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Volumn 35, Issue 3, 2015, Pages 348-358

Cannabinoids in experimental stroke: A systematic review and meta-analysis

Author keywords

cannabinoid; meta analysis; neuroprotection; preclinical; stroke

Indexed keywords

CANNABIDIOL; CANNABINOID; DRONABINOL; ENDOCANNABINOID; LIGAND; NEUROPROTECTIVE AGENT;

EID: 84938508710     PISSN: 07438346     EISSN: 14765543     Source Type: Journal    
DOI: 10.1038/jcbfm.2014.218     Document Type: Review
Times cited : (70)

References (62)
  • 1
    • 0033863179 scopus 로고    scopus 로고
    • Cb1 cannabinoid receptor induction in experimental stroke
    • Jin KL, Mao XO, Goldsmith PC, Greenberg DA. CB1 cannabinoid receptor induction in experimental stroke. Ann Neurol 2000; 48: 257-261.
    • (2000) Ann Neurol , vol.48 , pp. 257-261
    • Jin, K.L.1    Mao, X.O.2    Goldsmith, P.C.3    Greenberg, D.A.4
  • 2
    • 33846047809 scopus 로고    scopus 로고
    • Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid cb2 receptor in the brain
    • Ashton JC, Rahman RM, Nair SM, Sutherland BA, Glass M, Appleton I et al. Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid CB2 receptor in the brain. Neurosci Lett 2007; 412: 114-117.
    • (2007) Neurosci Lett , vol.412 , pp. 114-117
    • Ashton, J.C.1    Rahman, R.M.2    Nair, S.M.3    Sutherland, B.A.4    Glass, M.5    Appleton, I.6
  • 3
    • 18244396915 scopus 로고    scopus 로고
    • Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1a receptordependent mechanism
    • Mishima K, Hayakawa K, Abe K, Ikeda T, Egashira N, Iwasaki K et al. Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptordependent mechanism. Stroke 2005; 36: 1077-1082.
    • (2005) Stroke , vol.36 , pp. 1077-1082
    • Mishima, K.1    Hayakawa, K.2    Abe, K.3    Ikeda, T.4    Egashira, N.5    Iwasaki, K.6
  • 4
    • 0036330324 scopus 로고    scopus 로고
    • Release of fatty acid amides in a patient with hemispheric stroke: A microdialysis study
    • Schabitz WR, Giuffrida A, Berger C, Aschoff A, Schwaninger M, Schwab S et al. Release of fatty acid amides in a patient with hemispheric stroke: a microdialysis study. Stroke 2002; 33: 2112-2114.
    • (2002) Stroke , vol.33 , pp. 2112-2114
    • Schabitz, W.R.1    Giuffrida, A.2    Berger, C.3    Aschoff, A.4    Schwaninger, M.5    Schwab, S.6
  • 5
    • 8444250235 scopus 로고    scopus 로고
    • Anandamide content is increased and cb1 cannabinoid receptor blockade is protective during transient, focal cerebral ischemia
    • Muthian S, Rademacher DJ, Roelke CT, Gross GJ, Hillard CJ. Anandamide content is increased and CB1 cannabinoid receptor blockade is protective during transient, focal cerebral ischemia. Neuroscience 2004; 129: 743-750.
    • (2004) Neuroscience , vol.129 , pp. 743-750
    • Muthian, S.1    Rademacher, D.J.2    Roelke, C.T.3    Gross, G.J.4    Hillard, C.J.5
  • 6
    • 0042320663 scopus 로고    scopus 로고
    • Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility
    • Franklin A, Parmentier-Batteur S, Walter L, Greenberg DA, Stella N. Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility. J Neurosci 2003; 23: 7767-7775.
    • (2003) J Neurosci , vol.23 , pp. 7767-7775
    • Franklin, A.1    Parmentier-Batteur, S.2    Walter, L.3    Greenberg, D.A.4    Stella, N.5
  • 7
    • 36248967129 scopus 로고    scopus 로고
    • Changes in brain levels of n-Acylethanolamines and 2-Arachidonoylglycerol in focal cerebral ischemia in mice
    • Degn M, Lambertsen KL, Petersen G, Meldgaard M, Artmann A, Clausen BH et al. Changes in brain levels of N-Acylethanolamines and 2-Arachidonoylglycerol in focal cerebral ischemia in mice. J Neurochem 2007; 103: 1907-1916.
    • (2007) J Neurochem , vol.103 , pp. 1907-1916
    • Degn, M.1    Lambertsen, K.L.2    Petersen, G.3    Meldgaard, M.4    Artmann, A.5    Clausen, B.H.6
  • 9
    • 77952302634 scopus 로고    scopus 로고
    • Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment
    • Murikinati S, Juttler E, Keinert T, Ridder DA, Muhammad S, Waibler Z et al. Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment. FASEB J 2010; 24: 788-798.
    • (2010) FASEB J , vol.24 , pp. 788-798
    • Murikinati, S.1    Juttler, E.2    Keinert, T.3    Ridder, D.A.4    Muhammad, S.5    Waibler, Z.6
  • 10
    • 0041621495 scopus 로고    scopus 로고
    • Drug-induced hypothermia reduces ischemic damage: Effects of the cannabinoid hu-210
    • Leker RR, Gai N, Mechoulam R, Ovadia H. Drug-induced hypothermia reduces ischemic damage: effects of the cannabinoid HU-210. Stroke 2003; 34: 2000-2006.
    • (2003) Stroke , vol.34 , pp. 2000-2006
    • Leker, R.R.1    Gai, N.2    Mechoulam, R.3    Ovadia, H.4
  • 11
    • 40949116660 scopus 로고    scopus 로고
    • Modulation of the balance between cannabinoid cb(1) and cb 2) receptor activation during cerebral ischemic/reperfusion injury
    • Zhang M, Martin BR, Adler MW, Razdan RK, Ganea D, Tuma RF et al. Modulation of the balance between cannabinoid CB(1) and CB(2) receptor activation during cerebral ischemic/reperfusion injury. Neuroscience 2008; 152: 753-760.
    • (2008) Neuroscience , vol.152 , pp. 753-760
    • Zhang, M.1    Martin, B.R.2    Adler, M.W.3    Razdan, R.K.4    Ganea, D.5    Tuma, R.F.6
  • 12
    • 33947161433 scopus 로고    scopus 로고
    • Delta9-tetrahydrocannabinol (delta9-thc) prevents cerebral infarction via hypothalamicindependent hypothermia
    • Hayakawa K, Mishima K, Nozako M, Hazekawa M, Ogata A, Fujioka M et al. Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamicindependent hypothermia. Life Sci 2007; 80: 1466-1471.
    • (2007) Life Sci , vol.80 , pp. 1466-1471
    • Hayakawa, K.1    Mishima, K.2    Nozako, M.3    Hazekawa, M.4    Ogata, A.5    Fujioka, M.6
  • 13
    • 78650120798 scopus 로고    scopus 로고
    • International union of basic and clinical pharmacology. Lxxix. Cannabinoid receptors and their ligands: Beyond cb(1) and cb(2)
    • Pertwee RG, Howlett AC, Abood ME, Alexander SP, Di Marzo V, Elphick MR et al. International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB(1) and CB(2). Pharmacol Rev 2010; 62: 588-631.
    • (2010) Pharmacol Rev , vol.62 , pp. 588-631
    • Pertwee, R.G.1    Howlett, A.C.2    Abood, M.E.3    Alexander, S.P.4    Di Marzo, V.5    Elphick, M.R.6
  • 14
    • 38349158960 scopus 로고    scopus 로고
    • The diverse cb1 and cb2 receptor pharmacology of three plant cannabinoids: Delta 9)-tetrahydrocannabinol, cannabidiol and delta 9)-tetrahydrocannabivarin
    • Pertwee RG. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Delta(9)-tetrahydrocannabinol, cannabidiol and Delta(9)-tetrahydrocannabivarin. Br J Pharmacol 2008; 153: 199-215.
    • (2008) Br J Pharmacol , vol.153 , pp. 199-215
    • Pertwee, R.G.1
  • 15
    • 0344065373 scopus 로고    scopus 로고
    • Recommendations for standards regarding preclinical neuroprotective and restorative drug development
    • STAIR
    • STAIR. Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke 1999; 30: 2752-2758.
    • (1999) Stroke , vol.30 , pp. 2752-2758
  • 16
    • 38849190685 scopus 로고    scopus 로고
    • Progesterone for the treatment of experimental brain injury; A systematic review
    • Gibson CL, Gray LJ, Bath PM, Murphy SP. Progesterone for the treatment of experimental brain injury; a systematic review. Brain 2008; 131: 318-328.
    • (2008) Brain , vol.131 , pp. 318-328
    • Gibson, C.L.1    Gray, L.J.2    Bath, P.M.3    Murphy, S.P.4
  • 17
    • 70449672355 scopus 로고    scopus 로고
    • Granulocyte-colony stimulating factor in experimental stroke and its effects on infarct size and functional outcome: A systematic review
    • England TJ, Gibson CL, Bath PM. Granulocyte-colony stimulating factor in experimental stroke and its effects on infarct size and functional outcome: a systematic review. Brain Res Rev 2009; 62: 71-82.
    • (2009) Brain Res Rev , vol.62 , pp. 71-82
    • England, T.J.1    Gibson, C.L.2    Bath, P.M.3
  • 18
    • 84866385818 scopus 로고    scopus 로고
    • Reduction of ischemic brain injury by administration of palmitoylethanolamide after transient middle cerebral artery occlusion in rats
    • Ahmad A, Genovese T, Impellizzeri D, Crupi R, Velardi E, Marino A et al. Reduction of ischemic brain injury by administration of palmitoylethanolamide after transient middle cerebral artery occlusion in rats. Brain Res 2012; 1477: 45-58.
    • (2012) Brain Res , vol.1477 , pp. 45-58
    • Ahmad, A.1    Genovese, T.2    Impellizzeri, D.3    Crupi, R.4    Velardi, E.5    Marino, A.6
  • 19
    • 33746899346 scopus 로고    scopus 로고
    • Estimation of the hypothermic component in neuroprotection provided by cannabinoids following cerebral ischemia
    • Bonfils PK, Reith J, Hasseldam H, Johansen FF. Estimation of the hypothermic component in neuroprotection provided by cannabinoids following cerebral ischemia. Neurochem Int 2006; 49: 508-518.
    • (2006) Neurochem Int , vol.49 , pp. 508-518
    • Bonfils, P.K.1    Reith, J.2    Hasseldam, H.3    Johansen, F.F.4
  • 20
    • 1442348425 scopus 로고    scopus 로고
    • Massive accumulation of n-Acylethanolamines after stroke cell signalling in acute cerebral ischemia?
    • Berger C, Schmid PC, Schabitz WR, Wolf M, Schwab S, Schmid HH et al. Massive accumulation of N-Acylethanolamines after stroke. Cell signalling in acute cerebral ischemia? J Neurochem 2004; 88: 1159-1167.
    • (2004) J Neurochem , vol.88 , pp. 1159-1167
    • Berger, C.1    Schmid, P.C.2    Schabitz, W.R.3    Wolf, M.4    Schwab, S.5    Schmid, H.H.6
  • 21
    • 0028884634 scopus 로고
    • Hu-211, a novel noncompetitive n-methyl-d-Aspartate antagonist, improves neurological deficit and reduces infarct volume after reversible focal cerebral ischemia in the rat
    • discussion 2319-20
    • Belayev L, Busto R, Zhao W, Ginsberg MD. HU-211, a novel noncompetitive N-methyl-D-Aspartate antagonist, improves neurological deficit and reduces infarct volume after reversible focal cerebral ischemia in the rat. Stroke 1995; 26: 2313-2319, discussion 2319-20.
    • (1995) Stroke , vol.26 , pp. 2313-2319
    • Belayev, L.1    Busto, R.2    Zhao, W.3    Ginsberg, M.D.4
  • 22
    • 0028973635 scopus 로고
    • Post-ischemic administration of hu-211, a novel non-competitive nmda antagonist, protects against blood-brain barrier disruption in photochemical cortical infarction in rats: A quantitative study
    • Belayev L, Busto R, Watson BD, Ginsberg MD. Post-ischemic administration of HU-211, a novel non-competitive NMDA antagonist, protects against blood-brain barrier disruption in photochemical cortical infarction in rats: a quantitative study. Brain Res 1995; 702: 266-270.
    • (1995) Brain Res , vol.702 , pp. 266-270
    • Belayev, L.1    Busto, R.2    Watson, B.D.3    Ginsberg, M.D.4
  • 23
    • 74449090257 scopus 로고    scopus 로고
    • Intracellular mechanisms of n-Acylethanolamine-mediated neuroprotection in a rat model of stroke
    • Garg P, Duncan RS, Kaja S, Koulen P. Intracellular mechanisms of N-Acylethanolamine-mediated neuroprotection in a rat model of stroke. Neuroscience 2010; 166: 252-262.
    • (2010) Neuroscience , vol.166 , pp. 252-262
    • Garg, P.1    Duncan, R.S.2    Kaja, S.3    Koulen, P.4
  • 24
    • 79952438703 scopus 로고    scopus 로고
    • Lauroylethanolamide and linoleoylethanolamide improve functional outcome in a rodent model for stroke
    • Garg P, Duncan RS, Kaja S, Zabaneh A, Chapman KD, Koulen P et al. Lauroylethanolamide and linoleoylethanolamide improve functional outcome in a rodent model for stroke. Neurosci Lett 2011; 492: 134-138.
    • (2011) Neurosci Lett , vol.492 , pp. 134-138
    • Garg, P.1    Duncan, R.S.2    Kaja, S.3    Zabaneh, A.4    Chapman, K.D.5    Koulen, P.6
  • 25
    • 77956188895 scopus 로고    scopus 로고
    • Neuroprotective effect of win 55212-2 pretreatment against focal cerebral ischemia through activation of extracellular signal-regulated kinases in rats
    • Hu B, Wang Q, Chen Y, Du J, Zhu X, Lu Y et al. Neuroprotective effect of WIN 55212-2 pretreatment against focal cerebral ischemia through activation of extracellular signal-regulated kinases in rats. Eur J Pharmacol 2010; 645: 102-107.
    • (2010) Eur J Pharmacol , vol.645 , pp. 102-107
    • Hu, B.1    Wang, Q.2    Chen, Y.3    Du, J.4    Zhu, X.5    Lu, Y.6
  • 26
    • 0035906513 scopus 로고    scopus 로고
    • Long term cerebroprotective effects of dexanabinol in a model of focal cerebral ischemia
    • Lavie G, Teichner A, Shohami E, Ovadia H, Leker RR. Long term cerebroprotective effects of dexanabinol in a model of focal cerebral ischemia. Brain Res 2001; 901: 195-201.
    • (2001) Brain Res , vol.901 , pp. 195-201
    • Lavie, G.1    Teichner, A.2    Shohami, E.3    Ovadia, H.4    Leker, R.R.5
  • 27
    • 0033556581 scopus 로고    scopus 로고
    • Dexanabinol; A novel neuroprotective drug in experimental focal cerebral ischemia
    • Leker RR, Shohami E, Abramsky O, Ovadia H. Dexanabinol; a novel neuroprotective drug in experimental focal cerebral ischemia. J Neurol Sci 1999; 162: 114-119.
    • (1999) J Neurol Sci , vol.162 , pp. 114-119
    • Leker, R.R.1    Shohami, E.2    Abramsky, O.3    Ovadia, H.4
  • 28
    • 84880922473 scopus 로고    scopus 로고
    • Cerebroprotective effects of tak-937, a novel cannabinoid receptor agonist, in permanent and thrombotic focal cerebral ischemia in rats: Therapeutic time window, combination with t-pa and efficacy in aged rats
    • Murakami K, Suzuki M, Suzuki N, Hamajo K, Tsukamoto T, Shimojo M et al. Cerebroprotective effects of TAK-937, a novel cannabinoid receptor agonist, in permanent and thrombotic focal cerebral ischemia in rats: therapeutic time window, combination with t-PA and efficacy in aged rats. Brain Res 2013; 1526: 84-93.
    • (2013) Brain Res , vol.1526 , pp. 84-93
    • Murakami, K.1    Suzuki, M.2    Suzuki, N.3    Hamajo, K.4    Tsukamoto, T.5    Shimojo, M.6
  • 29
    • 0033561159 scopus 로고    scopus 로고
    • Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures
    • Nagayama T, Sinor AD, Simon RP, Chen J, Graham SH, Jin K et al. Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures. J Neurosci 1999; 19: 2987-2995.
    • (1999) J Neurosci , vol.19 , pp. 2987-2995
    • Nagayama, T.1    Sinor, A.D.2    Simon, R.P.3    Chen, J.4    Graham, S.H.5    Jin, K.6
  • 30
    • 54549098992 scopus 로고    scopus 로고
    • Endocannabinoids mediate neuroprotection after transient focal cerebral ischemia
    • Schomacher M, Muller HD, Sommer C, Schwab S, Schabitz WR. Endocannabinoids mediate neuroprotection after transient focal cerebral ischemia. Brain Res 2008; 1240: 213-220.
    • (2008) Brain Res , vol.1240 , pp. 213-220
    • Schomacher, M.1    Muller, H.D.2    Sommer, C.3    Schwab, S.4    Schabitz, W.R.5
  • 31
    • 84874022883 scopus 로고    scopus 로고
    • Win55212-2 promotes differentiation of oligodendrocyte precursor cells and improve remyelination through regulation of the phosphorylation level of the erk 1/2 via cannabinoid receptor 1 after stroke-induced demyelination
    • Sun J, Fang Y, Chen T, Guo J, Yan J, Song S et al. WIN55212-2 promotes differentiation of oligodendrocyte precursor cells and improve remyelination through regulation of the phosphorylation level of the ERK 1/2 via cannabinoid receptor 1 after stroke-induced demyelination. Brain Res 2013; 1491: 225-235.
    • (2013) Brain Res , vol.1491 , pp. 225-235
    • Sun, J.1    Fang, Y.2    Chen, T.3    Guo, J.4    Yan, J.5    Song, S.6
  • 32
    • 84872081847 scopus 로고    scopus 로고
    • Win55212-2 protects oligodendrocyte precursor cells in stroke penumbra following permanent focal cerebral ischemia in rats
    • Sun J, Fang YQ, Ren H, Chen T, Guo JJ, Yan J et al. WIN55212-2 protects oligodendrocyte precursor cells in stroke penumbra following permanent focal cerebral ischemia in rats. Acta Pharmacol Sin 2013; 34: 119-128.
    • (2013) Acta Pharmacol Sin , vol.34 , pp. 119-128
    • Sun, J.1    Fang, Y.Q.2    Ren, H.3    Chen, T.4    Guo, J.J.5    Yan, J.6
  • 33
    • 84864018408 scopus 로고    scopus 로고
    • Contribution of hypothermia and cb1 receptor activation to protective effects of tak-937, a cannabinoid receptor agonist, in rat transient mcao model
    • Suzuki N, Suzuki M, Hamajo K, Murakami K, Tsukamoto T, Shimojo M et al. Contribution of hypothermia and CB1 receptor activation to protective effects of TAK-937, a cannabinoid receptor agonist, in rat transient MCAO model. PLoS ONE 2012; 7: e40889.
    • (2012) PLoS ONE , vol.7 , pp. e40889
    • Suzuki, N.1    Suzuki, M.2    Hamajo, K.3    Murakami, K.4    Tsukamoto, T.5    Shimojo, M.6
  • 34
    • 0043198114 scopus 로고    scopus 로고
    • Combination of dexanabinol and tempol in focal cerebral ischemia: Is there a ceiling effect?
    • Teichner A, Ovadia H, Lavie G, Leker RR. Combination of dexanabinol and tempol in focal cerebral ischemia: is there a ceiling effect? Exp Neurol 2003; 182: 353-360.
    • (2003) Exp Neurol , vol.182 , pp. 353-360
    • Teichner, A.1    Ovadia, H.2    Lavie, G.3    Leker, R.R.4
  • 35
    • 69949148000 scopus 로고    scopus 로고
    • Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism
    • Hayakawa K, Irie K, Sano K, Watanabe T, Higuchi S, Enoki M et al. Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism. Biol Pharmaceutical Bull 2009; 32: 1538-1544.
    • (2009) Biol Pharmaceutical Bull , vol.32 , pp. 1538-1544
    • Hayakawa, K.1    Irie, K.2    Sano, K.3    Watanabe, T.4    Higuchi, S.5    Enoki, M.6
  • 36
    • 8444238592 scopus 로고    scopus 로고
    • Cannabidiol prevents infarction via the non-cb1 cannabinoid receptor mechanism
    • Hayakawa K, Mishima K, Abe K, Hasebe N, Takamatsu F, Yasuda H et al. Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. Neuroreport 2004; 15: 2381-2385.
    • (2004) Neuroreport , vol.15 , pp. 2381-2385
    • Hayakawa, K.1    Mishima, K.2    Abe, K.3    Hasebe, N.4    Takamatsu, F.5    Yasuda, H.6
  • 37
    • 56249131093 scopus 로고    scopus 로고
    • Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism
    • Hayakawa K, Mishima K, Irie K, Hazekawa M, Mishima S, Fujioka M et al. Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism. Neuropharmacology 2008; 55: 1280-1286.
    • (2008) Neuropharmacology , vol.55 , pp. 1280-1286
    • Hayakawa, K.1    Mishima, K.2    Irie, K.3    Hazekawa, M.4    Mishima, S.5    Fujioka, M.6
  • 38
    • 34547870158 scopus 로고    scopus 로고
    • Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism
    • Hayakawa K, Mishima K, Nozako M, Hazekawa M, Irie K, Fujioka M et al. Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism. J Neurochem 2007; 102: 1488-1496.
    • (2007) J Neurochem , vol.102 , pp. 1488-1496
    • Hayakawa, K.1    Mishima, K.2    Nozako, M.3    Hazekawa, M.4    Irie, K.5    Fujioka, M.6
  • 39
    • 33847261953 scopus 로고    scopus 로고
    • Repeated treatment with cannabidiol but not delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance
    • Hayakawa K, Mishima K, Nozako M, Ogata A, Hazekawa M, Liu AX et al. Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance. Neuropharmacology 2007; 52: 1079-1087.
    • (2007) Neuropharmacology , vol.52 , pp. 1079-1087
    • Hayakawa, K.1    Mishima, K.2    Nozako, M.3    Ogata, A.4    Hazekawa, M.5    Liu, A.X.6
  • 41
    • 84855343503 scopus 로고    scopus 로고
    • Cannabinoid type 2 receptor activation downregulates strokeinduced classic and alternative brain macrophage/microglial activation concomitant to neuroprotection
    • Zarruk JG, Fernandez-Lopez D, Garcia-Yebenes I, Garcia-Gutierrez MS, Vivancos J, Nombela F et al. Cannabinoid type 2 receptor activation downregulates strokeinduced classic and alternative brain macrophage/microglial activation concomitant to neuroprotection. Stroke 2012; 43: 211-219.
    • (2012) Stroke , vol.43 , pp. 211-219
    • Zarruk, J.G.1    Fernandez-Lopez, D.2    Garcia-Yebenes, I.3    Garcia-Gutierrez, M.S.4    Vivancos, J.5    Nombela, F.6
  • 42
    • 67349193286 scopus 로고    scopus 로고
    • Cb2 receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury
    • Zhang M, Adler MW, Abood ME, Ganea D, Jallo J, Tuma RF et al. CB2 receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury. Microvasc Res 2009; 78: 86-94.
    • (2009) Microvasc Res , vol.78 , pp. 86-94
    • Zhang, M.1    Adler, M.W.2    Abood, M.E.3    Ganea, D.4    Jallo, J.5    Tuma, R.F.6
  • 43
  • 44
    • 84861977370 scopus 로고    scopus 로고
    • Orally administered oleoylethanolamide protects mice from focal cerebral ischemic injury by activating peroxisome proliferator-Activated receptor alpha
    • Zhou Y, Yang L, Ma A, Zhang X, Li W, Yang W et al. Orally administered oleoylethanolamide protects mice from focal cerebral ischemic injury by activating peroxisome proliferator-Activated receptor alpha. Neuropharmacology 2012; 63: 242-249.
    • (2012) Neuropharmacology , vol.63 , pp. 242-249
    • Zhou, Y.1    Yang, L.2    Ma, A.3    Zhang, X.4    Li, W.5    Yang, W.6
  • 45
    • 83655201126 scopus 로고    scopus 로고
    • Cerebroprotective effects of tak-937, a cannabinoid receptor agonist, on ischemic brain damage in middle cerebral artery occluded rats and non-human primates
    • Suzuki N, Suzuki M, Murakami K, Hamajo K, Tsukamoto T, Shimojo M et al. Cerebroprotective effects of TAK-937, a cannabinoid receptor agonist, on ischemic brain damage in middle cerebral artery occluded rats and non-human primates. Brain Res 2012; 1430: 93-100.
    • (2012) Brain Res , vol.1430 , pp. 93-100
    • Suzuki, N.1    Suzuki, M.2    Murakami, K.3    Hamajo, K.4    Tsukamoto, T.5    Shimojo, M.6
  • 46
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-Analysis detected by a simple, graphical test
    • Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-Analysis detected by a simple, graphical test. BMJ 1997; 315: 629-634.
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Davey Smith, G.2    Schneider, M.3    Minder, C.4
  • 47
    • 0029937282 scopus 로고    scopus 로고
    • Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal cultures
    • Shen M, Piser TM, Seybold VS, Thayer SA. Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal cultures. J Neurosci 1996; 16: 4322-4334.
    • (1996) J Neurosci , vol.16 , pp. 4322-4334
    • Shen, M.1    Piser, T.M.2    Seybold, V.S.3    Thayer, S.A.4
  • 48
    • 0037111836 scopus 로고    scopus 로고
    • Increased severity of stroke in cb1 cannabinoid receptor knock-out mice
    • Parmentier-Batteur S, Jin K, Mao XO, Xie L, Greenberg DA. Increased severity of stroke in CB1 cannabinoid receptor knock-out mice. J Neurosci 2002; 22: 9771-9775.
    • (2002) J Neurosci , vol.22 , pp. 9771-9775
    • Parmentier-Batteur, S.1    Jin, K.2    Mao, X.O.3    Xie, L.4    Greenberg, D.A.5
  • 50
    • 84861336596 scopus 로고    scopus 로고
    • Cb.1)-independent mechanisms of delta(9)-thcv, am251 and sr141716 (rimonabant)
    • Raffa RB, Ward SJ. CB. (1)-independent mechanisms of Delta(9)-THCV, AM251 and SR141716 (rimonabant). J Clin Pharm Ther 2012; 37: 260-265.
    • (2012) J Clin Pharm Ther , vol.37 , pp. 260-265
    • Raffa, R.B.1    Ward, S.J.2
  • 51
    • 77951765198 scopus 로고    scopus 로고
    • Combination of tissue-plasminogen activator with erythropoietin induces blood-brain barrier permeability, extracellular matrix disaggregation, and DNA fragmentation after focal cerebral ischemia in mice
    • Zechariah A, ElAli A, Hermann DM. Combination of tissue-plasminogen activator with erythropoietin induces blood-brain barrier permeability, extracellular matrix disaggregation, and DNA fragmentation after focal cerebral ischemia in mice. Stroke 2010; 41: 1008-1012.
    • (2010) Stroke , vol.41 , pp. 1008-1012
    • Zechariah, A.1    ElAli, A.2    Hermann, D.M.3
  • 52
    • 66849097996 scopus 로고    scopus 로고
    • Update of the stroke therapy academic industry roundtable preclinical recommendations
    • Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI et al. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke 2009; 40: 2244-2250.
    • (2009) Stroke , vol.40 , pp. 2244-2250
    • Fisher, M.1    Feuerstein, G.2    Howells, D.W.3    Hurn, P.D.4    Kent, T.A.5    Savitz, S.I.6
  • 54
    • 84876488583 scopus 로고    scopus 로고
    • A double-blind, randomized, placebo-controlled, parallel-group study of thc/cbd oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis
    • Langford RM, Mares J, Novotna A, Vachova M, Novakova I, Notcutt W et al. A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis. J Neurol 2013; 260: 984-997.
    • (2013) J Neurol , vol.260 , pp. 984-997
    • Langford, R.M.1    Mares, J.2    Novotna, A.3    Vachova, M.4    Novakova, I.5    Notcutt, W.6
  • 59
    • 77950572352 scopus 로고    scopus 로고
    • Publication bias in reports of animal stroke studies leads to major overstatement of efficacy
    • Sena ES, van der Worp HB, Bath PM, Howells DW, Macleod MR. Publication bias in reports of animal stroke studies leads to major overstatement of efficacy. PLoS Biol 2010; 8: e1000344.
    • (2010) PLoS Biol , vol.8 , pp. e1000344
    • Sena, E.S.1    Van Der Worp, H.B.2    Bath, P.M.3    Howells, D.W.4    Macleod, M.R.5
  • 60
    • 41249090758 scopus 로고    scopus 로고
    • Empirical evidence of bias in the design of experimental stroke studies: A metaepidemiologic approach
    • Crossley NA, Sena E, Goehler J, Horn J, van der Worp B, Bath PM et al. Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach. Stroke 2008; 39: 929-934.
    • (2008) Stroke , vol.39 , pp. 929-934
    • Crossley, N.A.1    Sena, E.2    Goehler, J.3    Horn, J.4    Van Der Worp, B.5    Bath, P.M.6
  • 62
    • 77952835462 scopus 로고    scopus 로고
    • A double-blind, randomized, placebo-controlled, parallel-group study of sativex, in subjects with symptoms of spasticity due to multiple sclerosis
    • Collin C, Ehler E, Waberzinek G, Alsindi Z, Davies P, Powell K et al. A double-blind, randomized, placebo-controlled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis. Neurol Res 2010; 32: 451-459.
    • (2010) Neurol Res , vol.32 , pp. 451-459
    • Collin, C.1    Ehler, E.2    Waberzinek, G.3    Alsindi, Z.4    Davies, P.5    Powell, K.6


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