-
1
-
-
79960096827
-
Normalization of the vasculature for treatment of cancer and other diseases
-
Goel S, Duda DG, Xu L, et al. Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev. 2011;91(3):1071–1121.
-
(2011)
Physiol Rev
, vol.91
, Issue.3
, pp. 1071-1121
-
-
Goel, S.1
Duda, D.G.2
Xu, L.3
-
2
-
-
84655161946
-
HIF1α and HIF2α: Sibling rivalry in hypoxic tumour growth and progression
-
Keith B, Johnson RS, Simon MC. HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer. 2012;12(1):9–22.
-
(2012)
Nat Rev Cancer
, vol.12
, Issue.1
, pp. 9-22
-
-
Keith, B.1
Johnson, R.S.2
Simon, M.C.3
-
3
-
-
84897019542
-
Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology
-
Semenza GL. Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. Annu Rev Pathol. 2014;9:47–71.
-
(2014)
Annu Rev Pathol
, vol.9
, pp. 47-71
-
-
Semenza, G.L.1
-
4
-
-
84883501150
-
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
-
Semenza GL. HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. J Clin Invest. 2013;123(9):3664–3671.
-
(2013)
J Clin Invest
, vol.123
, Issue.9
, pp. 3664-3671
-
-
Semenza, G.L.1
-
5
-
-
84888085891
-
Targeting hypoxia for sensitization of tumors to radio- and chemotherapy
-
Ghattass K, Assah R, El-Sabban M, Gali-Muhtasib H. Targeting hypoxia for sensitization of tumors to radio- and chemotherapy. Curr Cancer Drug Targets. 2013;13(6):670–685.
-
(2013)
Curr Cancer Drug Targets
, vol.13
, Issue.6
, pp. 670-685
-
-
Ghattass, K.1
Assah, R.2
El-Sabban, M.3
Gali-Muhtasib, H.4
-
6
-
-
34047272690
-
Regulation of HIF-1α stability through S-nitrosylation
-
Li F, Sonveaux P, Rabbani ZN, et al. Regulation of HIF-1α stability through S-nitrosylation. Mol Cell. 2007;26(1):63–74.
-
(2007)
Mol Cell
, vol.26
, Issue.1
, pp. 63-74
-
-
Li, F.1
Sonveaux, P.2
Rabbani, Z.N.3
-
7
-
-
0035917313
-
HIFα targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
-
Ivan M, Kondo K, Yang H, et al. HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science. 2001;292(5516):464–468.
-
(2001)
Science
, vol.292
, Issue.5516
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
-
8
-
-
0035917808
-
Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola P, Mole DR, Tian YM, et al. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science. 2001;292(5516):468–472.
-
(2001)
Science.
, vol.292
, Issue.5516
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
-
9
-
-
0027210562
-
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
-
Wang GL, Semenza GL. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci U S A. 1993;90(9):4304–4308.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, Issue.9
, pp. 4304-4308
-
-
Wang, G.L.1
Semenza, G.L.2
-
10
-
-
79958191830
-
Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways
-
Rohwer N, Cramer T. Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways. Drug Resist Updat. 2011;14(3):191–201.
-
(2011)
Drug Resist Updat
, vol.14
, Issue.3
, pp. 191-201
-
-
Rohwer, N.1
Cramer, T.2
-
11
-
-
0037096732
-
Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene
-
Comerford KM, Wallace TJ, Karhausen J, Louis NA, Montalto MC, Colgan SP. Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res. 2002;62(12):3387–3394.
-
(2002)
Cancer Res
, vol.62
, Issue.12
, pp. 3387-3394
-
-
Comerford, K.M.1
Wallace, T.J.2
Karhausen, J.3
Louis, N.A.4
Montalto, M.C.5
Colgan, S.P.6
-
12
-
-
0142241212
-
Cloning and characterization of the murine and rat mrp1 promoter regions
-
Muredda M, Nunoya K, Burtch-Wright RA, Kurz EU, Cole SP, Deeley RG. Cloning and characterization of the murine and rat mrp1 promoter regions. Mol Pharmacol. 2003;64(5):1259–1269.
-
(2003)
Mol Pharmacol
, vol.64
, Issue.5
, pp. 1259-1269
-
-
Muredda, M.1
Nunoya, K.2
Burtch-Wright, R.A.3
Kurz, E.U.4
Cole, S.P.5
Deeley, R.G.6
-
13
-
-
67349202281
-
Effect of hypoxia-inducible factor-1α silencing on the sensitivity of human brain glioma cells to doxorubicin and etoposide
-
Chen L, Feng P, Li S, et al. Effect of hypoxia-inducible factor-1α silencing on the sensitivity of human brain glioma cells to doxorubicin and etoposide. Neurochem Res. 2009;34(5):984–990.
-
(2009)
Neurochem Res
, vol.34
, Issue.5
, pp. 984-990
-
-
Chen, L.1
Feng, P.2
Li, S.3
-
14
-
-
36949000697
-
Hypoxia-inducible factor-1 alpha contributes to hypoxia-induced chemoresistance in gastric cancer
-
Liu L, Ning X, Sun L, et al. Hypoxia-inducible factor-1 alpha contributes to hypoxia-induced chemoresistance in gastric cancer. Cancer Sci. 2008;99(1):121–128.
-
(2008)
Cancer Sci
, vol.99
, Issue.1
, pp. 121-128
-
-
Liu, L.1
Ning, X.2
Sun, L.3
-
15
-
-
0344608877
-
Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism
-
Chen J, Zhao S, Nakada K, et al. Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathol. 2003;162(4):1283–1291.
-
(2003)
Am J Pathol
, vol.162
, Issue.4
, pp. 1283-1291
-
-
Chen, J.1
Zhao, S.2
Nakada, K.3
-
16
-
-
84903209196
-
CoCl2, a mimic of hypoxia, induces formation of polyploid giant cells with stem characteristics in colon cancer
-
Lopez-Sanchez LM, Jimenez C, Valverde A, et al. CoCl2, a mimic of hypoxia, induces formation of polyploid giant cells with stem characteristics in colon cancer. PloS One. 2014;9(6):e99143.
-
(2014)
Plos One
, vol.9
, Issue.6
-
-
Lopez-Sanchez, L.M.1
Jimenez, C.2
Valverde, A.3
-
17
-
-
84872967522
-
Cancer statistics, 2013
-
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63(1):11–30.
-
(2013)
CA Cancer J Clin
, vol.63
, Issue.1
, pp. 11-30
-
-
Siegel, R.1
Naishadham, D.2
Jemal, A.3
-
18
-
-
84894484422
-
Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway
-
Wang H, Zhao L, Zhu LT, et al. Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway. Mol Carcinog. 2014;53(Suppl 1):E107–E118.
-
(2014)
Mol Carcinog
, vol.53
, Issue.1
, pp. E107-E118
-
-
Wang, H.1
Zhao, L.2
Zhu, L.T.3
-
19
-
-
84875384007
-
Mad1 mediates hypoxia-induced doxorubicin resistance in colon cancer cells by inhibiting mitochondrial function
-
Cho K, Shin HW, Kim YI, et al. Mad1 mediates hypoxia-induced doxorubicin resistance in colon cancer cells by inhibiting mitochondrial function. Free Radic Biol Med. 2013;60:201–210.
-
(2013)
Free Radic Biol Med
, vol.60
, pp. 201-210
-
-
Cho, K.1
Shin, H.W.2
Kim, Y.I.3
-
20
-
-
84863352583
-
SN-38 overcomes chemoresistance of colorectal cancer cells induced by hypoxia, through HIF1α
-
Murono K, Tsuno NH, Kawai K, et al. SN-38 overcomes chemoresistance of colorectal cancer cells induced by hypoxia, through HIF1α. Anticancer Res. 2012;32(3):865–872.
-
(2012)
Anticancer Res
, vol.32
, Issue.3
, pp. 865-872
-
-
Murono, K.1
Tsuno, N.H.2
Kawai, K.3
-
21
-
-
84960987950
-
The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
-
Gray LH, Conger AD, Ebert M, Hornsey S, Scott OC. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol. 1953;26(312):638–648.
-
(1953)
Br J Radiol
, vol.26
, Issue.312
, pp. 638-648
-
-
Gray, L.H.1
Conger, A.D.2
Ebert, M.3
Hornsey, S.4
Scott, O.C.5
-
22
-
-
0017840706
-
Studies with bleomycin and misonidazole on aerated and hypoxic cells
-
Roizin-Towle L, Hall EJ. Studies with bleomycin and misonidazole on aerated and hypoxic cells. Br J Cancer. 1978;37(2):254–260.
-
(1978)
Br J Cancer
, vol.37
, Issue.2
, pp. 254-260
-
-
Roizin-Towle, L.1
Hall, E.J.2
-
23
-
-
10644234769
-
The role of hypoxia-induced factors in tumor progression
-
Vaupel P. The role of hypoxia-induced factors in tumor progression. Oncologist. 2004;9(Suppl 5):10–17.
-
(2004)
Oncologist
, vol.9
, Issue.5
, pp. 10-17
-
-
Vaupel, P.1
-
24
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases
-
Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res. 1999;59(22):5830–5835.
-
(1999)
Cancer Res
, vol.59
, Issue.22
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
-
25
-
-
0033870281
-
The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
-
Talks KL, Turley H, Gatter KC, et al. The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol. 2000;157(2):411–421.
-
(2000)
Am J Pathol
, vol.157
, Issue.2
, pp. 411-421
-
-
Talks, K.L.1
Turley, H.2
Gatter, K.C.3
-
26
-
-
57149142495
-
The impact of O2 availability on human cancer
-
Bertout JA, Patel SA, Simon MC. The impact of O2 availability on human cancer. Nat Rev Cancer. 2008;8(12):967–975.
-
(2008)
Nat Rev Cancer
, vol.8
, Issue.12
, pp. 967-975
-
-
Bertout, J.A.1
Patel, S.A.2
Simon, M.C.3
-
27
-
-
76349095132
-
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
-
Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene. 2010;29(5):625–634.
-
(2010)
Oncogene
, vol.29
, Issue.5
, pp. 625-634
-
-
Semenza, G.L.1
-
28
-
-
31044444974
-
Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1
-
Brown LM, Cowen RL, Debray C, et al. Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1. Mol Pharmacol. 2006;69(2):411–418.
-
(2006)
Mol Pharmacol
, vol.69
, Issue.2
, pp. 411-418
-
-
Brown, L.M.1
Cowen, R.L.2
Debray, C.3
-
29
-
-
77957601337
-
Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells
-
Ding Z, Yang L, Xie X, et al. Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells. J Cancer Res Clin Oncol. 2010;136(11):1697–1707.
-
(2010)
J Cancer Res Clin Oncol
, vol.136
, Issue.11
, pp. 1697-1707
-
-
Ding, Z.1
Yang, L.2
Xie, X.3
-
30
-
-
84902532046
-
HIF-1alpha inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1/P-glycoprotein
-
Chen J, Ding Z, Peng Y, et al. HIF-1alpha inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1/P-glycoprotein. PloS one. 2014;9(6):e98882.
-
(2014)
Plos One
, vol.9
, Issue.6
-
-
Chen, J.1
Ding, Z.2
Peng, Y.3
-
31
-
-
84902532046
-
HIF-1α inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1/P-glycoprotein
-
Chen J, Ding Z, Peng Y, et al. HIF-1α inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1/P-glycoprotein. PloS One. 2014;9(6):e98882.
-
(2014)
Plos One
, vol.9
, Issue.6
-
-
Chen, J.1
Ding, Z.2
Peng, Y.3
-
32
-
-
0028106023
-
Cloning and sequence analysis of the promoter region of the MRP gene of HL60 cells isolated for resistance to adriamycin
-
Zhu Q, Center MS. Cloning and sequence analysis of the promoter region of the MRP gene of HL60 cells isolated for resistance to adriamycin. Cancer Res. 1994;54(16):4488–4492.
-
(1994)
Cancer Res
, vol.54
, Issue.16
, pp. 4488-4492
-
-
Zhu, Q.1
Center, M.S.2
-
33
-
-
0032190614
-
Hypoxia-inducible factor 1: Master regulator of O2 homeostasis
-
Semenza GL. Hypoxia-inducible factor 1: master regulator of O2 homeostasis. Curr Opin Genet Dev. 1998;8(5):588–594.
-
(1998)
Curr Opin Genet Dev
, vol.8
, Issue.5
, pp. 588-594
-
-
Semenza, G.L.1
|