WIN55,212-2 protects oligodendrocyte precursor cells in stroke penumbra following permanent focal cerebral ischemia in rats

Acta Pharmacologica Sinica

Volumn 34, Issue 1, 2013, Pages 119-128

  Sun, Jing ^a   Fang, Yin Quan ^a   Ren, Hong ^a   Chen, Tao ^a   Guo, Jing Jing ^a   Yan, Jun ^a   Song, Shu ^b   Zhang, Lu Yong ^a   Liao, Hong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Yancheng City No1 People's Hospital   (China)

Author keywords

cannabinoid receptor type 1 (CB1); neural glial antigen 2 (NG2); oligodendrocyte precursor cells; penumbra; permanent focal cerebral ischemia; rimonabant; stroke; tau 1; WIN55,212 2

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABINOID 1 RECEPTOR; RIMONABANT; TAU PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN REGION; CELL PROLIFERATION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DRUG ANTAGONISM; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; OLIGODENDROGLIA; PROTEIN EXPRESSION; RAT; STROKE PENUMBRA; SUBVENTRICULAR ZONE; SWELLING;

ANIMALS; ANTIBODIES, MONOCLONAL; BENZOXAZINES; BRAIN; CANNABINOID RECEPTOR AGONISTS; CELL PROLIFERATION; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MORPHOLINES; NAPHTHALENES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1;

EID: 84872081847     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.141     Document Type: Article

References (38)

1. Arai K, Lo EH. Oligovascular signaling in white matter stroke. Biol Pharm Bull 2009;32:1639-44.
2. Leonardo P, Garcia JH, Gutierrez JA. Cerebral white matter is highly vulnerable to ischemia. Stroke 1996;27:1641-6.
3. Skoff RP, Bessert DA, Barks JD, Song D, Cerghet M, Svilverstein FS. Hypoxic-ischemic injury results in acute disruption of myelin gene expression and death of oligodendroglial precursors in neonatal mice. Int J Devl Neurosci 2001;19:197-208. (Pubitemid 32194655)
4. Mekhail M, Almazan G, Tabrizian M. Oligodendrocyte-protection and remyelination post-spinal cord injuries: a review. Prog Neurobiol 2012;96:322-39.
5. Imai H, Masayasu H, Dewar D, Graham DI, Macrae IM. Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia. Stroke 2001;32:2149-54.
6. Guimarães JS, Freire MA, Lima RR, Picanço-Diniz CW, Pereira A, Gomes-Leal W. Minocycline treatment reduces white matter damage after excitotoxic striatal injury. Brain Res 2010;1329:182-93.
7. Klein C, Kramer EM, Cardine AM, Schraven B, Brandt R, Trotter J. Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau. J Neurosci 2002;22:698-707. (Pubitemid 34141750)
8. Nishiyama A, Komitova M, Suzuki R, Zhu X. Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity. Nat Rev Neurosci 2009;1:9-22.
9. Mangin JM, Gallo V. The curious case of NG2 cells: transient trend or game changer? ASN Neuro 2011;3:e00052.
10. Hillard CJ. Role of cannabinoids and endocannabinoids in cerebral ischemia. Curr Pharm Des 2008;23:2347-61.
11. Koizumi J, Yoshida Y, Nakazawa T, Ooneda G. Experimental studies of ischemic brain edema: 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn Stroke J 1986;8:1-8.
12. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989;20:84-91. (Pubitemid 19040218)
13. Ulrich D and Group, Members on the MCAO-SOP. Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse. Available from Nature Precedings (2009).
14. Wojtowicz JM, Kee N. BrdU assay for neurogenesis in rodents. Nat Protoc 2006;3:1399-405.
15. Leker RR, Gai N, Mechoulam R, Ovadia H. Drug-induced hypothermia reduces ischemic damage: effects of the cannabinoid HU-210. Stroke 2003;34:2000-6. (Pubitemid 36944797)
16. Oida Y, Hamanaka J, Hyakkoku K, Shimazawa M, Kudo T, Imaizumi K, et al. Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice. Neurosci Lett 2010;484:43-6.
17. Kramer M, Dang J, Baertling F, Denecke B, Clarner T, Kirsch C, et al. TTC staining of damaged brain areas after MCA occlusion in the rat does not constrict quantitative gene and protein analyses. J Neurosci Methods 2010;187:84-9.
18. Benjamin DH, Theo DP, Gary KS. Neurogenesis in rats after focal cerebral ischemia is enhanced by indomethacin. Stroke 2005;36:2718-24.
19. Solbrig MV, Fan Y, Hermanowicz N, Morgese MG, Giuffrida A. A synthetic cannabinoid agonist promotes oligodendrogliogenesis during viral encephalitis in rats. Exp Neurol 2010;226:231-41.
20. Hu B, Wang Q, Chen Y, Du J, Zhu X, Lu Y, et al. Neuroprotective effect of WIN55, 212-2 pretreatment against focal cerebral ischemia through activation of extracellular signal-regulated kinases in rats. Eur J Pharmacol 2010;645:102-7.
21. Taupin P. BrdU immunohistochemistry for studying adult neurogenesis: Paradigms, pitfalls, limitations, and validation. Brain Res Rev 2007;1:198-214. (Pubitemid 44854215)
22. Zhang L, Michael C, Ruilan Z, Lei W, Jing Z, Ying W. Erythropoietin amplifies stroke-induced oligodendrogenesis in the rat. PloS One 2010;6:e11016.
23. Anke P, Nadine J, Otto WW, Christiane F. Identifcation of ischemic regions in a rat model of stroke. PLoS One 2009;4:e4764.
24. McMahon LR. Characterization of cannabinoid agonists and apparent pA2 analysis of cannabinoid antagonists in rhesus monkeys discriminating Delta9-tetrahydrocannabinol. J Pharmacol Exp Ther 2006;319:1211-8.
25. Ken A, Eng HL. Experimental models for analysis of oligodendrocyte patho physiology in stroke. Exp Transl Stroke Med 2009;1:6.
26. Zehr C, Lewis J, McGowan E, Crook J, Lin WL, Godwin K, et al. Apoptosis in oligodendrocytes is associated with axonal degeneration in P301L tau mice. Neurobiol Dis 2004;3:553-62. (Pubitemid 38429970)
27. Rico B, Beggs HE, Schahin-Reed D, Kimes N, Schmidt A, Reichardt LF. Control of axonal branching and synapse formation by focal adhesion kinase. Nat Neurosci 2004;7:1059-69. (Pubitemid 41184446)
28. Mandell JW, Banker GA. A spatial gradient of tau protein phos phoryl ation in nascent axons. J Neurosci 1996;16:5727-40. (Pubitemid 26293396)
29. Azevedo FA, Carvalho LR, Grinberg LT, Farfel JM, Ferretti RE, Leite RE, et al. Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain. J Comp Neurol 2009;513:532-41.
30. Zambrano CA, Egaña JT, Núñez MT, Maccioni RB, González-Billault C. Oxidative stress promotes tau dephosphorylation in neuronal cells: the roles of cdk5 and PP1. Free Radic Biol Med 2004;36:1393-402. (Pubitemid 38596799)
31. Liu R, Pei JJ, Wang XC, Zhou XW, Tian Q, Winblad B, et al. Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms. J Neurochem 2005;94:1225-34. (Pubitemid 41232578)
32. Idan-Feldman A, Ostritsky R, Gozes I. Tau and caspase 3 as targets for neuroprotection. Int J Alzheimers Dis 2012; doi:10.1155/2012/493670.
33. Liu XA, Liao K, Liu R, Wang HH, Zhang Y, Zhang Q, et al. Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2. J Alzheimers Dis 2010;19:953-62.
34. Molina-Holgado E, Vela JM, Arévalo-Martín A, Almazán G, Molina-Holgado F, Borrell J. Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phos phatidylinositol-3 kinase/Akt signaling. J Neurosci 2002;22:9742-53. (Pubitemid 35332857)
35. Xu X, Wang P, Zou X, Li D, Fang L, Gong K, et al. The effects of sympathetic outflow on upregulation of vanilloid receptors TRPV 1 in primary afferent neurons evoked by intradermal capsaicin. Exp Neurol 2010;222:93-107.
36. Ho KW, Ward NJ, Calkins DJ. TRPV1: a stress response protein in the central nervous system. Am J Neurodegener Dis 2012;30:1-14.
37. Jeske NA, Patwardhan AM, Gamper N, Price TJ, Akopian AN, Hargreaves KM. Cannabinoid WIN 55, 212-2 regulates TRPV1 phosphoryl a tion in sensory neurons. J Biol Chem 2006;281:32879-90. (Pubitemid 46036843)
38. Muzzi M, Felici R, Cavone L, Gerace E, Minassi A, Appendino G, et al. Ischemic neuroprotection by TRPV1 receptor-induced hypothermia. J Cereb Blood Flow Metab 2012;32:978-82.