Inhibition of SH2-domain-containing inositol 5-phosphatase (SHIP2) ameliorates palmitate induced-apoptosis through regulating Akt/FOXO1 pathway and ROS production in HepG2 cells

Biochemical and Biophysical Research Communications

Volumn 464, Issue 2, 2015, Pages 441-446

  Gorgani Firuzjaee, Sattar ^a   Adeli, Khosrow ^b   Meshkani, Reza ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Akt; Apoptosis; FOXO 1; HepG2; Lipoapoptosis; Liver; Palmitate; ROS; SHIP2

Indexed keywords

ASCORBIC ACID; CASPASE 3; CYTOCHROME C; PALMITIC ACID; PHOSPHATASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SH2 DOMAIN CONTAINING INOSITOL 5 PHOSPHATASE; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN; INPPL1 PROTEIN, HUMAN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; MTT ASSAY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENZYME ACTIVATION; HEK293 CELL LINE; METABOLISM; PHOSPHORYLATION;

APOPTOSIS; CASPASE 3; CYTOCHROMES C; ENZYME ACTIVATION; FORKHEAD TRANSCRIPTION FACTORS; HEK293 CELLS; HEP G2 CELLS; HUMANS; PALMITIC ACID; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES;

EID: 84938423966     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.06.134     Document Type: Article

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