Contribution of hypothermia and CB1 receptor activation to protective effects of TAK-937, a cannabinoid receptor agonist, in rat transient MCAO model

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Suzuki, Noriko ^a   Suzuki, Motohisa ^a   Hamajo, Kazuhiro ^a   Murakami, Koji ^a,b   Tsukamoto, Tetsuya ^a   Shimojo, Masato ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR AGONIST; N [7 (1 HYDROXYETHYL) 3 (4 ISOPROPYLPHENYL) 4,6 DIMETHYL 2,3 DIHYDRO 1 BENZOFURAN 5 YL] 3,3 DIMETHYLBUTANAMIDE; TAK 937; UNCLASSIFIED DRUG; AMIDE; BENZOFURAN DERIVATIVE; N (7 (1 HYDROXYETHYL) 3 (4 ISOPROPYLPHENYL) 4,6 DIMETHYL 2,3 DIHYDRO 1 BENZOFURAN 5 YL) 3,3 DIMETHYLBUTANAMIDE; N-(7-(1-HYDROXYETHYL)-3-(4-ISOPROPYLPHENYL)-4,6-DIMETHYL-2,3-DIHYDRO-1-BENZOFURAN-5-YL)-3,3-DIMETHYLBUTANAMIDE; NEUROPROTECTIVE AGENT; PIPERIDINE DERIVATIVE; PYRAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION; BRAIN PROTECTION; BRAIN TEMPERATURE; CONTROLLED STUDY; DRUG MECHANISM; INDUCED HYPOTHERMIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; RAT; ANIMAL; BODY TEMPERATURE; CEREBRAL ARTERY DISEASE; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; HYPOTHERMIA; MALE; METABOLISM; SPRAGUE DAWLEY RAT;

RATTUS;

AMIDES; ANIMALS; BENZOFURANS; BODY TEMPERATURE; DISEASE MODELS, ANIMAL; HYPOTHERMIA; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEUROPROTECTIVE AGENTS; PIPERIDINES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1;

EID: 84864018408     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040889     Document Type: Article

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