A novel L-isoleucine metabolism in Bacillus thuringiensis generating (2S,3R,4S)-4-hydroxyisoleucine, a potential insulinotropic and anti-obesity amino acid

Applied Microbiology and Biotechnology

Volumn 89, Issue 6, 2011, Pages 1929-1938

  Ogawa, Jun ^a   Kodera, Tomohiro ^b   Smirnov, Sergey V ^c   Hibi, Makoto ^a   Samsonova, Natalia N ^c   Koyama, Ryoukichi ^a   Yamanaka, Hiroyuki ^a   Mano, Junichi ^a   Kawashima, Takashi ^a   Yokozeki, Kenzo ^a,b   Shimizu, Sakayu ^a  

^a KYOTO UNIVERSITY   (Japan)

^b AJINOMOTO CO INC   (Japan)

^c Ajinomoto Genetika Research Institute   (Russian Federation)

Author keywords

2 Amino 3 methyl 4 ketopentanoic acid; 4 Hydroxyisoleucine; Bacillus thuringiensis; L Isoleucine dioxygenase; NAD+ dependent dehydrogenase; TCA cycle

Indexed keywords

2-AMINO-3-METHYL-4-KETOPENTANOIC ACID; 4-HYDROXYISOLEUCINE; BACILLUS THURINGIENSIS; L-ISOLEUCINE; NAD+-DEPENDENT DEHYDROGENASE; TCA CYCLE;

AMINO ACIDS; BACTERIOLOGY; METABOLISM; NUTRITION;

BACILLI;

2 AMINO 3 METHYL 4 KETOPENTANOIC ACID; 2 OXOGLUTARIC ACID; 4 HYDROXYISOLEUCINE; ANTIBIOTIC AGENT; ANTIMETABOLITE; ATCC 35646; ISOLEUCINE; NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASE; TRICARBOXYLIC ACID; UNCLASSIFIED DRUG;

AMINO ACID; ANTIBIOTICS; BACTERIUM; CATALYSIS; DIABETES; DRUG; ENZYME ACTIVITY; KETONE; METABOLISM; METABOLITE; OBESITY; ORGANIC ACID; OXIDATION; SEED; VITAMIN;

AMINO ACID METABOLISM; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS THURINGIENSIS; CATALYSIS; DEHYDROGENATION; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INSULIN LIKE ACTIVITY; NONHUMAN; NUCLEOTIDE SEQUENCE; STEREOCHEMISTRY;

BACILLUS THURINGIENSIS; BIOSYNTHETIC PATHWAYS; COENZYMES; DIOXYGENASES; ISOLEUCINE; KETO ACIDS; NAD; OXIDATION-REDUCTION; OXIDOREDUCTASES; PENTANOIC ACIDS;

BACILLUS THURINGIENSIS; TRIGONELLA FOENUM-GRAECUM;

EID: 79952575690     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-010-2983-7     Document Type: Article

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