Biotransformation of the anthraquinones emodin and chrysophanol by cytochrome P450 enzymes: Bioactivation to genotoxic metabolites

Drug Metabolism and Disposition

Volumn 26, Issue 6, 1998, Pages 540-546

  Mueller, Stefan O ^b   Stopper, Helga ^b   Dekant, Wolfgang ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYEMODIN; ANTHRAQUINONE DERIVATIVE; CHRYSOPHANIC ACID; CYTOCHROME P450; DANTRON; EMODIN; OMEGA HYDROXYEMODIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER; CANCER RISK; CHEMICAL CARCINOGENESIS; DRUG ACTIVATION; DRUG METABOLISM; DRUG TRANSFORMATION; FEMALE; GENOTOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTHRAQUINONES; BIOTRANSFORMATION; CYTOCHROME P-450 ENZYME SYSTEM; EMODIN; FEMALE; HYDROXYLATION; KINETICS; LYMPHOMA; MALE; MICE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICROSOMES, LIVER; MUTAGENS; RATS; RATS, WISTAR;

EID: 0031793967     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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