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Volumn 110, Issue 14, 2013, Pages 5510-5515

Protein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin

Author keywords

Growth factors; PI3 kinase

Indexed keywords

ACTIN; G ALPHA INTERACTING VESICLE ASSOCIATED PROTEIN; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; LYSOPHOSPHATIDIC ACID RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C THETA; UNCLASSIFIED DRUG;

EID: 84875849098     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1303392110     Document Type: Article
Times cited : (32)

References (33)
  • 1
    • 24144496081 scopus 로고    scopus 로고
    • Akt/PKB regulates actin organization and cell motility via Girdin/APE
    • Enomoto A, et al. (2005) Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev Cell 9(3):389-402.
    • (2005) Dev Cell , vol.9 , Issue.3 , pp. 389-402
    • Enomoto, A.1
  • 2
    • 77954208220 scopus 로고    scopus 로고
    • A Galphai-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate
    • Ghosh P, et al. (2010) A Galphai-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate. Mol Biol Cell 21(13):2338-2354.
    • (2010) Mol Biol Cell , vol.21 , Issue.13 , pp. 2338-2354
    • Ghosh, P.1
  • 3
    • 40449105942 scopus 로고    scopus 로고
    • An actin-binding protein Girdin regulates the motility of breast cancer cells
    • Jiang P, et al. (2008) An actin-binding protein Girdin regulates the motility of breast cancer cells. Cancer Res 68(5):1310-1318.
    • (2008) Cancer Res , vol.68 , Issue.5 , pp. 1310-1318
    • Jiang, P.1
  • 4
    • 40249116837 scopus 로고    scopus 로고
    • Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin
    • Kitamura T, et al. (2008) Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin. Nat Cell Biol 10(3):329-337.
    • (2008) Nat Cell Biol , vol.10 , Issue.3 , pp. 329-337
    • Kitamura, T.1
  • 5
    • 79952343266 scopus 로고    scopus 로고
    • A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals
    • Garcia-Marcos M, Ear J, Farquhar MG, Ghosh P (2011) A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals. Mol Biol Cell 22(5):673-686.
    • (2011) Mol Biol Cell , vol.22 , Issue.5 , pp. 673-686
    • Garcia-Marcos, M.1    Ear, J.2    Farquhar, M.G.3    Ghosh, P.4
  • 6
    • 62549124627 scopus 로고    scopus 로고
    • GIV is a nonreceptorGEF forGalpha iwith a unique motif that regulates Akt signaling
    • Garcia-Marcos M, Ghosh P, Farquhar MG(2009)GIV is a nonreceptorGEF forGalpha iwith a unique motif that regulates Akt signaling. Proc Natl Acad Sci USA 106(9):3178-3183.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.9 , pp. 3178-3183
    • Garcia-Marcos, M.1    Ghosh, P.2    Farquhar, M.G.3
  • 7
    • 48249106623 scopus 로고    scopus 로고
    • Activation of Galphai3 triggers cell migration via regulation of GIV
    • Ghosh P, Garcia-Marcos M, Bornheimer SJ, Farquhar MG (2008) Activation of Galphai3 triggers cell migration via regulation of GIV. J Cell Biol 182(2):381-393.
    • (2008) J Cell Biol , vol.182 , Issue.2 , pp. 381-393
    • Ghosh, P.1    Garcia-Marcos, M.2    Bornheimer, S.J.3    Farquhar, M.G.4
  • 8
    • 77951248135 scopus 로고    scopus 로고
    • A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration
    • Garcia-Marcos M, Ghosh P, Ear J, Farquhar MG (2010) A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. J Biol Chem 285(17):12765-12777.
    • (2010) J Biol Chem , vol.285 , Issue.17 , pp. 12765-12777
    • Garcia-Marcos, M.1    Ghosh, P.2    Ear, J.3    Farquhar, M.G.4
  • 9
    • 85046980000 scopus 로고    scopus 로고
    • GIV/Girdin is a rheostat that finetunes growth factor signals during tumor progression
    • Ghosh P, Garcia-Marcos M, Farquhar MG (2011) GIV/Girdin is a rheostat that finetunes growth factor signals during tumor progression. Cell Adhes Migr 5(3):237-248.
    • (2011) Cell Adhes Migr , vol.5 , Issue.3 , pp. 237-248
    • Ghosh, P.1    Garcia-Marcos, M.2    Farquhar, M.G.3
  • 10
    • 34447544399 scopus 로고    scopus 로고
    • Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways
    • Enomoto A, Ping J, Takahashi M (2006) Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways. Ann N Y Acad Sci 1086:169-184.
    • (2006) Ann N y Acad Sci , vol.1086 , pp. 169-184
    • Enomoto, A.1    Ping, J.2    Takahashi, M.3
  • 11
    • 80053257932 scopus 로고    scopus 로고
    • Tyrosine phosphorylated GIV/Girdin binds and activates PI3-kinase during cell migration
    • Lin C, et al. (2011) Tyrosine phosphorylated GIV/Girdin binds and activates PI3-kinase during cell migration. Sci Signal 4(192):ra64.
    • (2011) Sci Signal , vol.4 , Issue.192
    • Lin, C.1
  • 12
    • 84857128930 scopus 로고    scopus 로고
    • Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling
    • Garcia-Marcos M, et al. (2012) Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling. Proc Natl Acad Sci USA 109(6):1961-1966.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.6 , pp. 1961-1966
    • Garcia-Marcos, M.1
  • 13
    • 0031012892 scopus 로고    scopus 로고
    • Determination of the specific substrate sequence motifs of protein kinase C isozymes
    • Nishikawa K, Toker A, Johannes FJ, Songyang Z, Cantley LC (1997) Determination of the specific substrate sequence motifs of protein kinase C isozymes. J Biol Chem 272(2):952-960.
    • (1997) J Biol Chem , vol.272 , Issue.2 , pp. 952-960
    • Nishikawa, K.1    Toker, A.2    Johannes, F.J.3    Songyang, Z.4    Cantley, L.C.5
  • 14
    • 0023080143 scopus 로고
    • Phorbol esters as signal transducers and tumor promoters
    • Castagna M (1987) Phorbol esters as signal transducers and tumor promoters. Biol Cell 59(1):3-13.
    • (1987) Biol Cell , vol.59 , Issue.1 , pp. 3-13
    • Castagna, M.1
  • 15
    • 0035962664 scopus 로고    scopus 로고
    • Histone H3 phosphorylation and cell division
    • Hans F, Dimitrov S (2001) Histone H3 phosphorylation and cell division. Oncogene 20(24):3021-3027.
    • (2001) Oncogene , vol.20 , Issue.24 , pp. 3021-3027
    • Hans, F.1    Dimitrov, S.2
  • 16
    • 58849125814 scopus 로고    scopus 로고
    • Cell proliferation method: Click chemistry based on BrdU coupling for multiplex antibody staining
    • Unit7.34
    • Cappella P, Gasparri F, Pulici M, Moll J (2008) Cell proliferation method: Click chemistry based on BrdU coupling for multiplex antibody staining. Curr Protoc Cytom Chap 7:Unit7.34.
    • (2008) Curr Protoc Cytom Chap , vol.7
    • Cappella, P.1    Gasparri, F.2    Pulici, M.3    Moll, J.4
  • 17
    • 0029060391 scopus 로고
    • Protein kinase C and lipid signaling for sustained cellular responses
    • Nishizuka Y (1995) Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 9(7):484-496.
    • (1995) FASEB J , vol.9 , Issue.7 , pp. 484-496
    • Nishizuka, Y.1
  • 18
    • 0027178468 scopus 로고
    • Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein
    • Wu D, Katz A, Simon MI (1993) Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein. Proc Natl Acad Sci USA 90(11): 5297-5301.
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.11 , pp. 5297-5301
    • Wu, D.1    Katz, A.2    Simon, M.I.3
  • 19
    • 67349190509 scopus 로고    scopus 로고
    • Phosphatidic acid regulates signal output by G protein coupled receptors through direct interaction with phospholipase C-beta(1)
    • Litosch I, Pujari R, Lee SJ (2009) Phosphatidic acid regulates signal output by G protein coupled receptors through direct interaction with phospholipase C-beta(1). Cell Signal 21(9):1379-1384.
    • (2009) Cell Signal , vol.21 , Issue.9 , pp. 1379-1384
    • Litosch, I.1    Pujari, R.2    Lee, S.J.3
  • 20
    • 0032559830 scopus 로고    scopus 로고
    • Role of cytoplasmic tail of the type 1A angiotensin II receptor in agonist- and phorbol ester-induced desensitization
    • Tang H, Guo DF, Porter JP, Wanaka Y, Inagami T (1998) Role of cytoplasmic tail of the type 1A angiotensin II receptor in agonist- and phorbol ester-induced desensitization. Circ Res 82(5):523-531.
    • (1998) Circ Res , vol.82 , Issue.5 , pp. 523-531
    • Tang, H.1    Guo, D.F.2    Porter, J.P.3    Wanaka, Y.4    Inagami, T.5
  • 21
    • 0030699386 scopus 로고    scopus 로고
    • Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor
    • Diviani D, Lattion AL, Cotecchia S (1997) Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor. J Biol Chem 272(45):28712-28719.
    • (1997) J Biol Chem , vol.272 , Issue.45 , pp. 28712-28719
    • Diviani, D.1    Lattion, A.L.2    Cotecchia, S.3
  • 22
    • 0031817517 scopus 로고    scopus 로고
    • Phosphorylation and functional desensitization of the alpha2Aadrenergic receptor by protein kinase C
    • Liang M, et al. (1998) Phosphorylation and functional desensitization of the alpha2Aadrenergic receptor by protein kinase C. Mol Pharmacol 54(1):44-49.
    • (1998) Mol Pharmacol , vol.54 , Issue.1 , pp. 44-49
    • Liang, M.1
  • 23
    • 0030809962 scopus 로고    scopus 로고
    • Turning off the signal: Mechanisms that attenuate signaling byGprotein-coupled receptors
    • Grady EF, Böhm SK, Bunnett NW (1997) Turning off the signal: Mechanisms that attenuate signaling byGprotein-coupled receptors.AmJ Physiol 273(3 Pt 1):G586-G601.
    • (1997) AmJ Physiol , vol.273 , Issue.3 PART. 1
    • Grady, E.F.1    Böhm, S.K.2    Bunnett, N.W.3
  • 24
    • 77953798290 scopus 로고    scopus 로고
    • Heterotrimeric G protein signaling outside the realm of seven transmembrane domain receptors
    • Marty C, Ye RD (2010) Heterotrimeric G protein signaling outside the realm of seven transmembrane domain receptors. Mol Pharmacol 78(1):12-18.
    • (2010) Mol Pharmacol , vol.78 , Issue.1 , pp. 12-18
    • Marty, C.1    Ye, R.D.2
  • 25
    • 80051486142 scopus 로고    scopus 로고
    • G protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs
    • Garcia-Marcos M, Kietrsunthorn PS, Wang H, Ghosh P, Farquhar MG (2011) G protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs. J Biol Chem 286(32):28138-28149.
    • (2011) J Biol Chem , vol.286 , Issue.32 , pp. 28138-28149
    • Garcia-Marcos, M.1    Kietrsunthorn, P.S.2    Wang, H.3    Ghosh, P.4    Farquhar, M.G.5
  • 26
    • 80052774779 scopus 로고    scopus 로고
    • Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway
    • Mittal Y, Pavlova Y, Garcia-Marcos M, Ghosh P (2011) Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway. J Biol Chem 286(37):32404-32415.
    • (2011) J Biol Chem , vol.286 , Issue.37 , pp. 32404-32415
    • Mittal, Y.1    Pavlova, Y.2    Garcia-Marcos, M.3    Ghosh, P.4
  • 27
    • 34548461710 scopus 로고    scopus 로고
    • Rapid T cell receptor-mediated SHP-1 S591 phosphorylation regulates SHP-1 cellular localization and phosphatase activity
    • Liu Y, Kruhlak MJ, Hao JJ, Shaw S (2007) Rapid T cell receptor-mediated SHP-1 S591 phosphorylation regulates SHP-1 cellular localization and phosphatase activity. J Leukoc Biol 82(3):742-751.
    • (2007) J Leukoc Biol , vol.82 , Issue.3 , pp. 742-751
    • Liu, Y.1    Kruhlak, M.J.2    Hao, J.J.3    Shaw, S.4
  • 28
    • 0035943657 scopus 로고    scopus 로고
    • Complex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation cascade in Jurkat T cells
    • Bauer B, et al. (2001) Complex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation cascade in Jurkat T cells. J Biol Chem 276(34):31627-31634.
    • (2001) J Biol Chem , vol.276 , Issue.34 , pp. 31627-31634
    • Bauer, B.1
  • 29
    • 2442502621 scopus 로고    scopus 로고
    • Akt mediates insulin-stimulated phosphorylation of Ndrg2: Evidence for cross-talk with protein kinase C theta
    • Burchfield JG, et al. (2004) Akt mediates insulin-stimulated phosphorylation of Ndrg2: Evidence for cross-talk with protein kinase C theta. J Biol Chem 279(18):18623-18632.
    • (2004) J Biol Chem , vol.279 , Issue.18 , pp. 18623-18632
    • Burchfield, J.G.1
  • 30
    • 8544233570 scopus 로고    scopus 로고
    • Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)
    • Li Y, et al. (2004) Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). J Biol Chem 279(44):45304-45307.
    • (2004) J Biol Chem , vol.279 , Issue.44 , pp. 45304-45307
    • Li, Y.1
  • 31
    • 0027418818 scopus 로고
    • Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells
    • Baier G, et al. (1993) Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. J Biol Chem 268(7):4997-5004.
    • (1993) J Biol Chem , vol.268 , Issue.7 , pp. 4997-5004
    • Baier, G.1
  • 32
    • 21744435268 scopus 로고    scopus 로고
    • Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange
    • Johnston CA, et al. (2005) Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange. Structure 13(7):1069-1080.
    • (2005) Structure , vol.13 , Issue.7 , pp. 1069-1080
    • Johnston, C.A.1
  • 33
    • 20444472383 scopus 로고    scopus 로고
    • Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles
    • Le-Niculescu H, Niesman I, Fischer T, De Vries L, Farquhar MG (2005) Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles. J Biol Chem 280(23):22012-22020.
    • (2005) J Biol Chem , vol.280 , Issue.23 , pp. 22012-22020
    • Le-Niculescu, H.1    Niesman, I.2    Fischer, T.3    De Vries, L.4    Farquhar, M.G.5


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