miR-502 inhibits cell proliferation and tumor growth in hepatocellular carcinoma through suppressing phosphoinositide 3-kinase catalytic subunit gamma

Biochemical and Biophysical Research Communications

Volumn 464, Issue 2, 2015, Pages 500-505

  Chen, Suling ^a   Li, Fang ^a   Chai, Haiyun ^a   Tao, Xin ^a   Wang, Haili ^a   Ji, Aifang ^a  

^a CHANGZHI MEDICAL COLLEGE   (China)

Author keywords

Hepatocellular carcinoma; miR 502; PIK3CG; Proliferation

Indexed keywords

MESSENGER RNA; MICRORNA; MICRORNA 502; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; UNCLASSIFIED DRUG; MIRN502 MICRORNA, HUMAN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PIK3CG PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG CARCINOGENICITY; DRUG MECHANISM; ENZYME REPRESSION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BAGG ALBINO MOUSE; ENZYMOLOGY; LIVER TUMOR; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; FEMALE; HETEROGRAFTS; HUMANS; LIVER NEOPLASMS; MICE; MICE, INBRED BALB C; MICRORNAS;

EID: 84938326037     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.06.168     Document Type: Article

References (28)

1. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, and D. Forman Global cancer statistics CA Cancer J. Clin. 61 2012 69 90
2. L. Rossi, F. Zoratto, A. Papa, F. Iodice, M. Minozzi, L. Frati, and S. Tomao Current approach in the treatment of hepatocellular carcinoma World J. Gastrointest. Oncol. 2 2010 348 359
3. R. Garzon, G.A. Calin, and C.M. Croce MicroRNAs in cancer Annu Rev. Med. 60 2009 167 179
4. J. Liu Control of protein synthesis and mRNA degradation by microRNAs Curr. Opin. Cell. Biol. 20 2008 214 221
5. V. Ambros The functions of animal microRNAs Nature 431 2004 350 355
6. M. Carleton, M.A. Cleary, and P.S. Linsley MicroRNAs and cell cycle regulation Cell. Cycle 6 2007 2127 2132
7. Y. Zhao, and D. Srivastava A developmental view of microRNA function Trends Biochem. Sci. 32 2007 189 197
8. Y. Fang, J.L. Xue, Q. Shen, J. Chen, and L. Tian MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinoma Hepatology 55 2012 1852 1862
9. J. Hou, L. Lin, W. Zhou, Z. Wang, G. Ding, Q. Dong, L. Qin, X. Wu, Y. Zheng, Y. Yang, W. Tian, Q. Zhang, C. Wang, S.M. Zhuang, L. Zheng, A. Liang, W. Tao, and X. Cao Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma Cancer Cell. 19 2011 232 243
10. J. Kota, R.R. Chivukula, K.A. O'Donnell, E.A. Wentzel, C.L. Montgomery, H.W. Hwang, T.C. Chang, P. Vivekanandan, M. Torbenson, K.R. Clark, J.R. Mendell, and J.T. Mendell Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model Cell 137 2009 1005 1017
11. H. Zhai, B. Song, X. Xu, W. Zhu, and J. Ju Inhibition of autophagy and tumor growth in colon cancer by miR-502 Oncogene 32 2013 1570 1579
12. L.L. Sun, J. Wang, Z.J. Zhao, N. Liu, A.L. Wang, H.Y. Ren, F. Yang, K.X. Diao, W.N. Fu, E.H. Wan, and X.Y. Mi Suppressive role of miR-502-5p in breast cancer via downregulation of TRAF2 Oncol. Rep. 31 2014 2085 2092
13. X. Yang, L. Liang, X.F. Zhang, H.L. Jia, Y. Qin, X.C. Zhu, X.M. Gao, P. Qiao, Y. Zheng, Y.Y. Sheng, J.W. Wei, H.J. Zhou, N. Ren, Q.H. Ye, Q.Z. Dong, and L.X. Qin MicroRNA-26a suppresses tumor growth and metastasis of human hepatocellular carcinoma by targeting interleukin-6-Stat3 pathway Hepatology 58 2013 158 170
14. X. Tian, H. Du, X. Fu, K. Li, A. Li, and Y. Zhang Smad4 restoration leads to a suppression of Wnt/beta-catenin signaling activity and migration capacity in human colon carcinoma cells Biochem. Biophys. Res. Commun. 380 2009 478 483
15. B.P. Lewis, I.H. Shih, M.W. Jones-Rhoades, D.P. Bartel, and C.B. Burge Prediction of mammalian microRNA targets Cell 115 2003 787 798
16. B. John, A.J. Enright, A. Aravin, T. Tuschl, C. Sander, and D.S. Marks Human MicroRNA targets PLoS Biol. 2 2004 e363
17. J.A. Engelman Targeting PI3K signalling in cancer: opportunities, challenges and limitations Nat. Rev. Cancer 9 2009 550 562
18. F. Song, H. Zheng, B. Liu, S. Wei, H. Dai, L. Zhang, G.A. Calin, X. Hao, Q. Wei, W. Zhang, and K. Chen An miR-502-binding site single-nucleotide polymorphism in the 3′-untranslated region of the SET8 gene is associated with early age of breast cancer onset Clin. Cancer Res. 15 2009 6292 6300
19. Z. Guo, C. Wu, X. Wang, C. Wang, R. Zhang, and B. Shan A polymorphism at the miR-502 binding site in the 3′-untranslated region of the histone methyltransferase SET8 is associated with hepatocellular carcinoma outcome Int. J. Cancer 131 2012 1318 1322
20. C. Wang, Z. Guo, C. Wu, Y. Li, and S. Kang A polymorphism at the miR-502 binding site in the 3′ untranslated region of the SET8 gene is associated with the risk of epithelial ovarian cancer Cancer Genet. 205 2012 373 376
21. A. Toker, and L.C. Cantley Signalling through the lipid products of phosphoinositide-3-OH kinase Nature 387 1997 673 676
22. H.W. Chang, M. Aoki, D. Fruman, K.R. Auger, A. Bellacosa, P.N. Tsichlis, L.C. Cantley, T.M. Roberts, and P.K. Vogt Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase Science 276 1997 1848 1850
23. B. Stoyanov, S. Volinia, T. Hanck, I. Rubio, M. Loubtchenkov, D. Malek, S. Stoyanova, B. Vanhaesebroeck, R. Dhand, B. Nurnberg, and et al. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase Science 269 1995 690 693
24. L.R. Stephens, A. Eguinoa, H. Erdjument-Bromage, M. Lui, F. Cooke, J. Coadwell, A.S. Smrcka, M. Thelen, K. Cadwallader, P. Tempst, and P.T. Hawkins The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101 Cell 89 1997 105 114
25. C.E. Edling, F. Selvaggi, R. Buus, T. Maffucci, P. Di Sebastiano, H. Friess, P. Innocenti, H.M. Kocher, and M. Falasca Key role of phosphoinositide 3-kinase class IB in pancreatic cancer Clin. Cancer Res. 16 2010 4928 4937
26. J.A. Brazzatti, M. Klingler-Hoffmann, S. Haylock-Jacobs, Y. Harata-Lee, M. Niu, M.D. Higgins, M. Kochetkova, P. Hoffmann, and S.R. McColl Differential roles for the p101 and p84 regulatory subunits of PI3Kgamma in tumor growth and metastasis Oncogene 31 2012 2350 2361
27. F. Dituri, A. Mazzocca, L. Lupo, C.E. Edling, A. Azzariti, S. Antonaci, M. Falasca, and G. Giannelli PI3K class IB controls the cell cycle checkpoint promoting cell proliferation in hepatocellular carcinoma Int. J. Cancer 130 2012 2505 2513
28. S. Hohenester, A. Gates, R. Wimmer, U. Beuers, M.S. Anwer, C. Rust, and C.R. Webster Phosphatidylinositol-3-kinase p110gamma contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells J. Hepatol. 53 2010 918 926