메뉴 건너뛰기




Volumn 26, Issue 1, 2013, Pages 10-21

Bone morphogenetic protein 4 expression in multiple normal and tumor tissues reveals its importance beyond development

Author keywords

Bone morphogenetic protein 4; breast cancer; cancer; immunohistochemistry; normal tissue; protein expression; tissue microarray

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4;

EID: 84871925853     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2012.128     Document Type: Article
Times cited : (45)

References (52)
  • 1
    • 75649127963 scopus 로고    scopus 로고
    • Bone morphogeneticprotein receptors and signal transduction
    • Miyazono K, Kamiya Y, Morikawa M. Bone morphogeneticprotein receptors and signal transduction.J Biochem 2012;147:35-51
    • (2012) J Biochem , vol.147 , pp. 35-51
    • Miyazono, K.1    Kamiya, Y.2    Morikawa, M.3
  • 2
    • 0031105160 scopus 로고    scopus 로고
    • Bone morphogenetic proteins: An unconventional approach to isolation of first mammalian morphogens
    • DOI 10.1016/S1359-6101(96)00049-4, PII S1359610196000494
    • Reddi AH. Bone morphogenetic proteins: an unconventionalapproach to isolation of first mammalianmorphogens. Cytokine Growth Factor Rev 1997;8:11-20 (Pubitemid 27214686)
    • (1997) Cytokine and Growth Factor Reviews , vol.8 , Issue.1 , pp. 11-20
    • Reddi, A.H.1
  • 3
    • 0037250476 scopus 로고    scopus 로고
    • Consequences of knocking out BMP signalingin the mouse
    • Zhao GQ. Consequences of knocking out BMP signalingin the mouse. Genesis 2003;35:43-56
    • (2003) Genesis , vol.35 , pp. 43-56
    • Zhao, G.Q.1
  • 4
    • 0029149656 scopus 로고
    • Bonemorphogenetic protein-4 is required for mesodermformation and patterning in the mouse
    • Winnier G, Blessing M, Labosky PA, et al. Bonemorphogenetic protein-4 is required for mesodermformation and patterning in the mouse. Genes Dev1995;9:2105-2116
    • (1995) Genes Dev , vol.9 , pp. 2105-2116
    • Winnier, G.1    Blessing, M.2    Labosky, P.A.3
  • 5
    • 67349109704 scopus 로고    scopus 로고
    • BMP andBMP receptor expression during murine organogenesis
    • Danesh SM, Villasenor A, Chong D, et al. BMP andBMP receptor expression during murine organogenesis.Gene Expr Patterns 2009;9:255-265
    • (2009) Gene Expr Patterns , vol.9 , pp. 255-265
    • Danesh, S.M.1    Villasenor, A.2    Chong, D.3
  • 6
    • 0029737070 scopus 로고    scopus 로고
    • Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
    • Hogan BL. Bone morphogenetic proteins: multifunctionalregulators of vertebrate development. Genes Dev1996;10:1580-1594 (Pubitemid 26268864)
    • (1996) Genes and Development , vol.10 , Issue.13 , pp. 1580-1594
    • Hogan, B.L.M.1
  • 7
    • 36249018809 scopus 로고    scopus 로고
    • Cooperation of signalling pathways in embryonic mammary gland development
    • DOI 10.1038/nrg2227, PII NRG2227
    • Robinson GW. Cooperation of signalling pathwaysin embryonic mammary gland development. Nat RevGenet 2007;8:963-972 (Pubitemid 350129174)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.12 , pp. 963-972
    • Robinson, G.W.1
  • 8
    • 36448936383 scopus 로고    scopus 로고
    • TGFβ-SMAD signal transduction: Molecular specificity and functional flexibility
    • DOI 10.1038/nrm2297, PII NRM2297
    • Schmierer B, Hill CS. TGFbeta-SMAD signal transduction:molecular specificity and functional flexibility.Nat Rev Mol Cell Biol 2007;8:970-982 (Pubitemid 350174642)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.12 , pp. 970-982
    • Schmierer, B.1    Hill, C.S.2
  • 10
    • 79151473137 scopus 로고    scopus 로고
    • Bonemorphogenetic proteins: A critical review
    • Bragdon B, Moseychuk O, Saldanha S, et al. Bonemorphogenetic proteins: a critical review. Cell Signal2011;23:609-620
    • (2011) Cell Signal , vol.23 , pp. 609-620
    • Bragdon, B.1    Moseychuk, O.2    Saldanha, S.3
  • 11
    • 33750529555 scopus 로고    scopus 로고
    • Potential roles of bone morphogenetic proteins (BMPs) in skeletal repair and regeneration
    • DOI 10.1007/s00774-006-0718-8
    • Nakase T, Yoshikawa H. Potential roles of bonemorphogenetic proteins (BMPs) in skeletal repair andregeneration. J Bone Miner Metab 2006;24:425-433 (Pubitemid 44663413)
    • (2006) Journal of Bone and Mineral Metabolism , vol.24 , Issue.6 , pp. 425-433
    • Nakase, T.1    Yoshikawa, H.2
  • 12
    • 76049083237 scopus 로고    scopus 로고
    • Multiple endocrine regulation by bonemorphogenetic protein system
    • Otsuka F. Multiple endocrine regulation by bonemorphogenetic protein system. Endocr J 2010;57:3-14
    • (2010) Endocr J , vol.57 , pp. 3-14
    • Otsuka, F.1
  • 13
    • 33847256507 scopus 로고    scopus 로고
    • BMP4-BMPR1Asignaling in beta cells is required for and augmentsglucose-stimulated insulin secretion
    • Goulley J, Dahl U, Baeza N, et al. BMP4-BMPR1Asignaling in beta cells is required for and augmentsglucose-stimulated insulin secretion. Cell Metab2007;5:207-219
    • (2007) Cell Metab , vol.5 , pp. 207-219
    • Goulley, J.1    Dahl, U.2    Baeza, N.3
  • 14
    • 79955020013 scopus 로고    scopus 로고
    • Stress erythropoiesis: Newsignals and new stress progenitor cells
    • Paulson RF, Shi L, Wu DC. Stress erythropoiesis: newsignals and new stress progenitor cells. Curr OpinHematol 2011;18:139-145
    • (2011) Curr OpinHematol , vol.18 , pp. 139-145
    • Paulson, R.F.1    Shi, L.2    Wu, D.C.3
  • 17
    • 77956402484 scopus 로고    scopus 로고
    • The yin and yang of bonemorphogenetic proteins in cancer
    • Singh A, Morris RJ. The yin and yang of bonemorphogenetic proteins in cancer. Cytokine GrowthFactor Rev 2010;21:299-313
    • (2010) Cytokine GrowthFactor Rev , vol.21 , pp. 299-313
    • Singh, A.1    Morris, R.J.2
  • 19
    • 12544259720 scopus 로고    scopus 로고
    • Bonemorphogenic proteins are overexpressed in malignantmelanoma and promote cell invasion and migration
    • Rothhammer T, Poser I, Soncin F, et al. Bonemorphogenic proteins are overexpressed in malignantmelanoma and promote cell invasion and migration.Cancer Res 2005;65:448-456
    • (2005) Cancer Res , vol.65 , pp. 448-456
    • Rothhammer, T.1    Poser, I.2    Soncin, F.3
  • 20
    • 33847017335 scopus 로고    scopus 로고
    • Bone morphogenetic protein-4 is overexpressed in colonic adenocarcinomas and promotes migration and invasion of HCT116 cells
    • DOI 10.1016/j.yexcr.2006.12.020, PII S0014482707000043
    • Deng H, Makizumi R, Ravikumar TS, et al. Bonemorphogenetic protein-4 is overexpressed in colonicadenocarcinomas and promotes migration and invasionof HCT116 cells. Exp Cell Res 2007;313:1033-1044 (Pubitemid 46273448)
    • (2007) Experimental Cell Research , vol.313 , Issue.5 , pp. 1033-1044
    • Deng, H.1    Makizumi, R.2    Ravikumar, T.S.3    Dong, H.4    Yang, W.5    Yang, W.-L.6
  • 21
    • 35848963864 scopus 로고    scopus 로고
    • Bone morphogenetic protein 4 induces epithelial-mesenchymal transition through MSX2 induction on pancreatic cancer cell line
    • DOI 10.1002/jcp.21148
    • Hamada S, Satoh K, Hirota M, et al. Bone morphogeneticprotein 4 induces epithelial-mesenchymaltransition through MSX2 induction on pancreaticcancer cell line. J Cell Physiol 2007;213:768-774 (Pubitemid 350058270)
    • (2007) Journal of Cellular Physiology , vol.213 , Issue.3 , pp. 768-774
    • Hamada, S.1    Satoh, K.2    Hirota, M.3    Kimura, K.4    Kanno, A.5    Masamune, A.6    Shimosegawa, T.7
  • 22
    • 34447319929 scopus 로고    scopus 로고
    • BMP4 induces EMT and Rho GTPase activation in human ovarian cancer cells
    • DOI 10.1093/carcin/bgm015
    • Theriault BL, Shepherd TG, Mujoomdar ML, et al.BMP4 induces EMT and rho GTPase activation inhuman ovarian cancer cells. Carcinogenesis 2007;28:1153-1162 (Pubitemid 47062673)
    • (2007) Carcinogenesis , vol.28 , Issue.6 , pp. 1153-1162
    • Theriault, B.L.1    Shepherd, T.G.2    Mujoomdar, M.L.3    Nachtigal, M.W.4
  • 23
    • 78649334675 scopus 로고    scopus 로고
    • Parallelinhibition of cell growth and induction of cellmigration and invasion in breast cancer cells by bonemorphogenetic protein 4
    • Ketolainen JM, Alarmo EL, Tuominen VJ, et al. Parallelinhibition of cell growth and induction of cellmigration and invasion in breast cancer cells by bonemorphogenetic protein 4. Breast Cancer Res Treat2010;124:377-386
    • (2010) Breast Cancer Res Treat , vol.124 , pp. 377-386
    • Ketolainen, J.M.1    Alarmo, E.L.2    Tuominen, V.J.3
  • 24
    • 78549294898 scopus 로고    scopus 로고
    • Insulinlikegrowth factor i suppresses bone morphogeneticprotein signaling in prostate cancer cells by activatingmTOR signaling
    • Wahdan-Alaswad RS, Song K, Krebs TL, et al. Insulinlikegrowth factor I suppresses bone morphogeneticprotein signaling in prostate cancer cells by activatingmTOR signaling. Cancer Res 2010;70:9106-9117
    • (2010) Cancer Res , vol.70 , pp. 9106-9117
    • Wahdan-Alaswad, R.S.1    Song, K.2    Krebs, T.L.3
  • 25
    • 79960834796 scopus 로고    scopus 로고
    • Bonemorphogenetic protein-4 and-5 in pancreatic cancer-novel bidirectional players
    • Virtanen S, Alarmo EL, Sandstrom S, et al. Bonemorphogenetic protein-4 and-5 in pancreatic cancer-novel bidirectional players. Exp Cell Res 2011;317:2136-2146
    • (2011) Exp Cell Res , vol.317 , pp. 2136-2146
    • Virtanen, S.1    Alarmo, E.L.2    Sandstrom, S.3
  • 26
    • 56749176944 scopus 로고    scopus 로고
    • Meta-analysisof genome-wide association data identifies four newsusceptibility loci for colorectal cancer
    • Houlston RS, Webb E, Broderick P, et al. Meta-analysisof genome-wide association data identifies four newsusceptibility loci for colorectal cancer. Nat Genet2008;40:1426-1435
    • (2008) Nat Genet , vol.40 , pp. 1426-1435
    • Houlston, R.S.1    Webb, E.2    Broderick, P.3
  • 27
    • 34547692446 scopus 로고    scopus 로고
    • Expression of bonemorphogenetic proteins, the subfamily of the transforminggrowth factor-beta superfamily, in renal cellcarcinoma
    • Kwak C, Park YH, Kim IY, et al. Expression of bonemorphogenetic proteins, the subfamily of the transforminggrowth factor-beta superfamily, in renal cellcarcinoma. J Urol 2007;178:1062-1067
    • (2007) J Urol , vol.178 , pp. 1062-1067
    • Kwak, C.1    Park, Y.H.2    Kim, I.Y.3
  • 28
    • 79956226373 scopus 로고    scopus 로고
    • Expression of bonemorphogenic protein-4 is inversely related to prevalenceof lymph node metastasis in gastric adenocarcinoma
    • Kim SG, Park HR, Min SK, et al. Expression of bonemorphogenic protein-4 is inversely related to prevalenceof lymph node metastasis in gastric adenocarcinoma.Surg Today 2011;41:688-692
    • (2011) Surg Today , vol.41 , pp. 688-692
    • Kim, S.G.1    Park, H.R.2    Min, S.K.3
  • 29
    • 80052338570 scopus 로고    scopus 로고
    • BMP-4 expressionhas prognostic significance in advanced serous ovariancarcinoma and is affected by cisplatin in OVCAR-3cells
    • Laatio L, Myllynen P, Serpi R, et al. BMP-4 expressionhas prognostic significance in advanced serous ovariancarcinoma and is affected by cisplatin in OVCAR-3cells. Tumour Biol 2011;32:985-995
    • (2011) Tumour Biol , vol.32 , pp. 985-995
    • Laatio, L.1    Myllynen, P.2    Serpi, R.3
  • 30
    • 79955707080 scopus 로고    scopus 로고
    • Bone morphogenetic protein-4-induced epithelial-mesenchymal transition andinvasiveness through Smad1-mediated signal pathwayin squamous cell carcinoma of the head and neck
    • Xu T, Yu CY, Sun JJ, et al. Bone morphogenetic protein-4-induced epithelial-mesenchymal transition andinvasiveness through Smad1-mediated signal pathwayin squamous cell carcinoma of the head and neck.Arch Med Res 2011;42:128-137
    • (2011) Arch Med Res , vol.42 , pp. 128-137
    • Xu, T.1    Yu, C.Y.2    Sun, J.J.3
  • 31
    • 84863365843 scopus 로고    scopus 로고
    • The activation ofMEK/ERK signaling pathway by bone morphogeneticprotein 4 to increase hepatocellular carcinoma cellproliferation and migration
    • Chiu CY, Kuo KK, Kuo TL, et al. The activation ofMEK/ERK signaling pathway by bone morphogeneticprotein 4 to increase hepatocellular carcinoma cellproliferation and migration. Mol Cancer Res 2012;10:415-427
    • (2012) Mol Cancer Res , vol.10 , pp. 415-427
    • Chiu, C.Y.1    Kuo, K.K.2    Kuo, T.L.3
  • 32
    • 77953590859 scopus 로고    scopus 로고
    • Bone morphogeneticproteins in breast cancer: Dual role in tumourigenesis?
    • Alarmo EL, Kallioniemi A. Bone morphogeneticproteins in breast cancer: Dual role in tumourigenesis?Endocr Relat Cancer 2010;17:R123-R139
    • (2010) Endocr Relat Cancer , vol.17
    • Alarmo, E.L.1    Kallioniemi, A.2
  • 33
    • 34249036783 scopus 로고    scopus 로고
    • A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7
    • DOI 10.1007/s10549-006-9362-1
    • Alarmo EL, Kuukasjarvi T, Karhu R, et al. A comprehensiveexpression survey of bone morphogeneticproteins in breast cancer highlights the importance ofBMP4 and BMP7. Breast Cancer Res Treat 2007;103:239-246 (Pubitemid 46789146)
    • (2007) Breast Cancer Research and Treatment , vol.103 , Issue.2 , pp. 239-246
    • Alarmo, E.-L.1    Kuukasjarvi, T.2    Karhu, R.3    Kallioniemi, A.4
  • 34
    • 1842607121 scopus 로고    scopus 로고
    • A comparison of the biological and clinical features of invasive lobular and ductal carcinomas of the breast
    • DOI 10.1023/B:BREA.0000021038.97593.8b
    • Korhonen T, Huhtala H, Holli K. A comparison of thebiological and clinical features of invasive lobular andductal carcinomas of the breast. Breast Cancer ResTreat 2004;85:23-29 (Pubitemid 38437980)
    • (2004) Breast Cancer Research and Treatment , vol.85 , Issue.1 , pp. 23-29
    • Korhonen, T.1    Huhtala, H.2    Holli, K.3
  • 36
    • 33745065756 scopus 로고    scopus 로고
    • Common criticalpathways in embryogenesis and cancer
    • Kelleher FC, Fennelly D, Rafferty M. Common criticalpathways in embryogenesis and cancer. Acta Oncol2006;45:375-388
    • (2006) Acta Oncol , vol.45 , pp. 375-388
    • Kelleher, F.C.1    Fennelly, D.2    Rafferty, M.3
  • 37
    • 75749141315 scopus 로고    scopus 로고
    • Bone morphogeneticproteins and cancer: Review of the literature
    • Thawani JP, Wang AC, Than KD, et al. Bone morphogeneticproteins and cancer: review of the literature.Neurosurgery 2010;66:233-246
    • (2010) Neurosurgery , vol.66 , pp. 233-246
    • Thawani, J.P.1    Wang, A.C.2    Than, K.D.3
  • 41
    • 77950355069 scopus 로고    scopus 로고
    • Head and necksquamous cancer stromal fibroblasts produce growthfactors influencing phenotype of normal humankeratinocytes
    • Strnad H, Lacina L, Kolar M, et al. Head and necksquamous cancer stromal fibroblasts produce growthfactors influencing phenotype of normal humankeratinocytes. Histochem Cell Biol 2010;133:201-211
    • (2010) Histochem Cell Biol , vol.133 , pp. 201-211
    • Strnad, H.1    Lacina, L.2    Kolar, M.3
  • 42
    • 84863990305 scopus 로고    scopus 로고
    • Upregulation of bonemorphogenetic protein 4 is associated with poorprognosis in patients with hepatocellular carcinoma
    • Guo X, Xiong L, Zou L, et al. Upregulation of bonemorphogenetic protein 4 is associated with poorprognosis in patients with hepatocellular carcinoma.Pathol Oncol Res 2012;18:635-640
    • (2012) Pathol Oncol Res , vol.18 , pp. 635-640
    • Guo, X.1    Xiong, L.2    Zou, L.3
  • 43
    • 23944480887 scopus 로고    scopus 로고
    • Expression of bone morphogenetic proteins in human lung carcinomas
    • DOI 10.1016/j.athoracsur.2005.03.094, PII S0003497505005540
    • Langenfeld EM, Bojnowski J, Perone J, et al. Expressionof bone morphogenetic proteins in human lungcarcinomas. Ann Thorac Surg 2005;80:1028-1032 (Pubitemid 41196808)
    • (2005) Annals of Thoracic Surgery , vol.80 , Issue.3 , pp. 1028-1032
    • Langenfeld, E.M.1    Bojnowski, J.2    Perone, J.3    Langenfeld, J.4
  • 44
    • 70350622991 scopus 로고    scopus 로고
    • The positivecorrelation between gene expression of the twoangiogenic factors: VEGF and BMP-2 in lung cancerpatients
    • Bieniasz M, Oszajca K, Eusebio M, et al. The positivecorrelation between gene expression of the twoangiogenic factors: VEGF and BMP-2 in lung cancerpatients. Lung Cancer 2009;66:319-326
    • (2009) Lung Cancer , vol.66 , pp. 319-326
    • Bieniasz, M.1    Oszajca, K.2    Eusebio, M.3
  • 47
    • 67650911313 scopus 로고    scopus 로고
    • Bonemorphogenetic protein 4 is induced in hepatocellularcarcinoma by hypoxia and promotes tumour progression
    • Maegdefrau U, Amann T, Winklmeier A, et al. Bonemorphogenetic protein 4 is induced in hepatocellularcarcinoma by hypoxia and promotes tumour progression.J Pathol 2009;218:520-529
    • (2009) J Pathol , vol.218 , pp. 520-529
    • Maegdefrau, U.1    Amann, T.2    Winklmeier, A.3
  • 48
    • 33845997387 scopus 로고    scopus 로고
    • Bone morphogenetic protein-4 abrogates lumen formation by mammary epithelial cells and promotes invasive growth
    • DOI 10.1016/j.bbrc.2006.12.109, PII S0006291X06027811
    • Montesano R. Bone morphogenetic protein-4 abrogateslumen formation by mammary epithelial cellsand promotes invasive growth. Biochem Biophys ResCommun 2007;353:817-822 (Pubitemid 46048745)
    • (2007) Biochemical and Biophysical Research Communications , vol.353 , Issue.3 , pp. 817-822
    • Montesano, R.1
  • 49
    • 47749155179 scopus 로고    scopus 로고
    • Bone morphogeneticprotein-4 strongly potentiates growth factorinducedproliferation of mammary epithelial cells
    • Montesano R, Sarkozi R, Schramek H. Bone morphogeneticprotein-4 strongly potentiates growth factorinducedproliferation of mammary epithelial cells.Biochem Biophys Res Commun 2008;374:164-168
    • (2008) Biochem Biophys Res Commun , vol.374 , pp. 164-168
    • Montesano, R.1    Sarkozi, R.2    Schramek, H.3
  • 50
    • 58849143465 scopus 로고    scopus 로고
    • DNAmethylation markers predict outcome in nodepositive,estrogen receptor-positive breast cancer withadjuvant anthracycline-based chemotherapy
    • Hartmann O, Spyratos F, Harbeck N, et al. DNAmethylation markers predict outcome in nodepositive,estrogen receptor-positive breast cancer withadjuvant anthracycline-based chemotherapy. ClinCancer Res 2009;15:315-323
    • (2009) ClinCancer Res , vol.15 , pp. 315-323
    • Hartmann, O.1    Spyratos, F.2    Harbeck, N.3
  • 51
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptoticactions of TGF-beta in homeostasis and cancer
    • Siegel PM, Massague J. Cytostatic and apoptoticactions of TGF-beta in homeostasis and cancer. NatRev Cancer 2003;3:807-821
    • (2003) NatRev Cancer , vol.3 , pp. 807-821
    • Siegel, P.M.1    Massague, J.2
  • 52
    • 33646562542 scopus 로고    scopus 로고
    • The logic of TGFbeta signaling
    • Massague J, Gomis RR. The logic of TGFbeta signaling.FEBS Lett 2006;580:2811-2820
    • (2006) FEBS Lett , vol.580 , pp. 2811-2820
    • Massague, J.1    Gomis, R.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.