Calcific aortic stenosis - Time to look more closely at the valve

New England Journal of Medicine

Volumn 359, Issue 13, 2008, Pages 1395-1398

  Otto, Catherine M ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILIPEMIC AGENT; EZETIMIBE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NOTCH1 RECEPTOR; SIMVASTATIN;

AORTA VALVE REPLACEMENT; AORTA VALVE STENOSIS; ATHEROSCLEROSIS; CALCIFIC AORTA VALVE STENOSIS; CALCIFICATION; CARDIOVASCULAR RISK; CLINICAL TRIAL; CORONARY ARTERY BYPASS GRAFT; DISEASE COURSE; DOPPLER ECHOCARDIOGRAPHY; EDITORIAL; GENE MUTATION; HEART INFARCTION; HEART LEFT VENTRICLE OUTFLOW TRACT OBSTRUCTION; HUMAN; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 52649161365     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMe0807001     Document Type: Editorial

References (10)

1. Roberts WC, Ko JM. Frequency by decades of unicuspid, bicuspid, and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated aortic regurgitation. Circulation 2005;111:920-5.
2. Katz R, Wong ND, Kronmal R, et al. Features of the metabolic syndrome and diabetes mellitus as predictors of aortic valve calcification in the Multi-Ethnic Study of Atherosclerosis. Circulation 2006;113:2113-9.
3. Garg V, Muth AN, Ransom JF, et al. Mutations in NOTCH1 cause aortic valve disease. Nature 2005;437:270-4.
4. Helske S, Oksjoki R, Lindstedt KA, et al. Complement system is activated in stenotic aortic valves. Atherosclerosis 2008;196:190-200.
5. Akat K, Borggrefe M, Kaden JJ. Aortic valve calcification - basic science to clinical practice. Heart 2008 July 16 (Epub ahead of print).
6. Weiss RM, Ohashi M, Miller JD, Young SG, Heistad DD. Calcific aortic valve stenosis in old hypercholesterolemic mice. Circulation 2006;114:2065-9.
7. Rajamannan NM, Subramaniam M, Caira F, Stock SR, Spelsberg TC. Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway. Circulation 2005;112:Suppl:I229-I234.
8. Rossebø AB, Pedersen TR, Boman K, et al. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med 2008;359:1343-56.
9. Anger T, Pohle FK, Kandler L, et al. VAP-1, Eotaxin3 and MIG as potential atherosclerotic triggers of severe calcified and stenotic human aortic valves: effects of statins. Exp Mol Pathol 2007;83:435-42.
10. Aikawa E, Nahrendorf M, Sosnovik D, et al. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation 2007;115:377-86.