The actin-binding protein girdin and its akt-mediated phosphorylation regulate neointima formation after vascular injury

Circulation Research

Volumn 108, Issue 10, 2011, Pages 1170-1179

  Miyake, Hiroshi ^a   Maeda, Kengo ^a   Asai, Naoya ^a   Shibata, Rei ^a   Ichimiya, Hitoshi ^a   Isotani Sakakibara, Mayu ^a,b   Yamamura, Yumiko ^a   Kato, Katsuhiro ^a   Enomoto, Atsushi ^a   Takahashi, Masahide ^a   Murohara, Toyoaki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

Author keywords

Akt; Girdin; neointima; vascular remodeling; vascular smooth muscle

Indexed keywords

ACTIN BINDING PROTEIN; ADENOVIRUS VECTOR; GIRDIN; PROTEIN KINASE B; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL INJURY; CAROTID ARTERY; CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSKELETON; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; NEOINTIMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; RNA INTERFERENCE; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; CAROTID ARTERY INJURIES; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; FEMORAL ARTERY; GENE KNOCK-IN TECHNIQUES; HUMANS; MICE; MICE, INBRED C57BL; MICROFILAMENT PROTEINS; MODELS, ANIMAL; MUSCLE, SMOOTH, VASCULAR; NEOINTIMA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION; VESICULAR TRANSPORT PROTEINS;

EID: 79957487934     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.236174     Document Type: Article

References (29)

1. Costa MA, Simon DI. Molecular basis of restenosis and drug-eluting stents. Circulation. 2005;111:2257-2273. (Pubitemid 40632443)
2. Mitra AK, Agrawal DK. In stent restenosis: bane of the stent era. J Clin Pathol. 2006;59:232-239. (Pubitemid 43344881)
3. Luscher TF, Steffel J, Eberli FR, Joner M, Nakazawa G, Tanner FC, Virmani R. Drug-eluting stent and coronary thrombosis: biological mechanisms and clinical implications. Circulation. 2007;115: 1051-1058. (Pubitemid 46328299)
4. Brazil DP, Park J, Hemmings BA. PKB binding proteins. Getting in on the Akt. Cell. 2002;111:293-303. (Pubitemid 35341386)
5. Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three AKTs. Genes Dev. 1999;13:2905-2927.
6. Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase Akt pathway in human cancer. Nat Rev Cancer. 2002;2:489-501. (Pubitemid 37328931)
7. Stabile E, Zhou YF, Saji M, Castagna M, Shou M, Kinnaird TD, Baffour R, Ringel MD, Epstein SE, Fuchs S. Akt controls vascular smooth muscle cell proliferation in vitro and in vivo by delaying G1/S exit. Circ Res. 2003;93:1059-1065. (Pubitemid 37485036)
8. Shigematsu K, Koyama H, Olson NE, Cho A, Reidy MA. Phosphatidylinositol 3-kinase signaling is important for smooth muscle cell replication after arterial injury. Arterioscler Thromb Vasc Biol. 2000; 20:2373-2378.
9. Lee HY, Chung JW, Youn SW, Kim JY, Park KW, Koo BK, Oh BH, Park YB, Chaqour B, Walsh K, Kim HS. Forkhead transcription factor FOXO3A is a negative regulator of angiogenic immediate early gene Cyr61, leading to inhibition of vascular smooth muscle cell proliferation and neointimal hyperplasia. Circ Res. 2007;100:372-380.
10. Park KW, Yang HM, Youn SW, Yang HJ, Chae IH, Oh BH, Lee MM, Park YB, Choi YS, Kim HS, Walsh K. Constitutively active glycogen synthase kinase-3beta gene transfer sustains apoptosis, inhibits proliferation of vascular smooth muscle cells, and reduces neointima formation after balloon injury in rats. Arterioscler Thromb Vasc Biol. 2003;23: 1364-1369. (Pubitemid 36994523)
11. Huang J, Niu XL, Pippen AM, Annex BH, Kontos CD. Adenovirusmediated intraarterial delivery of PTEN inhibits neointimal hyperplasia. Arterioscler Thromb Vasc Biol. 2005;25:354-358. (Pubitemid 40189157)
12. Enomoto A, Murakami H, Asai N, Morone N, Watanabe T, Kawai K, Murakumo Y, Usukura J, Kaibuchi K, Takahashi M. Akt/PKB regulates actin organization and cell motility via girdin/APE. Dev Cell. 2005;9: 389-402. (Pubitemid 41235808)
13. Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, Ono H, Fujishiro M, Fukushima Y, Horike N, Viana A, Kikuchi M, Noguchi N, Takahashi S, Takata K, Oka Y, Uchijima Y, Kurihara H, Asano T. A novel protein kinase B (PKB)/Akt-binding protein enhances PKB kinase activity and regulates DNA synthesis. J Biol Chem. 2005;280: 18525-18535. (Pubitemid 41389103)
14. Le-Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar MG. Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles. J Biol Chem. 2005;280:22012-22020. (Pubitemid 40827855)
15. Kitamura T, Asai N, Enomoto A, Maeda K, Kato T, Ishida M, Jiang P, Watanabe T, Usukura J, Kondo T, Costantini F, Murohara T, Takahashi M. Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate girdin. Nat Cell Biol. 2008;10:329-337. (Pubitemid 351331020)
16. Garcia-Marcos M, Ghosh P, Farquhar MG. GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling. Proc Natl Acad Sci USA. 2009;106:3178-3183.
17. Sandirasegarane L, Charles R, Bourbon N, Kester M. No regulates pdgf-induced activation of PKB but not ERK in A7r5 cells: implications for vascular growth arrest. Am J Physiol Cell Physiol. 2000; 279:C225-C235. (Pubitemid 30616637)
18. Takahashi T, Taniguchi T, Konishi H, Kikkawa U, Ishikawa Y, Yokoyama M. Activation of Akt/protein kinase B after stimulation with angiotensin II in vascular smooth muscle cells. Am J Physiol. 1999;276: H1927-H1934. (Pubitemid 29323476)
19. Ghosh P, Garcia-Marcos M, Bornheimer SJ, Farquhar MG. Activation of G alphai3 triggers cell migration via regulation of GIV. J Cell Biol. 2008;182:381-393.
20. Asahara T, Bauters C, Pastore C, Kearney M, Rossow S, Bunting S, Ferrara N, Symes JF, Isner JM. Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery. Circulation. 1995;91: 2793-2801.
21. Clowes AW, Reidy MA, Clowes MM. Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium. Lab Invest. 1983;49:327-333. (Pubitemid 13012062)
22. Clowes AW, Schwartz SM. Significance of quiescent smooth muscle migration in the injured rat carotid artery. Circ Res. 1985;56:139-145. (Pubitemid 15130249)
23. Bochaton-Piallat ML, Gabbiani F, Redard M, Desmouliere A, Gabbiani G. Apoptosis participates in cellularity regulation during rat aortic intimal thickening. Am J Pathol. 1995;146:1059-1064.
24. Gallo R, Padurean A, Jayaraman T, Marx S, Roque M, Adelman S, Chesebro J, Fallon J, Fuster V, Marks A, Badimon JJ. Inhibition of intimal thickening after balloon angioplasty in porcine coronary arteries by targeting regulators of the cell cycle. Circulation. 1999; 99:2164-2170. (Pubitemid 29196802)
25. Fang S, Sharma RV, Bhalla RC. Enhanced recovery of injury-caused downregulation of paxillin protein by eNOS gene expression in rat carotid artery. Mechanism of no inhibition of intimal hyperplasia? Arterioscler Thromb Vasc Biol. 1999;19:147-152. (Pubitemid 29031923)
26. Clowes AW, Reidy MA, Clowes MM. Mechanisms of stenosis after arterial injury. Lab Invest. 1983;49:208-215. (Pubitemid 13039947)
27. Enomoto A, Asai N, Namba T, Wang Y, Kato T, Tanaka M, Tatsumi H, Taya S, Tsuboi D, Kuroda K, Kaneko N, Sawamoto K, Miyamoto R, Jijiwa M, Murakumo Y, Sokabe M, Seki T, Kaibuchi K, Takahashi M. Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus. Neuron. 2009;63: 774-787.
28. Shibata R, Kai H, Seki Y, Kato S, Morimatsu M, Kaibuchi K, Imaizumi T. Role of Rho-associated kinase in neointima formation after vascular injury. Circulation. 2001;103:284-289. (Pubitemid 32095416)
29. Jiang P, Enomoto A, Jijiwa M, Kato T, Hasegawa T, Ishida M, Sato T, Asai N, Murakumo Y, Takahashi M. An actin-binding protein girdin regulates the motility of breast cancer cells. Cancer Res. 2008;68:1310-1318. (Pubitemid 351346837)