Chronic NOS inhibition actuates endothelial-mesenchymal transformation

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 292, Issue 1, 2007, Pages

  O'Riordan, Edmond ^b   Mendelev, Natalia ^b   Patschan, Susann ^b   Patschan, Daniel ^b   Eskander, Jonathan ^b   Cohen Gould, Leona ^b   Chander, Praveen ^b   Goligorsky, Michael S ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b NONE

Author keywords

Connective tissue growth factor; Endostatin; Endothelial dysfunction; Transforming growth factor

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANGIOPOIETIN RECEPTOR; CALPONIN; COLLAGEN TYPE 18; CONNECTIVE TISSUE GROWTH FACTOR; ENDOSTATIN; FIBRONECTIN; GREEN FLUORESCENT PROTEIN; N(G) NITROARGININE METHYL ESTER; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; HUMAN; HUMAN CELL; KIDNEY PARENCHYMA; MESENCHYME CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIAL GROWTH FACTORS; ENZYME INHIBITORS; HUMANS; MESENCHYMAL STEM CELLS; MICE; MICE, KNOCKOUT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TRANSFORMING GROWTH FACTORS;

EID: 33846205660     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00560.2006     Document Type: Article

References (60)

1. Abdollahi A, Hahnfeldt P, Maercker C, Grone HJ, Debus J, Ansorge W, Folkman J, Hlatky L, Huber P. Endostatin's antiangiogenic signaling network. Mol Cell 13: 649-663, 2004.
2. Arenillas J, Alvarez-Sabin J, Montaner J, Rosell J, Molina C, Rovira A, Ribo M, Sanchez E, Quintana M. Angiogenesis in symptomatic intracranial atherosclerosis: predominance of the inhibitor endostatin is related to a greater extent and risk of recurrence. Stroke 36: 92-97, 2005.
3. Baylis C, Mitruka B, Deng A. Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage. J Clin Invest 90: 278-281, 1992.
4. Bohle A, Mackensen-Haen S, von Gise H. Significance of tubulointerstitial changes in the renal cortex for the excretory function and concentration ability of the kidney. Am J Nephrol 7: 421-433, 1987.
5. Brenner B. Remission of renal disease: recounting the challenge, acquiring the goal. J Clin Invest 110: 1753-1758, 2002.
6. Bucala R, Tracey K, Cerami A. Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilation in experimental diabetes. J Clin Invest 87: 432-438, 1991.
7. Carvalhaes L, Gervasio O, Guatimosim C, Heljasvaara R, Sormunen R, Pihlajaniemi T, Kitten G. Collagen XVIII/endostatin is associated with the epithelial-mesenchymal transformation in the atrioventricular valves during cardiac development. Dev Dyn 235: 132-142, 2006.
8. Chander P, Gealekman O, Brodsky SV, Elitok S, Tojo A, Crabtree M, Gross SS, Goligorsky MS. Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen. J Am Soc Nephrol 15: 2391-2403, 2004.
9. Chatziantoniou C, Boffa J, Ardaillou R, Dussaule J. Nitric oxide inhibition induces early activation of type I collagen gene in renal resistance vessels and glomeruli in transgenic mice. Role of endothelin. J Clin Invest 101: 2780-2789, 1998.
10. Craven PA, Studer R, Felder J, Phillips S, DeRubertis FR. Nitric oxide inhibition of transforming growth factor-β and collagen synthesis in mesangial cells. Diabetes 46: 671-681, 1997.
11. DeRuiter M, Poelmann R, VanMunsteren J, Mironov V, Markwald R, Gittenberger-de Groot A. Embryonic endothelial cells transdifferentiate into mesenchymal cells expressing smooth muscle actins in vivo and in vitro. Circ Res 80: 444-451, 1997.
12. Eddy A. Molecular insights into renal interstitial fibrosis. J Am Soc Nephrol 7: 2495-2508, 1996.
13. Eitner F, Floege J. Novel insights into renal fibrosis. Curr Opin Nephrol Hypertens 12: 227-232, 2003.
14. Erdely A, Wagner L, Muller V, Szabo A, Baylis C. Protection of Wistar Furth rat from chronic renal disease is associated with maintained renal nitric oxide synthase. J Am Soc Nephrol 14: 2526-2533, 2003.
15. Faulkner J, Szcykalski L, Springer F, Barnes J. Origin of interstitial fibroblasts in an accelerated model of angiotensin II-induced renal fibrosis. Am J Pathol 167: 1193-1205, 2005.
16. Fliser D, Kielstein JT, Haller H, Bode-Boger SM. Asymmetric dimethylarginine: a cardiovascular risk factor in renal disease? Kidney Int Suppl 84: 37-40, 2003.
17. Fogo A. Renal fibrosis and the renin-angiotensin system. Adv Nephrol Necker Hosp 31: 69-87, 2001.
18. Frid M, Kale V, Stenmark K. Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation. Circ Res 90: 1189-1196, 2002.
19. Gealikman O, Brodsky SV, Zhang F, Chander P, Friedli C, Nasjletti A, Goligorsky MS. Angiogenic incompetence, and microvasculopathy in the Zucker diabetic fat rat are ameliorated with Ebselen treatment: endothelial dysfunction as a modifier of angiogenic response. Kidney Int 66: 2337-2347, 2004.
20. Gonzalez MA, Pinder SE, Wencyk PM, Bell JA, Elston CW, Nicholson RI, Robertson JF, Blamey RW, Ellis IO. An immunohistochemical examination of the expression of E-cadherin, α- and β/γcatenins and α2- and β1-integrins in invasive breast cancer. J Pathol 187: 253-259, 1999.
21. Gschwend S, Buikema H, Navis G, Henning R, DeZeeuw D, van Dokkum R. Endothelial dilatory function predicts individual susceptibility to renal damage in 5/6 nephrectomized rat. J Am Soc Nephrol 13: 2909-2915, 2002.
22. Hogaboam C, Galliant C, Bone-Larson C, Chensue S, Lukacs N, Strieter R, Kunkel SL. Collagen deposition in a non-fibrotic lung granuloma model after nitric oxide inhibition. Am J Pathol 153: 1861-1872, 1998.
23. Ishizaki A, Hayashi H, Li A, Imamura T. Human umbilical vein endothelium-derived cells retain potential to differentiate into smooth muscle-like cells. J Biol Chem 278: 1303-1309, 2003.
24. Iwano M, Plieth D, Danoff T, Xue C, Okada H, Neilson E. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 110: 341-350, 2002.
25. Jankowski J, van der Giet M, Jankowski V, Schmidt S, Hemeier M, Mahn B, Giebing G, Tölle M, Luftmann H, Schlü ter H, Zidek W, Tepel M. Increased plasma phenylacetic acid in patients with end-stage renal failure inhibits iNOS expression. J Clin Invest 112: 256-264, 2003.
26. Kalluri R, Neilson E. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112: 1776-1784, 2003.
27. Kang D, Joly A, Mazali M, Johnson R. Impaired angiogenesis in the remnant kidney model. J Am Soc Nephrol 12: 1448-1457, 2001.
28. Kang D, Joly A, Oh S, Johnson R. Impaired angiogenesis in the remnant kidney model. J Am Soc Nephrol 12: 1434-1447, 2001.
29. Kang D, Kanellis J, Hugo C, Johnson R. Role of microvascular endothelium in progressive renal disease. J Am Soc Nephrol 13: 806-816, 2002.
30. Kang D, Nakagawa T, Feng L, Johnson R. Nitric oxide modulates vascular disease in the remnant kidney model. Am J Pathol 161: 239-248, 2002.
31. Kawashima H, Watanabe N, Hirose M, Sun X, Atarashi K, Kimura T, Shikata K, Matsuda M, Ogawa D, Heljasvaara R, Rehn M, Pihlajaniemi T, Miyasaka M. Collagen XVIII, a basement membrane heparin sulfate proteoglycan, interacts with L-selectin and monocyte chemoattractant protein-1. J Biol Chem 278: 13069-13076, 2003.
32. Kunz K, Petitjean P, Lisri M, Chantrel F, Koehl C, Wiesel ML, Cazenave JP, Moulin B, Hannedouche TP. Cardiovascular morbidity and endothelial dysfunction in chronic haemodialysis patients: is homocyst(e)ine the missing link? Nephrol Dial Transplant 14: 1934-1942, 1999.
33. Lan H. Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells. Curr Opin Nephrol Hypertens 12: 25-29, 2003.
34. Lee L, Meyer T, Pollock A, Lovett DH. Endothelial cell injury initiates glomerular sclerosis in the rat remnant kidney. J Clin Invest 96: 953-964, 1995.
35. Lee L, Meyer T, Pollock A, Lovett D. Endothelial cell injury initiates glomerular sclerosis in the rat remnant kidney. J Clin Invest 96: 953-964, 1995.
36. Li Q, Olsen B. Increased angiogenic response in aortic explants of collagen XVIII/endostatin-null mice. Am J Pathol 165: 415-424, 2004.
37. Liu J. Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanisms, and therapeutic intervention. J Am Soc Nephrol 15: 1-12, 2004.
38. MacAllister RJ, Vallance P. Endogenous inhibitors of nitric oxide synthesis in renal disease: how important are they? Exp Nephrol 6: 195-199, 1998.
39. MacAllister RJ, Whitley GS, Vallance P. Effects of guanidino and uremic compounds on nitric oxide pathways. Kidney Int 45: 737-742, 1994.
40. Motoike T, Loughna S, Perens E, Roman BL, Liao W, Chau TC, Richardson CD, Kawate T, Kuno J, Weinstein BM, Stainier DY, Sato TN. Universal GFP reporter for the study of vascular development. Genesis 28: 75-81, 2000.
41. Musso O, Rehn M, Saarela J, Theret N, Lietard J, Hintikka E, Lotrian D, Campion JP, Pihlajaniemi T, Clement B. Collagen XVIII is localized in sinusoids and basement membrane zones and expressed by hepatocytes and activated stellate cells in fibrotic human liver. Hepatology 28: 98-107, 1998.
42. Myers PR, Tannner MA. Vascular endothelial cell regulation of extracellular matrix collagen: role of nitric oxide. Arterioscler Thromb Vasc Biol 18: 717-722, 1998.
43. Nagata M, Scharer K, Kriz W. Glomerular damage after uninephrectomy in young rats. Hypertrophy and distortion of capillary architecture. Kidney Int 42: 136-147, 1992.
44. Nakagawa T, Kang D, Ohashi R, Suga S, Herrera-Acosta J, Rodriguez-Iturbe B, Johnson R. Tubulointerstitial disease: role of ischemia and microvascular disease. Curr Opin Nephrol Hypertens 12: 233-241, 2003.
45. Nakanishi K, Mattson DL, Cowley AW. Role of renal medullary blood flow in the development of L-NAME hypertension in rats. Am J Physiol Regul Integr Comp Physiol 268: R317-R323, 1995.
46. Ohashi R, Shimizu A, Masuda Y, Johnson R. Peritubular capillary regression during progression of experimental obstructive nephropathy. J Am Soc Nephrol 13: 1795-1805, 2002.
47. Ohashi R, Kitamura H, Yamanaka N, Johnson R. Peritubular capillary injury during progression of experimental glomerulonephritis in rats. J Am Soc Nephrol 11: 47-56, 2000.
48. O'Reilly M, Boehm T, Shing Y, Fukai N, Vasios G, Lane W, Flynn E, Birkhead J, Olsen B, Folkman J. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88: 277-285, 1997.
49. Paddenberg R, Faulhammer P, Goldenberg A, Kummer W. Hypoxia-induced increase of endostatin in murine aorta and lung. Histochem Cell Biol 125: 497-508, 2006.
50. Peters H, Daig U, Martini S, Ruckert M, Schaper F, Leifeldt L, Kramer S, Neumayer H. NO mediates antifibrotic actions of L-arginine supplementation following induction of anti-Thy1 glomerulonephritis. Kidney Int 64: 509-518, 2003.
51. Pfeffer JM, Pfeffer MA, Frohlich ED. Validity of the indirect tail-cuff method for determining systolic arterial pressure in unanethesised normotensive and spontaneously hypertensive rats. J Lab Clin Med 78: 183-193, 1071.
52. Ribiero MO, Antunes E, deNucci G, Lovisolo SM, Zatz R. Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension. Hypertension 20: 298-303, 1992.
53. Schanstra J, Neau E, Drogoz P, Gomez M, Lopez-Novoa J, Calise D, Pecher C, Bader M, Girolami J, Bascands J. In vivo bradikinin B2 receptor activation reduces renal fibrosis. J Clin Invest 110: 371-379, 2002.
54. Thiery JP. Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 15: 740-746, 2003.
55. Vallance P, Leone A, Calver A, Collier J, Moncada S. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339: 572-575, 1992.
56. Yamashita J, Itoh H, Hirashima M, Ogawa M, Nishikawa S, Yurugi T, Naito M, Nakao K, Nishikawa S. Flk-1-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature 408: 92-96, 2000.
57. Zatz R, Baylis C. Chronic nitric oxide inhibition model six years on. Hypertension 32: 958-964, 1998.
58. Zhang X, Jin H, Li H, Ebin Z, Brodsky S, Goligorsky MS. Effects of homocysteine on nitric oxide production by endothelial cells. Am J Physiol Renal Physiol 279: F671-F678, 2000.
59. Zoja C, Benigni A, Camozzi D, Corna D, Longaretti L, Todeschini M, Remuzzi G. Combining lisinopril and L-arginine slows disease progression and reduces endothelin-1 in passive Heymann nephritis. Kidney Int 64: 857-863, 2003.
60. Zou AP, Cowley AW. Nitric oxide in renal cortex and medulla. Hypertension 29: 194-198, 1997.