High-density lipoproteins reduce endothelial-to-mesenchymal transition

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 35, Issue 8, 2015, Pages 1774-1777

  Spillmann, Frank ^a   Miteva, Kapka ^a   Pieske, Burkert ^a,b,c   Tschöpe, Carsten ^a,c   Van Linthout, Sophie ^a,c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DEUTSCHES HERZZENTRUM BERLIN   (Germany)

^c DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

aortic endothelial cells; endothelial to mesenchymal transition; fibrosis; HDL; transforming growth factor

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HIGH DENSITY LIPOPROTEIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SCAVENGER RECEPTOR BI; SMAD7 PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR ZEB1; TRANSFORMING GROWTH FACTOR BETA1; ACTA2 PROTEIN, HUMAN; ACTIN; CADHERIN; COLLAGEN; LEUKOCYTE ANTIGEN; SCARB1 PROTEIN, HUMAN; SCAVENGER RECEPTOR B; VASCULAR ENDOTHELIAL CADHERIN;

ARTICLE; CELL SHAPE; CELL STIMULATION; CELL TRANSFORMATION; DOWN REGULATION; ENDOTHELIAL TO MESENCHYMAL TRANSITION; ENDOTHELIUM CELL; ENZYME INHIBITION; FLOW CYTOMETRY; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPINDLE CELL; CELL CULTURE; DRUG EFFECTS; EPITHELIAL MESENCHYMAL TRANSITION; FIBROSIS; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY; PHENOTYPE; RNA INTERFERENCE;

ACTINS; ANTIGENS, CD; CADHERINS; CELL SHAPE; CELLS, CULTURED; COLLAGEN; ENDOTHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FIBROSIS; HUMANS; LIPOPROTEINS, HDL; PHENOTYPE; PHOSPHATIDYLINOSITOL 3-KINASE; RNA INTERFERENCE; SCAVENGER RECEPTORS, CLASS B; SIGNAL TRANSDUCTION; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84938061989     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.115.305887     Document Type: Article

References (28)

1. Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, Gustafsson E, Chandraker A, Yuan X, Pu WT, Roberts AB, Neilson EG, Sayegh MH, Izumo S, Kalluri R., Endothelial-To-mesenchymal transition contributes to cardiac fibrosis. Nat Med 2007 13 952 961. doi: 10.1038/nm1613
2. Murdoch CE, Chaubey S, Zeng L, Yu B, Ivetic A, Walker SJ, Vanhoutte D, Heymans S, Grieve DJ, Cave AC, Brewer AC, Zhang M, Shah AM., Endothelial NADPH oxidase-2 promotes interstitial cardiac fibrosis and diastolic dysfunction through proinflammatory effects and endothelial-mesenchymal transition. J Am Coll Cardiol 2014 63 2734 2741. doi: 10.1016/j.jacc.2014.02.572
3. Cooley BC, Nevado J, Mellad J, TGF-beta signaling mediates endothelial-To-mesenchymal transition (EndMT) during vein graft remodeling. Sci Transl Med 2014 6 227ra34. doi: 10.1126/scitranslmed.3006927
4. O'Riordan E, Mendelev N, Patschan S, Patschan D, Eskander J, Cohen-Gould L, Chander P, Goligorsky MS., Chronic NOS inhibition actuates endothelial-mesenchymal transformation. Am J Physiol Heart Circ Physiol 2007 292 H285 H294. doi: 10.1152/ajpheart.00560.2006
5. Wendt N, Schulz A, Qadri F, Bolbrinker J, Kossmehl P, Winkler K, Stoll M, Vetter R, Kreutz R., Genetic analysis of salt-sensitive hypertension in Dahl rats reveals a link between cardiac fibrosis and high cholesterol. Cardiovasc Res 2009 81 618 626. doi: 10.1093/cvr/cvn263
6. Van Linthout S, Spillmann F, Lorenz M, Meloni M, Jacobs F, Egorova M, Stangl V, De Geest B, Schultheiss HP, Tschöpe C., Vascular-protective effects of high-density lipoprotein include the downregulation of the angiotensin II type 1 receptor. Hypertension 2009 53 682 687. doi: 10.1161/HYPERTENSIONAHA.108.118919
7. Van Linthout S, Spillmann F, Riad A, Human apolipoprotein A-I gene transfer reduces the development of experimental diabetic cardiomyopathy. Circulation 2008 117 1563 1573. doi: 10.1161/CIRCULATIONAHA.107.710830
8. Van Linthout S, Spillmann F, Schultheiss HP, Tschöpe C., High-density lipoprotein at the interface of type 2 diabetes mellitus and cardiovascular disorders. Curr Pharm Des 2010 16 1504 1516
9. Van Linthout S, Spillmann F, Graiani G, Miteva K, Peng J, Van Craeyveld E, Meloni M, Tölle M, Escher F, Subasigüller A, Doehner W, Quaini F, De Geest B, Schultheiss HP, Tschöpe C., Down-regulation of endothelial TLR4 signalling after apo A-I gene transfer contributes to improved survival in an experimental model of lipopolysaccharide-induced inflammation. J Mol Med (Berl) 2011 89 151 160. doi: 10.1007/s00109-010-0690-6
10. Radojkovic C, Genoux A, Pons V, Combes G, de Jonge H, Champagne E, Rolland C, Perret B, Collet X, Tercé F, Martinez LO., Stimulation of cell surface F1-ATPase activity by apolipoprotein A-I inhibits endothelial cell apoptosis and promotes proliferation. Arterioscler Thromb Vasc Biol 2009 29 1125 1130. doi: 10.1161/ATVBAHA.109.187997
11. Seetharam D, Mineo C, Gormley AK, Gibson LL, Vongpatanasin W, Chambliss KL, Hahner LD, Cummings ML, Kitchens RL, Marcel YL, Rader DJ, Shaul PW., High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I. Circ Res 2006 98 63 72. doi: 10.1161/01.RES.0000199272.59432.5b
12. Feng Y, Jacobs F, Van Craeyveld E, Brunaud C, Snoeys J, Tjwa M, Van Linthout S, De Geest B., Human ApoA-I transfer attenuates transplant arteriosclerosis via enhanced incorporation of bone marrow-derived endothelial progenitor cells. Arterioscler Thromb Vasc Biol 2008 28 278 283. doi: 10.1161/ATVBAHA.107.158741
13. Feng Y, van Eck M, Van Craeyveld E, Jacobs F, Carlier V, Van Linthout S, Erdel M, Tjwa M, De Geest B., Critical role of scavenger receptor-BI-expressing bone marrow-derived endothelial progenitor cells in the attenuation of allograft vasculopathy after human apo A-I transfer. Blood 2009 113 755 764. doi: 10.1182/blood-2008-06-161794
14. Spillmann F, Miteva K, Warstat K, Perisic S, Ringe J, Tschope C, Van Linthout S., High-density lipoproteins induce the migration capacity of mesenchymal stromal cells. J Stem Cell Res Ther 2014 4 3
15. Covas DT, Panepucci RA, Fontes AM, Silva WA Jr, Orellana MD, Freitas MC, Neder L, Santos AR, Peres LC, Jamur MC, Zago MA., Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts. Exp Hematol 2008 36 642 654. doi: 10.1016/j.exphem.2007.12.015
16. Hung SC, Pochampally RR, Chen SC, Hsu SC, Prockop DJ., Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis. Stem Cells 2007 25 2363 2370. doi: 10.1634/stemcells.2006-0686
17. Ubil E, Duan J, Pillai IC, Rosa-Garrido M, Wu Y, Bargiacchi F, Lu Y, Stanbouly S, Huang J, Rojas M, Vondriska TM, Stefani E, Deb A., Mesenchymal-endothelial transition contributes to cardiac neovascularization. Nature 2014 514 585 590. doi: 10.1038/nature13839
18. Lupattelli G, Marchesi S, Roscini AR, Siepi D, Gemelli F, Pirro M, Sinzinger H, Schillaci G, Mannarino E., Direct association between high-density lipoprotein cholesterol and endothelial function in hyperlipemia. Am J Cardiol 2002 90 648 650
19. Spieker LE, Sudano I, Hürlimann D, Lerch PG, Lang MG, Binggeli C, Corti R, Ruschitzka F, Lüscher TF, Noll G., High-density lipoprotein restores endothelial function in hypercholesterolemic men. Circulation 2002 105 1399 1402
20. Kruger AL, Peterson S, Turkseven S, Kaminski PM, Zhang FF, Quan S, Wolin MS, Abraham NG., D-4F induces heme oxygenase-1 and extracellular superoxide dismutase, decreases endothelial cell sloughing, and improves vascular reactivity in rat model of diabetes. Circulation 2005 111 3126 3134. doi: 10.1161/CIRCULATIONAHA.104.517102
21. Nofer JR, van der Giet M, Tölle M, HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3. J Clin Invest 2004 113 569 581. doi: 10.1172/JCI18004
22. Harrison DG., Cellular and molecular mechanisms of endothelial cell dysfunction. J Clin Invest 1997 100 2153 2157. doi: 10.1172/JCI119751
23. Tschöpe C, Van Linthout S., New insights in (inter)cellular mechanisms by heart failure with preserved ejection fraction. Curr Heart Fail Rep 2014 11 436 444. doi: 10.1007/s11897-014-0219-3
24. Sheppard D., Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis. Proc Am Thorac Soc 2006 3 413 417. doi: 10.1513/pats.200601-008AW
25. Kumarswamy R, Volkmann I, Jazbutyte V, Dangwal S, Park DH, Thum T., Transforming growth factor-β-induced endothelial-To-mesenchymal transition is partly mediated by microRNA-21. Arterioscler Thromb Vasc Biol 2012 32 361 369. doi: 10.1161/ATVBAHA.111.234286
26. Loeffler I, Wolf G., Transforming growth factor-β and the progression of renal disease. Nephrol Dial Transplant 2014 29 Suppl 1 i37 i45. doi: 10.1093/ndt/gft267
27. Dave N, Guaita-Esteruelas S, Gutarra S, Frias À Beltran M, Peiró S, de Herreros AG., Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition. J Biol Chem 2011 286 12024 12032. doi: 10.1074/jbc.M110.168625
28. Bellosta S, Gomaraschi M, Canavesi M, Rossoni G, Monetti M, Franceschini G, Calabresi L., Inhibition of MMP-2 activation and release as a novel mechanism for HDL-induced cardioprotection. FEBS Lett 2006 580 5974 5978. doi: 10.1016/j.febslet.2006.10.006