Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 21, 2014, Pages 7683-7688

  Wang, Pan ^a   Han, Limin ^a   Shen, Hong ^a   Wang, Pengfeng ^a   Lv, Cuicui ^a   Zhao, Ganye ^a   Niu, Jing ^b   Xue, Lixiang ^a   Wang, Qiming Jane ^c   Tong, Tanjun ^a   Chen, Jun ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE; PROTEIN KINASE D1; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL TRANSFORMATION; CHROMATIN IMMUNOPRECIPITATION; ENZYME ACTIVATION; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE;

ANIMALS; CELL AGING; CHROMATIN IMMUNOPRECIPITATION; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOBLOTTING; MICE; MICE, INBRED NOD; PROTEIN KINASE C; PROTEIN KINASE C-DELTA; RAS PROTEINS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84901649819     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1310972111     Document Type: Article

References (43)

1. Kuilman T, Michaloglou C, Mooi WJ, Peeper DS (2010) The essence of senescence. Genes Dev 24(22):2463-2479.
2. Collado M, Serrano M (2010) Senescence in tumours: Evidence from mice and humans. Nat Rev Cancer 10(1):51-57.
3. Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88(5):593-602. (Pubitemid 27152402)
4. Lee AC, et al. (1999) Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J Biol Chem 274(12):7936-7940.
5. Wu C, Miloslavskaya I, Demontis S, Maestro R, Galaktionov K (2004) Regulation of cellular response to oncogenic and oxidative stress by Seladin-1. Nature 432(7017): 640-645. (Pubitemid 39626272)
6. Takahashi A, et al. (2006) Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat Cell Biol 8(11):1291-1297. (Pubitemid 44660595)
7. Moiseeva O, Bourdeau V, Roux A, Deschênes-Simard X, Ferbeyre G (2009) Mito-chondrial dysfunction contributes to oncogene-induced senescence. Mol Cell Biol 29(16):4495-4507.
8. Roy N, et al. (2010) DDB2, an essential mediator of premature senescence. Mol Cell Biol 30(11):2681-2692.
9. Freund A, Orjalo AV, Desprez PY, Campisi J (2010) Inflammatory networks during cellular senescence: Causes and consequences. Trends Mol Med 16(5):238-246.
10. Rodier F, Campisi J (2011) Four faces of cellular senescence. J Cell Biol 192(4):547-556.
11. Acosta JC, et al. (2008) Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 133(6):1006-1018. (Pubitemid 351795610)
12. Kuilman T, et al. (2008) Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 133(6):1019-1031. (Pubitemid 351787746)
13. Kang TW, et al. (2011) Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 479(7374):547-551.
14. Krizhanovsky V, et al. (2008) Senescence of activated stellate cells limits liver fibrosis. Cell 134(4):657-667.
15. Campisi J (2013) Aging, cellular senescence, and cancer. Annu Rev Physiol 75:685-705.
16. Rodier F, et al. (2009) Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol 11(8):973-979.
17. Freund A, Patil CK, Campisi J (2011) p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J 30(8):1536-1548.
18. Orjalo AV, Bhaumik D, Gengler BK, Scott GK, Campisi J (2009) Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. Proc Natl Acad Sci USA 106(40):17031-17036.
19. Bhaumik D, et al. (2009) MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany, NY Online) 1(4): 402-411.
20. Liu F, Wu S, Ren H, Gu J (2011) Klotho suppresses RIG-I-mediated senescence-associated inflammation. Nat Cell Biol 13(3):254-262.
21. Franceschi C, et al. (2007) Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 128(1):92-105. (Pubitemid 46073065)
22. Zhou R, Yazdi AS, Menu P, Tschopp J (2011) A role for mitochondria in NLRP3 in-flammasome activation. Nature 469(7329):221-225.
23. Fu Y, Rubin CS (2011) Protein kinase D: Coupling extracellular stimuli to the regulation of cell physiology. EMBO Rep 12(8):785-796.
24. Rozengurt E (2011) Protein kinase D signaling: Multiple biological functions in health and disease. Physiology (Bethesda) 26(1):23-33.
25. Storz P, Toker A (2003) Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway. EMBO J 22(1):109-120. (Pubitemid 36091274)
26. Storz P, Döppler H, Toker A (2005) Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species. Mol Cell Biol 25(19):8520-8530. (Pubitemid 41369173)
27. Young AR, et al. (2009) Autophagy mediates the mitotic senescence transition. Genes Dev 23(7):798-803.
28. Zugaza JL, Sinnett-Smith J, Van Lint J, Rozengurt E (1996) Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway. EMBO J 15(22):6220-6230. (Pubitemid 26397895)
29. Waldron RT, Rozengurt E (2003) Protein kinase C phosphorylates protein kinase D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin ho-mology domain. J Biol Chem 278(1):154-163. (Pubitemid 36043557)
30. Storz P, Döppler H, Toker A (2004) Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling. Mol Cell Biol 24(7):2614-2626. (Pubitemid 38381256)
31. Gschwendt M, et al. (1996) Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett 392(2):77-80. (Pubitemid 26276722)
32. Lin AW, et al. (1998) Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev 12(19):3008-3019. (Pubitemid 28469303)
33. Wang Y, et al. (2002) The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins. Mol Cell Biol 22(3):916-926. (Pubitemid 34053068)
34. Eiseler T, Döppler H, Yan IK, Goodison S, Storz P (2009) Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion. Breast Cancer Res 11(1):R13.
35. Seger YR, et al. (2002) Transformation of normal human cells in the absence of te-lomerase activation. Cancer Cell 2(5):401-413. (Pubitemid 41039106)
36. Passos JF, et al. (2010) Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol Syst Biol 6:347.
37. Finkel T (2003) Oxidant signals and oxidative stress. Curr Opin Cell Biol 15(2):247-254. (Pubitemid 36332201)
38. Guha S, Tanasanvimon S, Sinnett-Smith J, Rozengurt E (2010) Role of protein kinase D signaling in pancreatic cancer. Biochem Pharmacol 80(12):1946-1954.
39. LaValle CR, et al. (2010) Protein kinase D as a potential new target for cancer therapy. Biochim Biophys Acta 1806(2):183-192.
40. Shabelnik MY, et al. (2011) Differential expression of PKD1 and PKD2 in gastric cancer and analysis of PKD1 and PKD2 function in the model system. Exp Oncol 33(4): 206-211.
41. Kim M, et al. (2008) Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion. Carcinogenesis 29(3):629-637. (Pubitemid 351404881)
42. Collado M, Blasco MA, Serrano M (2007) Cellular senescence in cancer and aging. Cell 130(2):223-233. (Pubitemid 47081143)
43. Gruber J, Schaffer S, Halliwell B (2008) The mitochondrial free radical theory of ageing-where do we stand? Front Biosci 13:6554-6579.