Simultaneous determination of ten compounds in rat plasma by UPLC-MS/MS: Application in the pharmacokinetic study of Ma-Zi-Ren-Wan

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 1000, Issue , 2015, Pages 136-146

  Hu, Dong Dong ^a,b   Han, Quan Bin ^b   Zhong, Linda Li Dan ^b   Li, Yan Hong ^b   Lin, Cheng Yuan ^b   Ho, Hing Man ^b   Zhang, Man ^b,c   Lin, Shu Hai ^b   Zhao, Ling ^b   Huang, Tao ^b   Mi, Hong ^b,d   Tan, Hong Sheng ^a   Xu, Hong Xi ^a   Bian, Zhao Xiang ^b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^c GUANGZHOU MEDICAL UNIVERSITY   (China)

^d GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Active ingredient; Ma Zi Ren Wan; Pharmacokinetics; Rat plasma; UPLC MS MS

Indexed keywords

BODY FLUIDS; CHROMATOGRAPHY; DRUG PRODUCTS; FLAVONOIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ALGEBRA; PHARMACOKINETICS;

ACTIVE INGREDIENTS; LOWER LIMIT OF QUANTIFICATIONS; MULTIPLE REACTION MONITORING; RAT PLASMA; RELATIVE STANDARD DEVIATIONS; SIMULTANEOUS DETERMINATIONS; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (UPLC MS/MS); UPLC-MS/MS;

RATS;

ALBIFLORIN; ALOE EMODIN; AMYGDALIN; AURANTIIN; CHINESE DRUG; EMODIN; GASTROINTESTINAL AGENT; GENIPOSIDE; HESPERIDIN; HONOKIOL; LIQUIRITIN; MA ZI REN WAN; MAGNOLOL; PAEONIFLORIN; RHEIN; UNCLASSIFIED DRUG; ANTHRAQUINONE DERIVATIVE; BIPHENYL DERIVATIVE; FLAVONOID; GLYCOSIDE; HERBACEOUS AGENT; LIGNAN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; CHINESE HERB; CHROMATOGRAPH; CONTROLLED STUDY; DRUG HALF LIFE; DRUG QUALITY; DRUG STABILITY; DRUG STRUCTURE; EXTRACTION; IONIZATION; LIMIT OF QUANTITATION; MALE; MAXIMUM PLASMA CONCENTRATION; MEASUREMENT ACCURACY; MONITORING; MULTIPLE REACTION MONITORING; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RAT; SINGLE DRUG DOSE; STANDARD; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; BLOOD; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; STATISTICAL MODEL;

ALOE; RATTUS;

ANIMALS; ANTHRAQUINONES; BIPHENYL COMPOUNDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; FLAVONOIDS; GLYCOSIDES; LIGNANS; LINEAR MODELS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84938073887     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2015.07.003     Document Type: Article

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