Brain-derived neurotrophic factor Val66Met polymorphism and antidepressant efficacy of ketamine in depressed patients

Biological Psychiatry

Volumn 72, Issue 11, 2012, Pages

  Laje, Gonzalo ^a   Lally, Níall ^b   Mathews, Daniel ^c   Brutsche, Nancy ^c   Chemerinski, Anat ^a   Akula, Nirmala ^a   Kelmendi, Benjamin ^d   Simen, Arthur ^d   McMahon, Francis J ^a   Sanacora, Gerard ^d   Zarate Jr , Carlos ^c  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; KETAMINE;

AMINO ACID SUBSTITUTION; BRAIN DEPTH STIMULATION; BRAIN DERIVED NEUROTROPHIC FACTOR GENE; DEPRESSION; DRUG EFFICACY; ELECTROCONVULSIVE THERAPY; EXON; GENE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; HAMILTON SCALE; HUMAN; LETTER; MAJOR DEPRESSION; PREFRONTAL CORTEX; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SYNAPTOGENESIS; TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT RESPONSE;

ADULT; ANTIDEPRESSIVE AGENTS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CROSS-OVER STUDIES; DEPRESSIVE DISORDER; DOUBLE-BLIND METHOD; FEMALE; HUMANS; KETAMINE; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; TREATMENT OUTCOME;

EID: 84868208976     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2012.05.031     Document Type: Letter

References (15)

1. C.A. Zarate Jr, J.B. Singh, P.J. Carlson, N.E. Brutsche, R. Ameli, D.A. Luckenbaugh A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression Arch Gen Psychiatry 63 2006 856 864
2. G.W. Valentine, G.F. Mason, R. Gomez, M. Fasula, J. Watzl, B. Pittman The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS Psychiatry Res 191 2011 122 127
3. N. Diazgranados, L. Ibrahim, N.E. Brutsche, A. Newberg, P. Kronstein, S. Khalife A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression Arch Gen Psychiatry 67 2010 793 802
4. N. Li, B. Lee, R.J. Liu, M. Banasr, J.M. Dwyer, M. Iwata mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists Science 329 2010 959 964
5. A.E. Autry, M. Adachi, E. Nosyreva, E.S. Na, M.F. Los, P.F. Cheng NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses Nature 475 2011 91 95
6. S.S. Pattwell, K.G. Bath, R. Perez-Castro, F.S. Lee, M.V. Chao, I. Ninan The BDNF Val66Met polymorphism impairs synaptic transmission and plasticity in the infralimbic medial prefrontal cortex J Neuroscience 32 2012 2410 2421
7. K. Martinowich, H. Manji, B. Lu New insights into BDNF function in depression and anxiety Nat Neuroscience 10 2007 1089 1093
8. R.J. Liu, F.S. Lee, X.Y. Li, F. Bambico, R.S. Duman, G.K. Aghajanian Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex Biol Psychiatry 71 2011 996 1005
9. L. Ibrahim, N. Diazgranados, J. Franco-Chaves, N. Brutsche, I.D. Henter, P. Kronstein Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: Results from a 4-week, double-blind, placebo-controlled study Neuropsychopharmacology 37 2012 1526 1533
10. M. Hamilton A rating scale for depression J Neurol Neurosurg Psychiatry 23 1960 56 62
11. M. Nibuya, S. Morinobu, R.S. Duman Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments J Neuroscience 15 1995 7539 7547
12. M.B. Muller, N. Toschi, A.E. Kresse, A. Post, M.E. Keck Long-term repetitive transcranial magnetic stimulation increases the expression of brain-derived neurotrophic factor and cholecystokinin mRNA, but not neuropeptide tyrosine mRNA in specific areas of rat brain Neuropsychopharmacology 23 2000 205 215
13. F. Gomez-Pinilla, Z. Ying, R.R. Roy, R. Molteni, V.R. Edgerton Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity J Neurophysiology 88 2002 2187 2195
14. K. Domschke, B. Lawford, G. Laje, K. Berger, R. Young, P. Morris Brain-derived neurotrophic factor (BDNF) gene: No major impact on antidepressant treatment response Int J Neuropsychopharmacology 13 2010 93 101
15. G. Sanacora, G. Treccani, M. Popoli Towards a glutamate hypothesis of depression: An emerging frontier of neuropsychopharmacology for mood disorders Neuropharmacology 62 2012 63 77