메뉴 건너뛰기




Volumn 9, Issue JUL, 2015, Pages

Antidepressant mechanism of ketamine: Perspective from preclinical studies

Author keywords

GSK 3 inhibitor; Ketamine; Lithium; Major depressive disorder; MTOR; NMDA antagonist; Therapeutic potential

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3; KETAMINE; LITHIUM; MAMMALIAN TARGET OF RAPAMYCIN;

EID: 84938539210     PISSN: 16624548     EISSN: 1662453X     Source Type: Journal    
DOI: 10.3389/fnins.2015.00249     Document Type: Short Survey
Times cited : (50)

References (68)
  • 1
    • 71649098114 scopus 로고    scopus 로고
    • Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression
    • Aan Het Rot, M., Collins, K. A., Murrough, J. W., Perez, A. M., Reich, D. L., Charney, D. S., et al. (2010). Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression. Biol. Psychiatry 67, 139-145. doi: 10.1016/j.biopsych.2009.08.038.
    • (2010) Biol. Psychiatry , vol.67 , pp. 139-145
    • Aan Het Rot, M.1    Collins, K.A.2    Murrough, J.W.3    Perez, A.M.4    Reich, D.L.5    Charney, D.S.6
  • 2
    • 79960057257 scopus 로고    scopus 로고
    • NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
    • Autry, A. E., Adachi, M., Nosyreva, E., Na, E. S., Los, M. F., Cheng, P. F., et al. (2011). NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses. Nature 475, 91-95. doi: 10.1038/nature10130.
    • (2011) Nature , vol.475 , pp. 91-95
    • Autry, A.E.1    Adachi, M.2    Nosyreva, E.3    Na, E.S.4    Los, M.F.5    Cheng, P.F.6
  • 3
    • 84858165817 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and neuropsychiatric disorders
    • Autry, A. E., and Monteggia, L. M. (2012). Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol. Rev. 64, 238-258. doi: 10.1124/pr.111.005108.
    • (2012) Pharmacol. Rev , vol.64 , pp. 238-258
    • Autry, A.E.1    Monteggia, L.M.2
  • 4
    • 79960213948 scopus 로고    scopus 로고
    • CD-1 and Balb/cJ mice do not show enduring antidepressant-like effects of ketamine in tests of acute antidepressant efficacy
    • Bechtholt-Gompf, A. J., Smith, K. L., John, C. S., Kang, H. H., Carlezon, W. A. Jr., Cohen, B. M., et al. (2011). CD-1 and Balb/cJ mice do not show enduring antidepressant-like effects of ketamine in tests of acute antidepressant efficacy. Psychopharmacol. (Berl). 215, 689-695. doi: 10.1007/s00213-011-2169-8.
    • (2011) Psychopharmacol. (Berl) , vol.215 , pp. 689-695
    • Bechtholt-Gompf, A.J.1    Smith, K.L.2    John, C.S.3    Kang, H.H.4    Carlezon, W.A.5    Cohen, B.M.6
  • 6
    • 84923265392 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases
    • Beurel, E., Grieco, S. F., and Jope, R. S. (2015). Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases. Pharmacol. Ther. 148, 114-131. doi: 10.1016/j.pharmthera.2014.11.016.
    • (2015) Pharmacol. Ther , vol.148 , pp. 114-131
    • Beurel, E.1    Grieco, S.F.2    Jope, R.S.3
  • 7
    • 85028117370 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice
    • Beurel, E., Song, L., and Jope, R. S. (2011). Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice. Mol. Psychiatry 16, 1068-1070. doi: 10.1038/mp.2011.47.
    • (2011) Mol. Psychiatry , vol.16 , pp. 1068-1070
    • Beurel, E.1    Song, L.2    Jope, R.S.3
  • 8
    • 84875222862 scopus 로고    scopus 로고
    • GLYX-13, a NMDA receptor glycine-site functional partial agonist, induces antidepressant-like effects without ketamine-like side effects
    • Burgdorf, J., Zhang, X. L., Nicholson, K. L., Balster, R. L., Leander, J. D., Stanton, P. K., et al. (2013). GLYX-13, a NMDA receptor glycine-site functional partial agonist, induces antidepressant-like effects without ketamine-like side effects. Neuropsychopharmacology 38, 729-742. doi: 10.1038/npp.2012.246.
    • (2013) Neuropsychopharmacology , vol.38 , pp. 729-742
    • Burgdorf, J.1    Zhang, X.L.2    Nicholson, K.L.3    Balster, R.L.4    Leander, J.D.5    Stanton, P.K.6
  • 9
    • 84876952127 scopus 로고    scopus 로고
    • Sex differences in the antidepressant-like effects of ketamine
    • Carrier, N., and Kabbaj, M. (2013). Sex differences in the antidepressant-like effects of ketamine. Neuropharmacology 70, 27-34. doi: 10.1016/j.neuropharm.2012.12.009.
    • (2013) Neuropharmacology , vol.70 , pp. 27-34
    • Carrier, N.1    Kabbaj, M.2
  • 10
    • 0033587742 scopus 로고    scopus 로고
    • Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons
    • Chalecka-Franaszek, E., and Chuang, D. M. (1999). Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. Proc. Natl. Acad. Sci. U.S.A. 96, 8745-8750. doi: 10.1073/pnas.96.15.8745.
    • (1999) Proc. Natl. Acad. Sci. U.S.A , vol.96 , pp. 8745-8750
    • Chalecka-Franaszek, E.1    Chuang, D.M.2
  • 11
    • 84981484055 scopus 로고    scopus 로고
    • The mood stabilizer lithium potentiates the antidepressant-like effects and ameliorates oxidative stress induced by acute ketamine in a mouse model of stress
    • Chiu, C. T., Scheuing, L., Liu, G., Liao, H. M., Linares, G. R., Lin, D., et al. (2014). The mood stabilizer lithium potentiates the antidepressant-like effects and ameliorates oxidative stress induced by acute ketamine in a mouse model of stress. Int. J. Neuropsychopharmacol. 18:pyu102. doi: 10.1093/ijnp/pyu102.
    • (2014) Int. J. Neuropsychopharmacol , vol.18
    • Chiu, C.T.1    Scheuing, L.2    Liu, G.3    Liao, H.M.4    Linares, G.R.5    Lin, D.6
  • 12
    • 18044387888 scopus 로고    scopus 로고
    • Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trials
    • Cipriani, A., Pretty, H., Hawton, K., and Geddes, J. R. (2005). Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trials. Am. J. Psychiatry 162, 1805-1819. doi: 10.1176/appi.ajp.162.10.1805.
    • (2005) Am. J. Psychiatry , vol.162 , pp. 1805-1819
    • Cipriani, A.1    Pretty, H.2    Hawton, K.3    Geddes, J.R.4
  • 13
    • 84881425599 scopus 로고    scopus 로고
    • The state of US health, 1990-2010: burden of diseases, injuries, and risk factors
    • Collaborators, U. S. B. O. D. (2013). The state of US health, 1990-2010: burden of diseases, injuries, and risk factors. JAMA 310, 591-608. doi: 10.1001/jama.2013.13805.
    • (2013) JAMA , vol.310 , pp. 591-608
  • 14
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross, D. A., Alessi, D. R., Cohen, P., Andjelkovich, M., and Hemmings, B. A. (1995). Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378, 785-789. doi: 10.1038/378785a0.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 17
    • 77955891255 scopus 로고    scopus 로고
    • A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression
    • Diazgranados, N., Ibrahim, L., Brutsche, N. E., Newberg, A., Kronstein, P., Khalife, S., et al. (2010). A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression. Arch. Gen. Psychiatry 67, 793-802. doi: 10.1001/archgenpsychiatry.2010.90.
    • (2010) Arch. Gen. Psychiatry , vol.67 , pp. 793-802
    • Diazgranados, N.1    Ibrahim, L.2    Brutsche, N.E.3    Newberg, A.4    Kronstein, P.5    Khalife, S.6
  • 18
    • 0037462449 scopus 로고    scopus 로고
    • The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
    • Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., et al. (2003). The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257-269. doi: 10.1016/S0092-8674(03)00035-7.
    • (2003) Cell , vol.112 , pp. 257-269
    • Egan, M.F.1    Kojima, M.2    Callicott, J.H.3    Goldberg, T.E.4    Kolachana, B.S.5    Bertolino, A.6
  • 19
    • 84902132275 scopus 로고    scopus 로고
    • Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial
    • Feder, A., Parides, M. K., Murrough, J. W., Perez, A. M., Morgan, J. E., Saxena, S., et al. (2014). Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial. JAMA Psychiatry 71, 681-688. doi: 10.1001/jamapsychiatry.2014.62.
    • (2014) JAMA Psychiatry , vol.71 , pp. 681-688
    • Feder, A.1    Parides, M.K.2    Murrough, J.W.3    Perez, A.M.4    Morgan, J.E.5    Saxena, S.6
  • 20
    • 78650239404 scopus 로고    scopus 로고
    • Functions and regulation of the 70kDa ribosomal S6 kinases
    • Fenton, T. R., and Gout, I. T. (2011). Functions and regulation of the 70kDa ribosomal S6 kinases. Int. J. Biochem. Cell Biol. 43, 47-59. doi: 10.1016/j.biocel.2010.09.018.
    • (2011) Int. J. Biochem. Cell Biol , vol.43 , pp. 47-59
    • Fenton, T.R.1    Gout, I.T.2
  • 21
    • 58149357209 scopus 로고    scopus 로고
    • Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression
    • Feyissa, A. M., Chandran, A., Stockmeier, C. A., and Karolewicz, B. (2009). Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 33, 70-75. doi: 10.1016/j.pnpbp.2008.10.005.
    • (2009) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.33 , pp. 70-75
    • Feyissa, A.M.1    Chandran, A.2    Stockmeier, C.A.3    Karolewicz, B.4
  • 22
    • 84856702223 scopus 로고    scopus 로고
    • Inhibition of GSK3 by lithium, from single molecules to signaling networks
    • Freland, L., and Beaulieu, J. M. (2012). Inhibition of GSK3 by lithium, from single molecules to signaling networks. Front. Mol. Neurosci. 5:14. doi: 10.3389/fnmol.2012.00014.
    • (2012) Front. Mol. Neurosci , vol.5 , pp. 14
    • Freland, L.1    Beaulieu, J.M.2
  • 23
    • 84885604333 scopus 로고    scopus 로고
    • Rapamycin inhibition of mTORC1 reverses lithium-induced proliferation of renal collecting duct cells
    • Gao, Y., Romero-Aleshire, M. J., Cai, Q., Price, T. J., and Brooks, H. L. (2013). Rapamycin inhibition of mTORC1 reverses lithium-induced proliferation of renal collecting duct cells. Am. J. Physiol. Renal Physiol. 305, F1201-1208. doi: 10.1152/ajprenal.00153.2013.
    • (2013) Am. J. Physiol. Renal Physiol , vol.305 , pp. F1201-F1208
    • Gao, Y.1    Romero-Aleshire, M.J.2    Cai, Q.3    Price, T.J.4    Brooks, H.L.5
  • 24
    • 38349097619 scopus 로고    scopus 로고
    • Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus
    • Garcia, L. S., Comim, C. M., Valvassori, S. S., Reus, G. Z., Barbosa, L. M., Andreazza, A. C., et al. (2008). Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus. Prog. Neuropsychopharmacol. Biol. Psychiatry 32, 140-144. doi: 10.1016/j.pnpbp.2007.07.027.
    • (2008) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.32 , pp. 140-144
    • Garcia, L.S.1    Comim, C.M.2    Valvassori, S.S.3    Reus, G.Z.4    Barbosa, L.M.5    Andreazza, A.C.6
  • 25
    • 0035498939 scopus 로고    scopus 로고
    • Hierarchical phosphorylation of the translation inhibitor 4E-BP1
    • Gingras, A. C., Raught, B., Gygi, S. P., Niedzwiecka, A., Miron, M., Burley, S. K., et al. (2001). Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev. 15, 2852-2864. doi: 10.1101/gad.912401.
    • (2001) Genes Dev , vol.15 , pp. 2852-2864
    • Gingras, A.C.1    Raught, B.2    Gygi, S.P.3    Niedzwiecka, A.4    Miron, M.5    Burley, S.K.6
  • 26
    • 67349252254 scopus 로고    scopus 로고
    • The acute effects of NMDA antagonism: from the rodent to the human brain
    • Gunduz-Bruce, H. (2009). The acute effects of NMDA antagonism: from the rodent to the human brain. Brain Res. Rev. 60, 279-286. doi: 10.1016/j.brainresrev.2008.07.006.
    • (2009) Brain Res. Rev , vol.60 , pp. 279-286
    • Gunduz-Bruce, H.1
  • 27
    • 0037434847 scopus 로고    scopus 로고
    • Lithium-induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against N-methyl-D-aspartate receptor-mediated excitotoxicity
    • Hashimoto, R., Fujimaki, K., Jeong, M. R., Christ, L., and Chuang, D. M. (2003). Lithium-induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against N-methyl-D-aspartate receptor-mediated excitotoxicity. FEBS Lett. 538, 145-148. doi: 10.1016/S0014-5793(03)00167-4.
    • (2003) FEBS Lett , vol.538 , pp. 145-148
    • Hashimoto, R.1    Fujimaki, K.2    Jeong, M.R.3    Christ, L.4    Chuang, D.M.5
  • 28
    • 0036328597 scopus 로고    scopus 로고
    • Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation
    • Hashimoto, R., Hough, C., Nakazawa, T., Yamamoto, T., and Chuang, D. M. (2002). Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation. J. Neurochem. 80, 589-597. doi: 10.1046/j.0022-3042.2001.00728.x.
    • (2002) J. Neurochem , vol.80 , pp. 589-597
    • Hashimoto, R.1    Hough, C.2    Nakazawa, T.3    Yamamoto, T.4    Chuang, D.M.5
  • 29
    • 85047684623 scopus 로고    scopus 로고
    • The STAR*D trial: revealing the need for better treatments
    • Insel, T. R., and Wang, P. S. (2009). The STAR*D trial: revealing the need for better treatments. Psychiatr. Serv. 60, 1466-1467. doi: 10.1176/ps.2009.60.11.1466.
    • (2009) Psychiatr. Serv , vol.60 , pp. 1466-1467
    • Insel, T.R.1    Wang, P.S.2
  • 31
    • 84868540518 scopus 로고    scopus 로고
    • Synaptic mechanisms underlying rapid antidepressant action of ketamine
    • Kavalali, E. T., and Monteggia, L. M. (2012). Synaptic mechanisms underlying rapid antidepressant action of ketamine. Am. J. Psychiatry 169, 1150-1156. doi: 10.1176/appi.ajp.2012.12040531.
    • (2012) Am. J. Psychiatry , vol.169 , pp. 1150-1156
    • Kavalali, E.T.1    Monteggia, L.M.2
  • 32
    • 0037178786 scopus 로고    scopus 로고
    • mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • Kim, D. H., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument-Bromage, H., et al. (2002). mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110, 163-175. doi: 10.1016/S0092-8674(02)00808-5.
    • (2002) Cell , vol.110 , pp. 163-175
    • Kim, D.H.1    Sarbassov, D.D.2    Ali, S.M.3    King, J.E.4    Latek, R.R.5    Erdjument-Bromage, H.6
  • 33
    • 0142095005 scopus 로고    scopus 로고
    • NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development
    • Krystal, J. H., D'souza, D. C., Mathalon, D., Perry, E., Belger, A., and Hoffman, R. (2003). NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development. Psychopharmacol. (Berl). 169, 215-233. doi: 10.1007/s00213-003-1582-z.
    • (2003) Psychopharmacol. (Berl) , vol.169 , pp. 215-233
    • Krystal, J.H.1    D'souza, D.C.2    Mathalon, D.3    Perry, E.4    Belger, A.5    Hoffman, R.6
  • 34
    • 24344462681 scopus 로고    scopus 로고
    • Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive function
    • Krystal, J. H., Perry, E. B. Jr., Gueorguieva, R., Belger, A., Madonick, S. H., Abi-Dargham, A., et al. (2005). Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive function. Arch. Gen. Psychiatry 62, 985-994. doi: 10.1001/archpsyc.62.9.985.
    • (2005) Arch. Gen. Psychiatry , vol.62 , pp. 985-994
    • Krystal, J.H.1    Perry, E.B.2    Gueorguieva, R.3    Belger, A.4    Madonick, S.H.5    Abi-Dargham, A.6
  • 35
    • 84868208976 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor Val66Met polymorphism and antidepressant efficacy of ketamine in depressed patients
    • Laje, G., Lally, N., Mathews, D., Brutsche, N., Chemerinski, A., Akula, N., et al. (2012). Brain-derived neurotrophic factor Val66Met polymorphism and antidepressant efficacy of ketamine in depressed patients. Biol. Psychiatry 72, e27-e28. doi: 10.1016/j.biopsych.2012.05.031.
    • (2012) Biol. Psychiatry , vol.72 , pp. e27-e28
    • Laje, G.1    Lally, N.2    Mathews, D.3    Brutsche, N.4    Chemerinski, A.5    Akula, N.6
  • 36
    • 85006269731 scopus 로고    scopus 로고
    • Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression
    • Lally, N., Nugent, A. C., Luckenbaugh, D. A., Ameli, R., Roiser, J. P., and Zarate, C. A. (2014). Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression. Transl. Psychiatry 4, e469. doi: 10.1038/tp.2014.105.
    • (2014) Transl. Psychiatry , vol.4
    • Lally, N.1    Nugent, A.C.2    Luckenbaugh, D.A.3    Ameli, R.4    Roiser, J.P.5    Zarate, C.A.6
  • 38
    • 77955909841 scopus 로고    scopus 로고
    • mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists
    • Li, N., Lee, B., Liu, R. J., Banasr, M., Dwyer, J. M., Iwata, M., et al. (2010). mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science 329, 959-964. doi: 10.1126/science.1190287.
    • (2010) Science , vol.329 , pp. 959-964
    • Li, N.1    Lee, B.2    Liu, R.J.3    Banasr, M.4    Dwyer, J.M.5    Iwata, M.6
  • 39
    • 79953166373 scopus 로고    scopus 로고
    • Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure
    • Li, N., Liu, R. J., Dwyer, J. M., Banasr, M., Lee, B., Son, H., et al. (2011). Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biol. Psychiatry 69, 754-761. doi: 10.1016/j.biopsych.2010.12.015.
    • (2011) Biol. Psychiatry , vol.69 , pp. 754-761
    • Li, N.1    Liu, R.J.2    Dwyer, J.M.3    Banasr, M.4    Lee, B.5    Son, H.6
  • 40
    • 84884288609 scopus 로고    scopus 로고
    • GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine
    • Liu, R. J., Fuchikami, M., Dwyer, J. M., Lepack, A. E., Duman, R. S., and Aghajanian, G. K. (2013). GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine. Neuropsychopharmacology 38, 2268-2277. doi: 10.1038/npp.2013.128.
    • (2013) Neuropsychopharmacology , vol.38 , pp. 2268-2277
    • Liu, R.J.1    Fuchikami, M.2    Dwyer, J.M.3    Lepack, A.E.4    Duman, R.S.5    Aghajanian, G.K.6
  • 41
    • 84857083262 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex
    • Liu, R. J., Lee, F. S., Li, X. Y., Bambico, F., Duman, R. S., and Aghajanian, G. K. (2012). Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex. Biol. Psychiatry 71, 996-1005. doi: 10.1016/j.biopsych.2011.09.030.
    • (2012) Biol. Psychiatry , vol.71 , pp. 996-1005
    • Liu, R.J.1    Lee, F.S.2    Li, X.Y.3    Bambico, F.4    Duman, R.S.5    Aghajanian, G.K.6
  • 42
    • 38349186799 scopus 로고    scopus 로고
    • Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors
    • Maeng, S., Zarate, C. A. Jr., Du, J., Schloesser, R. J., Mccammon, J., Chen, G., et al. (2008). Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors. Biol. Psychiatry 63, 349-352. doi: 10.1016/j.biopsych.2007.05.028.
    • (2008) Biol. Psychiatry , vol.63 , pp. 349-352
    • Maeng, S.1    Zarate, C.A.2    Du, J.3    Schloesser, R.J.4    Mccammon, J.5    Chen, G.6
  • 43
    • 84920279509 scopus 로고    scopus 로고
    • Antidepressant actions of ketamine: from molecular mechanisms to clinical practice
    • Monteggia, L. M., and Zarate, C. Jr. (2015). Antidepressant actions of ketamine: from molecular mechanisms to clinical practice. Curr. Opin. Neurobiol. 30, 139-143. doi: 10.1016/j.conb.2014.12.004.
    • (2015) Curr. Opin. Neurobiol , vol.30 , pp. 139-143
    • Monteggia, L.M.1    Zarate, C.2
  • 44
    • 84871099014 scopus 로고    scopus 로고
    • Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
    • Murray, C. J., Vos, T., Lozano, R., Naghavi, M., Flaxman, A. D., Michaud, C., et al. (2012). Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2197-2223. doi: 10.1016/S0140-6736(12)61689-4.
    • (2012) Lancet , vol.380 , pp. 2197-2223
    • Murray, C.J.1    Vos, T.2    Lozano, R.3    Naghavi, M.4    Flaxman, A.D.5    Michaud, C.6
  • 45
    • 84885214350 scopus 로고    scopus 로고
    • Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial
    • Murrough, J. W., Iosifescu, D. V., Chang, L. C., Al Jurdi, R. K., Green, C. E., Perez, A. M., et al. (2013a). Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. Am. J. Psychiatry 170, 1134-1142. doi: 10.1176/appi.ajp.2013.13030392.
    • (2013) Am. J. Psychiatry , vol.170 , pp. 1134-1142
    • Murrough, J.W.1    Iosifescu, D.V.2    Chang, L.C.3    Al Jurdi, R.K.4    Green, C.E.5    Perez, A.M.6
  • 46
    • 84880767967 scopus 로고    scopus 로고
    • Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression
    • Murrough, J. W., Perez, A. M., Pillemer, S., Stern, J., Parides, M. K., Aan Het Rot, M., et al. (2013b). Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression. Biol. Psychiatry 74, 250-256. doi: 10.1016/j.biopsych.2012.06.022.
    • (2013) Biol. Psychiatry , vol.74 , pp. 250-256
    • Murrough, J.W.1    Perez, A.M.2    Pillemer, S.3    Stern, J.4    Parides, M.K.5    Aan Het Rot, M.6
  • 47
    • 50849139232 scopus 로고    scopus 로고
    • Oxidative stress in psychiatric disorders: evidence base and therapeutic implications
    • Ng, F., Berk, M., Dean, O., and Bush, A. I. (2008). Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int. J. Neuropsychopharmacol. 11, 851-876. doi: 10.1017/S1461145707008401.
    • (2008) Int. J. Neuropsychopharmacol , vol.11 , pp. 851-876
    • Ng, F.1    Berk, M.2    Dean, O.3    Bush, A.I.4
  • 48
    • 84876276051 scopus 로고    scopus 로고
    • Acute suppression of spontaneous neurotransmission drives synaptic potentiation
    • Nosyreva, E., Szabla, K., Autry, A. E., Ryazanov, A. G., Monteggia, L. M., and Kavalali, E. T. (2013). Acute suppression of spontaneous neurotransmission drives synaptic potentiation. J. Neurosci. 33, 6990-7002. doi: 10.1523/JNEUROSCI.4998-12.2013.
    • (2013) J. Neurosci , vol.33 , pp. 6990-7002
    • Nosyreva, E.1    Szabla, K.2    Autry, A.E.3    Ryazanov, A.G.4    Monteggia, L.M.5    Kavalali, E.T.6
  • 49
    • 84929942840 scopus 로고    scopus 로고
    • Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons
    • Park, S. W., Lee, J. G., Seo, M. K., Lee, C. H., Cho, H. Y., Lee, B. J., et al. (2014). Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons. Int. J. Neuropsychopharmacol. 17, 1831-1846. doi: 10.1017/S1461145714000534.
    • (2014) Int. J. Neuropsychopharmacol , vol.17 , pp. 1831-1846
    • Park, S.W.1    Lee, J.G.2    Seo, M.K.3    Lee, C.H.4    Cho, H.Y.5    Lee, B.J.6
  • 50
    • 77955662883 scopus 로고    scopus 로고
    • Population genetic study of the brain-derived neurotrophic factor (BDNF) gene
    • Petryshen, T. L., Sabeti, P. C., Aldinger, K. A., Fry, B., Fan, J. B., Schaffner, S. F., et al. (2010). Population genetic study of the brain-derived neurotrophic factor (BDNF) gene. Mol. Psychiatry 15, 810-815. doi: 10.1038/mp.2009.24.
    • (2010) Mol. Psychiatry , vol.15 , pp. 810-815
    • Petryshen, T.L.1    Sabeti, P.C.2    Aldinger, K.A.3    Fry, B.4    Fan, J.B.5    Schaffner, S.F.6
  • 51
    • 44249084403 scopus 로고    scopus 로고
    • Lack of persistent effects of ketamine in rodent models of depression
    • Popik, P., Kos, T., Sowa-Kucma, M., and Nowak, G. (2008). Lack of persistent effects of ketamine in rodent models of depression. Psychopharmacol. (Berl). 198, 421-430. doi: 10.1007/s00213-008-1158-z.
    • (2008) Psychopharmacol. (Berl) , vol.198 , pp. 421-430
    • Popik, P.1    Kos, T.2    Sowa-Kucma, M.3    Nowak, G.4
  • 52
    • 84899072984 scopus 로고    scopus 로고
    • Effects of ketamine on explicit and implicit suicidal cognition: a randomized controlled trial in treatment-resistant depression
    • Price, R. B., Iosifescu, D. V., Murrough, J. W., Chang, L. C., Al Jurdi, R. K., Iqbal, S. Z., et al. (2014). Effects of ketamine on explicit and implicit suicidal cognition: a randomized controlled trial in treatment-resistant depression. Depress. Anxiety 31, 335-343. doi: 10.1002/da.22253.
    • (2014) Depress. Anxiety , vol.31 , pp. 335-343
    • Price, R.B.1    Iosifescu, D.V.2    Murrough, J.W.3    Chang, L.C.4    Al Jurdi, R.K.5    Iqbal, S.Z.6
  • 53
    • 68049121850 scopus 로고    scopus 로고
    • Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression
    • Price, R. B., Nock, M. K., Charney, D. S., and Mathew, S. J. (2009). Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression. Biol. Psychiatry 66, 522-526. doi: 10.1016/j.biopsych.2009.04.029.
    • (2009) Biol. Psychiatry , vol.66 , pp. 522-526
    • Price, R.B.1    Nock, M.K.2    Charney, D.S.3    Mathew, S.J.4
  • 54
    • 84902656355 scopus 로고    scopus 로고
    • Lithium and the other mood stabilizers effective in bipolar disorder target the rat brain arachidonic acid cascade
    • Rapoport, S. I. (2014). Lithium and the other mood stabilizers effective in bipolar disorder target the rat brain arachidonic acid cascade. ACS Chem. Neurosci. 5, 459-467. doi: 10.1021/cn500058v.
    • (2014) ACS Chem. Neurosci , vol.5 , pp. 459-467
    • Rapoport, S.I.1
  • 55
    • 84888327414 scopus 로고    scopus 로고
    • Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: proof-of-concept
    • Rodriguez, C. I., Kegeles, L. S., Levinson, A., Feng, T., Marcus, S. M., Vermes, D., et al. (2013). Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: proof-of-concept. Neuropsychopharmacology 38, 2475-2483. doi: 10.1038/npp.2013.150.
    • (2013) Neuropsychopharmacology , vol.38 , pp. 2475-2483
    • Rodriguez, C.I.1    Kegeles, L.S.2    Levinson, A.3    Feng, T.4    Marcus, S.M.5    Vermes, D.6
  • 56
    • 84924690161 scopus 로고    scopus 로고
    • Ketamine: promising path or false prophecy in the development of novel therapeutics for mood disorders?
    • Sanacora, G., and Schatzberg, A. F. (2015). Ketamine: promising path or false prophecy in the development of novel therapeutics for mood disorders? Neuropsychopharmacology 40, 1307. doi: 10.1038/npp.2014.338.
    • (2015) Neuropsychopharmacology , vol.40 , pp. 1307
    • Sanacora, G.1    Schatzberg, A.F.2
  • 57
    • 33947726165 scopus 로고    scopus 로고
    • Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative-antioxidative systems
    • Sarandol, A., Sarandol, E., Eker, S. S., Erdinc, S., Vatansever, E., and Kirli, S. (2007). Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative-antioxidative systems. Hum. Psychopharmacol. 22, 67-73. doi: 10.1002/hup.829.
    • (2007) Hum. Psychopharmacol , vol.22 , pp. 67-73
    • Sarandol, A.1    Sarandol, E.2    Eker, S.S.3    Erdinc, S.4    Vatansever, E.5    Kirli, S.6
  • 58
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov, D. D., Ali, S. M., Kim, D. H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., et al. (2004). Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14, 1296-1302. doi: 10.1016/j.cub.2004.06.054.
    • (2004) Curr. Biol , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6
  • 59
    • 27544500981 scopus 로고    scopus 로고
    • Growing roles for the mTOR pathway
    • Sarbassov, D. D., Ali, S. M., and Sabatini, D. M. (2005). Growing roles for the mTOR pathway. Curr. Opin. Cell Biol. 17, 596-603. doi: 10.1016/j.ceb.2005.09.009.
    • (2005) Curr. Opin. Cell Biol , vol.17 , pp. 596-603
    • Sarbassov, D.D.1    Ali, S.M.2    Sabatini, D.M.3
  • 60
    • 0027515127 scopus 로고
    • Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling
    • Sutherland, C., Leighton, I. A., and Cohen, P. (1993). Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling. Biochem. J. 296(Pt 1), 15-19.
    • (1993) Biochem. J , vol.296 , pp. 15-19
    • Sutherland, C.1    Leighton, I.A.2    Cohen, P.3
  • 61
    • 0025157918 scopus 로고
    • Functional antagonists at the NMDA receptor complex exhibit antidepressant actions
    • Trullas, R., and Skolnick, P. (1990). Functional antagonists at the NMDA receptor complex exhibit antidepressant actions. Eur. J. Pharmacol. 185, 1-10. doi: 10.1016/0014-2999(90)90204-J.
    • (1990) Eur. J. Pharmacol , vol.185 , pp. 1-10
    • Trullas, R.1    Skolnick, P.2
  • 62
    • 58049196879 scopus 로고    scopus 로고
    • The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons
    • Yasuda, S., Liang, M. H., Marinova, Z., Yahyavi, A., and Chuang, D. M. (2009). The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons. Mol. Psychiatry 14, 51-59. doi: 10.1038/sj.mp.4002099.
    • (2009) Mol. Psychiatry , vol.14 , pp. 51-59
    • Yasuda, S.1    Liang, M.H.2    Marinova, Z.3    Yahyavi, A.4    Chuang, D.M.5
  • 63
    • 0036370601 scopus 로고    scopus 로고
    • Prolonged effect of an anesthetic dose of ketamine on behavioral despair
    • Yilmaz, A., Schulz, D., Aksoy, A., and Canbeyli, R. (2002). Prolonged effect of an anesthetic dose of ketamine on behavioral despair. Pharmacol. Biochem. Behav. 71, 341-344. doi: 10.1016/S0091-3057(01)00693-1.
    • (2002) Pharmacol. Biochem. Behav , vol.71 , pp. 341-344
    • Yilmaz, A.1    Schulz, D.2    Aksoy, A.3    Canbeyli, R.4
  • 64
    • 84861099072 scopus 로고    scopus 로고
    • Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled add-on trial
    • Zarate, C. A. Jr., Brutsche, N. E., Ibrahim, L., Franco-Chaves, J., Diazgranados, N., Cravchik, A., et al. (2012b). Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled add-on trial. Biol. Psychiatry 71, 939-946. doi: 10.1016/j.biopsych.2011.12.010.
    • (2012) Biol. Psychiatry , vol.71 , pp. 939-946
    • Zarate, C.A.1    Brutsche, N.E.2    Ibrahim, L.3    Franco-Chaves, J.4    Diazgranados, N.5    Cravchik, A.6
  • 65
    • 84864286398 scopus 로고    scopus 로고
    • Relationship of ketamine's plasma metabolites with response, diagnosis, and side effects in major depression
    • Zarate, C. A. Jr., Brutsche, N., Laje, G., Luckenbaugh, D. A., Venkata, S. L., Ramamoorthy, A., et al. (2012a). Relationship of ketamine's plasma metabolites with response, diagnosis, and side effects in major depression. Biol. Psychiatry 72, 331-338. doi: 10.1016/j.biopsych.2012.03.004.
    • (2012) Biol. Psychiatry , vol.72 , pp. 331-338
    • Zarate, C.A.1    Brutsche, N.2    Laje, G.3    Luckenbaugh, D.A.4    Venkata, S.L.5    Ramamoorthy, A.6
  • 66
    • 33746896935 scopus 로고    scopus 로고
    • A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression
    • Zarate, C. A. Jr., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., et al. (2006). A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch. Gen. Psychiatry 63, 856-864. doi: 10.1001/archpsyc.63.8.856.
    • (2006) Arch. Gen. Psychiatry , vol.63 , pp. 856-864
    • Zarate, C.A.1    Singh, J.B.2    Carlson, P.J.3    Brutsche, N.E.4    Ameli, R.5    Luckenbaugh, D.A.6
  • 67
    • 84888304705 scopus 로고    scopus 로고
    • Ketamine: synaptogenesis, immunomodulation and glycogen synthase kinase-3 as underlying mechanisms of its antidepressant properties
    • Zunszain, P. A., Horowitz, M. A., Cattaneo, A., Lupi, M. M., and Pariante, C. M. (2013). Ketamine: synaptogenesis, immunomodulation and glycogen synthase kinase-3 as underlying mechanisms of its antidepressant properties. Mol. Psychiatry 18, 1236-1241. doi: 10.1038/mp.2013.87.
    • (2013) Mol. Psychiatry , vol.18 , pp. 1236-1241
    • Zunszain, P.A.1    Horowitz, M.A.2    Cattaneo, A.3    Lupi, M.M.4    Pariante, C.M.5
  • 68
    • 33847046039 scopus 로고    scopus 로고
    • Effect of MK-801 and ketamine on hydroxyl radical generation in the posterior cingulate and retrosplenial cortex of free-moving mice, as determined by in vivo microdialysis
    • Zuo, D. Y., Wu, Y. L., Yao, W. X., Cao, Y., Wu, C. F., and Tanaka, M. (2007). Effect of MK-801 and ketamine on hydroxyl radical generation in the posterior cingulate and retrosplenial cortex of free-moving mice, as determined by in vivo microdialysis. Pharmacol. Biochem. Behav. 86, 1-7. doi: 10.1016/j.pbb.2006.05.010.
    • (2007) Pharmacol. Biochem. Behav , vol.86 , pp. 1-7
    • Zuo, D.Y.1    Wu, Y.L.2    Yao, W.X.3    Cao, Y.4    Wu, C.F.5    Tanaka, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.