and their characterization. Multimerization between the isoforms and their interaction with N-methyl-D-aspartate receptors and SAP90/PSD-95-associated protein
    • Hirao K, Hata Y, Yao I et al. Three isoforms of synaptic scaffolding molecule and their characterization. Multimerization between the isoforms and their interaction with N-methyl-D-aspartate receptors and SAP90/PSD-95-associated protein. J Biol Chem 2000; 275: 2966-2972
    • (2000) J Biol Chem , vol.275 , pp. 2966-2972
    • Hirao, K.1    Hata, Y.2    Yao, I.3
  • 24
    • 80052720433 scopus 로고    scopus 로고
    • A wt1-controlled chromatin switching mechanism underpins tissue-specific wnt4 activation and repression
    • Essafi A, Webb A, Berry RL, Slight J et al. A wt1-controlled chromatin switching mechanism underpins tissue-specific wnt4 activation and repression. Dev Cell 2011; 21: 559-574
    • (2011) Dev Cell , vol.21 , pp. 559-574
    • Essafi, A.1    Webb, A.2    Berry, R.L.3    Slight, J.4
  • 25
    • 84907902009 scopus 로고    scopus 로고
    • MAGI-2 is critical for the formation and maintenance of the glomerular filtration barrier in mouse kidney
    • Ihara KI, Asanuma K, Fukuda T et al. MAGI-2 is critical for the formation and maintenance of the glomerular filtration barrier in mouse kidney. Am J Pathol 2014; 184: 2699-2708
    • (2014) Am J Pathol , vol.184 , pp. 2699-2708
    • Ihara, K.I.1    Asanuma, K.2    Fukuda, T.3
  • 26
    • 84907907279 scopus 로고    scopus 로고
    • MAGI-2 scaffold protein is critical for kidney barrier function
    • Balbas MD, Burgess MR, Murali R et al. MAGI-2 scaffold protein is critical for kidney barrier function. Proc Natl Acad Sci USA 2014; 111: 14876-14881
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 14876-14881
    • Balbas, M.D.1    Burgess, M.R.2    Murali, R.3
  • 27
    • 85047691168 scopus 로고    scopus 로고
    • Induction of B7-1 in podocytes is associated with nephrotic syndrome
    • Reiser J, von Gersdorff G, Loos M et al. Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest 2004; 113: 1390-1397
    • (2004) J Clin Invest , vol.113 , pp. 1390-1397
    • Reiser, J.1    Von Gersdorff, G.2    Loos, M.3
  • 28
    • 16644374992 scopus 로고    scopus 로고
    • WT1 activates a glomerularspecific enhancer identified from the human nephrin gene
    • Guo G, Morrison DJ, Licht JD, Quaggin SE. WT1 activates a glomerularspecific enhancer identified from the human nephrin gene. J Am Soc Nephrol 2004; 15: 2851-2856
    • (2004) J Am Soc Nephrol , vol.15 , pp. 2851-2856
    • Guo, G.1    Morrison, D.J.2    Licht, J.D.3    Quaggin, S.E.4
  • 29
    • 84871917753 scopus 로고    scopus 로고
    • Transcription of nephrin-Neph3 gene pair is synergistically activated by WT1 and NF-kappaB and silenced by DNA methylation
    • Ristola M, Arpiainen S, Saleem MA et al. Transcription of nephrin-Neph3 gene pair is synergistically activated by WT1 and NF-kappaB and silenced by DNA methylation. Nephrol Dial Transplant 2012; 27: 1737-1745
    • (2012) Nephrol Dial Transplant , vol.27 , pp. 1737-1745
    • Ristola, M.1    Arpiainen, S.2    Saleem, M.A.3
  • 30
    • 79960139810 scopus 로고    scopus 로고
    • WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier
    • Schumacher VA, Schlotzer-Schrehardt U, Karumanchi SA et al. WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier. J Am Soc Nephrol 2011; 22: 1286-1296
    • (2011) J Am Soc Nephrol , vol.22 , pp. 1286-1296
    • Schumacher, V.A.1    Schlotzer-Schrehardt, U.2    Karumanchi, S.A.3
  • 31
    • 77649321533 scopus 로고    scopus 로고
    • A murine model of Denys-Drash syndrome reveals novel transcriptional targets of WT1 in podocytes
    • Ratelade J, Arrondel C, Hamard G et al. A murine model of Denys-Drash syndrome reveals novel transcriptional targets of WT1 in podocytes. Hum Mol Genet 2010; 19: 1-15
    • (2010) Hum Mol Genet , vol.19 , pp. 1-15
    • Ratelade, J.1    Arrondel, C.2    Hamard, G.3
  • 32
    • 84878425125 scopus 로고    scopus 로고
    • Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1
    • Gebeshuber CA, Kornauth C, Dong L et al. Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1. Nat Med 2013; 19: 481-487
    • (2013) Nat Med , vol.19 , pp. 481-487
    • Gebeshuber, C.A.1    Kornauth, C.2    Dong, L.3
  • 33
    • 80053107072 scopus 로고    scopus 로고
    • Wt1a Foxc1a, and the Notch mediator Rbpj physically interact and regulate the formation of podocytes in zebrafish
    • O'Brien LL, Grimaldi M, Kostun Z et al. Wt1a, Foxc1a, and the Notch mediator Rbpj physically interact and regulate the formation of podocytes in zebrafish. Dev Biol 2011; 358: 318-330
    • (2011) Dev Biol , vol.358 , pp. 318-330
    • O'Brien, L.L.1    Grimaldi, M.2    Kostun, Z.3
  • 34
    • 44149089568 scopus 로고    scopus 로고
    • A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation
    • Miyamoto Y, Taniguchi H, Hamel F et al. A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation. BMC Mol Biol 2008; 9: 44
    • (2008) BMC Mol Biol , vol.9 , pp. 44
    • Miyamoto, Y.1    Taniguchi, H.2    Hamel, F.3
  • 35
    • 33746491157 scopus 로고    scopus 로고
    • Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling
    • Dai C, Stolz DB, Bastacky SI et al. Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling. J Am Soc Nephrol 2006; 17: 2164-2175
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2164-2175
    • Dai, C.1    Stolz, D.B.2    Bastacky, S.I.3
  • 36
    • 77951766263 scopus 로고    scopus 로고
    • New loci associated with kidney function and chronic kidney disease
    • Kottgen A, Pattaro C, Boger CA et al. New loci associated with kidney function and chronic kidney disease. Nat Genet 2010; 42: 376-384
    • (2010) Nat Genet , vol.42 , pp. 376-384
    • Kottgen, A.1    Pattaro, C.2    Boger, C.A.3
  • 38
    • 33644859921 scopus 로고    scopus 로고
    • Rapid isolation of glomeruli coupled with gene expression profiling identifies downstream targets in Pod1 knockout mice
    • Cui S, Li C, Ema M et al. Rapid isolation of glomeruli coupled with gene expression profiling identifies downstream targets in Pod1 knockout mice. J Am Soc Nephrol 2005; 16: 3247-3255
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3247-3255
    • Cui, S.1    Li, C.2    Ema, M.3
  • 39
    • 79958171563 scopus 로고    scopus 로고
    • The GUDMAP database-an online resource for genitourinary research
    • Harding SD, Armit C, Armstrong J et al. The GUDMAP database-an online resource for genitourinary research. Development 2011; 138: 2845-2853
    • (2011) Development , vol.138 , pp. 2845-2853
    • Harding, S.D.1    Armit, C.2    Armstrong, J.3
  • 40
    • 0036733653 scopus 로고    scopus 로고
    • A new method for large scale isolation of kidney glomeruli from mice
    • Takemoto M, Asker N, Gerhardt H et al. A new method for large scale isolation of kidney glomeruli from mice. Am J Pathol 2002; 161: 799-805
    • (2002) Am J Pathol , vol.161 , pp. 799-805
    • Takemoto, M.1    Asker, N.2    Gerhardt, H.3
  • 41
    • 84887311096 scopus 로고    scopus 로고
    • The inactivation of Arx in pancreatic alpha-cells triggers their neogenesis and conversion into functional beta-like cells
    • Courtney M, Gjernes E, Druelle N et al. The inactivation of Arx in pancreatic alpha-cells triggers their neogenesis and conversion into functional beta-like cells. PLoS Genet 2013; 9: e1003934
    • (2013) PLoS Genet , vol.9 , pp. e1003934
    • Courtney, M.1    Gjernes, E.2    Druelle, N.3
  • 42
    • 84887448046 scopus 로고    scopus 로고
    • Caspase-generated fragment of the Met receptor favors apoptosis via the intrinsic pathway independently of its tyrosine kinase activity
    • Lefebvre J, Muharram G, Leroy C et al. Caspase-generated fragment of the Met receptor favors apoptosis via the intrinsic pathway independently of its tyrosine kinase activity. Cell Death Dis 2013; 4: e871
    • (2013) Cell Death Dis , vol.4 , pp. e871
    • Lefebvre, J.1    Muharram, G.2    Leroy, C.3
  • 43
    • 0035880233 scopus 로고    scopus 로고
    • Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria
    • Holt DS, Botto M, Bygrave AE et al. Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria. Blood 2001; 98: 442-449
    • (2001) Blood , vol.98 , pp. 442-449
    • Holt, D.S.1    Botto, M.2    Bygrave, A.E.3
  • 44
    • 79952375230 scopus 로고    scopus 로고
    • TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice
    • Yabuta Y, Ohta H, Abe T et al. TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice. J Cell Biol 2011; 192: 781-795
    • (2011) J Cell Biol , vol.192 , pp. 781-795
    • Yabuta, Y.1    Ohta, H.2    Abe, T.3
  • 45
    • 1542297629 scopus 로고    scopus 로고
    • Enhanced long-Term potentiation in vivo in dentate gyrus of NELL2-deficient mice
    • Matsuyama S, Aihara K, Nishino N et al. Enhanced long-Term potentiation in vivo in dentate gyrus of NELL2-deficient mice. Neuroreport 2004; 15: 417-420
    • (2004) Neuroreport , vol.15 , pp. 417-420
    • Matsuyama, S.1    Aihara, K.2    Nishino, N.3
  • 46
    • 19944430075 scopus 로고    scopus 로고
    • Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins
    • Gu C, Yoshida Y, Livet J et al. Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science 2005; 307: 265-268
    • (2005) Science , vol.307 , pp. 265-268
    • Gu, C.1    Yoshida, Y.2    Livet, J.3
  • 47
    • 2942737775 scopus 로고    scopus 로고
    • A complete genetic analysis of neuronal Rab3 function
    • Schluter OM, Schmitz F, Jahn R et al. A complete genetic analysis of neuronal Rab3 function. J Neurosci 2004; 24: 6629-6637
    • (2004) J Neurosci , vol.24 , pp. 6629-6637
    • Schluter, O.M.1    Schmitz, F.2    Jahn, R.3
  • 48
    • 0034814053 scopus 로고    scopus 로고
    • The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection
    • Sosinowski T, Killeen N, Weiss A. The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. Immunity 2001; 15: 457-466
    • (2001) Immunity , vol.15 , pp. 457-466
    • Sosinowski, T.1    Killeen, N.2    Weiss, A.3
  • 49
    • 0029829425 scopus 로고    scopus 로고
    • Collagen COL4A3 knockout: A mouse model for autosomal Alport syndrome
    • Cosgrove D, Meehan DT, Grunkemeyer JA et al. Collagen COL4A3 knockout: a mouse model for autosomal Alport syndrome. Genes Dev 1996; 10: 2981-2992
    • (1996) Genes Dev , vol.10 , pp. 2981-2992
    • Cosgrove, D.1    Meehan, D.T.2    Grunkemeyer, J.A.3
  • 50
    • 0347986678 scopus 로고    scopus 로고
    • Early glomerular filtration defect and severe renal disease in podocin-deficient mice
    • Roselli S, Heidet L, Sich M et al. Early glomerular filtration defect and severe renal disease in podocin-deficient mice. Mol Cell Biol 2004; 24: 550-560
    • (2004) Mol Cell Biol , vol.24 , pp. 550-560
    • Roselli, S.1    Heidet, L.2    Sich, M.3
  • 51
    • 0033722475 scopus 로고    scopus 로고
    • Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate
    • Wharram BL, Goyal M, Gillespie PJ et al. Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate. J Clin Invest 2000; 106: 1281-1290
    • (2000) J Clin Invest , vol.106 , pp. 1281-1290
    • Wharram, B.L.1    Goyal, M.2    Gillespie, P.J.3
  • 52
    • 79952398627 scopus 로고    scopus 로고
    • Renal thrombotic microangiopathy in mice with combined deletion of endocytic recycling regulators EHD3 and EHD4
    • George M, Rainey MA, Naramura M et al. Renal thrombotic microangiopathy in mice with combined deletion of endocytic recycling regulators EHD3 and EHD4. PLoS One 2011; 6: e17838
    • (2011) PLoS One , vol.6 , pp. e17838
    • George, M.1    Rainey, M.A.2    Naramura, M.3
  • 53
    • 84864088343 scopus 로고    scopus 로고
    • Mitochondrial topoisomerase i is critical for mitochondrial integrity and cellular energy metabolism
    • Douarre C, Sourbier C, Dalla Rosa I et al. Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism. PLoS One 2012; 7: e41094
    • (2012) PLoS One , vol.7 , pp. e41094
    • Douarre, C.1    Sourbier, C.2    Dalla Rosa, I.3
  • 54
    • 84897494657 scopus 로고    scopus 로고
    • Serine protease HTRA1 antagonizes transforming growth factor-beta signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation
    • Graham JR, Chamberland A, Lin Q et al. Serine protease HTRA1 antagonizes transforming growth factor-beta signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation. PLoS One 2013; 8: e74094
    • (2013) PLoS One , vol.8 , pp. e74094
    • Graham, J.R.1    Chamberland, A.2    Lin, Q.3
  • 55
    • 0034943543 scopus 로고    scopus 로고
    • Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D 4) synthesis in vivo and attenuation of the acute inflammatory response
    • Shi ZZ, Han B, Habib GM et al. Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response. Mol Cell Biol 2001; 21: 5389-5395
    • (2001) Mol Cell Biol , vol.21 , pp. 5389-5395
    • Shi, Z.Z.1    Han, B.2    Habib, G.M.3
  • 56
    • 33646007919 scopus 로고    scopus 로고
    • Hexose-6-phosphate dehydrogenase knock-out mice lack 11 beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation
    • Lavery GG, Walker EA, Draper N et al. Hexose-6-phosphate dehydrogenase knock-out mice lack 11 beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation. J Biol Chem 2006; 281: 6546-6551
    • (2006) J Biol Chem , vol.281 , pp. 6546-6551
    • Lavery, G.G.1    Walker, E.A.2    Draper, N.3
  • 57
    • 0033582228 scopus 로고    scopus 로고
    • Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting
    • Sun X, Funk CD, Deng C et al. Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting. Proc Natl Acad Sci USA 1999; 96: 628-633
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 628-633
    • Sun, X.1    Funk, C.D.2    Deng, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.