4-hydroxyisoleucine improves hepatic insulin resistance by restoring glycogen synthesis in vitro

International Journal of Clinical and Experimental Medicine

Volumn 8, Issue 6, 2015, Pages 8626-8633

  Lu, Furong ^a   Cai, Qin ^a   Zafar, Mohammad Ishraq ^a   Cai, Lun ^b   Du, Wen ^a   Jian, Liumeng ^a   Li, Liping ^a   Gao, Feng ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b WUHAN CENTRAL HOSPITAL   (China)

Author keywords

3T3 L1 adipocytes; Fenugreek; Insulin resistance; JNK signaling pathway; L6 myotubes

Indexed keywords

4 HYDROXYISOLEUCINE; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; GLYCOGEN SYNTHESIS; HUMAN; HUMAN CELL; INSULIN RESISTANCE; LIVER; PHOSPHORYLATION; PROTEIN EXPRESSION; WESTERN BLOTTING;

TRIGONELLA FOENUM-GRAECUM;

EID: 84938372240     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. [1] Goldstein BJ. Insulin resistance as the core defect in type 2 diabetes mellitus. Am J Cardiol 2002; 90: 3G-10G.
2. [2] Li Y, Ding L, Hassan W, Abdelkader D, Shang J. Adipokines and hepatic insulin resistance. J Diabetes Res 2013; 2013: 170532.
3. [3] Leclercq IA, Da Silva Morais A, Schroyen B, Van Hul N, Geerts A. Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences. J Hepatol 2007; 47: 142-156.
4. [4] Valverde AM, Kahn CR, Benito M. Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis. Diabetes 1999; 48: 2122-2131.
5. [5] Bloomgarden ZT. American Diabetes Association Annual Meeting, 1999: insulin action and the development of type 2 diabetes. Diabetes Care 2000; 23: 248-252.
6. [6] Boura-Halfon S, Zick Y. Phosphorylation of IRS proteins, insulin action, and insulin resistance. Am J Physiol Endocrinol Metab 2009; 296: E581-E591.
7. [7] Bonadonna RC, Del Prato S, Bonora E, Saccomani MP, Gulli G, Natali A, Frascerra S, Pecori N, Ferrannini E, Bier D, Cobelli C, DeFronzo RA. Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM. Diabetes 1996; 45: 915-925.
8. [8] Mueckler M, Thorens B. The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med 2013; 34: 121-138.
9. [9] Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006; 440: 944-948.
10. [10] Capaldo B, Napoli R, Di Marino L, Picardi A, Riccardi G, Sacca L. Quantitation of forearm glucose and free fatty acid (FFA) disposal in normal subjects and type II diabetic patients: evidence against an essential role for FFA in the pathogenesis of insulin resistance. J Clin Endocrinol Metab 1988; 67: 893-898.
11. [11] Groop LC, Saloranta C, Shank M, Bonadonna RC, Ferrannini E, DeFronzo RA. The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulindependent diabetes mellitus. J Clin Endocrinol Metab 1991; 72: 96-107.
12. [12] Boden G. Free fatty acids-the link between obesity and insulin resistance. Endocr Pract 2001; 7: 44-51.
13. [13] Zou C, Shao J. Role of adipocytokines in obesity-associated insulin resistance. J Nutr Biochem 2008; 19: 277-286.
14. [14] Zhuang XF, Zhao MM, Weng CL, Sun NL. Adipocytokines: a bridge connecting obesity and insulin resistance. Med Hypotheses 2009; 73: 981-985.
15. [15] Moller DE. Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol Metab 2000; 11: 212-217.
16. [16] Li L, He Q, Huang X, Man Y, Zhou Y, Wang S, Wang J, Li J. NOX3-derived reactive oxygen species promote TNF-alpha-induced reductions in hepatocyte glycogen levels via a JNK pathway. FEBS Lett 2010; 584: 995-1000.
17. [17] Upaganlawar A, Badole S, Bodhankar S. Antidiabetic potential of trigonelline and 4-hydroxyisoleucine in fenugreek. San Diego: Academic Press; 2013.
18. [18] Broca C, Manteghetti M, Gross R, Baissac Y, Jacob M, Petit P, Sauvaire Y, Ribes G. 4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion. Eur J Pharmacol 2000; 390: 339-345.
19. [19] Sauvaire Y, Petit P, Broca C, Manteghetti M, Baissac Y, Fernandez-Alvarez J, Gross R, Roye M, Leconte A, Gomis R, Ribes G. 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion. Diabetes 1998; 47: 206-210.
20. [20] Broca C, Gross R, Petit P, Sauvaire Y, Manteghetti M, Tournier M, Masiello P, Gomis R, Ribes G. 4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties. Am J Physiol 1999; 277: E617-E623.
21. [21] Broca C, Breil V, Cruciani-Guglielmacci C, Manteghetti M, Rouault C, Derouet M, Rizkalla S, Pau B, Petit P, Ribes G, Ktorza A, Gross R, Reach G, Taouis M. Insulinotropic agent ID-1101 (4-hydroxyisoleucine) activates insulin signaling in rat. Am J Physiol Endocrinol Metab 2004; 287: E463-E471.
22. [22] Jetté L, Harvey L, Eugeni K, Levens N. 4-Hydroxyisoleucine: a plant-derived treatment for metabolic syndrome. Curr Opin Investig Drugs 2009; 10: 353-358.
23. [23] Ogawa J, Kodera T, Smirnov S V, Hibi M, Samsonova NN, Koyama R, Yamanaka H, Mano J, Kawashima T, Yokozeki K, Shimizu S. A novel L-isoleucine metabolism in Bacillus thuringiensis generating (2S,3R,4S)-4-hydroxyisoleucine, a potential insulinotropic and anti-obesity amino acid. Appl Microbiol Biotechnol 2011; 89: 1929-1938.
24. [24] Maurya CK, Singh R, Jaiswal N, Venkateswarlu K, Narender T, Tamrakar AK. 4-Hydroxyisoleucine ameliorates fatty acid-induced insulin resistance and inflammatory response in skeletal muscle cells. Mol Cell Endocrinol 2014; 395: 51-60.
25. [25] Yu H, Wu M, Lu FR, Xie J, Zheng N, Qin Y, Gao F, Du W, Jian LM. [Effect of Trigonella foenumgraecum 4-hydroxyisoleucine on high-glucose induced insulin resistance in 3T3-L1 adipocytes of mice]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2013; 33: 1394-1399.
26. [26] Ishikawa M, Yoshida K, Okamura H, Ochiai K, Takamura H, Fujiwara N, Ozaki K. Oral Porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3β signaling pathway. Biochim Biophys Acta 2013; 1832: 2035-2043.
27. [27] Gao D, Nong S, Huang X, Lu Y, Zhao H, Lin Y, Man Y, Wang S, Yang J, Li J. The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways. J Biol Chem 2010; 285: 29965-29973.
28. [28] Bouma ME, Rogier E, Verthier N, Labarre C, Feldmann G. Further cellular investigation of the human hepatoblastoma-derived cell line HepG2: morphology and immunocytochemical studies of hepatic-secreted proteins. In Vitro Cell Dev Biol 1989; 25: 267-275.
29. [29] Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112: 1796-1808.
30. [30] Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003; 112: 1821-1830.
31. [31] Parameswaran N, Patial S. Tumor necrosis factor-α signaling in macrophages. Crit Rev Eukaryot Gene Expr 2010; 20: 87-103.
32. [32] Ramírez Alvarado MM, Sánchez Roitz C. [Tumor necrosis factor-α, insulin resistance, the lipoprotein metabolism and obesity in humans]. Nutr Hosp 27: 1751-1757.
33. [33] Kong P, Chi R, Zhang L, Wang N, Lu Y. Effects of paeoniflorin on tumor necrosis factor-α-induced insulin resistance and changes of adipokines in 3T3-L1 adipocytes. Fitoterapia 2013; 91: 44-50.
34. [34] Nguyen MTA, Satoh H, Favelyukis S, Babendure JL, Imamura T, Sbodio JI, Zalevsky J, Dahiyat BI, Chi NW, Olefsky JM. JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J Biol Chem 2005; 280: 35361-35371.
35. [35] Rawat AK, Korthikunta V, Gautam S, Pal S, Tadigoppula N, Tamrakar AK, Srivastava AK. 4-Hydroxyisoleucine improves insulin resistance by promoting mitochondrial biogenesis and act through AMPK and Akt dependent pathway. Fitoterapia 2014; 99: 307-317.