G protein coupled growth factor receptor tyrosine kinase: no longer an oxymoron

Cell Cycle

Volumn 14, Issue 16, 2015, Pages 2561-2565

  Ghosh, Pradipta ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

G protein coupled receptors; GIV; Growth factor receptor tyrosine kinases; Heterotrimeric G proteins

Indexed keywords

ADAPTOR PROTEIN; EPIDERMAL GROWTH FACTOR; G PROTEIN COUPLED GROWTH FACTOR RECEPTOR TYROSINE KINASE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHOTYROSINE; PROTEIN SH2; PROTEIN TYROSINE KINASE; SOMATOMEDIN; UNCLASSIFIED DRUG; VASCULOTROPIN; GROWTH FACTOR RECEPTOR; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN;

ARTICLE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE PERMEABILITY; CELL MIGRATION; ENERGY TRANSFER; ENZYME ACTIVATION; GENE THERAPY; PROTEIN DOMAIN; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; HUMAN; MOLECULAR MODEL; PHYSIOLOGY; PROTEIN PROTEIN INTERACTION;

ANIMALS; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; MODELS, MOLECULAR; PROTEIN INTERACTION MAPS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 84938315730     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.1080/15384101.2015.1066538     Document Type: Article

References (37)

1. Schlessinger J. Receptor tyrosine kinases: legacy of the first two decades. Cold Spring Harb Perspect Biol, 2014; 6(3): pii: a008912; PMID: 24591517; http://dx. doi. org/10. 1101/cshperspect. a008912.
2. Gilman AG. G proteins: transducers of receptorgenerated signals. Annu Rev Biochem, 1987; 56: p. 615-49; http://dx. doi. org/10. 1146/annurev. bi. 56. 070187. 003151.
3. Garcia-Marcos M, P Ghosh, MG Farquhar. GIV/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation. J Biol Chem, 2015; 290(11): p. 6697-704; http://dx. doi. org/10. 1074/jbc. R114. 613414.
4. Garcia-Marcos M, P Ghosh, MG Farquhar. GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling. Proc Natl Acad Sci U S A, 2009; 106(9): p. 3178-83; PMID: 19211784; http://dx. doi. org/10. 1073/pnas. 0900294106.
5. Midde KK, Aznar N, Laederich MB, Ma GS, Kunkel MT, Newton AC, Ghosh P. Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors. Proc Natl Acad Sci U S A, 2015; 112(9): p. E937-46; PMID: 25713130; http://dx. doi. org/10. 1073/pnas. 1420140112.
6. Lohse MJ, Hein P, Hoffmann C, Nikolaev VO, Vilardaga JP, Bünemann M. Kinetics of G-protein-coupled receptor signals in intact cells. Br J Pharmacol, 2008; 153 Suppl 1: p. S125-32; PMID: 18193071.
7. Garcia-Marcos M, Ear J, Farquhar MG, Ghosh P. A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals. Mol Biol Cell, 2011; 22(5): p. 673-86; PMID: 21209316; http://dx. doi. org/10. 1091/mbc. E10-08-0738.
8. Lo IC, Gupta V, Midde KK, Taupin V, Lopez-Sanchez I, Kufareva I, Abagyan R, Randazzo PA, Farquhar MG, Ghosh P. Activation of Galphai at the Golgi by GIV/Girdin Imposes Finiteness in Arf1 Signaling. Dev Cell, 2015; 33(2): p. 189-203; PMID: 25865347; http://dx. doi. org/10. 1016/j. devcel. 2015. 02. 009.
9. Ma GS, Aznar N, Kalogriopoulos N, Midde KK, Lopez-Sanchez I, Sato E, Dunkel Y, Gallo RL, Ghosh P. Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors. Proc Natl Acad Sci U S A, 2015; 112(20): E2602-10; PMID: 25926659; http://dx. doi. org/10. 1073/pnas. 1505543112.
10. Garcia-Marcos M, P Ghosh, MG Farquhar. GIV/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation. J Biol Chem, 2015; 290(11): 6697-704; PMID: 25605737; http://dx. doi. org/10. 1074/jbc. R114. 613414.
11. Ghosh P, Beas AO, Bornheimer SJ, Garcia-Marcos M, Forry EP, Johannson C, Ear J, Jung BH, Cabrera B, Carethers JM, et al., A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate. Mol Biol Cell, 2010; 21(13): p. 2338-54; PMID: 20462955; http://dx. doi. org/10. 1091/mbc. E10-01-0028.
12. Ghosh P, Garcia-Marcos M, Bornheimer SJ, Farquhar MG. Activation of Galphai3 triggers cell migration via regulation of GIV. J Cell Biol, 2008; 182(2): p. 381-93; http://dx. doi. org/10. 1083/jcb. 200712066.
13. Ghosh P, M Garcia-Marcos, MG Farquhar. GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression. Cell Adh Migr, 2011; 5(3): p. 237-48; PMID: 21546796; http://dx. doi. org/10. 4161/cam. 5. 3. 15909.
14. Wang H, Misaki T, Taupin V, Eguchi A, Ghosh P, Farquhar MG. GIV/girdin links vascular endothelial growth factor signaling to Akt survival signaling in podocytes independent of nephrin. J Am Soc Nephrol, 2015; 26(2): p. 314-27; PMID: 25012178; http://dx. doi. org/10. 1681/ASN. 2013090985.
15. Lopez-Sanchez I, Garcia-Marcos M, Mittal Y, Aznar N, Farquhar MG, Ghosh P. Protein kinase C-theta (PKCtheta) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin. Proc Natl Acad Sci U S A, 2013; 110(14): p. 5510-5; http://dx. doi. org/10. 1073/pnas. 1303392110.
16. Garcia-Marcos M, Ghosh P, Ear J, Farquhar MG. A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. J Biol Chem, 2010. 285(17): p. 12765-77; PMID: 20157114; http://dx. doi. org/10. 1074/jbc. M109. 045161.
17. Beas AO, Taupin V, Teodorof C, Nguyen LT, Garcia-Marcos M, Farquhar MG. Galphas promotes EEA1 endosome maturation and shuts down proliferative signaling through interaction with GIV (Girdin). Mol Biol Cell, 2012; 23(23): p. 4623-34; http://dx. doi. org/10. 1091/mbc. E12-02-0133.
18. Lopez-Sanchez I, Dunkel Y, Roh YS, Mittal Y, De Minicis S, Muranyi A, Singh S, Shanmugam K, Aroonsakool N, Murray F, et al., GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Nat Commun, 2014; 5: p. 4451; PMID: 25043713; http://dx. doi. org/10. 1038/ncomms5451.
19. Ohara K, Enomoto A, Kato T, Hashimoto T, Isotani-Sakakibara M, Asai N, Ishida-Takagishi M, Weng L, Nakayama M, Watanabe T, et al., Involvement of Girdin in the determination of cell polarity during cell migration. PLoS One, 2012; 7(5): p. e36681; PMID: 22574214; http://dx. doi. org/10. 1371/journal. pone. 0036681.
20. Mao JZ, Jiang P, Cui SP, Ren YL, Zhao J, Yin XH, Enomoto A, Liu HJ, Hou L, Takahashi M, et al., Girdin locates in centrosome and midbody and plays an important role in cell division. Cancer Sci, 2012; 103 (10): p. 1780-7; PMID: 22755556; http://dx. doi. org/10. 1111/j. 1349-7006. 2012. 02378. x.
21. Weng L, Enomoto A, Miyoshi H, Takahashi K, Asai N, Morone N, Jiang P, An J, Kato T, Kuroda K, et al., Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin. EMBO J, 2014; 33 (18): p. 2098-112; PMID: 25061227; http://dx. doi. org/10. 15252/embj. 201488289.
22. Ichimiya H, Maeda K, Enomoto A, Weng L, Takahashi M, Murohara T, et al., Girdin/GIV regulates transendothelial permeability by controlling VE-cadherin trafficking through the small GTPase, R-Ras. Biochem Biophys Res Commun, 2015; 461(2): 260-7; PMID: 25869066.
23. Enomoto A, Asai N, Namba T, Wang Y, Kato T, Tanaka M, Tatsumi H, Taya S, Tsuboi D, Kuroda K, et al., Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus. Neuron, 2009; 63(6): p. 774-87; PMID: 19778507; http://dx. doi. org/10. 1016/j. neuron. 2009. 08. 015.
24. Wang Y, Kaneko N, Asai N, Enomoto A, Isotani-Sakakibara M, Kato T, Asai M, Murakumo Y, Ota H, Hikita T, et al., Girdin is an intrinsic regulator of neuroblast chain migration in the rostral migratory stream of the postnatal brain. J Neurosci, 2011; 31(22): p. 8109-22; PMID: 21632933; http://dx. doi. org/10. 1523/JNEUROSCI. 1130-11. 2011.
25. Puseenam A, Yoshioka Y, Nagai R, Hashimoto R, Suyari O, Itoh M, Enomoto A, Takahashi M, Yamaguchi M. A novel Drosophila Girdin-like protein is involved in Akt pathway control of cell size. Exp Cell Res, 2009; 315(19): p. 3370-80; http://dx. doi. org/10. 1016/j. yexcr. 2009. 06. 019.
26. Dunkel Y, Ong A, Notani D, Mittal Y, Lam M, Mi X, Ghosh P. STAT3 protein up-regulates Galphainteracting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis. J Biol Chem, 2012; 287 (50): p. 41667-83; PMID: 23066027; http://dx. doi. org/10. 1074/jbc. M112. 390781.
27. Enomoto A, Murakami H, Asai N, Morone N, Watanabe T, Kawai K, Murakumo Y, Usukura J, Kaibuchi K, Takahashi M. Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev Cell, 2005; 9(3): p. 389-402; PMID: 16139227; http://dx. doi. org/10. 1016/j. devcel. 2005. 08. 001.
28. Jiang P, Enomoto A, Jijiwa M, Kato T, Hasegawa T, Ishida M, Sato T, Asai N, Murakumo Y, Takahashi M. An actin-binding protein Girdin regulates the motility of breast cancer cells. Cancer Res, 2008; 68(5): p. 1310-8; PMID: 18316593; http://dx. doi. org/10. 1158/0008-5472. CAN-07-5111.
29. Natsume A, Kato T, Kinjo S, Enomoto A, Toda H, Shimato S, Ohka F, Motomura K, Kondo Y, Miyata T, et al., Girdin maintains the stemness of glioblastoma stem cells. Oncogene, 2012; 31(22): p. 2715-24; PMID: 22020337; http://dx. doi. org/10. 1038/onc. 2011. 466.
30. Zhang YJ, Li AJ, Han Y, Yin L, Lin MB. Inhibition of Girdin enhances chemosensitivity of colorectal cancer cells to oxaliplatin. World J Gastroenterol, 2014; 20 (25): p. 8229-36; http://dx. doi. org/10. 3748/wjg. v20. i25. 8229.
31. Yamamura Y, Asai N, Enomoto A, Kato T, Mii S, Kondo Y, Ushida K, Niimi K, Tsunoda N, Nagino M, et al., Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression. Cancer Res, 2015. 75(5): p. 813-23; http://dx. doi. org/10. 1158/0008-5472. CAN-14-1317.
32. Kitamura T, Asai N, Enomoto A, Maeda K, Kato T, Ishida M, Jiang P, Watanabe T, Usukura J, Kondo T, et al., Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin. Nat Cell Biol, 2008; 10 (3): p. 329-37; PMID: 18264090; http://dx. doi. org/10. 1038/ncb1695.
33. Ito T, Komeima K, Yasuma T, Enomoto A, Asai N, Asai M, Iwase S, Takahashi M, Terasaki H. Girdin and its phosphorylation dynamically regulate neonatal vascular development and pathological neovascularization in the retina. Am J Pathol, 2013; 182(2): p. 586-96; PMID: 23195430; http://dx. doi. org/10. 1016/j. ajpath. 2012. 10. 012.
34. Miyachi H, Mii S, Enomoto A, Murakumo Y, Kato T, Asai N, Komori K, Takahashi M. Role of Girdin in intimal hyperplasia in vein grafts and efficacy of atelocollagen-mediated application of small interfering RNA for vein graft failure. J Vasc Surg, 2014; 60(2): p. 479-489 e5; PMID: 23948670; http://dx. doi. org/10. 1016/j. jvs. 2013. 06. 080.
35. Miyake H, Maeda K, Asai N, Shibata R, Ichimiya H, Isotani-Sakakibara M, Yamamura Y, Kato K, Enomoto A, Takahashi M, et al., The actin-binding protein Girdin and its Akt-mediated phosphorylation regulate neointima formation after vascular injury. Circ Res, 2011; 108(10): p. 1170-9; PMID: 21415395; http://dx. doi. org/10. 1161/CIRCRESAHA. 110. 236174.
36. Nakai T, Nagai T, Tanaka M, Itoh N, Asai N, Enomoto A, Asai M, Yamada S, Saifullah AB, Sokabe M, et al., Girdin phosphorylation is crucial for synaptic plasticity and memory: a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor. J Neurosci, 2014; 34(45): p. 14995-5008; PMID: 25378165; http://dx. doi. org/10. 1523/JNEUROSCI. 2228-14. 2014.
37. Sasaki K, Kakuwa T, Akimoto K, Koga H, Ohno S. Regulation of epithelial cell polarity by PAR-3 depends on Girdin transcription and Girdin-Gai3 signaling. J Cell Sci 2015; 128(13): 2244-58; http://dx. doi. org/10. 1242/jcs. 160879.