TAT-ODD-p53 enhances the radiosensitivity of hypoxic breast cancer cells by inhibiting Parkin-mediated mitophagy

Oncotarget

Volumn 6, Issue 19, 2015, Pages 17417-17429

  Zheng, Rong ^a   Yao, Qiwei ^a   Xie, Guozhu ^a   Du, Shasha ^a   Ren, Chen ^a   Wang, Yuxia ^b   Yuan, Yawei ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

Mitophagy; p53; Parkin; Radiosensitivity

Indexed keywords

HYBRID PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PARKIN; PROTEIN P53; TAT ODD P53 FUSION PROTEIN; UNCLASSIFIED DRUG; HIF1A PROTEIN, HUMAN; SMALL INTERFERING RNA; TRANSACTIVATOR PROTEIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BREAST CANCER; CANCER RADIOTHERAPY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MITOCHONDRION; MITOPHAGY; MOLECULAR DYNAMICS; NONHUMAN; OXYGEN TENSION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TRANSPORT; RADIOSENSITIVITY; RADIOSENSITIZATION; ANIMAL; BREAST TUMOR; CELL HYPOXIA; CONFOCAL MICROSCOPY; DRUG EFFECTS; DRUG SCREENING; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MCF-7 CELL LINE; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PROTEIN TERTIARY STRUCTURE; RADIATION TOLERANCE; RNA INTERFERENCE; TUMOR CELL LINE; TUNEL ASSAY; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL HYPOXIA; CELL LINE, TUMOR; FEMALE; FLOW CYTOMETRY; GENE PRODUCTS, TAT; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN SITU NICK-END LABELING; MCF-7 CELLS; MICE; MICROSCOPY, CONFOCAL; MITOCHONDRIAL DEGRADATION; POLYMERASE CHAIN REACTION; PROTEIN STRUCTURE, TERTIARY; RADIATION TOLERANCE; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84938255743     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4002     Document Type: Article

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