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Volumn 2015, Issue , 2015, Pages

Ghrelin's Effects on Proinflammatory Cytokine Mediated Apoptosis and Their Impact on β-Cell Functionality

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; CASPASE 9; GAMMA INTERFERON; GHRELIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BCL 2; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA;

EID: 84938153187     PISSN: 16878337     EISSN: 16878345     Source Type: Journal    
DOI: 10.1155/2015/235727     Document Type: Article
Times cited : (8)

References (45)
  • 1
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa, "Ghrelin is a growth-hormone-releasing acylated peptide from stomach, " Nature, vol. 402, no. 6762, pp. 656-660, 1999.
    • (1999) Nature , vol.402 , Issue.6762 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 2
    • 1542343913 scopus 로고    scopus 로고
    • Ghrelin, appetite, and gastric motility: The emerging role of the stomach as an endocrine organ
    • A. Inui, A. Asakawa, C. Y. Bowers et al., "Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ, " The FASEB Journal, vol. 18, no. 3, pp. 439-456, 2004.
    • (2004) The FASEB Journal , vol.18 , Issue.3 , pp. 439-456
    • Inui, A.1    Asakawa, A.2    Bowers, C.Y.3
  • 4
    • 0016261369 scopus 로고
    • Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies
    • G. Bottazzo, A. Florin-Christensen, and D. Doniach, "ISLET-CELL ANTIBODIES IN DIABETES MELLITUS WITH AUTOIMMUNE POLYENDOCRINE DEFICIENCIES, " The Lancet, vol. 304, no. 7892, pp. 1279-1283, 1974.
    • (1974) The Lancet , vol.304 , Issue.7892 , pp. 1279-1283
    • Bottazzo, G.1    Florin-Christensen, A.2    Doniach, D.3
  • 5
    • 0016404198 scopus 로고
    • Antibodies to pancreatic islet cells in insulin-dependent diabetics with coexistent autoimmune disease
    • A. C. Maccuish, W. J. Irvine, E. W. Barnes, and L. J. P. Duncan, "Antibodies to pancreatic islet cells in insulin-dependent diabetics with coexistent autoimmune disease, " The Lancet, vol. 304, no. 7896, pp. 1529-1531, 1974.
    • (1974) The Lancet , vol.304 , Issue.7896 , pp. 1529-1531
    • Maccuish, A.C.1    Irvine, W.J.2    Barnes, E.W.3    Duncan, L.J.P.4
  • 6
    • 67649364114 scopus 로고    scopus 로고
    • The role of infammation in insulitis and beta-cell loss in type 1 diabetes
    • D. L. Eizirik, M. L. Colli, and F. Ortis, "The role of infammation in insulitis and beta-cell loss in type 1 diabetes, " Nature Reviews Endocrinology, vol. 5, no. 4, pp. 219-226, 2009.
    • (2009) Nature Reviews Endocrinology , vol.5 , Issue.4 , pp. 219-226
    • Eizirik, D.L.1    Colli, M.L.2    Ortis, F.3
  • 7
    • 0036266124 scopus 로고    scopus 로고
    • CFLIP protein prevents tumor necrosis factor-β-mediated induction of caspase-8-dependent apoptosis in insulin-secreting Tc-Tet cells
    • S. Cottet, P. Dupraz, F. Hamburger, W. Dolci, M. Jaquet, and B. Torens, "cFLIP protein prevents tumor necrosis factor-β-mediated induction of caspase-8-dependent apoptosis in insulin-secreting Tc-Tet cells, " Diabetes, vol. 51, no. 6, pp. 1805-1814, 2002.
    • (2002) Diabetes , vol.51 , Issue.6 , pp. 1805-1814
    • Cottet, S.1    Dupraz, P.2    Hamburger, F.3    Dolci, W.4    Jaquet, M.5    Torens, B.6
  • 8
    • 68049143316 scopus 로고    scopus 로고
    • Proinfamma-tory cytokines activate the intrinsic apoptotic pathway in β-cells
    • L. G. Grunnet, R. Aikin, M. F. Tonnesen et al., "Proinfamma-tory cytokines activate the intrinsic apoptotic pathway in β-cells, " Diabetes, vol. 58, no. 8, pp. 1807-1815, 2009.
    • (2009) Diabetes , vol.58 , Issue.8 , pp. 1807-1815
    • Grunnet, L.G.1    Aikin, R.2    Tonnesen, M.F.3
  • 9
    • 79952708318 scopus 로고    scopus 로고
    • Caspase-8 and bid: Caught in the act between death receptors and mitochondria
    • C. Kantari and H. Walczak, "Caspase-8 and bid: caught in the act between death receptors and mitochondria, " Biochimica et Biophysica Acta, vol. 1813, no. 4, pp. 558-563, 2011.
    • (2011) Biochimica et Biophysica Acta , vol.1813 , Issue.4 , pp. 558-563
    • Kantari, C.1    Walczak, H.2
  • 10
    • 58149337392 scopus 로고    scopus 로고
    • Cytokine-induced/3-cell death is independent of endoplasmic reticulum stress signaling
    • M. C. Akerfieldt, J. Howes, J. Y. Chan et al., "Cytokine-induced/3-cell death is independent of endoplasmic reticulum stress signaling, " Diabetes, vol. 57, no. 11, pp. 3034-3044, 2008.
    • (2008) Diabetes , vol.57 , Issue.11 , pp. 3034-3044
    • Akerfieldt, M.C.1    Howes, J.2    Chan, J.Y.3
  • 11
    • 84885038142 scopus 로고    scopus 로고
    • Mechanisms of toxicity by proinfammatory cytokines in a novel human pancreatic beta cell line, 1.1B4
    • S. Vasu, N. H. McClenaghan, J. T. McCluskey, and P. R. Flatt, "Mechanisms of toxicity by proinfammatory cytokines in a novel human pancreatic beta cell line, 1.1B4, " Biochimica et Biophysica Acta-General Subjects, vol. 1840, no. 1, pp. 136-145, 2014.
    • (2014) Biochimica et Biophysica Acta-General Subjects , vol.1840 , Issue.1 , pp. 136-145
    • Vasu, S.1    McClenaghan, N.H.2    McCluskey, J.T.3    Flatt, P.R.4
  • 12
    • 33644749322 scopus 로고    scopus 로고
    • Mechanisms of pancreatic/3-cell death in type 1 and type 2 diabetes: Many diferences, few similarities
    • M. Cnop, N. Welsh, J.-C. Jonas, A. Jorns, S. Lenzen, and D. L. Eizirik, "Mechanisms of pancreatic/3-cell death in type 1 and type 2 diabetes: many diferences, few similarities, " Diabetes, vol. 54, supplement 2, pp. S97-S107, 2005.
    • (2005) Diabetes , vol.54 , pp. S97-S107
    • Cnop, M.1    Welsh, N.2    Jonas, J.-C.3    Jorns, A.4    Lenzen, S.5    Eizirik, D.L.6
  • 13
    • 9244231766 scopus 로고    scopus 로고
    • Free fatty acids and cytokines induce pancreatic/3-cell apoptosis by diferent mechanisms: Role of nuclear factor-/cB and endoplasmic reticulum stress
    • I. Kharroubi, L. Ladriere, A. K. Cardozo, Z. Dogusan, M. Cnop, and D. L. Eizirik, "Free fatty acids and cytokines induce pancreatic/3-cell apoptosis by diferent mechanisms: role of nuclear factor-/cB and endoplasmic reticulum stress, " Endocrinology, vol. 145, no. 11, pp. 5087-5096, 2004.
    • (2004) Endocrinology , vol.145 , Issue.11 , pp. 5087-5096
    • Kharroubi, I.1    Ladriere, L.2    Cardozo, A.K.3    Dogusan, Z.4    Cnop, M.5    Eizirik, D.L.6
  • 14
    • 19944432792 scopus 로고    scopus 로고
    • Cytokines downreg-ulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic/3-cells
    • A. K. Cardozo, F. Ortis, J. Storling et al., "Cytokines downreg-ulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic/3-cells, " Diabetes, vol. 54, no. 2, pp. 452-461, 2005.
    • (2005) Diabetes , vol.54 , Issue.2 , pp. 452-461
    • Cardozo, A.K.1    Ortis, F.2    Storling, J.3
  • 15
    • 78650518771 scopus 로고    scopus 로고
    • Modulation of Bcl-2-related protein expression in pancreatic beta cells by proinfammatory cytokines and its dependence on the antioxida-tive defense status
    • I. Mehmeti, S. Lenzen, and S. Lortz, "Modulation of Bcl-2-related protein expression in pancreatic beta cells by proinfammatory cytokines and its dependence on the antioxida-tive defense status, " Molecular and Cellular Endocrinology, vol. 332, no. 1-2, pp. 88-96, 2011.
    • (2011) Molecular and Cellular Endocrinology , vol.332 , Issue.1-2 , pp. 88-96
    • Mehmeti, I.1    Lenzen, S.2    Lortz, S.3
  • 16
    • 0242363618 scopus 로고    scopus 로고
    • Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells
    • B. Kutlu, A. K. Cardozo, M. I. Darville et al., "Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells, " Diabetes, vol. 52, no. 11, pp. 2701-2719, 2003.
    • (2003) Diabetes , vol.52 , Issue.11 , pp. 2701-2719
    • Kutlu, B.1    Cardozo, A.K.2    Darville, M.I.3
  • 17
    • 33846435771 scopus 로고    scopus 로고
    • Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic/3-cells and human islets: Involvement of 3, 5-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-kinase/Akt signaling
    • R. Granata, F. Settanni, L. Biancone et al., "Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic/3-cells and human islets: involvement of 3, 5-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-kinase/Akt signaling, " Endocrinology, vol. 148, no. 2, pp. 512-529, 2007
    • (2007) Endocrinology , vol.148 , Issue.2 , pp. 512-529
    • Granata, R.1    Settanni, F.2    Biancone, L.3
  • 18
    • 67349108285 scopus 로고    scopus 로고
    • Exogenous ghrelin enhances endocrine and exocrine regeneration in pancreatec-tomized rats
    • M. Kerem, B. Salman, S. Ozsoy et al., "Exogenous ghrelin enhances endocrine and exocrine regeneration in pancreatec-tomized rats, " Journal of Gastrointestinal Surgery, vol. 13, no. 4, pp. 775-783, 2009.
    • (2009) Journal of Gastrointestinal Surgery , vol.13 , Issue.4 , pp. 775-783
    • Kerem, M.1    Salman, B.2    Ozsoy, S.3
  • 19
    • 33646534187 scopus 로고    scopus 로고
    • Ghrelin prevents development of diabetes at adult age in streptozotocin-treated newborn rats
    • T. Irako, T. Akamizu, H. Hosoda et al., "Ghrelin prevents development of diabetes at adult age in streptozotocin-treated newborn rats, " Diabetologia, vol. 49, no. 6, pp. 1264-1273, 2006.
    • (2006) Diabetologia , vol.49 , Issue.6 , pp. 1264-1273
    • Irako, T.1    Akamizu, T.2    Hosoda, H.3
  • 20
    • 77954749961 scopus 로고    scopus 로고
    • Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats
    • R. Granata, M. Volante, F. Settanni et al., "Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats, " Journal of Molecular Endocrinology, vol. 45, no. 1, pp. 9-17, 2010.
    • (2010) Journal of Molecular Endocrinology , vol.45 , Issue.1 , pp. 9-17
    • Granata, R.1    Volante, M.2    Settanni, F.3
  • 21
    • 84858731418 scopus 로고    scopus 로고
    • Des-acyl ghrelin fragments and analogues promote survival of pancreatic j3-cells and human pancreatic islets and prevent diabetes in streptozotocin-treated rats
    • R. Granata, F. Settanni, M. Julien et al., "Des-acyl ghrelin fragments and analogues promote survival of pancreatic j3-cells and human pancreatic islets and prevent diabetes in streptozotocin-treated rats, " Journal of Medicinal Chemistry, vol. 55, no. 6, pp. 2585-2596, 2012.
    • (2012) Journal of Medicinal Chemistry , vol.55 , Issue.6 , pp. 2585-2596
    • Granata, R.1    Settanni, F.2    Julien, M.3
  • 22
    • 0028900805 scopus 로고
    • Intraislet release of inter-leukin 1 inhibits j3 cell function by inducing j3 cell expression of inducible nitric oxide synthase
    • J. A. Corbett and M. L. McDaniel, "Intraislet release of inter-leukin 1 inhibits j3 cell function by inducing j3 cell expression of inducible nitric oxide synthase, " Journal of Experimental Medicine, vol. 181, no. 2, pp. 559-568, 1995.
    • (1995) Journal of Experimental Medicine , vol.181 , Issue.2 , pp. 559-568
    • Corbett, J.A.1    McDaniel, M.L.2
  • 23
    • 0842291578 scopus 로고    scopus 로고
    • Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells
    • A. Merglen, S. Teander, B. Rubi, G. Chafard, C. B. Wollheim, and P. Maechler, "Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells, " Endocrinology, vol. 145, no. 2, pp. 667-678, 2004.
    • (2004) Endocrinology , vol.145 , Issue.2 , pp. 667-678
    • Merglen, A.1    Teander, S.2    Rubi, B.3    Chafard, G.4    Wollheim, C.B.5    Maechler, P.6
  • 24
    • 48949088649 scopus 로고    scopus 로고
    • Anti-proliferative effect of pro-infammatory cytokines in cultured cells is associated with extracellular signal-regulated kinase 1/2 pathway inhibition: Protective role of glucagon-like peptide-1
    • M. Blandino-Rosano, G. Perez-Arana, J. M. Mellado-Gil, C. Segundo, and M. Aguilar-Diosdado, "Anti-proliferative effect of pro-infammatory cytokines in cultured cells is associated with extracellular signal-regulated kinase 1/2 pathway inhibition: protective role of glucagon-like peptide-1, " Journal of Molecular Endocrinology, vol. 41, no. 1-2, pp. 35-44, 2008.
    • (2008) Journal of Molecular Endocrinology , vol.41 , Issue.1-2 , pp. 35-44
    • Blandino-Rosano, M.1    Perez-Arana, G.2    Mellado-Gil, J.M.3    Segundo, C.4    Aguilar-Diosdado, M.5
  • 25
    • 12344270191 scopus 로고    scopus 로고
    • High glucose potentiates cytokine-and streptozotocin-induced apoptosis of rat islet cells: Effect on apoptosis-related genes
    • J. M. Mellado-Gil and M. Aguilar-Diosdado, "High glucose potentiates cytokine-and streptozotocin-induced apoptosis of rat islet cells: effect on apoptosis-related genes, " Journal of Endocrinology, vol. 183, no. 1, pp. 155-162, 2004.
    • (2004) Journal of Endocrinology , vol.183 , Issue.1 , pp. 155-162
    • Mellado-Gil, J.M.1    Aguilar-Diosdado, M.2
  • 26
    • 0020973549 scopus 로고
    • A subcellular fractionation approach for studying insulin release mechanisms and calcium metabolism in islets of Langerhans
    • M. L. McDaniel, J. R. Colca, N. Kotagal, and P. E. Lacy, "A subcellular fractionation approach for studying insulin release mechanisms and calcium metabolism in islets of Langerhans, " Methods in Enzymology, vol. 98, pp. 182-200, 1983.
    • (1983) Methods in Enzymology , vol.98 , pp. 182-200
    • McDaniel, M.L.1    Colca, J.R.2    Kotagal, N.3    Lacy, P.E.4
  • 27
    • 77949430065 scopus 로고    scopus 로고
    • The Akt/PKB family of protein kinases: A review of small molecule inhibitors and progress towards target validation: A 2009 update
    • C. W. Lindsley, "The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation: a 2009 update, " Current Topics in Medicinal Chemistry, vol. 10, no. 4, pp. 458-477, 2010.
    • (2010) Current Topics in Medicinal Chemistry , vol.10 , Issue.4 , pp. 458-477
    • Lindsley, C.W.1
  • 28
    • 0035029867 scopus 로고    scopus 로고
    • Identifcation of novel cytokine-induced genes in pancreatic β-cells by high-density oligonucleotide arrays
    • A. K. Cardozo, M. Kruhøfer, R. Leeman, T. Ørntof, and D. L. Eizirik, "Identifcation of novel cytokine-induced genes in pancreatic β-cells by high-density oligonucleotide arrays, " Diabetes, vol. 50, no. 5, pp. 909-920, 2001.
    • (2001) Diabetes , vol.50 , Issue.5 , pp. 909-920
    • Cardozo, A.K.1    Kruhøfer, M.2    Leeman, R.3    Ørntof, T.4    Eizirik, D.L.5
  • 29
    • 38349025873 scopus 로고    scopus 로고
    • Proteomics analysis of cytokine-induced dysfunction and death in insulin-producing INS-1E cells: New insights into the pathways involved
    • W. D'Hertog, L. Overbergh, K. Lage et al., "Proteomics analysis of cytokine-induced dysfunction and death in insulin-producing INS-1E cells: new insights into the pathways involved, " Molecular and Cellular Proteomics, vol. 6, no. 12, pp. 2180-2199, 2007.
    • (2007) Molecular and Cellular Proteomics , vol.6 , Issue.12 , pp. 2180-2199
    • D'Hertog, W.1    Overbergh, L.2    Lage, K.3
  • 30
    • 84901026842 scopus 로고    scopus 로고
    • Temporal profling of cytokine-induced genes in pancreatic β-cells by meta-analysis and network inference
    • M. Lopes, B. Kutlu, M. Miani et al., "Temporal profling of cytokine-induced genes in pancreatic β-cells by meta-analysis and network inference, " Genomics, vol. 103, no. 4, pp. 264-275, 2014.
    • (2014) Genomics , vol.103 , Issue.4 , pp. 264-275
    • Lopes, M.1    Kutlu, B.2    Miani, M.3
  • 31
    • 23944479411 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 protects beta cells from cytokine-induced apop-tosis and necrosis: Role of protein kinase B
    • L. Li, W. El-Kholy, C. J. Rhodes, and P. L. Brubaker, "Glucagon-like peptide-1 protects beta cells from cytokine-induced apop-tosis and necrosis: role of protein kinase B, " Diabetologia, vol. 48, no. 7, pp. 1339-1349, 2005.
    • (2005) Diabetologia , vol.48 , Issue.7 , pp. 1339-1349
    • Li, L.1    El-Kholy, W.2    Rhodes, C.J.3    Brubaker, P.L.4
  • 32
    • 34447290269 scopus 로고    scopus 로고
    • Ghrelin inhibit cell apoptosis in pancreatic cell line HIT-T15 via mitogen-activated protein kinase/phosphoinositide 3-kinase pathways
    • Y. Zhang, B. Ying, L. Shi et al., "Ghrelin inhibit cell apoptosis in pancreatic cell line HIT-T15 via mitogen-activated protein kinase/phosphoinositide 3-kinase pathways, " Toxicology, vol. 237, no. 1-3, pp. 194-202, 2007.
    • (2007) Toxicology , vol.237 , Issue.1-3 , pp. 194-202
    • Zhang, Y.1    Ying, B.2    Shi, L.3
  • 33
    • 33746594835 scopus 로고    scopus 로고
    • Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-B activation
    • F. Ortis, A. K. Cardozo, D. Crispim, J. Störling, T. Mandrup-Poulsen, and D. L. Eizirik, "Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-B activation, " Molecular Endocrinology, vol. 20, no. 8, pp. 1867-1879, 2006.
    • (2006) Molecular Endocrinology , vol.20 , Issue.8 , pp. 1867-1879
    • Ortis, F.1    Cardozo, A.K.2    Crispim, D.3    Störling, J.4    Mandrup-Poulsen, T.5    Eizirik, D.L.6
  • 34
    • 26244436171 scopus 로고    scopus 로고
    • Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt
    • J. Størling, J. Binzer, A. K. Andersson et al., "Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt, " Diabetologia, vol. 48, no. 10, pp. 2039-2050, 2005.
    • (2005) Diabetologia , vol.48 , Issue.10 , pp. 2039-2050
    • Størling, J.1    Binzer, J.2    Andersson, A.K.3
  • 35
    • 82255185820 scopus 로고    scopus 로고
    • PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein bim
    • I. Santin, F. Moore, M. L. Colli et al., "PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein bim, " Diabetes, vol. 60, no. 12, pp. 3279-3288, 2011.
    • (2011) Diabetes , vol.60 , Issue.12 , pp. 3279-3288
    • Santin, I.1    Moore, F.2    Colli, M.L.3
  • 36
    • 84856739052 scopus 로고    scopus 로고
    • The transcription factor C/EBP delta has anti-apoptotic and anti-infammatory roles in pancreatic beta cells
    • Article ID e31062
    • F. Moore, I. Santin, T. C. Nogueira et al., "The transcription factor C/EBP delta has anti-apoptotic and anti-infammatory roles in pancreatic beta cells, " PLoS ONE, vol. 7, no. 2, Article ID e31062, 2012.
    • (2012) PLoS ONE , vol.7 , Issue.2
    • Moore, F.1    Santin, I.2    Nogueira, T.C.3
  • 37
    • 77950368247 scopus 로고    scopus 로고
    • Ghrelin inhibits cell apoptosis induced by lipotoxicity in pancreatic β-cell line
    • W. Wang, D. Zhang, H. Zhao et al., "Ghrelin inhibits cell apoptosis induced by lipotoxicity in pancreatic β-cell line, " Regulatory Peptides, vol. 161, no. 1-3, pp. 43-50, 2010.
    • (2010) Regulatory Peptides , vol.161 , Issue.1-3 , pp. 43-50
    • Wang, W.1    Zhang, D.2    Zhao, H.3
  • 38
    • 70349925383 scopus 로고    scopus 로고
    • Ghrelin inhibits the development of acute pancreatitis and nuclear factor kappaB activation in pancreas and liver
    • X. Zhou and C. Xue, "Ghrelin inhibits the development of acute pancreatitis and nuclear factor kappaB activation in pancreas and liver, " Pancreas, vol. 38, no. 7, pp. 752-757, 2009.
    • (2009) Pancreas , vol.38 , Issue.7 , pp. 752-757
    • Zhou, X.1    Xue, C.2
  • 39
    • 84863900963 scopus 로고    scopus 로고
    • New insights into translational regulation in the endoplasmic reticulum unfolded protein response
    • G. D. Pavitt and D. Ron, "New insights into translational regulation in the endoplasmic reticulum unfolded protein response, " Cold Spring Harbor Perspectives in Biology, vol. 4, no. 6, 2012.
    • (2012) Cold Spring Harbor Perspectives in Biology , vol.4 , Issue.6
    • Pavitt, G.D.1    Ron, D.2
  • 40
    • 84856613896 scopus 로고    scopus 로고
    • Transgenic overex-pression of intraislet ghrelin does not afect insulin secretion or glucose metabolism in vivo
    • M. Bando, H. Iwakura, H. Ariyasu et al., "Transgenic overex-pression of intraislet ghrelin does not afect insulin secretion or glucose metabolism in vivo, " The American Journal of Physiology-Endocrinology and Metabolism, vol. 302, no. 4, pp. E403-E408, 2012.
    • (2012) The American Journal of Physiology-Endocrinology and Metabolism , vol.302 , Issue.4 , pp. E403-E408
    • Bando, M.1    Iwakura, H.2    Ariyasu, H.3
  • 41
    • 0035514596 scopus 로고    scopus 로고
    • Ghrelin causes hyperphagia and obesity in rats
    • A. M. Wren, C. J. Small, C. R. Abbott et al., "Ghrelin causes hyperphagia and obesity in rats, " Diabetes, vol. 50, no. 11, pp. 2540-2547, 2001.
    • (2001) Diabetes , vol.50 , Issue.11 , pp. 2540-2547
    • Wren, A.M.1    Small, C.J.2    Abbott, C.R.3
  • 42
    • 43049170316 scopus 로고    scopus 로고
    • Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis
    • K. Dezaki, H. Sone, and T. Yada, "Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis, " Pharmacology and Terapeutics, vol. 118, no. 2, pp. 239-249, 2008.
    • (2008) Pharmacology and Terapeutics , vol.118 , Issue.2 , pp. 239-249
    • Dezaki, K.1    Sone, H.2    Yada, T.3
  • 43
    • 79958016808 scopus 로고    scopus 로고
    • Effect of ghrelin on glucose-insulin homeostasis: Therapeutic implications
    • S. Sangiao-Alvarellos and F. Cordido, "Effect of ghrelin on glucose-insulin homeostasis: therapeutic implications, " International Journal of Peptides, vol. 2010, Article ID 234709, 25 pages, 2010.
    • (2010) International Journal of Peptides , vol.2010
    • Sangiao-Alvarellos, S.1    Cordido, F.2
  • 44
    • 77949534537 scopus 로고    scopus 로고
    • Insulin regimens in type 2 diabetes
    • F. Cordido, "Insulin regimens in type 2 diabetes, " The New England Journal of Medicine, vol. 362, no. 10, p. 960, 2010.
    • (2010) The New England Journal of Medicine , vol.362 , Issue.10 , pp. 960
    • Cordido, F.1
  • 45
    • 84879560047 scopus 로고    scopus 로고
    • Overexpression of intraislet ghrelin enhances β-cell proliferation after strepto-zotocin-induced β-cell injury in mice
    • M. Bando, H. Iwakura, H. Ariyasu et al., "Overexpression of intraislet ghrelin enhances β-cell proliferation after strepto-zotocin-induced β-cell injury in mice, " The American Journal of Physiology-Endocrinology and Metabolism, vol. 305, no. 1, pp. E140-E148, 2013.
    • (2013) The American Journal of Physiology-Endocrinology and Metabolism , vol.305 , Issue.1 , pp. E140-E148
    • Bando, M.1    Iwakura, H.2    Ariyasu, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.