Vaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 30, 2015, Pages 9346-9351

  Winarski, Katie L ^a   Thornburg, Natalie J ^a   Yu, Yingchun ^a   Sapparapu, Gopal ^a   Crowe, James E ^a   Spiller, Benjamin W ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Affinity maturation; Antigen recognition; Immunity; Influenza; Structural biology

Indexed keywords

HUMAN MONOCLONAL ANTIBODY; HUMAN MONOCLONAL ANTIBODY H5.3; INFLUENZA VACCINE; INFLUENZA VIRUS HEMAGGLUTININ; NEUTRALIZING ANTIBODY; SIALIC ACID; UNCLASSIFIED DRUG; IMMUNOGLOBULIN FRAGMENT; MONOCLONAL ANTIBODY; N ACETYLNEURAMINIC ACID; PROTEIN BINDING; VIRUS ANTIBODY;

ARTICLE; CRYSTAL STRUCTURE; DRUG BINDING SITE; HOST RANGE; HUMAN; HYDROGEN BOND; INFLUENZA VIRUS A H5N1; PRIORITY JOURNAL; RECEPTOR BINDING; VIRUS NEUTRALIZATION; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; CONFORMATION; GENETIC VARIABILITY; IMMUNOLOGY; INFLUENZA; INFLUENZA A VIRUS (H5N1); MOLECULAR GENETICS; MUTATION; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

MUSTELA; ORTHOMYXOVIRIDAE;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; GENETIC VARIATION; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; IMMUNOGLOBULIN FRAGMENTS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA VACCINES; INFLUENZA, HUMAN; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MUTATION; N-ACETYLNEURAMINIC ACID; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84938151168     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1502762112     Document Type: Article

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