Brca1 is expressed in human microglia and is dysregulated in human and animal model of ALS

Molecular Neurodegeneration

Volumn 10, Issue 1, 2015, Pages

  Noristani, Harun Najib ^a   Sabourin, Jean Charles ^b   Gerber, Yannick Nicolas ^a,b   Teigell, Marisa ^a   Sommacal, Andreas ^c   Vivanco, Maria D M ^d   Weber, Markus ^c   Perrin, Florence Evelyne ^a,b,e  

^a INSERM   (France)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^c CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^d CIC BIOGUNE   (Spain)

^e UNIV MONTPELLIER   (France)

Author keywords

ALS patients; Brca1; hSOD1^{G93A< sup> mice; Microglia; Transcriptomics}

Indexed keywords

BRCA1 PROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; INTERLEUKIN 1BETA; PROTEIN P120; PROTEIN P90; BRCA1 PROTEIN, HUMAN; BRCA1 PROTEIN, MOUSE; NERVE PROTEIN; RECOMBINANT PROTEIN; SOD1 PROTEIN, HUMAN; SOD1 PROTEIN, MOUSE; SUPEROXIDE DISMUTASE; TRANSCRIPTOME; TUMOR SUPPRESSOR PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANGIOGENESIS; ANIMAL CELL; ARTICLE; CANCER INHIBITION; CHEMOTAXIS; CONTROLLED STUDY; DISEASE COURSE; DNA REPAIR; DOWN REGULATION; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; MICROARRAY ANALYSIS; MICROGLIA; MOLECULAR INTERACTION; MOTONEURON; NERVE DEGENERATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROCESSING; QUANTITATIVE ANALYSIS; RNA EXTRACTION; TRANSCRIPTOMICS; UPREGULATION; AGE; ANIMAL; BIOSYNTHESIS; CYTOLOGY; DISEASE MODEL; DNA DAMAGE; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORK; GENETICS; GLIOSIS; METABOLISM; MISSENSE MUTATION; MOUSE; PATHOLOGY; PHYSIOLOGY; POINT MUTATION; SPINAL CORD; TRANSGENIC MOUSE;

ANIMALIA; MUS;

AGE FACTORS; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BRCA1 PROTEIN; DISEASE MODELS, ANIMAL; DNA DAMAGE; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORKS; GLIOSIS; HUMANS; MICE; MICE, TRANSGENIC; MICROGLIA; MOTOR NEURONS; MUTATION, MISSENSE; NERVE TISSUE PROTEINS; POINT MUTATION; RECOMBINANT PROTEINS; SPINAL CORD; SUPEROXIDE DISMUTASE; SUPEROXIDE DISMUTASE-1; TRANSCRIPTOME; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 84938313541     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/s13024-015-0023-x     Document Type: Article

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