Cerebroprotective effects of TAK-937, a novel cannabinoid receptor agonist, in permanent and thrombotic focal cerebral ischemia in rats: Therapeutic time window, combination with t-PA and efficacy in aged rats

Brain Research

Volumn 1526, Issue , 2013, Pages 84-93

  Murakami, Koji ^a,b   Suzuki, Motohisa ^a   Suzuki, Noriko ^a   Hamajo, Kazuhiro ^a   Tsukamoto, Tetsuya ^a   Shimojo, Masato ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

Age; Cannabinoid receptor agonist; Combination therapy; Middle cerebral artery occlusion; Tissue type plasminogen activator

Indexed keywords

CANNABINOID RECEPTOR AGONIST; TAK 937; TISSUE PLASMINOGEN ACTIVATOR; TRIPHENYLTETRAZOLIUM; UNCLASSIFIED DRUG;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN HEMORRHAGE; BRAIN INFARCTION SIZE; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG EFFICACY; MALE; MEAN ARTERIAL PRESSURE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PARAMETERS; PRIORITY JOURNAL; RAT;

(2-HYDROXYPROPYL)-Β-CYCLODEXTRIN; 2,3,5-TRIPHENYLTETRAZOLIUM CHLORIDE; ACUTE ISCHEMIC STROKE; AGE; AIS; BDNF; BODY TEMPERATURE; BRAIN DERIVED NEUROTROPHIC FACTOR; BT; CANNABINOID; CANNABINOID RECEPTOR AGONIST; CB; CENTRAL NERVE SYSTEM; CNS; COMBINATION THERAPY; HEART RATE; HPBCD; HR; MABP; MCA; MCAO; MEAN ARTERIAL BLOOD PRESSURE; MIDDLE CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY OCCLUSION; OXYGEN SATURATION; PACO(2); PAO(2); PARTIAL ARTERIAL CARBON DIOXIDE; PARTIAL ARTERIAL OXYGEN; SD; SO(2); SPRAGUE-DAWLEY; T-PA; TISSUE-TYPE PLASMINOGEN ACTIVATOR; TTC;

AMIDES; ANIMALS; BENZOFURANS; CANNABINOID RECEPTOR AGONISTS; DISEASE MODELS, ANIMAL; FIBRINOLYTIC AGENTS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE PLASMINOGEN ACTIVATOR;

RATTUS;

EID: 84880922473     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2013.06.014     Document Type: Article

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